{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:04:30Z","timestamp":1772445870890,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ehlers-Danlos syndromes (EDS) are rare heritable connective tissue disorders, most commonly linked to collagen abnormalities. In dogs, reported cases are infrequent and typically involve skin fragility and joint laxity, with limited understanding of underlying genetic causes. This report describes an unusual, aggressive, and fatal case of an Ehlers\u2013Danlos\u2013like syndrome (EDlS) in a Maltese dog, with several uncommon features. Unlike most canine EDS cases, which show collagen defects, this case revealed minimal collagen alterations; instead, elastic fibers were primarily affected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A one-and-a-half-year-old male Maltese dog presented with progressive abdominal masses, skin fragility, joint deformities, and frequent bruising since early life. Clinical examination revealed hyperextensible, fragile skin, hematomas, and contractures of the hind limbs. Imaging confirmed a hernia lacking supportive connective structures. Histopathological analysis showed elastic fiber hypertrophy and fragmentation, with minimal collagen changes. Despite palliative wound management, the patient died within ten days of the initial consultation due to spontaneous evisceration and vascular rupture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The histological features are consistent with a possible Tenascin-X deficiency. Definitive molecular classification was beyond the scope of this case. This report expands the spectrum of EDlS in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-025-05271-0","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:35:14Z","timestamp":1768613714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A typical canine Ehlers-Danlos-like syndrome without collagen abnormalities: a suspected case of Tenascin-X deficiency"],"prefix":"10.1186","volume":"22","author":[{"given":"Bel\u00e9n M.","family":"Rivera\u00a0Gomez-Barris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Toro-Valdivieso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"issue":"1","key":"5271_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-020-0194-9","volume":"6","author":"F Malfait","year":"2020","unstructured":"Malfait F, Castori M, Francomano CA, Giunta C, Kosho T, Byers PH. The Ehlers-Danlos syndromes. Nat Rev Dis Primers. 2020;6(1):64. https:\/\/doi.org\/10.1038\/s41572-020-0194-9.","journal-title":"Nat Rev Dis Primers"},{"key":"5271_CR2","doi-asserted-by":"crossref","unstructured":"Roberts JH, Halper J. Connective tissue disorders in domestic animals. In: Progress in Heritable Soft Connective Tissue Diseases. Springer , Cham, Switzerland ; 2021. pp. 325\u201335.","DOI":"10.1007\/978-3-030-80614-9_15"},{"key":"5271_CR3","first-page":"602","volume-title":"Muller and Kirk's Small Animal Dermatology","author":"W.H. Miller","year":"2013","unstructured":"Miller WH, Griffin CE, Campbell KL. Congenital and hereditary defects. In: Muller and Kirk\u2019s Small Animal Dermatology. 7th ed. 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Anim Genet. 2019;50(5):546\u20139. https:\/\/doi.org\/10.1111\/age.12830.","journal-title":"Anim Genet"},{"issue":"5","key":"5271_CR6","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/age.12825","volume":"50","author":"JA Jaffey","year":"2019","unstructured":"Jaffey JA, Bullock G, Teplin E, Guo J, Villani NA, Mhlanga-Mutangadura T, et al. A homozygous ADAMTS2 nonsense mutation in a Doberman Pinscher dog with Ehlers Danlos syndrome and extreme skin fragility. Anim Genet. 2019;50(5):543\u20135. https:\/\/doi.org\/10.1111\/age.12825.","journal-title":"Anim Genet"},{"issue":"11","key":"5271_CR7","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/genes13112158","volume":"13","author":"JA Jaffey","year":"2022","unstructured":"Jaffey JA, Bullock G, Guo J, Mhlanga-Mutangadura T, O\u2019Brien DP, Coates JR, et al. Novel Homozygous ADAMTS2 Variants and Associated Disease Phenotypes in Dogs with Dermatosparactic Ehlers-Danlos Syndrome. Genes. 2022;13(11):2158. https:\/\/doi.org\/10.3390\/genes13112158.","journal-title":"Genes"},{"issue":"4","key":"5271_CR8","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1399-0004.2005.00401.x","volume":"67","author":"MC Zweers","year":"2005","unstructured":"Zweers MC, Dean WB, Van Kuppevelt TH, Bristow J, Schalkwijk J. Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations. Clin Genet. 2005;67(4):330\u20134. https:\/\/doi.org\/10.1111\/j.1399-0004.2005.00401.x.","journal-title":"Clin Genet"},{"key":"5271_CR9","doi-asserted-by":"publisher","unstructured":"Matveeva I, Myakinin O. Monte Carlo modelling of normal skin and skin cancer Raman spectra. In: Journal of Physics: Conference Series. vol. 1368. IOP Publishing; 2019. p. 042084. https:\/\/doi.org\/10.1088\/1742-6596\/1368\/4\/042084.","DOI":"10.1088\/1742-6596\/1368\/4\/042084"},{"issue":"1","key":"5271_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1939-165X.2003.tb00306.x","volume":"32","author":"OR Paciello","year":"2003","unstructured":"Paciello OR, Lamagna FR, Lamagna BA, Papparella SE. Ehlers-Danlos\u2013like syndrome in 2 dogs: clinical, histologic, and ultrastructural findings. Vet Clin Pathol. 2003;32(1):13\u20138. https:\/\/doi.org\/10.1111\/j.1939-165X.2003.tb00306.x.","journal-title":"Vet Clin Pathol"},{"issue":"2\u20133","key":"5271_CR11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jcpa.2014.12.013","volume":"152","author":"M Uri","year":"2015","unstructured":"Uri M, Verin R, Ressel L, Buckley L, McEwan N. Ehlers-Danlos syndrome associated with fatal spontaneous vascular rupture in a dog. 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Therefore, we believe the statement does not apply to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"146"}}