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The trial period lasted for 15\u2009days. On days 12 and 13, pigs in the STa and SG groups were orally administered with the recombinant <jats:italic>Escherichia coli<\/jats:italic> strain, while those in the control group were orally administered with normal saline at the same volume. On day 15, blood, intestinal tissues and colonic contents were collected for further analysis. Results showed that dietary SG supplementation had a tendency to increase average daily gain, and reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) feed to gain ratio, plasma glucose concentration, and mean corpuscular hemoglobin concentration as compared with control group on days 0-10 of trial. Additionally, dietary SG supplementation attenuated(<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the morphological abnormalities of small intestinal and the increase of the number of eosinophils in blood of pigs challenged with the recombinant <jats:italic>Escherichia coli<\/jats:italic> strain on day 15 of trial. Compared with control group, diarrhea rate and the number of eosinophils in blood and the concentrations of malondialdehyde in the jejunum were increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The height, width and surface area of the villi of the duodenum, the width and surface area of villi of jejunum and the height and width of villi of ileum were decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in pigs challenged with the recombinant <jats:italic>Escherichia coli<\/jats:italic> strain in the STa group compared with those in control group on day 15 of trial. However, these adverse effects were ameliorated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) by SG supplementation in the SG group on day 15 of trial. Furthermore, dietary SG supplementation could reduce (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) the total bacterial abundance in the colon, but SG did not restore the recombinant <jats:italic>Escherichia coli<\/jats:italic>-induced microbiota imbalance in colon.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In conclusion, dietary supplementation with SG could improve piglet growth performance and alleviate the recombinant <jats:italic>Escherichia coli<\/jats:italic>-induced intestinal injury, suggesting that SG may be a promising feed additive for swine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-022-03410-5","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T11:03:54Z","timestamp":1659783834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dietary supplementation with sodium gluconate improves the growth performance and intestinal function in weaned pigs challenged with a recombinant Escherichia coli strain"],"prefix":"10.1186","volume":"18","author":[{"given":"Yanyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"3410_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0301-6226(97)00057-2","volume":"51","author":"JR Pluske","year":"1997","unstructured":"Pluske JR, Hampson DJ, Williams IH. 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