{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T02:02:12Z","timestamp":1779760932766,"version":"3.53.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Guangxi Key Technologies R&D Program","award":["Gui Ke AB23026082"],"award-info":[{"award-number":["Gui Ke AB23026082"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 32360897"],"award-info":[{"award-number":["No. 32360897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"DOI":"10.1186\/s12917-026-05445-4","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:24:57Z","timestamp":1776151497000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel tulathromycin oil suspension injection: preparation, characterization, and pharmacokinetics in goats"],"prefix":"10.1186","volume":"22","author":[{"given":"Ziyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"issue":"1","key":"5445_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12917-023-03829-4","volume":"19","author":"J Li","year":"2023","unstructured":"Li J, Chen C, Gao L, Wang L, Wang W, Zhang J, Gong Z, Wang J, Guo Y. Analysis of histopathology and changes of major cytokines in the lesions caused by Mycoplasma ovipneumoniae infection. BMC Vet Res. 2023;19(1):273.","journal-title":"BMC Vet Res"},{"key":"5445_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.prevetmed.2019.04.006","volume":"168","author":"K Manlove","year":"2019","unstructured":"Manlove K, Branan M, Baker K, Bradway D, Cassirer EF, Marshall KL, Miller RS, Sweeney S, Cross PC, Besser TE. Risk factors and productivity losses associated with Mycoplasma ovipneumoniae infection in United States domestic sheep operations. Prev Vet Med. 2019;168:30\u20138.","journal-title":"Prev Vet Med"},{"key":"5445_CR3","doi-asserted-by":"publisher","first-page":"109334","DOI":"10.1016\/j.vetmic.2022.109334","volume":"265","author":"T Johnson","year":"2022","unstructured":"Johnson T, Jones K, Jacobson BT, Schearer J, Adams N, Thornton I, Mosdal C, Jones S, Jutila M, Rynda-Apple A, et al. Experimental infection of specific-pathogen-free domestic lambs with Mycoplasma ovipneumoniae causes asymptomatic colonization of the upper airways that is resistant to antibiotic treatment. Vet Microbiol. 2022;265:109334.","journal-title":"Vet Microbiol"},{"issue":"1","key":"5445_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13567-024-01439-y","volume":"56","author":"BT Jacobson","year":"2025","unstructured":"Jacobson BT, DeWit-Dibbert J, Zanca L, Sonar S, Hardy C, Throolin M, Brewster PC, Andujo K, Jones K, Sago J, et al. Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs. Vet Res. 2025;56(1):10.","journal-title":"Vet Res"},{"key":"5445_CR5","doi-asserted-by":"publisher","first-page":"110029","DOI":"10.1016\/j.vetmic.2024.110029","volume":"291","author":"I Kanishka","year":"2024","unstructured":"Kanishka I, Kamathewatta, Sathya N, Kulappu Arachchige ND, Young AK, Condello NK, Wawegama, Glenn F, Browning. Transcriptomic analysis of the effects of tylosin on the protective immunity provided by the Mycoplasma gallisepticum vaccine Vaxsafe MG ts-304. Vet Microbiol. 2024;291:110029.","journal-title":"Vet Microbiol"},{"issue":"5","key":"5445_CR6","doi-asserted-by":"publisher","first-page":"102572","DOI":"10.1016\/j.psj.2023.102572","volume":"102","author":"X Yan","year":"2023","unstructured":"Yan X, Liu J, Jia Y, Yao Z, Zhou M, Song S, Yuan S, Zhang D, Zhang N. The pharmacokinetics of tilmicosin in plasma and joint dialysate in an experimentally Mycoplasma synoviae infection model. Poult Sci. 2023;102(5):102572.","journal-title":"Poult Sci"},{"issue":"7","key":"5445_CR7","doi-asserted-by":"publisher","first-page":"e0339824","DOI":"10.1128\/spectrum.03398-24","volume":"13","author":"P Xie","year":"2025","unstructured":"Xie P, Liu J, Feng Y, Zhao T, Niu W, Fang Y, Zhang X, Zhao X, Wang F, Xin Y. Evolution and characteristics of tetracycline resistance in Mycoplasma pneumoniae. Microbiol Spectr. 2025;13(7):e0339824.","journal-title":"Microbiol Spectr"},{"issue":"22","key":"5445_CR8","doi-asserted-by":"publisher","first-page":"16262","DOI":"10.3390\/ijms242216262","volume":"24","author":"J Kang","year":"2023","unstructured":"Kang J, Chae H, Jeong S, Pervin R, Hossain MA. Evaluation of Biological Equivalence for Generic Tulathromycin Injections in Cattle, International journal of molecular sciences. Int J Mol Sci. 2023;24(22):16262.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"5445_CR9","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/jvp.12259","volume":"39","author":"A Gajda","year":"2016","unstructured":"Gajda A, Bladek T, Jablonski A, Posyniak A. The influence of Actinobacillus pleuropneumoniae infection on tulathromycin pharmacokinetics and lung tissue disposition in pigs, Journal of veterinary pharmacology and therapeutics. J Vet Pharmacol Ther. 2016;39(2):176\u201382.","journal-title":"J Vet Pharmacol Ther"},{"issue":"1","key":"5445_CR10","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/s12917-024-04254-x","volume":"20","author":"W Wheat","year":"2024","unstructured":"Wheat W, Chow L, Still-Brooks K, Moore-Foster R, Herman J, Hunter R, Garry F, Dow S. Immune modulatory effects of tulathromycin, gamithromycin, and oxytetracycline in cattle. BMC Vet Res. 2024;20(1):456.","journal-title":"BMC Vet Res"},{"issue":"4","key":"5445_CR11","doi-asserted-by":"publisher","first-page":"e834","DOI":"10.1002\/vetr.834","volume":"190","author":"JD Koster","year":"2022","unstructured":"Koster JD, Tena JK, Stegemann MR. Treatment of bovine respiratory disease with a single administration of tulathromycin and ketoprofen. Vet Rec. 2022;190(4):e834.","journal-title":"Vet Rec"},{"key":"5445_CR12","doi-asserted-by":"publisher","first-page":"109222","DOI":"10.1016\/j.vetmic.2021.109222","volume":"262","author":"AM Betlach","year":"2021","unstructured":"Betlach AM, Baumert D, Utrera V, Pantoja LG, Pieters M. Effect of antibiotic treatment on Mycoplasma hyopneumoniae detection and infectious potential. Vet Microbiol. 2021;262:109222.","journal-title":"Vet Microbiol"},{"issue":"1","key":"5445_CR13","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/s41598-024-85052-1","volume":"15","author":"U Klein","year":"2025","unstructured":"Klein U, F\u00f6ldi D, Nagy EZ, T\u00f3th L, Belecz N, K\u00f6lt\u0151 K, Wehmann E, Marton S, Merenda M, Gastaldelli M, et al. Gyuranecz, Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023. Sci Rep. 2025;15(1):1243.","journal-title":"Sci Rep"},{"issue":"1","key":"5445_CR14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12917-025-04504-6","volume":"21","author":"P Paulina","year":"2025","unstructured":"Paulina P, Dawid T. Serotyping and antimicrobial resistance of Actinobacillus pleuropneumoniae isolates from fattening pigs in Poland from 2019 to 2024. BMC Vet Res. 2025;21(1):40.","journal-title":"BMC Vet Res"},{"issue":"3","key":"5445_CR15","doi-asserted-by":"publisher","first-page":"e0190924","DOI":"10.1128\/aem.01909-24","volume":"91","author":"D Kos","year":"2025","unstructured":"Kos D, Jelinski M, Ruzzini A. Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease. Appl Environ Microbiol. 2025;91(3):e0190924.","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"5445_CR16","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.tvjl.2013.07.032","volume":"198","author":"N Villarino","year":"2013","unstructured":"Villarino N, Brown SA, Mart\u00edn-Jim\u00e9nez T. The role of the macrolide tulathromycin in veterinary medicine. Vet J. 2013;198(2):352\u20137.","journal-title":"Vet J"},{"issue":"10","key":"5445_CR17","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.addr.2004.02.005","volume":"56","author":"NJ Medlicott","year":"2004","unstructured":"Medlicott NJ, Waldron NA, Foster TP. Sustained release veterinary parenteral products. Adv Drug Deliv Rev. 2004;56(10):1345\u201365.","journal-title":"Adv Drug Deliv Rev"},{"key":"5445_CR18","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1057\/s41599-024-03898-2","volume":"11","author":"J Eberhart","year":"2024","unstructured":"Eberhart J. Marketing antibiotics as vaccines? Analyzing the successful marketing of a pharmaceutical innovation: the case of tulathromycin in veterinary medicine. Humanit Social Sci Commun. 2024;11:1381.","journal-title":"Humanit Social Sci Commun"},{"key":"5445_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.tvjl.2019.01.007","volume":"246","author":"Y Yang","year":"2019","unstructured":"Yang Y, Yuan L, Li J, Muhammad I, Cheng P, Xiao T, Zhang X. Preparation and evaluation of tilmicosin microspheres and lung-targeting studies in rabbits. Vet J. 2019;246:27\u201334.","journal-title":"Vet J"},{"key":"5445_CR20","doi-asserted-by":"publisher","first-page":"0761","DOI":"10.34133\/research.0761","volume":"8","author":"L He","year":"2025","unstructured":"He L, Pan R, Liang R, Li B, Zhang P, He S, Li B, Li Y. Nanomaterial Adjuvants for Veterinary Vaccines: Mechanisms and Applications. Research. 2025;8:0761.","journal-title":"Research"},{"issue":"11","key":"5445_CR21","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.3390\/ijms19113299","volume":"19","author":"DP Bai","year":"2018","unstructured":"Bai DP, Lin XY, Huang YF, Zhang XF. Theranostics Aspects of Various Nanoparticles in Veterinary Medicine. Int J Mol Sci. 2018;19(11):3299.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"5445_CR22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3390\/pharmaceutics17050626","volume":"17","author":"H Koppisetti","year":"2025","unstructured":"Koppisetti H, Abdella S, Nakmode DD, Abid F, Afinjuomo F, Kim S, Song Y, Garg S. Unveiling the Future: Opportunities in Long-Acting Injectable Drug Development for Veterinary Care. Pharmaceutics. 2025;17(5):626.","journal-title":"Pharmaceutics"},{"issue":"1","key":"5445_CR23","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/vms3.1050","volume":"9","author":"F Jafary","year":"2023","unstructured":"Jafary F, Motamedi S, Karimi I. Veterinary nanomedicine: Pros and cons. Veterinary Med Sci. 2023;9(1):494\u2013506.","journal-title":"Veterinary Med Sci"},{"key":"5445_CR24","doi-asserted-by":"publisher","first-page":"105393","DOI":"10.1016\/j.jddst.2024.105393","volume":"92","author":"T Wang","year":"2024","unstructured":"Wang T, Staufenbiel S. Preparation and characterization of stabilizer-free oily nanosuspensions. J Drug Deliv Sci Technol. 2024;92:105393.","journal-title":"J Drug Deliv Sci Technol"},{"key":"5445_CR25","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.2147\/IJN.S348822","volume":"17","author":"Y Mao","year":"2022","unstructured":"Mao Y, Chen Y, Liu C, He X, Zheng Y, Chen X, Wang Y, Chen W, Wu Y, Shen Y, et al. Cefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections. Int J Nanomed. 2022;17:2535\u201353.","journal-title":"Int J Nanomed"},{"issue":"1\u20132","key":"5445_CR26","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ijpharm.2017.06.055","volume":"528","author":"RW Kalicharan","year":"2017","unstructured":"Kalicharan RW, Oussoren C, Schot P, Rijk E, Vromans H. The contribution of the in-vivo fate of an oil depot to drug absorption. Int J Pharm. 2017;528(1\u20132):595\u2013601.","journal-title":"Int J Pharm"},{"key":"5445_CR27","doi-asserted-by":"publisher","first-page":"113793","DOI":"10.1016\/j.jconrel.2025.113793","volume":"383","author":"J Liu","year":"2025","unstructured":"Liu J, Xu Z, Wu D, Leithead A, Johnson AR, Zhang Y, Nie N, Wagner A, Barrett SE. Particle size matters: The impact of particle size on properties and performance of long-acting injectable crystalline aqueous suspensions. J Controlled Release. 2025;383:113793.","journal-title":"J Controlled Release"},{"key":"5445_CR28","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jconrel.2021.12.011","volume":"341","author":"MJ Ho","year":"2022","unstructured":"Ho MJ, Jeong MY, Jeong HT, Kim MS, Park HJ, Kim DY, Lee HC, Song WH, Kim CH, Lee CH, et al. Effect of particle size on in vivo performances of long-acting injectable drug suspension. J Controlled Release. 2022;341:533\u201347.","journal-title":"J Controlled Release"},{"issue":"3","key":"5445_CR29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0378-5173(94)90103-1","volume":"105","author":"J Zuidema","year":"1994","unstructured":"Zuidema J, Kadir F, Titulaer HAC, Oussoren C. Release and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II). Int J Pharm. 1994;105(3):189\u2013207.","journal-title":"Int J Pharm"},{"issue":"1","key":"5445_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2174\/156720110790396472","volume":"7","author":"MK Rawat","year":"2010","unstructured":"Rawat MK, Jain A, Mishra A, Muthu MS, Singh S. Development of Repaglinide Loaded Solid Lipid Nanocarrier: Selection of Fabrication Method. Curr Drug Deliv. 2010;7(1):44\u201350.","journal-title":"Curr Drug Deliv"},{"key":"5445_CR31","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.theriogenology.2021.09.019","volume":"177","author":"JE Romano","year":"2022","unstructured":"Romano JE, Barbarossa A, Pagliuca G, Villad\u00f3niga GB, Gazzotti T, Mislei B, Zironi E, Mari G. Pharmacokinetics of tulathromycin on plasma and semen of beef bulls. Theriogenology. 2022;177:50\u20135.","journal-title":"Theriogenology"},{"issue":"22","key":"5445_CR32","doi-asserted-by":"publisher","first-page":"16262","DOI":"10.3390\/ijms242216262","volume":"24","author":"J Kang","year":"2023","unstructured":"Kang J, Chae H, Jeong S, Pervin R, Hossain MA. Evaluation of Biological Equivalence for Generic Tulathromycin Injections in Cattle. Int J Mol Sci. 2023;24(22):16262.","journal-title":"Int J Mol Sci"},{"key":"5445_CR33","doi-asserted-by":"publisher","first-page":"119483","DOI":"10.1016\/j.ijpharm.2020.119483","volume":"585","author":"YT Goo","year":"2020","unstructured":"Goo YT, Park SY, Chae BR, Yoon HY, Kim CH, Choi JY, Song SH, Choi YW. Optimization of solid self-dispersing micelle for enhancing dissolution and oral bioavailability of valsartan using Box-Behnken design. Int J Pharm. 2020;585:119483.","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"5445_CR34","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ijpharm.2015.03.036","volume":"485","author":"P Sharma","year":"2015","unstructured":"Sharma P, Modi SR, Bansal AK. Co-processing of hydroxypropyl methylcellulose (HPMC) for improved aqueous dispersibility. Int J Pharm. 2015;485(1\u20132):348\u201356.","journal-title":"Int J Pharm"},{"key":"5445_CR35","doi-asserted-by":"publisher","first-page":"127660","DOI":"10.1016\/j.foodchem.2020.127660","volume":"336","author":"P Degot","year":"2021","unstructured":"Degot P, Huber V, Hofmann E, Hahn M, Touraud D, Kunz W. Solubilization and extraction of curcumin from Curcuma Longa using green, sustainable, and food-approved surfactant-free microemulsions. Food Chem. 2021;336:127660.","journal-title":"Food Chem"},{"issue":"5","key":"5445_CR36","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jechem.2015.08.001","volume":"24","author":"W Hu","year":"2015","unstructured":"Hu W, Zhang Y, Huang Y, Wang J, Gao J, Xu J. Selective esterification of glycerol with acetic acid to diacetin using antimony pentoxide as reusable catalyst. J Energy Chem. 2015;24(5):632\u20136.","journal-title":"J Energy Chem"},{"key":"5445_CR37","doi-asserted-by":"publisher","first-page":"107209","DOI":"10.1016\/j.jddst.2025.107209","volume":"111","author":"N Zulbeari","year":"2025","unstructured":"Zulbeari N, Dasous BA, Holm R. Exploring the physical short-term stability of naproxen suspensions: The impact of stabilizer and stabilizer concentration on the particle size profiles. J Drug Deliv Sci Technol. 2025;111:107209.","journal-title":"J Drug Deliv Sci Technol"},{"key":"5445_CR38","doi-asserted-by":"publisher","first-page":"125646","DOI":"10.1016\/j.ijpharm.2025.125646","volume":"677","author":"N Zulbeari","year":"2025","unstructured":"Zulbeari N, Holm R. Long-term versus short-term stress physical stability assessment of pharmaceutical nano- and microsuspensions. Int J Pharm. 2025;677:125646.","journal-title":"Int J Pharm"},{"issue":"1","key":"5445_CR39","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ijpharm.2015.09.019","volume":"495","author":"R Trastullo","year":"2015","unstructured":"Trastullo R, Dolci LS, Passerini N, Albertini B. Development of flexible and dispersible oral formulations containing praziquantel for potential schistosomiasis treatment of pre-school age children. Int J Pharm. 2015;495(1):536\u201350.","journal-title":"Int J Pharm"},{"issue":"3","key":"5445_CR40","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","volume":"94","author":"I Gulcin","year":"2020","unstructured":"Gulcin I. Antioxidants and antioxidant methods: an updated overview. Arch Toxicol. 2020;94(3):651\u2013715.","journal-title":"Arch Toxicol"},{"issue":"6","key":"5445_CR41","doi-asserted-by":"publisher","first-page":"e70416","DOI":"10.1002\/fsn3.70416","volume":"13","author":"B Alizadeh-Salmani","year":"2025","unstructured":"Alizadeh-Salmani B, Arab M, Sadeghizadeh-Yazdi J, Yousefi M, Jambarsang S. Buckwheat and Rosemary as Antioxidants in Soybean Oil: Comparison With Synthetic Antioxidant. Food Sci Nutr. 2025;13(6):e70416.","journal-title":"Food Sci Nutr"},{"key":"5445_CR42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2024.05.027","volume":"221","author":"N Noguchi","year":"2024","unstructured":"Noguchi N, Niki E. Vitamin E nomenclature. Is RRR-\u03b1-tocopherol the only vitamin E? Free Radic Biol Med. 2024;221:257\u201360.","journal-title":"Free Radic Biol Med"},{"key":"5445_CR43","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2021.11.012","volume":"179","author":"Q Jiang","year":"2022","unstructured":"Jiang Q. Metabolism of natural forms of vitamin E and biological actions of vitamin E metabolites. Free Radic Biol Med. 2022;179:375\u201387.","journal-title":"Free Radic Biol Med"},{"key":"5445_CR44","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev-nutr-082018-124228","volume":"41","author":"WS Blaner","year":"2021","unstructured":"Blaner WS, Shmarakov IO, Traber MG. Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up? Annu Rev Nutr. 2021;41:105\u201331.","journal-title":"Annu Rev Nutr"},{"key":"5445_CR45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.colsurfb.2012.05.006","volume":"98","author":"Y Wang","year":"2012","unstructured":"Wang Y, Zhu L, Dong Z, Xie S, Chen X, Lu M, Wang X, Li X, Zhou W. Preparation and stability study of norfloxacin-loaded solid lipid nanoparticle suspensions. Colloids Surf B Biointerfaces. 2012;98:105\u201311.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"6668","key":"5445_CR46","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1126\/science.ade9637","volume":"382","author":"Z Li","year":"2023","unstructured":"Li Z, Sun X, Zheng X, Li B, Gao D, Zhang S, Wu X, Li S, Gong J, Luther JM, et al. Stabilized hole-selective layer for high-performance inverted p-i-n perovskite solar cells. Sci (New York N Y). 2023;382(6668):284\u20139.","journal-title":"Sci (New York N Y)"},{"issue":"7603","key":"5445_CR47","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nature17967","volume":"533","author":"IB Seiple","year":"2016","unstructured":"Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, et al. : A platform for the discovery of new macrolide antibiotics. Nature. 2016;533(7603):338\u201345.","journal-title":"Nature"},{"issue":"2","key":"5445_CR48","first-page":"83","volume":"6","author":"NA Evans","year":"2005","unstructured":"Evans NA. Tulathromycin: an overview of a new triamilide antibiotic for livestock respiratory disease. Veterinary Therapeutics: Res Appl Veterinary Med. 2005;6(2):83\u201395.","journal-title":"Veterinary Therapeutics: Res Appl Veterinary Med"},{"issue":"6","key":"5445_CR49","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3390\/nano10061085","volume":"10","author":"A Murthy","year":"2020","unstructured":"Murthy A, Ravi PR, Kathuria H, Malekar S. Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers. Nanomaterials (Basel). 2020;10(6):1085.","journal-title":"Nanomaterials (Basel)"},{"issue":"5","key":"5445_CR50","first-page":"448","volume":"34","author":"KA Clothier","year":"2011","unstructured":"Clothier KA, Leavens T, Griffith RW, Wetzlich SE, Baynes RE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus). Res Vet Sci. 2011;34(5):448\u201354.","journal-title":"Res Vet Sci"},{"issue":"3","key":"5445_CR51","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.rvsc.2010.06.025","volume":"90","author":"G Young","year":"2011","unstructured":"Young G, Smith GW, Leavens TL, Wetzlich SE, Baynes RE, Mason SE, Riviere JE, Tell LA. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats. Res Vet Sci. 2011;90(3):477\u20139.","journal-title":"Res Vet Sci"},{"issue":"1","key":"5445_CR52","doi-asserted-by":"publisher","first-page":"e17270","DOI":"10.1111\/jvim.17270","volume":"39","author":"DM Foster","year":"2025","unstructured":"Foster DM, Halleran JL, Jacob ME, Hempstead S, Borst LB, Watanabe TTN, Enomoto H, Papich MG. Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica. J Vet Intern Med. 2025;39(1):e17270.","journal-title":"J Vet Intern Med"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-026-05445-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05445-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T01:02:37Z","timestamp":1779757357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12917-026-05445-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5445"],"URL":"https:\/\/doi.org\/10.1186\/s12917-026-05445-4","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"18 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures received prior approval from the Guangxi University Institutional Animal Care and Use Committee (IACUC Protocol No. GXU-2025-019) and complied with the recommendations of the academy\u2019s animal research guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}