{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:13:35Z","timestamp":1762899215375,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"German Ministry of Education and Science","award":["01ES1103"],"award-info":[{"award-number":["01ES1103"]}]},{"name":"German Ministry of Education and Science","award":["01ZX1309"],"award-info":[{"award-number":["01ZX1309"]}]},{"DOI":"10.13039\/501100005941","name":"Dietmar Hopp Stiftung (DE)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12920-015-0161-6","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T03:27:50Z","timestamp":1451446070000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells"],"prefix":"10.1186","volume":"8","author":[{"given":"Tobias","family":"Mei\u00dfner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Seckinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Bertsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asta","family":"Foersti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Haenel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Duering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Salwender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Goldschmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth J.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Hose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Weinhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"issue":"18","key":"161_CR1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMra041875","volume":"351","author":"RA Kyle","year":"2004","unstructured":"Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004; 351(18):1860\u201373. doi: 10.1056\/NEJMra041875 .","journal-title":"N Engl J Med"},{"key":"161_CR2","doi-asserted-by":"crossref","unstructured":"Barlogie B, Tricot G, Anaissie E, Shaughnessy J, Rasmussen E, van Rhee F, et al. Thalidomide and hematopoietic-cell transplantation for multiple myeloma. Technical Report 10. 2006. doi: http:\/\/dx.doi.org\/10.1056\/NEJMoa053583 http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa053583 .","DOI":"10.1056\/NEJMoa053583"},{"issue":"6","key":"161_CR3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-2141.2007.06921.x","volume":"140","author":"M Pineda-Roman","year":"2008","unstructured":"Pineda-Roman M, Zangari M, Haessler J, Anaissie E, Tricot G, van Rhee F, et al. Sustained complete remissions in multiple myeloma linked to bortezomib in total therapy 3: comparison with total therapy 2. Br J Haematol. 2008; 140(6):625\u201334. doi: 10.1111\/j.1365-2141.2007.06921.x .","journal-title":"Br J Haematol"},{"key":"161_CR4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/ijlh.12360","volume":"37 Suppl 1","author":"M Chesi","year":"2015","unstructured":"Chesi M, Bergsagel PL. Advances in the pathogenesis and diagnosis of multiple myeloma. Int J Lab Hematol. 2015; 37 Suppl 1:108\u201314. doi: 10.1111\/ijlh.12360 .","journal-title":"Int J Lab Hematol"},{"issue":"1","key":"161_CR5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","volume":"106","author":"PL Bergsagel","year":"2005","unstructured":"Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J. Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma. Blood. 2005; 106(1):296\u2013303. doi: 10.1182\/blood-2005-01-0034 .","journal-title":"Blood"},{"issue":"6","key":"161_CR6","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/blood-2005-11-013458","volume":"108","author":"F Zhan","year":"2006","unstructured":"Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, et al. The molecular classification of multiple myeloma. Blood. 2006; 108(6):2020\u20138. doi: 10.1182\/blood-2005-11-013458 .","journal-title":"Blood"},{"issue":"2","key":"161_CR7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3324\/haematol.2013.099358","volume":"99","author":"M Engelhardt","year":"2014","unstructured":"Engelhardt M, Terpos E, Kleber M, Gay F, W\u00e4sch R, Morgan G, et al. European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica. 2014; 99(2):232\u201342. doi: 10.3324\/haematol.2013.099358 .","journal-title":"Haematologica"},{"issue":"4","key":"161_CR8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.mayocp.2013.01.019","volume":"88","author":"JR Mikhael","year":"2013","unstructured":"Mikhael JR, Dingli D, Roy V, Reeder CB, Buadi FK, Hayman SR, et al. Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines 2013. Mayo Clin Proc. 2013; 88(4):360\u201376. doi: 10.1016\/j.mayocp.2013.01.019 .","journal-title":"Mayo Clin Proc"},{"key":"161_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2202\/1544-6115.1027","volume":"3","author":"GK Smyth","year":"2004","unstructured":"Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004; 3:3. doi: 10.2202\/1544-6115.1027 .","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"10","key":"161_CR10","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1073\/pnas.082099299","volume":"99","author":"R Tibshirani","year":"2002","unstructured":"Tibshirani R, Hastie T, Narasimhan B, Chu G. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci U S A. 2002; 99(10):6567\u201372. doi: 10.1073\/pnas.082099299 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"161_CR11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1371\/journal.pcbi.0040022","volume":"4","author":"D Kostka","year":"2008","unstructured":"Kostka D, Spang R. Microarray based diagnosis profits from better documentation of gene expression signatures. PLoS Comput Biol. 2008; 4(2):22. doi: 10.1371\/journal.pcbi.0040022 .","journal-title":"PLoS Comput Biol"},{"issue":"Web Server issu","key":"161_CR12","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/nar\/gki475","volume":"33","author":"B Zhang","year":"2005","unstructured":"Zhang B, Kirov S, Snoddy J. WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 2005; 33(Web Server issue):741\u20138. doi: 10.1093\/nar\/gki475 .","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"161_CR13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3324\/haematol.2010.030296","volume":"96","author":"D Hose","year":"2011","unstructured":"Hose D, R\u00e8me T, Hielscher T, Moreaux J, Messner T, Seckinger A, et al. Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma. Haematologica. 2011; 96(1):87\u201395. doi: 10.3324\/haematol.2010.030296 .","journal-title":"Haematologica"},{"issue":"29","key":"161_CR14","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1200\/JCO.2007.13.8545","volume":"26","author":"O Decaux","year":"2008","unstructured":"Decaux O, Lod\u00e9 L, Magrangeas F, Charbonnel C, Gouraud W, J\u00e9z\u00e9quel P, et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du My\u00e9lom. J Clin Oncol Off J Am Soc Clin Oncol. 2008; 26(29):4798\u2013805. doi: 10.1200\/JCO.2007.13.8545 .","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"6","key":"161_CR15","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1182\/blood-2006-07-038430","volume":"109","author":"JD Shaughnessy","year":"2007","unstructured":"Shaughnessy JD, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood. 2007; 109(6):2276\u201384. doi: 10.1182\/blood-2006-07-038430 .","journal-title":"Blood"},{"issue":"11","key":"161_CR16","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/leu.2012.127","volume":"26","author":"R Kuiper","year":"2012","unstructured":"Kuiper R, Broyl A, de Knegt Y, van Vliet MH, van Beers EH, van der Holt B, et al. A gene expression signature for high-risk multiple myeloma. Leukemia. 2012; 26(11):2406\u201313. doi: 10.1038\/leu.2012.127 .","journal-title":"Leukemia"},{"issue":"4","key":"161_CR17","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood-2011-09-379164","volume":"119","author":"K Neben","year":"2012","unstructured":"Neben K, Lokhorst HM, Jauch A, Bertsch U, Hielscher T, van der Holt B, et al. Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Blood. 2012; 119(4):940\u20138. doi: 10.1182\/blood-2011-09-379164 .","journal-title":"Blood"},{"issue":"34","key":"161_CR18","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1200\/JCO.2012.48.4923","volume":"31","author":"K Neben","year":"2013","unstructured":"Neben K, Jauch A, Hielscher T, Hillengass J, Lehners N, Seckinger A, et al. Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load. J Clin Oncol Off J Am Soc Clin Oncol. 2013; 31(34):4325\u201332. doi: 10.1200\/JCO.2012.48.4923 .","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"1","key":"161_CR19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/bioinformatics\/btg382","volume":"20","author":"JJ Goeman","year":"2003","unstructured":"Goeman JJ, van de Geer SA, de Kort F, van Houwelingen HC. A global test for groups of genes: testing association with a clinical outcome. Bioinformatics. 2003; 20(1):93\u20139. doi: 10.1093\/bioinformatics\/btg382 .","journal-title":"Bioinformatics"},{"issue":"3","key":"161_CR20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1158\/1055-9965.EPI-07-2649","volume":"17","author":"GJ Ahmann","year":"2008","unstructured":"Ahmann GJ, Chng WJ, Henderson KJ, Price-Troska TL, DeGoey RW, Timm MM, et al. Effect of tissue shipping on plasma cell isolation, viability, and RNA integrity in the context of a centralized good laboratory practice-certified tissue banking facility. Cancer Epidemiol Biomark Prev : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2008; 17(3):666\u201373. doi: 10.1158\/1055-9965.EPI-07-2649 .","journal-title":"Cancer Epidemiol Biomark Prev : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"issue":"2","key":"161_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2141.2004.05017.x","volume":"126","author":"S Breit","year":"2004","unstructured":"Breit S, Nees M, Schaefer U, Pfoersich M, Hagemeier C, Muckenthaler M, et al. Impact of pre-analytical handling on bone marrow mRNA gene expression. Br J Haematol. 2004; 126(2):231\u201343. doi: 10.1111\/j.1365-2141.2004.05017.x .","journal-title":"Br J Haematol"},{"issue":"47","key":"161_CR22","doi-asserted-by":"crossref","first-page":"16802","DOI":"10.1073\/pnas.1413374111","volume":"111","author":"H Dvinge","year":"2014","unstructured":"Dvinge H, Ries RE, Ilagan JO, Stirewalt DL, Meshinchi S, Bradley RK. Sample processing obscures cancer-specific alterations in leukemic transcriptomes. Proc Natl Acad Sci. 2014; 111(47):16802\u20137. doi: 10.1073\/pnas.1413374111 .","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"161_CR23","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/clinchem\/48.11.1883","volume":"48","author":"L Rainen","year":"2002","unstructured":"Rainen L, Oelmueller U, Jurgensen S, Wyrich R, Ballas C, Schram J, et al. Stabilization of mRNA Expression in Whole Blood Samples. Clin Chem. 2002; 48(11):1883\u201390.","journal-title":"Clin Chem"},{"issue":"5","key":"161_CR24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.gene.6364098","volume":"5","author":"EC Baechler","year":"2004","unstructured":"Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Moser K, Ortmann WA, et al. Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun. 2004; 5(5):347\u201353. doi: 10.1038\/sj.gene.6364098 .","journal-title":"Genes Immun"},{"issue":"12","key":"161_CR25","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/sj.leu.2402734","volume":"16","author":"MC M\u00fcller","year":"2002","unstructured":"M\u00fcller MC, Merx K, Weisser A, Kreil S, Lahaye T, Hehlmann R, et al. Improvement of molecular monitoring of residual disease in leukemias by bedside RNA stabilization. Leukemia. 2002; 16(12):2395\u20139. doi: 10.1038\/sj.leu.2402734 .","journal-title":"Leukemia"},{"issue":"3","key":"161_CR26","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nprot.2011.457","volume":"7","author":"O Stegle","year":"2012","unstructured":"Stegle O, Parts L, Piipari M, Winn J, Durbin R. Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses. Nat Protoc. 2012; 7(3):500\u20137. doi: 10.1038\/nprot.2011.457 .","journal-title":"Nat Protoc"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-015-0161-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T10:09:04Z","timestamp":1599991744000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1755-8794\/8\/85"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["161"],"URL":"https:\/\/doi.org\/10.1186\/s12920-015-0161-6","relation":{},"ISSN":["1755-8794"],"issn-type":[{"type":"electronic","value":"1755-8794"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"85"}}