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To evaluate the effect of the intra-articular administration of blood cell secretome and triamcinolone, 15 dogs with bilateral hip osteoarthritis were randomly assigned to a blood cell secretome (BCSG,<jats:italic>n<\/jats:italic>\u2009=\u20095), triamcinolone (TG) or their combination group (BCS\u2009+\u2009TG,<jats:italic>n<\/jats:italic>\u2009=\u20095). BCSG received a single intra-articular administration of 3\u00a0ml of blood cell secretome, TG 0.5\u00a0ml of triamcinolone acetonide 40\u00a0mg\/ml, and BCS\u2009+\u2009TG received the combined products. The volume to administrate was corrected to 3.5\u00a0ml with saline. On days 0, 8, 15, 30, 60, 90, 120, 150, and 180, a copy of the Canine Brief Pain Inventory (divided into pain interference score\u2014PIS and Pain Severity Score\u2014PSS), Liverpool Osteoarthritis in Dogs (LOAD), Hudson Visual Analogue Scale (HVAS), and Canine Orthopedic Index (COI, divided into function, gait, stiffness, and quality of life) was completed. Results were analyzed with the Kruskal\u2013Wallis test and the Kaplan\u2013Meier estimators were conducted and compared with the Log Rank test,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Animals in the sample had a mean age of 9.0\u2009\u00b1\u20092.9\u00a0years and a bodyweight of 28.8\u2009\u00b1\u20094.1\u00a0kg. Hips were classified as moderate (8) and severe (7) osteoarthritis. No differences were found between groups at T0 regarding considered evaluations. Significant differences were observed between groups in pain scores from\u2009+\u20098d-\u2009+\u2009150d, with BCS\u2009+\u2009TG exhibiting better results. The same was observed for HVAS and LOAD, from\u2009+\u20098d-\u2009+\u2009120d. Improvements were also observed in several dimensions of the COI. Kaplan\u2013Meier estimators showed that BCS\u2009+\u2009TG produced longer periods with better results, followed by BCSG and TG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intra-articular administration of blood cell secretome improved the clinical signs and scores of several clinical metrology instruments in dogs with hip OA, particularly when combined with triamcinolone. Further studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-022-03413-2","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:02:46Z","timestamp":1660356166000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis"],"prefix":"10.1186","volume":"18","author":[{"given":"J. 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