{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T14:50:04Z","timestamp":1794495004312,"version":"4.9.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"DOI":"10.1186\/s12917-026-05396-w","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:54:48Z","timestamp":1772690088000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of combined unilateral mastectomy and ovariohysterectomy on acute phase response and wound healing in dogs with mammary gland tumors"],"prefix":"10.1186","volume":"22","author":[{"given":"Grisnarong","family":"Wongbandue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phirom","family":"Prompiram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyakamol","family":"Chandrasakha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawarus","family":"Prapaiwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"5396_CR1","doi-asserted-by":"publisher","first-page":"e17077","DOI":"10.7717\/peerj.17077","volume":"12","author":"W Srisawat","year":"2024","unstructured":"Srisawat W, Pringproa K, Prachasilchai W, Thongtharb A, Sthitmatee N. Epidemiology and classification for canine and feline mammary gland tumors: a histopathological survey of 437 mammary gland tumor biopsies performed in a secondary care hospital in Chiang Mai, Thailand from 2012 to 2019. PeerJ. 2024;12:e17077. https:\/\/doi.org\/10.7717\/peerj.17077.","journal-title":"PeerJ"},{"issue":"1","key":"5396_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13028-023-00674-1","volume":"65","author":"MB Hornfeldt","year":"2023","unstructured":"Hornfeldt MB, Mortensen JK. Surgical dose and the clinical outcome in the treatment of mammary gland tumours in female dogs: a literature review. Acta Vet Scand. 2023;65(1):12. https:\/\/doi.org\/10.1186\/s13028-023-00674-1.","journal-title":"Acta Vet Scand"},{"issue":"4","key":"5396_CR3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.17221\/4\/2024-VETMED","volume":"69","author":"JR Rueda","year":"2024","unstructured":"Rueda JR, Porto CD, Franco RP, da Costa IB, Bueno LMC, Girio RJS, Manhoso FFR, Bueno P, Repetti CSF. Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspects. Vet Med (Praha). 2024;69(4):99\u2013114. https:\/\/doi.org\/10.17221\/4\/2024-VETMED.","journal-title":"Vet Med (Praha)"},{"issue":"1","key":"5396_CR4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/jvim.13812","volume":"30","author":"VM Kristiansen","year":"2016","unstructured":"Kristiansen VM, Pena L, Diez Cordova L, Illera JC, Skjerve E, Breen AM, Cofone MA, Langeland M, Teige J, Goldschmidt M, et al. Effect of ovariohysterectomy at the time of tumor removal in dogs with mammary carcinomas: A randomized controlled trial. J Vet Intern Med. 2016;30(1):230\u201341. https:\/\/doi.org\/10.1111\/jvim.13812.","journal-title":"J Vet Intern Med"},{"issue":"4","key":"5396_CR5","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/jvim.12110","volume":"27","author":"VM Kristiansen","year":"2013","unstructured":"Kristiansen VM, Nodtvedt A, Breen AM, Langeland M, Teige J, Goldschmidt M, Jonasdottir TJ, Grotmol T, Sorenmo K. Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial. J Vet Intern Med. 2013;27(4):935\u201342. https:\/\/doi.org\/10.1111\/jvim.12110.","journal-title":"J Vet Intern Med"},{"issue":"Suppl 6","key":"5396_CR6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/rda.12103","volume":"47","author":"S Jitpean","year":"2012","unstructured":"Jitpean S, Hagman R, Strom Holst B, Hoglund OV, Pettersson A, Egenvall A. Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs. Reprod Domest Anim. 2012;47(Suppl 6):347\u201350. https:\/\/doi.org\/10.1111\/rda.12103.","journal-title":"Reprod Domest Anim"},{"issue":"6","key":"5396_CR7","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","volume":"340","author":"C Gabay","year":"1999","unstructured":"Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448\u201354. https:\/\/doi.org\/10.1056\/NEJM199902113400607.","journal-title":"N Engl J Med"},{"issue":"3","key":"5396_CR8","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/bja\/aet077","volume":"111","author":"B Gibbison","year":"2013","unstructured":"Gibbison B, Angelini GD, Lightman SL. Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery. Br J Anaesth. 2013;111(3):347\u201360. https:\/\/doi.org\/10.1093\/bja\/aet077.","journal-title":"Br J Anaesth"},{"issue":"2","key":"5396_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1939-165x.2005.tb00019.x","volume":"34","author":"JJ Ceron","year":"2005","unstructured":"Ceron JJ, Eckersall PD, Martynez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol. 2005;34(2):85\u201399. https:\/\/doi.org\/10.1111\/j.1939-165x.2005.tb00019.x.","journal-title":"Vet Clin Pathol"},{"issue":"1","key":"5396_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.tvjl.2010.04.009","volume":"185","author":"PD Eckersall","year":"2010","unstructured":"Eckersall PD, Bell R. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J. 2010;185(1):23\u20137. https:\/\/doi.org\/10.1016\/j.tvjl.2010.04.009.","journal-title":"Vet J"},{"issue":"1","key":"5396_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.rvsc.2010.05.008","volume":"90","author":"A Tvarijonaviciute","year":"2011","unstructured":"Tvarijonaviciute A, Martinez S, Gutierrez A, Ceron JJ, Tecles F. Serum acute phase proteins concentrations in dogs during experimentally short-term induced overweight. A preliminary study. Res Vet Sci. 2011;90(1):31\u20134. https:\/\/doi.org\/10.1016\/j.rvsc.2010.05.008.","journal-title":"Res Vet Sci"},{"issue":"2","key":"5396_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF01839236","volume":"17","author":"S Yamamoto","year":"1993","unstructured":"Yamamoto S, Shida T, Miyaji S, Santsuka H, Fujise H, Mukawa K, Furukawa E, Nagae T, Naiki M. Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas. Vet Res Commun. 1993;17(2):85\u201393. https:\/\/doi.org\/10.1007\/BF01839236.","journal-title":"Vet Res Commun"},{"issue":"3","key":"5396_CR13","doi-asserted-by":"publisher","first-page":"e70323","DOI":"10.1002\/vms3.70323","volume":"11","author":"K Akar","year":"2025","unstructured":"Akar K, Sanioglu Golen G, Ekin IH. Investigation of the correlation between ELISA and serum amyloid A in the diagnosis of Bordetella bronchiseptica in dogs. Vet Med Sci. 2025;11(3):e70323. https:\/\/doi.org\/10.1002\/vms3.70323.","journal-title":"Vet Med Sci"},{"issue":"3\u20134","key":"5396_CR14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.vetpar.2011.03.032","volume":"180","author":"S Martinez-Subiela","year":"2011","unstructured":"Martinez-Subiela S, Strauss-Ayali D, Cer\u00f3n JJ, Baneth G. Acute phase protein response in experimental canine leishmaniosis. Vet Parasitol. 2011;180(3\u20134):197\u2013202. https:\/\/doi.org\/10.1016\/j.vetpar.2011.03.032.","journal-title":"Vet Parasitol"},{"key":"5396_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13028-015-0164-5","volume":"57","author":"MB Christensen","year":"2015","unstructured":"Christensen MB, Eriksen T, Kjelgaard-Hansen M. C-reactive protein: quantitative marker of surgical trauma and post-surgical complications in dogs: a systematic review. Acta Vet Scand. 2015;57:71. https:\/\/doi.org\/10.1186\/s13028-015-0164-5.","journal-title":"Acta Vet Scand"},{"issue":"3","key":"5396_CR16","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/vcp.12063","volume":"42","author":"M Kjelgaard-Hansen","year":"2013","unstructured":"Kjelgaard-Hansen M, Strom H, Mikkelsen LF, Eriksen T, Jensen AL, Luntang-Jensen M. Canine serum C-reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery. Vet Clin Pathol. 2013;42(3):342\u20135. https:\/\/doi.org\/10.1111\/vcp.12063.","journal-title":"Vet Clin Pathol"},{"issue":"11","key":"5396_CR17","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1292\/jvms.58.11_1079","volume":"58","author":"T Yamagami","year":"1996","unstructured":"Yamagami T, Kobayashi T, Takahashi K, Sugiyama M. Prognosis for canine malignant mammary tumors based on TNM and histologic classification. J Vet Med Sci. 1996;58(11):1079\u201383. https:\/\/doi.org\/10.1292\/jvms.58.11_1079.","journal-title":"J Vet Med Sci"},{"issue":"5","key":"5396_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.48165\/ijvsbt.18.5.04","volume":"18","author":"RG Kantia","year":"2022","unstructured":"Kantia RG, Jhala SK, Suthar DN, Dabas VS. Propofol\/Etomidate induced and isoflurane maintained anaesthesia in dogs. Indian J Vet Sci Biotechnol. 2022;18(5):19\u201323. https:\/\/doi.org\/10.48165\/ijvsbt.18.5.04.","journal-title":"Indian J Vet Sci Biotechnol"},{"issue":"2","key":"5396_CR19","first-page":"82","volume":"LXIV","author":"R Tudor","year":"2018","unstructured":"Tudor R, Degan A, Costea R, Predoi G. Postoperative analgesic management of geriatric dogs that underwent soft tissue surgery. Sci Works Ser C Vet Med. 2018;LXIV(2):82\u20137.","journal-title":"Sci Works Ser C Vet Med"},{"issue":"3","key":"5396_CR20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/jvim.16420","volume":"36","author":"E Behling-Kelly","year":"2022","unstructured":"Behling-Kelly E, Haak CE, Carney P, Waffle J, Eaton K, Goggs R. Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome. J Vet Intern Med. 2022;36(3):993\u20131004. https:\/\/doi.org\/10.1111\/jvim.16420.","journal-title":"J Vet Intern Med"},{"issue":"1","key":"5396_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/vsu.13894","volume":"52","author":"JL Carvajal","year":"2023","unstructured":"Carvajal JL, Kim SE. Serum acute-phase protein concentrations following uncomplicated total hip arthroplasty in dogs. Vet Surg. 2023;52(1):81\u20136. https:\/\/doi.org\/10.1111\/vsu.13894.","journal-title":"Vet Surg"},{"issue":"7","key":"5396_CR22","doi-asserted-by":"publisher","first-page":"844","DOI":"10.18805\/IJAR.B-4134","volume":"55","author":"A Kumari","year":"2021","unstructured":"Kumari A, Guha SK, Tiwary R, Kumar R. C-reactive protein as a quantitative biomarker in female dogs undergoing laparoscopic and open elective ovariectomy. Indian J Anim Res. 2021;55(7):844\u20138. https:\/\/doi.org\/10.18805\/IJAR.B-4134.","journal-title":"Indian J Anim Res"},{"issue":"2","key":"5396_CR23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.14202\/vetworld.2021.393-404","volume":"14","author":"I Hernandez-Avalos","year":"2021","unstructured":"Hernandez-Avalos I, Flores-Gasca E, Mota-Rojas D, Casas-Alvarado A, Miranda-Cortes AE, Dominguez-Oliva A. Neurobiology of anesthetic-surgical stress and induced behavioral changes in dogs and cats: A review. Vet World. 2021;14(2):393\u2013404. https:\/\/doi.org\/10.14202\/vetworld.2021.393-404.","journal-title":"Vet World"},{"issue":"1","key":"5396_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.47278\/journal.ijvs\/2022.167","volume":"12","author":"A Szarkova","year":"2023","unstructured":"Szarkova A, Tothova C, Weissova T, Lukac B, Turna H, Kottferova L, Nagy O. Evaluation of acute phase proteins in dogs suffering from various diseases. Int J Vet Sci. 2023;12(1):82\u20138. https:\/\/doi.org\/10.47278\/journal.ijvs\/2022.167.","journal-title":"Int J Vet Sci"},{"issue":"9","key":"5396_CR25","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.3390\/ani15091214","volume":"15","author":"G Giambrone","year":"2025","unstructured":"Giambrone G, Catone G, Marino G, Sfacteria A, Miloro R, Vullo C. Perioperative pain management for mastectomy in dogs: A narrative review. Anim (Basel). 2025;15(9):1214. https:\/\/doi.org\/10.3390\/ani15091214.","journal-title":"Anim (Basel)"},{"key":"5396_CR26","doi-asserted-by":"publisher","first-page":"1513853","DOI":"10.3389\/fvets.2024.1513853","volume":"11","author":"C Iwe","year":"2024","unstructured":"Iwe C, Schiele A, Passenegg V, Corona D, Bettschart-Wolfensberger R, Heitzmann V. Does perioperative electroacupuncture reduce postoperative pain in dogs undergoing ovariohysterectomy? Front Vet Sci. 2024;11:1513853. https:\/\/doi.org\/10.3389\/fvets.2024.1513853.","journal-title":"Front Vet Sci"},{"key":"5396_CR27","doi-asserted-by":"publisher","first-page":"1534685","DOI":"10.3389\/fvets.2025.1534685","volume":"12","author":"TR Pedersen","year":"2025","unstructured":"Pedersen TR, Berendt M, Rusbridge C. Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician. Front Vet Sci. 2025;12:1534685. https:\/\/doi.org\/10.3389\/fvets.2025.1534685.","journal-title":"Front Vet Sci"},{"key":"5396_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s13104-016-2193-1","volume":"9","author":"T Srithunyarat","year":"2016","unstructured":"Srithunyarat T, Hoglund OV, Hagman R, Olsson U, Stridsberg M, Lagerstedt AS, Pettersson A. Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy. BMC Res Notes. 2016;9:381. https:\/\/doi.org\/10.1186\/s13104-016-2193-1.","journal-title":"BMC Res Notes"},{"key":"5396_CR29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-12-394596-9.00005-6","volume":"105","author":"C Cray","year":"2012","unstructured":"Cray C. Acute phase proteins in animals. Prog Mol Biol Transl Sci. 2012;105:113\u201350. https:\/\/doi.org\/10.1016\/B978-0-12-394596-9.00005-6.","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"1","key":"5396_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13028-018-0385-5","volume":"60","author":"K Lofqvist","year":"2018","unstructured":"Lofqvist K, Kjelgaard-Hansen M, Nielsen MBM. Usefulness of C-reactive protein and serum amyloid A in early detection of postoperative infectious complications to tibial plateau leveling osteotomy in dogs. Acta Vet Scand. 2018;60(1):30. https:\/\/doi.org\/10.1186\/s13028-018-0385-5.","journal-title":"Acta Vet Scand"},{"issue":"2","key":"5396_CR31","first-page":"161","volume":"55","author":"MB Christensen","year":"2014","unstructured":"Christensen MB, Langhorn R, Goddard A, Andreasen EB, Moldal E, Tvarijonaviciute A, Kirpensteijn J, Jakobsen S, Persson F, Kjelgaard-Hansen M. Comparison of serum amyloid A and C-reactive protein as diagnostic markers of systemic inflammation in dogs. Can Vet J. 2014;55(2):161\u20138.","journal-title":"Can Vet J"},{"issue":"20","key":"5396_CR32","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.3390\/ani12202888","volume":"12","author":"K Malin","year":"2022","unstructured":"Malin K, Witkowska-Pilaszewicz O. C-reactive protein as a diagnostic marker in dogs: A review. Anim (Basel). 2022;12(20):2888. https:\/\/doi.org\/10.3390\/ani12202888.","journal-title":"Anim (Basel)"},{"issue":"2","key":"5396_CR33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.theriogenology.2006.07.019","volume":"67","author":"R Dabrowski","year":"2007","unstructured":"Dabrowski R, Wawron W, Kostro K. Changes in CRP, SAA and haptoglobin produced in response to ovariohysterectomy in healthy bitches and those with pyometra. Theriogenology. 2007;67(2):321\u20137. https:\/\/doi.org\/10.1016\/j.theriogenology.2006.07.019.","journal-title":"Theriogenology"},{"issue":"6\u20137","key":"5396_CR34","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ejcb.2011.09.008","volume":"91","author":"JG Bode","year":"2012","unstructured":"Bode JG, Albrecht U, H\u00e4ussinger D, Heinrich PC, Schaper F. Hepatic acute phase proteins\u2013regulation by IL-6-and IL-1-type cytokines involving STAT3 and its crosstalk with NF-\u03baB-dependent signaling. Eur J Cell Biol. 2012;91(6\u20137):496\u2013505. https:\/\/doi.org\/10.1016\/j.ejcb.2011.09.008.","journal-title":"Eur J Cell Biol"},{"key":"5396_CR35","doi-asserted-by":"publisher","first-page":"652479","DOI":"10.3389\/fvets.2021.652479","volume":"8","author":"A Brunner","year":"2021","unstructured":"Brunner A, Schuller S, Hettlich B, Marti E, Lehmann A, Peters LM, Adamik KN. Kinetics of plasma cytokines, angiopoietin-2, and C-reactive protein in dogs with gastric dilatation volvulus. Front Vet Sci. 2021;8:652479. https:\/\/doi.org\/10.3389\/fvets.2021.652479.","journal-title":"Front Vet Sci"},{"key":"5396_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fvets.2018.00179","volume":"5","author":"R Goggs","year":"2018","unstructured":"Goggs R, Letendre JA. High mobility group Box-1 and pro-inflammatory cytokines are increased in dogs after trauma but do not predict survival. Front Vet Sci. 2018;5:179. https:\/\/doi.org\/10.3389\/fvets.2018.00179.","journal-title":"Front Vet Sci"},{"key":"5396_CR37","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cyto.2018.06.024","volume":"113","author":"DO Avazi","year":"2019","unstructured":"Avazi DO, Awasum AC, Hassan AZ, Ayo JO, Aluwong T, Muhammed ST, Simon AY, Suleiman MH, Kudi AC. Evaluation of levels of interleukin-6, interleukin-8 and some haematologic parameters of dogs with cutaneous wounds. Cytokine. 2019;113:128\u201338. https:\/\/doi.org\/10.1016\/j.cyto.2018.06.024.","journal-title":"Cytokine"},{"issue":"1","key":"5396_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0885066610395678","volume":"26","author":"RS Jawa","year":"2011","unstructured":"Jawa RS, Anillo S, Huntoon K, Baumann H, Kulaylat M. Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science. J Intensive Care Med. 2011;26(1):3\u201312. https:\/\/doi.org\/10.1177\/0885066610395678.","journal-title":"J Intensive Care Med"},{"issue":"4","key":"5396_CR39","doi-asserted-by":"publisher","first-page":"79","DOI":"10.21608\/bjas.2022.253615","volume":"7","author":"OA Khalifa","year":"2022","unstructured":"Khalifa OA, Alakraa AM, Elkasapy AH. Modulation of immune response in canine chronic wound stimulated with Class C CpG oligonucleotide. Benha J Appl Sci. 2022;7(4):79\u201384. https:\/\/doi.org\/10.21608\/bjas.2022.253615.","journal-title":"Benha J Appl Sci"},{"issue":"1","key":"5396_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cvex.2015.08.002","volume":"19","author":"MA Mickelson","year":"2016","unstructured":"Mickelson MA, Mans C, Colopy SA. Principles of wound management and wound healing in exotic pets. Vet Clin North Am Exot Anim Pract. 2016;19(1):33\u201353. https:\/\/doi.org\/10.1016\/j.cvex.2015.08.002.","journal-title":"Vet Clin North Am Exot Anim Pract"},{"issue":"11","key":"5396_CR41","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.3390\/ijms18112325","volume":"18","author":"HC Horng","year":"2017","unstructured":"Horng HC, Chang WH, Yeh CC, Huang BS, Chang CP, Chen YJ, Tsui KH, Wang PH. Estrogen effects on wound healing. Int J Mol Sci. 2017;18(11):2325. https:\/\/doi.org\/10.3390\/ijms18112325.","journal-title":"Int J Mol Sci"},{"key":"5396_CR42","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3389\/fvets.2019.00506","volume":"6","author":"A Gautier","year":"2019","unstructured":"Gautier A, Graff EC, Bacek L, Fish EJ, White A, Palmer L, Kuo K. Effects of ovariohysterectomy and hyperbaric oxygen therapy on systemic inflammation and oxidation in dogs. Front Vet Sci. 2019;6:506. https:\/\/doi.org\/10.3389\/fvets.2019.00506.","journal-title":"Front Vet Sci"},{"issue":"5","key":"5396_CR43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1055\/s-0038-1623776","volume":"42","author":"L Muraro","year":"2014","unstructured":"Muraro L, White RS. Complications of ovariohysterectomy procedures performed in 1880 dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2014;42(5):297\u2013302.","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"5396_CR44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cvsm.2011.05.004","volume":"37","author":"MCJ Benavides","year":"2018","unstructured":"Benavides MCJ, Asta\u00edza MJM, Rojas ML. Complications of surgical sterilization by ovariohysterectomy in female dogs: A systematic review. Rev med Vet. 2018;37:83\u201393. https:\/\/doi.org\/10.1016\/j.cvsm.2011.05.004.","journal-title":"Rev med Vet"},{"issue":"11","key":"5396_CR45","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1590\/1678-5150-pvb-5132","volume":"38","author":"EMS Schmidt","year":"2018","unstructured":"Schmidt EMS, Rubio CP, Thomas F, Ferreira JCP, Eckersall DP. Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy. Pesq Vet Bras. 2018;38(11):2124\u20138. https:\/\/doi.org\/10.1590\/1678-5150-pvb-5132.","journal-title":"Pesq Vet Bras"},{"issue":"4","key":"5396_CR46","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3138\/jvme.0813-120R","volume":"41","author":"LJ Freeman","year":"2014","unstructured":"Freeman LJ, Huse D, Lee R, Inoue T, Weil AB, Constable PD. Teaching veterinary anesthesia and surgery: the impact of instructor availability on anesthesia, operative, and recovery times in dogs undergoing ovariohysterectomy or castration. J Vet Med Educ. 2014;41(4):390\u20139. https:\/\/doi.org\/10.3138\/jvme.0813-120R.","journal-title":"J Vet Med Educ"},{"issue":"4","key":"5396_CR47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3390\/vetsci12040377","volume":"12","author":"AF Carceles","year":"2025","unstructured":"Carceles AF, Degani M, Soler C, Serra CI, Fernandez-Salesa N, Garcia de Carellan Mateo A, Herreria-Bustillo VJ, Di Franco C, Briganti A. Veterinary Enhanced Recovery After Surgery (Vet-ERAS) program in dogs undergoing emergency laparotomy. Vet Sci. 2025;12(4):377. https:\/\/doi.org\/10.3390\/vetsci12040377.","journal-title":"Vet Sci"},{"issue":"2","key":"5396_CR48","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1177\/104063870902100206","volume":"21","author":"F Tecles","year":"2009","unstructured":"Tecles F, Caldin M, Zanella A, Membiela F, Tvarijonaviciute A, Subiela SM, Ceron JJ. Serum acute phase protein concentrations in female dogs with mammary tumors. J Vet Diagn Invest. 2009;21(2):214\u20139. https:\/\/doi.org\/10.1177\/104063870902100206.","journal-title":"J Vet Diagn Invest"},{"issue":"3","key":"5396_CR49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1939-165X.2009.00139.x","volume":"38","author":"M Planellas","year":"2009","unstructured":"Planellas M, Bassols A, Siracusa C, Saco Y, Gimenez M, Pato R, Pastor J. Evaluation of serum haptoglobin and C-reactive protein in dogs with mammary tumors. Vet Clin Pathol. 2009;38(3):348\u201352. https:\/\/doi.org\/10.1111\/j.1939-165X.2009.00139.x.","journal-title":"Vet Clin Pathol"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-026-05396-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05396-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05396-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:05:41Z","timestamp":1776056741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12917-026-05396-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5396"],"URL":"https:\/\/doi.org\/10.1186\/s12917-026-05396-w","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"22 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were reviewed and approved by the Institute Animal Care and Use Committee of the Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand (Protocol No. MUVS-2023-10-65) in accordance with institutional and national guidelines for animal welfare. Informed consent was obtained from the owners of all client-owned dogs prior to participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"216"}}