{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:13:00Z","timestamp":1790737980317,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800804"],"award-info":[{"award-number":["2022YFD1800804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"Start-up Research Project of Maoming Laboratory","award":["2021TDQD002"],"award-info":[{"award-number":["2021TDQD002"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["cars-35"],"award-info":[{"award-number":["cars-35"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Porcine acute diarrhea syndrome coronavirus (SADS-CoV) is one of the novel pathogens responsible for piglet diarrhea, contributing to substantial economic losses in the farming sector. The broad host range of SADS-CoV raises concerns regarding its potential for cross-species transmission. Currently, there are no effective means of preventing or treating SADS-CoV infection, underscoring the urgent need for identifying efficient antiviral drugs. This study focuses on evaluating quercetin as an antiviral agent against SADS-CoV.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In vitro experiments showed that quercetin inhibited SADS-CoV proliferation in a concentration-dependent manner, targeting the adsorption and replication stages of the viral life cycle. Furthermore, quercetin disrupts the regulation of the P53 gene by the virus and inhibits host cell cycle progression induced by SADS-CoV infection. In vivo experiments revealed that quercetin effectively alleviated the clinical symptoms and intestinal pathological damage caused by SADS-CoV-infected piglets, leading to reduced expression levels of inflammatory factors such as TLR3, IL-6, IL-8, and TNF-\u03b1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Therefore, this study provides compelling evidence that quercetin has great potential and promising applications for anti- SADS-CoV action.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-024-03984-2","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:01:48Z","timestamp":1712124108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quercetin inhibition of porcine intestinal alpha coronavirus in vitro and in vivo"],"prefix":"10.1186","volume":"20","author":[{"given":"Yongzhi","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyou","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"9","key":"3984_CR1","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.3201\/eid2309.170915","volume":"23","author":"L Gong","year":"2017","unstructured":"Gong L, Li J, Zhou Q, Xu Z, Chen L, Zhang Y, Xue C, Wen Z, Cao Y. A new Bat-HKU2-like Coronavirus in Swine, China, 2017. EMERG INFECT DIS. 2017;23(9):1607\u20139.","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"3984_CR2","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1111\/tbed.13270","volume":"66","author":"L Zhou","year":"2019","unstructured":"Zhou L, Li QN, Su JN, Chen GH, Wu ZX, Luo Y, Wu RT, Sun Y, Lan T, Ma JY. The re-emerging of SADS-CoV infection in pig herds in Southern China. Transbound Emerg Dis. 2019;66(5):2180\u20133.","journal-title":"TRANSBOUND EMERG DIS"},{"issue":"4","key":"3984_CR3","doi-asserted-by":"publisher","first-page":"e0021023","DOI":"10.1128\/jvi.00210-23","volume":"97","author":"XN Chen","year":"2023","unstructured":"Chen XN, Liang YF, Weng ZJ, Quan WP, Hu C, Peng YZ, Sun YS, Gao Q, Huang Z, Zhang GH, et al. Porcine enteric Alphacoronavirus Entry through multiple pathways (Caveolae, Clathrin, and macropinocytosis) requires Rab GTPases for Endosomal Transport. J VIROL. 2023;97(4):e0021023.","journal-title":"J VIROL"},{"issue":"1\u20132","key":"3984_CR4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.virusres.2007.10.015","volume":"132","author":"DJ Cruz","year":"2008","unstructured":"Cruz DJ, Kim CJ, Shin HJ. The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize porcine epidemic diarrhea virus. VIRUS RES. 2008;132(1\u20132):192\u20136.","journal-title":"VIRUS RES"},{"issue":"7700","key":"3984_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41586-018-0010-9","volume":"556","author":"P Zhou","year":"2018","unstructured":"Zhou P, Fan H, Lan T, Yang XL, Shi WF, Zhang W, Zhu Y, Zhang YW, Xie QM, Mani S, et al. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. Nature. 2018;556(7700):255\u20138.","journal-title":"Nature"},{"key":"3984_CR6","doi-asserted-by":"crossref","unstructured":"Gao Q, Feng Y, Gong T, Wu D, Zheng X, Luo Y, Yang Y, Song Z, Gong L, Zhang G. Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication1. J Integr Agr 2023.","DOI":"10.1016\/j.jia.2023.10.010"},{"key":"3984_CR7","doi-asserted-by":"publisher","first-page":"978453","DOI":"10.3389\/fvets.2022.978453","volume":"9","author":"S Zheng","year":"2022","unstructured":"Zheng S, Wang X, Hu H, Xia Y, Diao X, Qiu W, Xue C, Cao Y, Xu Z. Emodin from Aloe inhibits swine acute diarrhea syndrome coronavirus in cell culture. Front Vet Sci. 2022;9:978453.","journal-title":"FRONT VET SCI"},{"key":"3984_CR8","doi-asserted-by":"crossref","unstructured":"Chen Y, You Y, Wang S, Jiang L, Tian L, Zhu S, An X, Song L, Tong Y, Fan H. Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus. Int J Mol Sci 2022, 23(19).","DOI":"10.3390\/ijms231911250"},{"key":"3984_CR9","doi-asserted-by":"crossref","unstructured":"Liu DL, Liu SJ, Hu SQ, Chen YC, Guo J. Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation. Int J Mol Sci 2022, 23(19).","DOI":"10.3390\/ijms231911163"},{"issue":"7","key":"3984_CR10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/j.1753-4887.2010.00301.x","volume":"68","author":"AJ Vargas","year":"2010","unstructured":"Vargas AJ, Burd R. Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. NUTR REV. 2010;68(7):418\u201328.","journal-title":"NUTR REV"},{"issue":"1","key":"3984_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/ptr.7309","volume":"36","author":"A Di Petrillo","year":"2022","unstructured":"Di Petrillo A, Orru G, Fais A, Fantini MC. Quercetin and its derivates as antiviral potentials: a comprehensive review. PHYTOTHER RES. 2022;36(1):266\u201378.","journal-title":"PHYTOTHER RES"},{"issue":"1","key":"3984_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0003-9861(03)00284-4","volume":"417","author":"K Murota","year":"2003","unstructured":"Murota K, Terao J. Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. ARCH BIOCHEM BIOPHYS. 2003;417(1):12\u20137.","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"3984_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/cdd.2017.172","volume":"25","author":"K Engeland","year":"2018","unstructured":"Engeland K. Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM. CELL DEATH DIFFER. 2018;25(1):114\u201332.","journal-title":"Cell Death Differ"},{"key":"3984_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.virusres.2018.09.012","volume":"257","author":"C Huo","year":"2018","unstructured":"Huo C, Jin Y, Zou S, Qi P, Xiao J, Tian H, Wang M, Hu Y. Lethal influenza A virus preferentially activates TLR3 and triggers a severe inflammatory response. VIRUS RES. 2018;257:102\u201312.","journal-title":"VIRUS RES"},{"key":"3984_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13020-019-0270-9","volume":"14","author":"H Luo","year":"2019","unstructured":"Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, Zhao M, Liu Q, Cheng Z, Zou J, et al. Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. CHIN MED-UK. 2019;14:48.","journal-title":"CHIN MED-UK"},{"issue":"2","key":"3984_CR16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s11756-021-00937-0","volume":"77","author":"J Bai","year":"2022","unstructured":"Bai J, Li Y. Effects of Chinese herbal medicines on the productive performance, nutrient retention, egg quality, immune function of laying hens. BIOLOGIA. 2022;77(2):385\u201393.","journal-title":"BIOLOGIA"},{"issue":"5","key":"3984_CR17","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/J.ENG.2017.03.017","volume":"3","author":"H Pu","year":"2017","unstructured":"Pu H, Li X, Du Q, Cui H, Xu Y. Research Progress in the application of Chinese Herbal Medicines in aquaculture: a review. Engineering. 2017;3(5):731\u20137.","journal-title":"Engineering"},{"issue":"10","key":"3984_CR18","doi-asserted-by":"publisher","first-page":"102986","DOI":"10.1016\/j.psj.2023.102986","volume":"102","author":"W Song","year":"2023","unstructured":"Song W, Zou Z, Chen X, Tan J, Liu L, Wei Q, Xiong P, Song Q, Chen J, Su W, et al. Effects of traditional Chinese herbal feed supplement on growth performance, immunity, antioxidant levels, and intestinal health in chickens: a study on Ningdu yellow chickens. Poult Sci. 2023;102(10):102986.","journal-title":"Poult Sci"},{"key":"3984_CR19","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.coviro.2021.08.003","volume":"50","author":"PE Jones","year":"2021","unstructured":"Jones PE, Perez-Segura C, Bryer AJ, Perilla JR, Hadden-Perilla JA. Molecular dynamics of the viral life cycle: progress and prospects. CURR OPIN VIROL. 2021;50:128\u201338.","journal-title":"CURR OPIN VIROL"},{"issue":"6","key":"3984_CR20","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/mmi.14907","volume":"117","author":"K Prydz","year":"2022","unstructured":"Prydz K, Saraste J. The life cycle and enigmatic egress of coronaviruses. MOL MICROBIOL. 2022;117(6):1308\u201316.","journal-title":"MOL MICROBIOL"},{"key":"3984_CR21","doi-asserted-by":"publisher","first-page":"1112610","DOI":"10.3389\/fphar.2023.1112610","volume":"14","author":"H Rao","year":"2023","unstructured":"Rao H, Su W, Zhang X, Wang Y, Li T, Li J, Zeng X, Li P. Hypericum japonicum extract inhibited porcine epidemic diarrhea virus in vitro and in vivo. FRONT PHARMACOL. 2023;14:1112610.","journal-title":"FRONT PHARMACOL"},{"key":"3984_CR22","doi-asserted-by":"crossref","unstructured":"Hu J, Li C, Zhou Y, Ding J, Li X, Li Y. Allicin inhibits Porcine Reproductive and respiratory syndrome virus infection in Vitro and alleviates inflammatory responses. VIRUSES-BASEL 2023, 15(5).","DOI":"10.3390\/v15051050"},{"key":"3984_CR23","doi-asserted-by":"crossref","unstructured":"Xu Z, Huang M, Xia Y, Peng P, Zhang Y, Zheng S, Wang X, Xue C, Cao Y. Emodin from Aloe Inhibits Porcine Reproductive and Respiratory Syndrome Virus via Toll-Like Receptor 3 Activation. VIRUSES-BASEL 2021, 13(7).","DOI":"10.3390\/v13071243"},{"key":"3984_CR24","doi-asserted-by":"publisher","first-page":"736780","DOI":"10.3389\/fmicb.2021.736780","volume":"12","author":"E Arabyan","year":"2021","unstructured":"Arabyan E, Hakobyan A, Hakobyan T, Grigoryan R, Izmailyan R, Avetisyan A, Karalyan Z, Jackman JA, Ferreira F, Elrod CC, et al. Flavonoid Library Screening reveals Kaempferol as a potential antiviral Agent against African Swine Fever Virus. FRONT MICROBIOL. 2021;12:736780.","journal-title":"FRONT MICROBIOL"},{"key":"3984_CR25","doi-asserted-by":"publisher","first-page":"1121830","DOI":"10.3389\/fmicb.2023.1121830","volume":"14","author":"G Lee","year":"2023","unstructured":"Lee G, Kang HR, Kim A, Park JH, Lee MJ, Kim SM. Preventive effects of quercetin against foot-and-mouth disease virus in vitro and in vivo by inducing type I interferon. FRONT MICROBIOL. 2023;14:1121830.","journal-title":"FRONT MICROBIOL"},{"key":"3984_CR26","doi-asserted-by":"publisher","first-page":"31777","DOI":"10.1038\/srep31777","volume":"6","author":"A Rojas","year":"2016","unstructured":"Rojas A, Del CJ, Clement S, Lemasson M, Garcia-Valdecasas M, Gil-Gomez A, Ranchal I, Bartosch B, Bautista JD, Rosenberg AR, et al. Effect of Quercetin on Hepatitis C Virus Life cycle: from viral to host targets. SCI REP-UK. 2016;6:31777.","journal-title":"SCI REP-UK"},{"key":"3984_CR27","doi-asserted-by":"crossref","unstructured":"Chen N, Liu Y, Bai T, Chen J, Zhao Z, Li J, Shao B, Zhang Z, Zhou Y, Wang X et al. Quercetin inhibits Hsp70 blocking of bovine viral diarrhea virus infection and replication in the early stage of virus infection. VIRUSES-BASEL 2022, 14(11).","DOI":"10.3390\/v14112365"},{"issue":"5","key":"3984_CR28","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/med.21664","volume":"40","author":"X Ji","year":"2020","unstructured":"Ji X, Li Z. Medicinal chemistry strategies toward host targeting antiviral agents. MED RES REV. 2020;40(5):1519\u201357.","journal-title":"MED RES REV"},{"key":"3984_CR29","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.3389\/fmicb.2019.01853","volume":"10","author":"P de Leon","year":"2019","unstructured":"de Leon P, Bustos MJ, Torres E, Canas-Arranz R, Sobrino F, Carrascosa AL. Inhibition of Porcine viruses by different cell-targeted antiviral drugs. FRONT MICROBIOL. 2019;10:1853.","journal-title":"FRONT MICROBIOL"},{"key":"3984_CR30","first-page":"356494083","volume":"35","author":"S Kausar","year":"2021","unstructured":"Kausar S, Said KF, Ishaq MURM, Akram M, Riaz M, Rasool G, Hamid KA, Saleem I, Shamim S, Malik A. A review: mechanism of action of antiviral drugs. INT J IMMUNOPATH PH. 2021;35:356494083.","journal-title":"INT J IMMUNOPATH PH"},{"key":"3984_CR31","doi-asserted-by":"crossref","unstructured":"D\u2019Orazi G. Recent Advances in p53. BIOMOLECULES 2021, 11(2).","DOI":"10.3390\/biom11020211"},{"issue":"6","key":"3984_CR32","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","volume":"170","author":"ER Kastenhuber","year":"2017","unstructured":"Kastenhuber ER, Lowe SW. Putting p53 in Context. Cell. 2017;170(6):1062\u201378.","journal-title":"Cell"},{"issue":"3","key":"3984_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1046\/j.1365-2184.2003.00266.x","volume":"36","author":"K Vermeulen","year":"2003","unstructured":"Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. CELL PROLIFERAT. 2003;36(3):131\u201349.","journal-title":"CELL PROLIFERAT"},{"issue":"34","key":"3984_CR34","doi-asserted-by":"publisher","first-page":"55938","DOI":"10.18632\/oncotarget.18997","volume":"8","author":"P Ning","year":"2017","unstructured":"Ning P, Hu C, Li X, Zhou Y, Hu A, Zhang Y, Gao L, Gong C, Guo K, Zhang X, et al. Classical swine fever virus Shimen infection increases p53 signaling to promote cell cycle arrest in porcine alveolar macrophages. Oncotarget. 2017;8(34):55938\u201349.","journal-title":"Oncotarget"},{"issue":"20","key":"3984_CR35","doi-asserted-by":"publisher","first-page":"10727","DOI":"10.1128\/JVI.00122-10","volume":"84","author":"G Rohaly","year":"2010","unstructured":"Rohaly G, Korf K, Dehde S, Dornreiter I. Simian virus 40 activates ATR-Delta p53 signaling to override cell cycle and DNA replication control. J VIROL. 2010;84(20):10727\u201347.","journal-title":"J VIROL"},{"issue":"1","key":"3984_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13567-016-0403-4","volume":"47","author":"D Xu","year":"2016","unstructured":"Xu D, Du Q, Han C, Wang Z, Zhang X, Wang T, Zhao X, Huang Y, Tong D. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. VET RES. 2016;47(1):120.","journal-title":"VET RES"}],"updated-by":[{"DOI":"10.1186\/s12917-024-04031-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000}}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-024-03984-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-024-03984-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-024-03984-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T06:05:43Z","timestamp":1714457143000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-024-03984-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3984"],"URL":"https:\/\/doi.org\/10.1186\/s12917-024-03984-2","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12917-024-04031-w","asserted-by":"object"}]},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"15 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12917-024-04031-w","URL":"https:\/\/doi.org\/10.1186\/s12917-024-04031-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics"}},{"value":"Animal experiments were approved by the Ethics Committee for Animal Experiments of South China Agricultural University (Certificate No. 2023C007). All methods were carried out in accordance with relevant guidelines and regulations of National Institutes of Health, and reported in accordance with ARRIVE guidelines for the reporting of animal experiments. Animal\u2019 owners gave written informed consent to permit us to do this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"134"}}