{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:15:08Z","timestamp":1789085708770,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":78,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Foundation of Key Technology Research Project of Henan Province","award":["262102110042"],"award-info":[{"award-number":["262102110042"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Vet Res"],"DOI":"10.1186\/s12917-026-05650-1","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:47:05Z","timestamp":1782388025000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artemisia argyi-enriched fermented soybean meal alleviates ETEC K88-induced intestinal injury in mice in association with gut microbiota remodeling and purine metabolic alterations"],"prefix":"10.1186","volume":"22","author":[{"given":"Weiwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huakai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"5650_CR1","doi-asserted-by":"publisher","first-page":"885253","DOI":"10.3389\/fimmu.2022.885253","volume":"13","author":"K Kim","year":"2022","unstructured":"Kim K, Song M, Liu Y, Ji P. Enterotoxigenic Escherichia coli infection of weaned pigs: intestinal challenges and nutritional intervention to enhance disease resistance. Front Immunol. 2022;13:885253.","journal-title":"Front Immunol"},{"key":"5650_CR2","doi-asserted-by":"publisher","first-page":"981207","DOI":"10.3389\/fvets.2022.981207","volume":"9","author":"J Castro","year":"2022","unstructured":"Castro J, Barros MM, Ara\u00fajo D, et al. Swine enteric colibacillosis: current treatment avenues and future directions. Front Vet Sci. 2022;9:981207.","journal-title":"Front Vet Sci"},{"key":"5650_CR3","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.aninu.2023.12.010","volume":"17","author":"X Han","year":"2024","unstructured":"Han X, Hu X, Jin W, Liu G. Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets. Anim Nutr. 2024;17:188\u2013207.","journal-title":"Anim Nutr"},{"key":"5650_CR4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.aninu.2024.03.006","volume":"17","author":"Q Tang","year":"2024","unstructured":"Tang Q, Lan T, Zhou C, et al. Nutrition strategies to control post-weaning diarrhea of piglets: from the perspective of feeds. Anim Nutr. 2024;17:297\u2013311.","journal-title":"Anim Nutr"},{"key":"5650_CR5","doi-asserted-by":"publisher","first-page":"1552482","DOI":"10.3389\/fvets.2025.1552482","volume":"12","author":"S Zheng","year":"2025","unstructured":"Zheng S, Li M, Luan X, Tong C, Li J, Zhang Z. The role of lycopene in alleviating soybean meal-induced intestinal injury in an early-weaned piglet model. Front Vet Sci. 2025;12:1552482.","journal-title":"Front Vet Sci"},{"issue":"18","key":"5650_CR6","doi-asserted-by":"publisher","first-page":"6500","DOI":"10.3390\/molecules28186500","volume":"28","author":"L Wang","year":"2023","unstructured":"Wang L, Liu Y, Zhang D, et al. Soybean antigen protein-induced intestinal barrier damage by trigging endoplasmic reticulum stress and disordering gut microbiota in weaned piglets. Molecules. 2023;28(18):6500.","journal-title":"Molecules"},{"key":"5650_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.aninu.2023.10.003","volume":"16","author":"MT Lambo","year":"2024","unstructured":"Lambo MT, Ma H, Zhang H, et al. Mechanism of action, benefits, and research gap in fermented soybean meal utilization as a high-quality protein source for livestock and poultry. Anim Nutr. 2024;16:130\u201346.","journal-title":"Anim Nutr"},{"issue":"6","key":"5650_CR8","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms25063199","volume":"25","author":"Y Qiu","year":"2024","unstructured":"Qiu Y, Tang J, Wang L, Yang X, Jiang Z. Fermented corn-soybean meal improved growth performance and reduced diarrhea incidence by modulating intestinal barrier function and gut microbiota in weaned piglets. Int J Mol Sci. 2024;25(6):3199.","journal-title":"Int J Mol Sci"},{"key":"5650_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12917-020-02466-5","volume":"16","author":"W Wang","year":"2020","unstructured":"Wang W, Wang Y, Hao X, et al. Dietary fermented soybean meal replacement alleviates diarrhea in weaned piglets challenged with enterotoxigenic Escherichia coli K88 by modulating inflammatory cytokine levels and cecal microbiota composition. BMC Vet Res. 2020;16:245.","journal-title":"BMC Vet Res"},{"key":"5650_CR10","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1038\/s41598-023-30698-6","volume":"13","author":"M Muniyappan","year":"2023","unstructured":"Muniyappan M, Shanmugam S, Park JH, et al. Effects of fermented soybean meal supplementation on the growth performance and apparent total tract digestibility by modulating the gut microbiome of weaned piglets. Sci Rep. 2023;13:3691.","journal-title":"Sci Rep"},{"issue":"16","key":"5650_CR11","first-page":"2327","volume":"14","author":"F Xie","year":"2024","unstructured":"Xie F, Zhou M, Li X, et al. Macrogenomic and metabolomic analyses reveal mechanisms of gut microbiota and microbial metabolites in diarrhea of weaned piglets. Anim (Basel). 2024;14(16):2327.","journal-title":"Anim (Basel)"},{"issue":"10","key":"5650_CR12","doi-asserted-by":"publisher","first-page":"7473","DOI":"10.1007\/s00210-024-03122-7","volume":"397","author":"H Wang","year":"2024","unstructured":"Wang H, Zhang Y, Yu D, et al. A review of the research progress on Artemisia argyi Folium: botany, phytochemistry, pharmacological activities, and clinical application. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(10):7473\u2013500.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"Pt 5","key":"5650_CR13","doi-asserted-by":"publisher","first-page":"136779","DOI":"10.1016\/j.ijbiomac.2024.136779","volume":"282","author":"P Zhang","year":"2024","unstructured":"Zhang P, Yang D, Xiao J, et al. Artemisia argyi polysaccharide alleviates osmotic diarrhea by enhancing intestinal barrier protection and anti-inflammation. Int J Biol Macromol. 2024;282(Pt 5):136779.","journal-title":"Int J Biol Macromol"},{"key":"5650_CR14","doi-asserted-by":"publisher","first-page":"155897","DOI":"10.1016\/j.phymed.2024.155897","volume":"132","author":"H Zhang","year":"2024","unstructured":"Zhang H, Hao Z, Zhang R, et al. Artemisia argyi polyphenols attenuates DSS-induced colitis in mice by regulating the structural composition of gut microbiota. Phytomedicine. 2024;132:155897.","journal-title":"Phytomedicine"},{"issue":"4","key":"5650_CR15","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1093\/jas\/skz047","volume":"97","author":"L Liu","year":"2019","unstructured":"Liu L, Zuo W, Li F. Dietary addition of Artemisia argyi reduces diarrhea and modulates the gut immune function without affecting growth performances of rabbits after weaning. J Anim Sci. 2019;97(4):1693\u2013700.","journal-title":"J Anim Sci"},{"issue":"7","key":"5650_CR16","doi-asserted-by":"publisher","first-page":"998","DOI":"10.3390\/foods13070998","volume":"13","author":"JY Lee","year":"2024","unstructured":"Lee JY, Kim JH, Choi JM, Noh BW, Kim HY, Cho EJ. Anti-inflammatory effects of Artemisia argyi H. fermented by Lactobacillus plantarum in the LPS-induced RAW 264.7 cells and DSS-induced colitis model. Foods. 2024;13(7):998.","journal-title":"Foods"},{"issue":"19","key":"5650_CR17","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.3390\/molecules25194481","volume":"25","author":"W Wang","year":"2020","unstructured":"Wang W, Ma H, Yu H, Qin G, Tan Z, Wang Y, Pang H. Screening of Lactobacillus plantarum subsp. plantarum with potential probiotic activities for inhibiting ETEC K88 in weaned piglets. Molecules. 2020;25(19):4481.","journal-title":"Molecules"},{"issue":"6","key":"5650_CR18","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/foods11060795","volume":"11","author":"W Wang","year":"2022","unstructured":"Wang W, Tan Z, Gu L, Ma H, Wang Z, Wang L, et al. Dynamic changes of microorganisms community and fermentation quality in soybean meal prepared with lactic acid bacteria and Artemisia argyi through fermentation and aerobic exposure processes. Foods. 2022;11(6):795.","journal-title":"Foods"},{"issue":"8","key":"5650_CR19","doi-asserted-by":"publisher","first-page":"skab196","DOI":"10.1093\/jas\/skab196","volume":"99","author":"J Hong","year":"2021","unstructured":"Hong J, Ariyibi S, Antony L, Scaria J, Dilberger-Lawson S, Francis D, Woyengo TA. Growth performance and gut health of Escherichia coli-challenged weaned pigs fed canola meal-containing diet. J Anim Sci. 2021;99(8):skab196.","journal-title":"J Anim Sci"},{"key":"5650_CR20","doi-asserted-by":"publisher","first-page":"650190","DOI":"10.3389\/fphys.2021.650190","volume":"12","author":"F Peng","year":"2021","unstructured":"Peng F, Zhang H, He X, Song Z. Effects of ursolic acid on intestinal health and gut bacteria antibiotic resistance in mice. Front Physiol. 2021;12:650190.","journal-title":"Front Physiol"},{"key":"5650_CR21","doi-asserted-by":"publisher","first-page":"113377","DOI":"10.1016\/j.jep.2020.113377","volume":"264","author":"L Yang","year":"2021","unstructured":"Yang L, Zhang Q, Huang J, Liu D, Lan Y, Yuan L, Chen Q. Xianglian Pill ameliorates antibiotic-associated diarrhea by restoring intestinal microbiota and attenuating mucosal damage. J Ethnopharmacol. 2021;264:113377.","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"5650_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u2206\u2206Ct method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"8","key":"5650_CR23","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019;37(8):852\u20137.","journal-title":"Nat Biotechnol"},{"issue":"7","key":"5650_CR24","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","volume":"13","author":"BJ Callahan","year":"2016","unstructured":"Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13(7):581\u20133.","journal-title":"Nat Methods"},{"issue":"Database issue","key":"5650_CR25","first-page":"D590","volume":"41","author":"C Quast","year":"2013","unstructured":"Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2013;41(Database issue):D590\u20136.","journal-title":"Nucleic Acids Res"},{"key":"5650_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41592-023-02092-7","volume":"21","author":"H Lin","year":"2024","unstructured":"Lin H, Peddada SD. Multigroup analysis of compositions of microbiomes with covariate adjustments and repeated measures. Nat Methods. 2024;21:83\u201391.","journal-title":"Nat Methods"},{"key":"5650_CR27","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11306-018-1367-3","volume":"14","author":"D Broadhurst","year":"2018","unstructured":"Broadhurst D, Goodacre R, Reinke SN, Kuligowski J, Wilson ID, Lewis MR, et al. Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies. Metabolomics. 2018;14:72.","journal-title":"Metabolomics"},{"key":"5650_CR28","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1038\/s41467-024-48009-6","volume":"15","author":"Z Pang","year":"2024","unstructured":"Pang Z, Xu L, Viau C, et al. MetaboAnalystR 4.0: a unified LC\u2013MS workflow for global metabolomics. Nat Commun. 2024;15:3675.","journal-title":"Nat Commun"},{"key":"5650_CR29","doi-asserted-by":"publisher","first-page":"1428287","DOI":"10.3389\/fmicb.2024.1428287","volume":"15","author":"X Nie","year":"2024","unstructured":"Nie X, Lu Q, Yin Y, He Z, Bai Y, Zhu C. Microbiome and metabolome analyses reveal significant alterations of gut microbiota and bile acid metabolism in ETEC-challenged weaned piglets by dietary berberine supplementation. Front Microbiol. 2024;15:1428287.","journal-title":"Front Microbiol"},{"key":"5650_CR30","doi-asserted-by":"publisher","first-page":"37080","DOI":"10.1038\/s41598-025-21011-8","volume":"15","author":"J Li","year":"2025","unstructured":"Li J, Liu X, Sun C, et al. Metabolomics reveals the hindgut metabolic changes and physiological impacts in weaned piglets subjected to ETEC infection and berberine intervention. Sci Rep. 2025;15:37080.","journal-title":"Sci Rep"},{"key":"5650_CR31","doi-asserted-by":"publisher","first-page":"1613054","DOI":"10.3389\/fvets.2025.1613054","volume":"12","author":"T Huang","year":"2025","unstructured":"Huang T, Dong J, Zhang W, Hu Z, Tan X, Li H, et al. Comparison of fecal microbiota and metabolites in diarrheal piglets pre- and post-weaning. Front Vet Sci. 2025;12:1613054.","journal-title":"Front Vet Sci"},{"key":"5650_CR32","doi-asserted-by":"publisher","first-page":"1460127","DOI":"10.3389\/fimmu.2024.1460127","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhang Z, Du M, Ji X, Liu X, Zhao C, et al. Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. Front Immunol. 2024;15:1460127.","journal-title":"Front Immunol"},{"key":"5650_CR33","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s40104-025-01209-6","volume":"16","author":"J Xu","year":"2025","unstructured":"Xu J, Andrani M, Kj\u00e6rup RB, et al. In-feed provision of binding proteins sustains piglet gut health and mitigates ETEC-induced post-weaning diarrhea. J Anim Sci Biotechnol. 2025;16:78.","journal-title":"J Anim Sci Biotechnol"},{"key":"5650_CR34","doi-asserted-by":"publisher","first-page":"1629044","DOI":"10.3389\/fimmu.2025.1629044","volume":"16","author":"M Wang","year":"2025","unstructured":"Wang M, Zhou X, H\u00fcbertz Birch Hansen L, Sheng Y, Yu B, He J, et al. Complex probiotics can reduce diarrhea by boosting immunity and balancing gut microbiota in weaned piglets. Front Immunol. 2025;16:1629044.","journal-title":"Front Immunol"},{"key":"5650_CR35","doi-asserted-by":"publisher","first-page":"100557","DOI":"10.1016\/j.animal.2022.100557","volume":"16","author":"H Yan","year":"2022","unstructured":"Yan H, Jin JQ, Yang P, Yu B, He J, Mao XB, et al. Fermented soybean meal increases nutrient digestibility via the improvement of intestinal function, anti-oxidative capacity and immune function of weaned pigs. Animal. 2022;16:100557.","journal-title":"Animal"},{"key":"5650_CR36","doi-asserted-by":"publisher","first-page":"1494348","DOI":"10.3389\/fnut.2024.1494348","volume":"11","author":"M Du","year":"2025","unstructured":"Du M, Liu X, Ji X, Wang Y, Liu X, Zhao C, et al. Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome. Front Nutr. 2025;11:1494348.","journal-title":"Front Nutr"},{"issue":"1","key":"5650_CR37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s42523-025-00446-4","volume":"7","author":"M Wang","year":"2025","unstructured":"Wang M, Liu X, Ji X, Wen A, Wang H, Jin E, Zhang F. Linarin alleviates enterotoxigenic Escherichia coli-induced small intestinal mucosal barrier damage in a piglet model by modulating the gut microbiota. Anim Microbiome. 2025;7(1):115.","journal-title":"Anim Microbiome"},{"key":"5650_CR38","doi-asserted-by":"publisher","first-page":"1631991","DOI":"10.3389\/fimmu.2025.1631991","volume":"16","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Liu X, Sun C, Wang M, Ji X, Li S, et al. Linarin alleviates colonic barrier dysfunction induced by enterotoxic Escherichia coli in weaned piglets by regulating the gut microbiota and metabolic pathways. Front Immunol. 2025;16:1631991.","journal-title":"Front Immunol"},{"issue":"4","key":"5650_CR39","doi-asserted-by":"publisher","first-page":"e0398823","DOI":"10.1128\/spectrum.03988-23","volume":"12","author":"M Li","year":"2024","unstructured":"Li M, Zhao D, Guo J, Pan T, Niu T, Jiang Y, et al. Bacillus halotolerans SW207 alleviates enterotoxigenic Escherichia coli-induced inflammatory responses in weaned piglets by modulating the intestinal epithelial barrier, the TLR4\/MyD88\/NF-\u03baB pathway, and intestinal microbiota. Microbiol Spectr. 2024;12(4):e0398823.","journal-title":"Microbiol Spectr"},{"key":"5650_CR40","doi-asserted-by":"publisher","first-page":"1558588","DOI":"10.3389\/fmicb.2025.1558588","volume":"16","author":"Z Fan","year":"2025","unstructured":"Fan Z, Lei L, Wu X, Xing R, Du P, Wang Z, et al. Dietary fatty acids promote gut health in weaned piglets by regulating gut microbiota and immune function. Front Microbiol. 2025;16:1558588.","journal-title":"Front Microbiol"},{"key":"5650_CR41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s40104-025-01313-7","volume":"16","author":"K Kim","year":"2025","unstructured":"Kim K, Park S, Jinno C, Ji P, Liu Y. Impact of dietary supplementation of Bacillus subtilis on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic Escherichia coli. J Anim Sci Biotechnol. 2025;16:167.","journal-title":"J Anim Sci Biotechnol"},{"key":"5650_CR42","doi-asserted-by":"publisher","first-page":"118038","DOI":"10.1016\/j.foodres.2025.118038","volume":"225","author":"Y Dong","year":"2026","unstructured":"Dong Y, Xie Y, Yao R, Mai Y, Zhang L, Wang H, et al. Lactobacillus fermentum ZNL16 attenuates ETEC-induced intestinal injury by regulating gut microbiota and short-chain fatty acid metabolism to suppress the IL-17\/JAK2-STAT3 pathway. Food Res Int. 2026;225:118038.","journal-title":"Food Res Int"},{"key":"5650_CR43","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s40104-025-01262-1","volume":"16","author":"Z Wang","year":"2025","unstructured":"Wang Z, Fang X, Yu Z, Huo X, Liu H, Du Y, et al. Bacillus velezensis MZ09 alleviates DSS-induced colitis in piglets by remodeling the intestinal microbiota, activating the SCFAs\u2013GPR43\u2013STAT3 pathway and suppressing NLRP3 inflammasome-mediated pyroptosis. J Anim Sci Biotechnol. 2025;16:120.","journal-title":"J Anim Sci Biotechnol"},{"key":"5650_CR44","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1038\/s41598-025-87105-5","volume":"15","author":"Q Xie","year":"2025","unstructured":"Xie Q, Yang M, Duanmu Q, Kang M, Wang J, Tan BE. Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles. Sci Rep. 2025;15:3993.","journal-title":"Sci Rep"},{"issue":"4","key":"5650_CR45","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.apsb.2023.12.015","volume":"14","author":"D Bai","year":"2024","unstructured":"Bai D, Zhao J, Wang R, Du J, Zhou C, Gu C, et al. Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier. Acta Pharm Sin B. 2024;14(4):1677\u201392.","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"5650_CR46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cmet.2025.10.007","volume":"38","author":"K Klag","year":"2026","unstructured":"Klag K, et al. Dietary fat disrupts a commensal-host lipid network that promotes metabolic health. Cell Metab. 2026;38(1):157\u201373.","journal-title":"Cell Metab"},{"issue":"7","key":"5650_CR47","doi-asserted-by":"publisher","first-page":"100670","DOI":"10.1016\/j.gastha.2025.100670","volume":"4","author":"M Martell","year":"2025","unstructured":"Martell M, Quarnstrom CF, Khoruts A, Vezys V, Staley C, Shmidt E. Chronic intestinal inflammation and microbial dysbiosis are associated with female reproductive outcomes in a mouse model of inflammatory bowel disease. Gastro Hep Adv. 2025;4(7):100670.","journal-title":"Gastro Hep Adv"},{"key":"5650_CR48","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s43587-025-00864-8","volume":"5","author":"SS Saeedi Saravi","year":"2025","unstructured":"Saeedi Saravi SS, Pugin B, Constancias F, et al. Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging. Nat Aging. 2025;5:1025\u201345.","journal-title":"Nat Aging"},{"issue":"6","key":"5650_CR49","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.chom.2023.05.011","volume":"31","author":"K Kasahara","year":"2023","unstructured":"Kasahara K, Kerby RL, Zhang Q, et al. Gut bacterial metabolism contributes to host global purine homeostasis. Cell Host Microbe. 2023;31(6):1038\u2013e105310.","journal-title":"Cell Host Microbe"},{"issue":"20","key":"5650_CR50","doi-asserted-by":"publisher","first-page":"e2409837","DOI":"10.1002\/advs.202409837","volume":"12","author":"L Gao","year":"2025","unstructured":"Gao L, Zhang Y, Hu Z, et al. Microbiota-derived inosine suppresses systemic autoimmunity via restriction of B cell differentiation and migration. Adv Sci (Weinh). 2025;12(20):e2409837.","journal-title":"Adv Sci (Weinh)"},{"key":"5650_CR51","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41538-025-00556-y","volume":"9","author":"J Ji","year":"2025","unstructured":"Ji J, An ZY, Khan A, et al. Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism. npj Sci Food. 2025;9:183.","journal-title":"npj Sci Food"},{"issue":"5","key":"5650_CR52","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/cells13050381","volume":"13","author":"M Stepanova","year":"2024","unstructured":"Stepanova M, Aherne CM. Adenosine in intestinal epithelial barrier function. Cells. 2024;13(5):381.","journal-title":"Cells"},{"issue":"1","key":"5650_CR53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41522-024-00514-8","volume":"10","author":"TP Jenkins","year":"2024","unstructured":"Jenkins TP, \u00c1cs N, Arendrup EW, et al. Protecting the piglet gut microbiota against ETEC-mediated post-weaning diarrhoea using specific binding proteins. npj Biofilms Microbiomes. 2024;10(1):42.","journal-title":"npj Biofilms Microbiomes"},{"key":"5650_CR54","doi-asserted-by":"publisher","first-page":"1627782","DOI":"10.3389\/fcimb.2025.1627782","volume":"15","author":"L Cantas","year":"2025","unstructured":"Cantas L, Fenton CG, Bato E, Paulssen RH, S\u00f8rum H. Impact of antibiotic choice on immune response and antibiotic resistance development in piglets experimentally infected with Escherichia coli. Front Cell Infect Microbiol. 2025;15:1627782.","journal-title":"Front Cell Infect Microbiol"}],"container-title":["BMC Veterinary Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12917-026-05650-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05650-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12917-026-05650-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:02:45Z","timestamp":1789084965000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12917-026-05650-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5650"],"URL":"https:\/\/doi.org\/10.1186\/s12917-026-05650-1","relation":{},"ISSN":["1746-6148"],"issn-type":[{"value":"1746-6148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"30 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures were authorized by the Committee for the Welfare of Laboratory Animals and the Ethical Review of Experiments at China Agricultural University (AW42405202-1-03) and were performed following the guidelines of the Institute of Nutrition and Health, China Agricultural University.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"536"}}