{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:51:22Z","timestamp":1781646682834,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      M\u00e9n\u00e9trier\u2019s disease is a rare protein-losing gastropathy characterized by markedly enlarged gastric folds, excessive mucus secretion, and hypoalbuminemia. Histologically, it features pronounced foveolar hyperplasia, cystic dilation of gastric glands, and loss of parietal and chief cells. Although first described in humans, a small number of comparable cases have been reported in dogs, where the condition is referred to as\n                      <jats:italic>M\u00e9n\u00e9trier-like disease<\/jats:italic>\n                      . In veterinary medicine, this disorder remains poorly defined and appears to be uncommon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 6-year-old intact male French Bulldog was referred for a severe progressive weight loss and acute onset anorexia. Clinical and laboratory findings were suggestive of a protein-losing enteropathy. Abdominal ultrasonography revealed marked thickening of the gastric and small intestinal walls. Gastroscopy showed severe, non-reducible hypertrophy of the gastric folds involving both the fundus and body of stomach. Endoscopic biopsies revealed marked foveolar hyperplasia and cystic glandular dilation without evidence of glandular atrophy. M\u00e9n\u00e9trier-like hypertrophic gastropathy was considered the most likely diagnosis. Given that the owner declined gastrectomy and treatment with somatostatin analogues for financial constraints, medical management with glucocorticoids and H\u2082-receptor antagonists was administered. After 10\u00a0days, the clinical condition progressively worsened, with the onset of new and evolving neurological deficits. The dog subsequently developed severe neurological signs, and euthanasia was ultimately elected.<\/jats:p>\n                    <jats:p>Histopathological examination of a full-thickness gastric sample confirmed mucosal hypertrophy characterized by branching foveolar hyperplasia and cystic dilation of the glands, again without evidence of parietal cell loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case suggests that canine M\u00e9n\u00e9trier-like disease may occur even in the absence of glandular atrophy, thereby broadening the currently recognized histologic spectrum of the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12917-026-05424-9","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:17:00Z","timestamp":1774448220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["M\u00e9n\u00e9trier-like disease in a dog without glandular atrophy: expanding the morphologic spectrum"],"prefix":"10.1186","volume":"22","author":[{"given":"Mario","family":"Pultrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyana","family":"Erba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"5424_CR1","first-page":"1003","volume-title":"Sleisenger and Fordtran\u2019s gastrointestinal and liver disease","author":"RJ Coffey","year":"2021","unstructured":"Coffey RJ. 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International, high standards of veterinary clinical care for the individual patient (\u2018best practice\u2019) were always followed. No cadavers were used in this study. Ethical approval from a committee was therefore not specifically required for publication in the\n                      BMC Veterinary Research\n                      Journal. Although not required, where ethical approval was still obtained, it is stated in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}