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Considering the increasing interest in rabbits as pets and the limited literature available on domestic rabbit tearing, the aim of this study was to establish normative data for examination of the tear film in domestic rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 75 client-owned domestic Holland Lop rabbits (150 eyes). The following examinations were performed in each eye: Schirmer tear test-1, tear osmometry, interferometry, tear meniscus height measurement and meibography (quantifying meibomian gland loss as a percentage). The resulting median (95% central range) values were 10.0 (5.0\u201317.3) mm\/min for the Schirmer tear test-1, 345.0 (280.5\u2013376.1) mOsm\/L for tear osmolarity, grade 2 (1\u20134) of interferometry, 0.28 (0.20\u20130.47) mm for tear meniscus height and 0.0 (0.0\u201367.6) % meibomian gland loss. A significant association was found between tear osmolarity and age, with an estimated decrease of \u2212\u20094.0\u2009mOsm\/L with each additional year of age (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). The distributions of interferometry grades were significantly different between males and females (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), with grade 1 and grade 2 being the most frequent in females and males, respectively. A weak negative correlation was also observed between interferometry grade and the percentage of meibomian gland loss (<jats:italic>r<\/jats:italic>\u00a0=\u2009\u2212\u20090.22,<jats:italic>p<\/jats:italic>\u00a0=\u20090.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is an original study that documents extensive tear film parameters in healthy Holland Lop rabbits. The results can be used as normative data for the examination of the tear film in this lagomorph breed.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12917-022-03492-1","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T04:29:27Z","timestamp":1668227367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical parameters obtained during tear film examination in domestic rabbits"],"prefix":"10.1186","volume":"18","author":[{"given":"Francesca","family":"Corsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Arteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Corsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Masi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Selleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Crasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Peruccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Guandalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"issue":"4","key":"3492_CR1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/00003226-200405000-00015","volume":"23","author":"S Nakamura","year":"2004","unstructured":"Nakamura S, Okada S, Umeda Y, Saito F. 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Furthermore, ethical approval under Directive 2010\/63\/EU was deemed unnecessary since the study applied minimally or noninvasive examinations and diagnostic tools, falling under the scope of Article 1 paragraph\u00a05(f) of the same Directive. Informed consent was obtained from all owners.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"398"}}