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The bone infection is usually caused by invasion of pathogen through the hematologic route. Mixed osteomyelitis caused by bacteria and fungi is rare, and to date, there have been no reports of mixed osteomyelitis with <jats:italic>Staphylococcus<\/jats:italic> spp. and <jats:italic>Microsporum canis<\/jats:italic>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>This essay reports an atypical presentation of mixed osteomyelitis (<jats:italic>Staphylococcus<\/jats:italic> spp. and <jats:italic>Microsporum canis<\/jats:italic>) in a domestic cat. A 15-month-old female Persian cat was presented to a veterinary service; the main complaint was the appearance of a nodule in the mandibular ventral rostral region. A radiographic exam performed on the animal showed proliferative and osteolytic bone lesions. The patient was submitted to a biopsy for histopathological evaluation, along with bacterial and fungal cultures. Results showed mixed osteomyelitis by <jats:italic>Staphylococcus<\/jats:italic> spp. and <jats:italic>Microsporum canis<\/jats:italic>. Microbial Sensitivity Test was performed to choose a more suitable treatment. Two surgical procedures were executed to resect and curette the lesion, and treatments with anti-inflammatory, antibiotic, and antifungal drugs were established, showing a positive clinical evolution. After 8 months of treatment, the patient\u2019s owner moved to a different city, and the animal was seen by other veterinarians, who followed along with the same treatment. However, due to complications and a diminishing quality of life over 4 years of diagnosis, the patient was euthanized.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Given the above, mixed osteomyelitis is difficult to treat and can cause losses of life quality resulting death, especially in infections where <jats:italic>M. canis<\/jats:italic> is the agent causing the disease. Bacterial osteomyelitis is more frequently reported. But the lack of investigation of microorganisms other than bacteria, such as fungal cases, may imply in underdiagnosed cases. Treatment of osteomyelitis can be difficult considering the difficulties in isolating the pathological agent, resistance to the drug used, prolonged treatment time, and cost.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-024-03904-4","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:02:47Z","timestamp":1708326167000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Osteomyelitis by Microsporum canis and Staphylococcus spp. in cat (Felis catus) \u2013 case report"],"prefix":"10.1186","volume":"20","author":[{"given":"Fernanda O.","family":"Soares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel R.","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V. 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All images used (Figs.\u00a0InternalRef removed and InternalRef removed) in the manuscript are images created by the authors during the diagnosis process.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}