{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:22:30Z","timestamp":1762273350248},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009169","name":"Assiut University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009169","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal uterine bleeding and endometriosis. There is a lack of detailed histological information regarding the effects of NETA on the uterine structure. So, the present study focuses on the uterine histological, histochemical and ultrastructure changes following the exposure to NETA in the albino rats. To do this aim, fourteen adult female albino rats were used. They were randomly divided into two equally groups: Control group and NETA treated group. Albino rats of control group were administered daily food, water and orally distilled water only, while rats of NETA treated group were administered daily orally 20\u00a0\u00b5g of NETA dissolved in 2\u00a0ml distilled water, food, and water. The experiment was continued for three weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The findings of the present work indicated that the use of NETA has negative effects on the endometrial epithelium (proliferation, autophagy and apoptosis), glands (necrotic, apoptotic or pseudosecretory glands) and stromal and myometrial reactions (granulocytes, connective tissue remodeling, apoptosis, myocytes hypertrophy).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This work revealed that NETA has desynchronized progestogenic effect on the uterine tissues of the albino rat and thereby prevent implantation and pregnancy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12917-024-04219-0","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T11:03:38Z","timestamp":1724929418000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study"],"prefix":"10.1186","volume":"20","author":[{"given":"Mahmoud","family":"Abd-Elkareem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman Mohammed","family":"Alnasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alotaibi","family":"Meshal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghda Ismail","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed U.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"4219_CR1","volume-title":"Progestin","author":"M Edwards","year":"2023","unstructured":"Edwards M, Can AS. In: StatPearls, editor. Progestin. Treasure Island (FL): StatPearls Publishing; 2023."},{"key":"4219_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2006.01.021","volume":"112","author":"J-W Yoo","year":"2006","unstructured":"Yoo J-W, Lee CH. Drug delivery systems for hormone therapy. J Controlled Release. 2006;112:1\u201314.","journal-title":"J Controlled Release"},{"key":"4219_CR3","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1080\/17512433.2020.1821649","volume":"13","author":"C Bastianelli","year":"2020","unstructured":"Bastianelli C, Farris M, Bruni V, Rosato E, Brosens I, Benagiano G. Effects of progestin-only contraceptives on the endometrium. Expert Rev Clin Pharmacol. 2020;13:1103\u201323.","journal-title":"Expert Rev Clin Pharmacol"},{"key":"4219_CR4","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/S0002-9378(99)70120-1","volume":"181","author":"R Rivera","year":"1999","unstructured":"Rivera R, Yacobson I, Grimes D. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol. 1999;181:1263\u20139.","journal-title":"Am J Obstet Gynecol"},{"key":"4219_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/bmjsrh-2020-200619","volume":"47","author":"E Huvinen","year":"2021","unstructured":"Huvinen E, Holopainen E, Heikinheimo O. Norethisterone and its acetate - what\u2019s so special about them? BMJ Sex Reprod Health. 2021;47:102\u20139.","journal-title":"BMJ Sex Reprod Health"},{"issue":"Suppl 1","key":"4219_CR6","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/j.maturitas.2003.09.014","volume":"46","author":"AE Schindler","year":"2003","unstructured":"Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, et al. Classification and pharmacology of progestins. Maturitas. 2003;46(Suppl 1):S7\u201316.","journal-title":"Maturitas"},{"key":"4219_CR7","first-page":"1","volume-title":"xPharm: the Comprehensive Pharmacology Reference","author":"K Marshall","year":"2007","unstructured":"Marshall K. Norethisterone. In: Enna SJ, Bylund DB, editors. xPharm: the Comprehensive Pharmacology Reference. New York: Elsevier; 2007. pp. 1\u20136."},{"key":"4219_CR8","doi-asserted-by":"crossref","unstructured":"Abdullah RI, Abd-Elkareem M, Abou-Elmagd Ahmed A, Sotohy SA. The effect of Norethisterone acetate (NETA) on the ovarian follicles of albino rats: histological study. New Val Vet J. 2024;4.","DOI":"10.21608\/nvvj.2023.227602.1034"},{"key":"4219_CR9","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0010-7824(88)90022-4","volume":"37","author":"T Bhowmik","year":"1988","unstructured":"Bhowmik T, Mukherjea M. Histological changes in the ovary and uterus of rat after injectable contraceptive therapy. Contraception. 1988;37:529\u201338.","journal-title":"Contraception"},{"key":"4219_CR10","first-page":"2073","volume":"65","author":"S Schrager","year":"2002","unstructured":"Schrager S. Abnormal uterine bleeding Associated with Hormonal Contraception. Am Fam Physician. 2002;65:2073\u201381.","journal-title":"Am Fam Physician"},{"key":"4219_CR11","doi-asserted-by":"crossref","unstructured":"Michel KG, Huijbregts RPH, Gleason JL, Richter HE, Hel Z. Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract. J Acquir Immune Defic Syndr. 1999. 2015;68:511\u20138.","DOI":"10.1097\/QAI.0000000000000531"},{"key":"4219_CR12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.13005\/bbra\/3115","volume":"20","author":"MIA Kader","year":"2023","unstructured":"Kader MIA, Karthikeyan V. A comparative study on efficacy of Norethisterone and Medroxyprogestrone in the management of dysfunctional uterine bleeding: a prospective observational study. Biosci Biotechnol Res Asia. 2023;20:617\u201325.","journal-title":"Biosci Biotechnol Res Asia"},{"key":"4219_CR13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/17425255.2018.1461840","volume":"14","author":"F Barra","year":"2018","unstructured":"Barra F, Scala C, Ferrero S. Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis. Expert Opin Drug Metab Toxicol. 2018;14:399\u2013415.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4219_CR14","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1093\/humrep\/14.9.2200","volume":"14","author":"G No\u00e9","year":"1999","unstructured":"No\u00e9 G, Suvisaari J, Martin C, Moo-Young AJ, Sundaram K, Saleh SI, et al. Gonadotrophin and testosterone suppression by 7alpha-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men. Hum Reprod Oxf Engl. 1999;14:2200\u20136.","journal-title":"Hum Reprod Oxf Engl"},{"key":"4219_CR15","unstructured":"Bancroft JD, Gamble M. Theory and Practice of Histological Techniques. 6th edition. Philadelphia, Pa: Churchill Livingstone; 2007."},{"key":"4219_CR16","first-page":"54","volume":"4","author":"MHA Kotob","year":"2021","unstructured":"Kotob MHA, Hussein A, Abd-Elkareem M. Histopathological changes of kidney tissue during aging. SVU-Int J Vet Sci. 2021;4:54\u201365.","journal-title":"SVU-Int J Vet Sci"},{"key":"4219_CR17","first-page":"73","volume":"12","author":"OH Hosny","year":"2022","unstructured":"Hosny OH, Abd-Elkareem M, Ali MM, Ahmed AF. Effect of autologous serum derived from Advanced platelet-rich fibrin on the Healing of experimentally-induced corneal Ulcer in donkeys (Equus asinus). J Adv Vet Res. 2022;12:73\u201385.","journal-title":"J Adv Vet Res"},{"key":"4219_CR18","unstructured":"Kani ZFA, Nasiri S, Rafiei R, Younespour S. Evaluation of Elastic fibers pattern with Orcein Staining in Differential diagnosis of Lichen Planopilaris and Discoid Lupus Erythematosus. Acta Med Iran. 2014;:220\u20137."},{"key":"4219_CR19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.anireprosci.2017.03.007","volume":"180","author":"M Abd-Elkareem","year":"2017","unstructured":"Abd-Elkareem M. Cell-specific immuno-localization of progesterone receptor alpha in the rabbit ovary during pregnancy and after parturition. Anim Reprod Sci. 2017;180:100\u201320.","journal-title":"Anim Reprod Sci"},{"key":"4219_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12917-024-03933-z","volume":"20","author":"M Abd-Elkareem","year":"2024","unstructured":"Abd-Elkareem M, Khormi MA, Mohamed RH, Ali F, Hassan MS. Histological, immunohistochemical and serological investigations of the ovary during follicular phase of estrous cycle in Saidi sheep. BMC Vet Res. 2024;20:98.","journal-title":"BMC Vet Res"},{"key":"4219_CR21","doi-asserted-by":"crossref","unstructured":"Abd-Elkareem M, AbouKhalil NS, Sayed AE-DH. Cytoprotective effect of Nigella sativa seed on 4-nonylphenol-induced renal damage in the African catfish (Clarias gariepinus). Chemosphere. 2020;:127379.","DOI":"10.1016\/j.chemosphere.2020.127379"},{"key":"4219_CR22","doi-asserted-by":"crossref","unstructured":"Ullah MI, Akhtar M, Iqbal Z, Shahid M, Awais MM. Immunomodulating and Antiprotozoal effects of different extracts of the Oyster Culinary-Medicinal mushroom Pleurotus Ostreatus (higher Basidiomycetes) against coccidiosis in Broiler. Int J Med Mushrooms. 2015;17.","DOI":"10.1615\/IntJMedMushrooms.v17.i3.100"},{"key":"4219_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40738-020-00074-3","volume":"6","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE. Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fertil Res Pract. 2020;6:5.","journal-title":"Fertil Res Pract"},{"key":"4219_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1177\/0192623308315665","volume":"36","author":"FR Westwood","year":"2008","unstructured":"Westwood FR. The Female Rat Reproductive cycle: a practical histological guide to staging. Toxicol Pathol. 2008;36:375\u201384.","journal-title":"Toxicol Pathol"},{"key":"4219_CR25","doi-asserted-by":"crossref","unstructured":"Dinh A, Sriprasert I, Williams AR, Archer DF. A review of the endometrial histologic effects of progestins and progesterone receptor modulators in reproductive age women. 2015.","DOI":"10.1016\/j.contraception.2015.01.008"},{"key":"4219_CR26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12958-021-00729-w","volume":"19","author":"HCM Allaway","year":"2021","unstructured":"Allaway HCM, Pierson RA, Invik J, Bloomfield SA. A rodent model of human dose-equivalent progestin-only implantable contraception. Reprod Biol Endocrinol. 2021;19:47.","journal-title":"Reprod Biol Endocrinol"},{"key":"4219_CR27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/actp.1984.010350105","volume":"35","author":"BR Maiti","year":"1984","unstructured":"Maiti BR, Sahu A. Effect of long-term administration of norethisterone (a progestogen-only contraceptive) on the female genital tract of the albino rat. Acta Physiol Pol. 1984;35:23\u201333.","journal-title":"Acta Physiol Pol"},{"key":"4219_CR28","doi-asserted-by":"publisher","first-page":"80","DOI":"10.21608\/ejhm.2006.18030","volume":"22","author":"AM Hassan","year":"2006","unstructured":"Hassan AM, Naim MM, Mahmoud SH, Badr FM. Effect of Monthly Injectable Contraceptive (Mesigyna) on the Uterus of adult female albino rat: histological and immunohistochemical study. Egypt J Hosp Med. 2006;22:80\u201397.","journal-title":"Egypt J Hosp Med"},{"key":"4219_CR29","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1095\/biolreprod.111.091470","volume":"85","author":"CA Stewart","year":"2011","unstructured":"Stewart CA, Fisher SJ, Wang Y, Stewart MD, Hewitt SC, Rodriguez KF, et al. Uterine gland formation in mice is a continuous process, requiring the Ovary after Puberty, but not after parturition. Biol Reprod. 2011;85:954\u201364.","journal-title":"Biol Reprod"},{"key":"4219_CR30","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/molehr\/gat031","volume":"19","author":"PS Cooke","year":"2013","unstructured":"Cooke PS, Spencer TE, Bartol FF, Hayashi K. Uterine glands: development, function and experimental model systems. Mol Hum Reprod. 2013;19:547\u201358.","journal-title":"Mol Hum Reprod"},{"key":"4219_CR31","first-page":"94","volume":"6","author":"L Deligdisch","year":"1993","unstructured":"Deligdisch L. Effects of hormone therapy on the endometrium. Mod Pathol off J U S Can Acad Pathol Inc. 1993;6:94\u2013106.","journal-title":"Mod Pathol off J U S Can Acad Pathol Inc"},{"key":"4219_CR32","first-page":"285","volume":"13","author":"L Deligdisch","year":"2000","unstructured":"Deligdisch L. Hormonal pathology of the endometrium. Mod Pathol off J U S Can Acad Pathol Inc. 2000;13:285\u201394.","journal-title":"Mod Pathol off J U S Can Acad Pathol Inc"},{"key":"4219_CR33","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1210\/en.2005-1555","volume":"147","author":"Q Zhang","year":"2006","unstructured":"Zhang Q, Paria BC. Importance of Uterine Cell Death, Renewal, and their hormonal regulation in Hamsters that show progesterone-dependent implantation. Endocrinology. 2006;147:2215\u201327.","journal-title":"Endocrinology"},{"key":"4219_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/(SICI)1097-0185(199705)248:1<76::AID-AR9>3.0.CO;2-D","volume":"248","author":"T Sato","year":"1997","unstructured":"Sato T, Fukazawa Y, Kojima H, Enari M, Iguchi T, Ohta Y. Apoptotic cell death during the estrous cycle in the rat uterus and vagina. Anat Rec. 1997;248:76\u201383.","journal-title":"Anat Rec"},{"key":"4219_CR35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/978-1-4612-1944-6_5","volume-title":"Cell death in Reproductive Physiology","author":"BC Moulton","year":"1997","unstructured":"Moulton BC, Akcali KC, Ogle TF, Brown TL, Motz J, Khan SA. Control of apoptosis in the Uterus during Decidualization. In: Tilly JL, Strauss JF, Tenniswood M, editors. Cell death in Reproductive Physiology. New York, NY: Springer; 1997. pp. 48\u201366."},{"issue":"70","key":"4219_CR36","first-page":"1","volume":"86","author":"J Choi","year":"2012","unstructured":"Choi J, Jo M, Lee E, Oh YK, Choi D. The role of Autophagy in Human Endometrium1. Biol Reprod. 2012;86(70):1\u201310.","journal-title":"Biol Reprod"},{"key":"4219_CR37","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.7150\/thno.55241","volume":"11","author":"H-H Shen","year":"2021","unstructured":"Shen H-H, Zhang T, Yang H-L, Lai Z-Z, Zhou W-J, Mei J, et al. Ovarian hormones-autophagy-immunity axis in menstruation and endometriosis. Theranostics. 2021;11:3512\u201326.","journal-title":"Theranostics"},{"key":"4219_CR38","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.7150\/jca.31742","volume":"10","author":"S Yang","year":"2019","unstructured":"Yang S, Wang H, Li D, Li M. Role of endometrial autophagy in physiological and pathophysiological processes. J Cancer. 2019;10:3459\u201371.","journal-title":"J Cancer"},{"key":"4219_CR39","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1080\/15548627.2020.1752548","volume":"17","author":"L Devis-Jauregui","year":"2021","unstructured":"Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Nav\u00e0s D. Autophagy in the physiological endometrium and cancer. Autophagy. 2021;17:1077\u201395.","journal-title":"Autophagy"},{"key":"4219_CR40","doi-asserted-by":"publisher","first-page":"e202201159","DOI":"10.1083\/jcb.202201159","volume":"221","author":"E Eskandari","year":"2022","unstructured":"Eskandari E, Eaves CJ. Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis. J Cell Biol. 2022;221:e202201159.","journal-title":"J Cell Biol"},{"key":"4219_CR41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"AG Porter","year":"1999","unstructured":"Porter AG, J\u00e4nicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999;6:99\u2013104.","journal-title":"Cell Death Differ"},{"key":"4219_CR42","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1023\/A:1004069731540","volume":"32","author":"W Tassell","year":"2000","unstructured":"Tassell W, Slater M, Barden JA, Murphy CR. Endometrial cell death during early pregnancy in the rat. Histochem J. 2000;32:373\u20139.","journal-title":"Histochem J"},{"key":"4219_CR43","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1038\/sj.cdd.4402148","volume":"14","author":"L Galluzzi","year":"2007","unstructured":"Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L, et al. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 2007;14:1237\u201343.","journal-title":"Cell Death Differ"},{"key":"4219_CR44","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JFR Kerr","year":"1972","unstructured":"Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a Basic Biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239\u201357.","journal-title":"Br J Cancer"},{"key":"4219_CR45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00418-007-0356-9","volume":"129","author":"DJ Taatjes","year":"2008","unstructured":"Taatjes DJ, Sobel BE, Budd RC. Morphological and cytochemical determination of cell death by apoptosis. Histochem Cell Biol. 2008;129:33\u201343.","journal-title":"Histochem Cell Biol"},{"key":"4219_CR46","doi-asserted-by":"publisher","first-page":"e821043","DOI":"10.1155\/2014\/821043","volume":"2014","author":"B Sangiuliano","year":"2014","unstructured":"Sangiuliano B, P\u00e9rez NM, Moreira DF, Beliz\u00e1rio JE. Cell Death-Associated Molecular-Pattern molecules: Inflammatory Signaling and Control. Mediators Inflamm. 2014;2014:e821043.","journal-title":"Mediators Inflamm"},{"key":"4219_CR47","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/cbin.11148","volume":"43","author":"ES Snigirevskaya","year":"2019","unstructured":"Snigirevskaya ES, Komissarchik YY. Ultrastructural traits of apoptosis. Cell Biol Int. 2019;43:728\u201338.","journal-title":"Cell Biol Int"},{"key":"4219_CR48","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/ncb1630","volume":"9","author":"MG Sun","year":"2007","unstructured":"Sun MG, Williams J, Munoz-Pinedo C, Perkins GA, Brown JM, Ellisman MH, et al. Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat Cell Biol. 2007;9:1057\u201365.","journal-title":"Nat Cell Biol"},{"key":"4219_CR49","doi-asserted-by":"crossref","unstructured":"Meyer N, Zenclussen AC. Immune cells in the uterine remodeling: are they the target of endocrine disrupting chemicals? Front Immunol. 2020;11.","DOI":"10.3389\/fimmu.2020.00246"},{"key":"4219_CR50","unstructured":"Mishra G. Macrophage-Mediated Efferocytosis in Rat Uterine Remodeling. Thesis. 2018."},{"key":"4219_CR51","doi-asserted-by":"publisher","first-page":"839248","DOI":"10.3389\/fcell.2022.839248","volume":"10","author":"Y Ge","year":"2022","unstructured":"Ge Y, Huang M, Yao Y. Efferocytosis and its role in Inflammatory disorders. Front Cell Dev Biol. 2022;10:839248.","journal-title":"Front Cell Dev Biol"},{"key":"4219_CR52","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1095\/biolreprod.108.070425","volume":"80","author":"P Jeyasuria","year":"2009","unstructured":"Jeyasuria P, Wetzel J, Bradley M, Subedi K, Condon JC. Progesterone-Regulated Caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through Fragmentation of Uterine Myocyte Contractile proteins. Biol Reprod. 2009;80:928\u201334.","journal-title":"Biol Reprod"},{"key":"4219_CR53","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0002-9378(98)70481-8","volume":"178","author":"PC Leppert","year":"1998","unstructured":"Leppert PC. Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone. Am J Obstet Gynecol. 1998;178:713\u201325.","journal-title":"Am J Obstet Gynecol"},{"key":"4219_CR54","doi-asserted-by":"crossref","first-page":"821","DOI":"10.16965\/ijar.2014.499","volume":"3","author":"G MS","year":"2015","unstructured":"MS G, Ma I, Hassan DHA. Histological and immunohistochemical changes in rabbit uterus under the effect of contraceptive pills. IJAR. 2015;3:821\u201333.","journal-title":"IJAR"},{"key":"4219_CR55","doi-asserted-by":"crossref","first-page":"821","DOI":"10.16965\/ijar.2014.499","volume":"3","author":"A DH","year":"2015","unstructured":"DH A, Ma I, Hassan B. Histological and immunohistochemical changes in rabbit uterus under the effect of contraceptive pills. IJAR. 2015;3:821\u201333.","journal-title":"IJAR"},{"key":"4219_CR56","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3181\/00379727-189-42788","volume":"189","author":"S Percival","year":"1988","unstructured":"Percival S, Starcher B. Identification of a uterine elastase in the pregnant rat Uterus. Proc Soc Exp Biol Med. 1988;189:117\u201329.","journal-title":"Proc Soc Exp Biol Med"},{"key":"4219_CR57","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3109\/03008209109006992","volume":"27","author":"PC Leppert","year":"1991","unstructured":"Leppert PC, Yu SY. Three-dimensional structures of uterine elastic fibers: scanning electron microscopic studies. Connect Tissue Res. 1991;27:15\u201331.","journal-title":"Connect Tissue Res"},{"key":"4219_CR58","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000102174","volume":"185","author":"CL Stumm","year":"2007","unstructured":"Stumm CL, Zorn TMT. Changes in Fibrillin-1 in the Endometrium during the early stages of pregnancy in mice. Cells Tissues Organs. 2007;185:258\u201368.","journal-title":"Cells Tissues Organs"},{"key":"4219_CR59","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.7150\/ijbs.45586","volume":"16","author":"J-W Shi","year":"2020","unstructured":"Shi J-W, Lai Z-Z, Yang H-L, Yang S-L, Wang C-J, Ao D, et al. Collagen at the maternal-fetal interface in human pregnancy. Int J Biol Sci. 2020;16:2220\u201334.","journal-title":"Int J Biol Sci"},{"key":"4219_CR60","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4161\/cam.22826","volume":"7","author":"M Aumailley","year":"2013","unstructured":"Aumailley M. The laminin family. Cell Adhes Migr. 2013;7:48.","journal-title":"Cell Adhes Migr"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-024-04219-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-024-04219-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-024-04219-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T11:06:57Z","timestamp":1724929617000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcvetres.biomedcentral.com\/articles\/10.1186\/s12917-024-04219-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4219"],"URL":"https:\/\/doi.org\/10.1186\/s12917-024-04219-0","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"4 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocol was approved by the Local Ethical Committee and by the Institutional Review Board of Molecular Biology Research and studies Institute, Assiut University and was carried out in accordance with relevant guidelines and regulations. This research was done in compliance with the ARRIVE guidelines and regulations (). All national and institutional guidelines for animal care and use have been followed throughout the study procedures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"384"}}