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The current study aimed to evaluate the impact of different doses of dexmedetomidine on the motility of selected parts of the gastrointestinal tracts in donkeys using transabdominal ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An experimental crossover study was conducted on 30 healthy donkeys of both sexes (15 males and 15 females; 160\u2009\u00b1\u200960\u2009kg). With a two-week washout period, each donkey received an injection of either a normal saline solution or three different doses of dexmedetomidine (3, 5, and 7\u2009\u03bcg\/kg, respectively). All medications were administered intravenously in equal volumes. The contractility of selected intestinal segments (duodenum, jejunum, left colon, right colon, and cecum) was measured 3 min before administration (zero time) and at 15, 30, 45, 60, 90, and 120\u2009minutes after administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Small and large intestinal motility was within the normal ranges before IV injection of normal isotonic saline or dexmedetomidine at a dose of 3, 5, and 7\u2009\u03bcg\/kg.<\/jats:p><jats:p>Two Way Repeated Measures ANOVA output of the data displayed a statistically significant the between time and treatments for the contractility of each of the duodenum (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0029), jejunum (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0033), left colon (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0073), right colon (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0035), and cecum (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0026), implying that the impact of treatment on the gastric motility varied among different time points. The simple main effect analysis revealed that the IV dexmedetomidine at 3, 5, and 7\u2009\u03bcg\/kg doses significantly inhibited (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.01) the bowel contractility compared to the administration of isotonic saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dose-dependent inhibitory effect of dexmedetomidine on intestinal motility was reported in donkeys following intravenous administration. This inhibitory effect on intestinal motility should be considered in clinical practice<jats:italic>.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-022-03376-4","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T07:02:58Z","timestamp":1657782178000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus)"],"prefix":"10.1186","volume":"18","author":[{"given":"Marwa","family":"Abass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Salci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"3376_CR1","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fvets.2019.00514","volume":"6","author":"C Laurenza","year":"2020","unstructured":"Laurenza C, Ansart L, Portier K. 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