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Fish and water samples were collected from private fish farms, and water drains at Dakahlia, and Giza, Egypt. Analysis of the water revealed inadequate water quality, particularly in the fish farms. Snails and piscivorous birds were abundant at fish collection sites. The recovered Clinostomid MCs morphological characteristics and COI gene sequence analysis identified them as <jats:italic>Clinostomum complanatum<\/jats:italic>, <jats:italic>C. phalacrocoracis<\/jats:italic>, and <jats:italic>Euclinostomum heterostomum<\/jats:italic>. Clinostomid MCs disturbed the fish\u2019s hematological and biochemical blood parameters. Bath treatment of parasitized fish with praziquantel (2\u00a0mg\/L for 24\u00a0h) revealed a significant reduction in the number of vital MCs vs. infected fish (non-treated). Praziquantel (PZQ) is an effective and safe therapy for controlling Clinostomid infections affecting farmed Nile tilapia. The current findings indicate a link between poor environmental conditions and <jats:italic>Clinostomum<\/jats:italic> infections in tilapia. The study highlights the impacts of Clinostomid MCs on fish health and recommends bath treatment with PZQ as an efficient control method for these dangerous parasites to protect human and fish health.<\/jats:p>","DOI":"10.1186\/s12917-024-04279-2","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T04:01:31Z","timestamp":1728100891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Praziquantel effectiveness in treating Nile tilapia clinostomid infections and its relationships to fish health and water quality"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-6538","authenticated-orcid":false,"given":"Olfat A.","family":"Mahdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman B","family":"Shaheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelsalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh Y.","family":"Elgendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai A.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"4279_CR1","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1111\/are.15286","volume":"52","author":"OA Mahdy","year":"2021","unstructured":"Mahdy OA, Abdel -Maogood SZ, Abdelsalam M, Shaalan M, Abdelrahman HA, Salem MA. 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