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Controlled antibiotics derived from probiotics have been examined as prospective solutions for preserving seroconversion in NDV-vaccinated fowl. In this study, the secondary metabolite \u201ctelomycin\u201d was extracted from <jats:italic>Streptomyces coeruleorubidus<\/jats:italic> (<jats:italic>S<\/jats:italic>. <jats:italic>coeruleorubidus<\/jats:italic>) isolated from Egypt's cultivated soil. The structure of telomycin was determined by the elucidation of spectroscopic analysis, including nuclear magnetic resonance (NMR) and mass spectrometry (MS) spectra, and comparison with the literature. The antiviral activity of the secondary metabolite was tested by checking its effect on NDV hemagglutination activity (HA). Moreover, HA of NDV was tested after inoculation of NDV (control) and a combination of telomycin and NDV in 10- days- specific pathogen-free embryonated chicken eggs (SPF-ECE) daily candling. Histopathological examination was performed for chorioallantoic membranes and liver of SPF-ECE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>S<\/jats:italic>. <jats:italic>coeruleorubidus<\/jats:italic> secondary metabolite \u201ctelomycin\u201d showed complete hemagglutination inhibition (HI) activity of NDV strain (MN635617) with log10<jats:sup>6<\/jats:sup> infectivity titers (EID50\/mL). The HA of NDV strain was 8 log<jats:sup>2<\/jats:sup> and 9 log<jats:sup>2<\/jats:sup> with 0.5% and 0.75% of chicken RBCs, respectively. Preserved structures of chorioallantoic-membranes (CAM) with dilated capillary networks were observed in the treated group inoculated with telomycin and NDV. Histological changes in SPF-ECE liver were examined after inoculation <jats:italic>in ova<\/jats:italic> to further characterize the telomycin effect. Telomycin and NDV mixture inoculated group showed preserved cytoarchitecture of hepatocytes with the presence of perivascular foci of lymphocytes. The group that was inoculated with telomycin alone showed normal histology of hepatic acini, central veins, and portal triads.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>S<\/jats:italic>. <jats:italic>coeruleorubidus<\/jats:italic> telomycin is a promising bioactive agent that might be a biological weapon against a deadly chicken NDV that costs farmers a lot of money.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-022-03349-7","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T05:02:52Z","timestamp":1656046972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Streptomyces coeruleorubidus as a potential biocontrol agent for Newcastle disease virus"],"prefix":"10.1186","volume":"18","author":[{"given":"Rewan","family":"Abdelaziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine H.","family":"Tartor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed B.","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"EL-Didamony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa A.","family":"El-Samadony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa A.","family":"Amer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Gado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"3349_CR1","unstructured":"Egorov N. 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