{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:11:39Z","timestamp":1764101499234},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"S1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1186\/s12920-016-0194-5","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T09:16:28Z","timestamp":1470993388000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discovering gene expression signatures responding to tyrosine kinase inhibitor treatment in chronic myeloid leukemia"],"prefix":"10.1186","volume":"9","author":[{"given":"Kihoon","family":"Cha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan-Su","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"issue":"5405","key":"194_CR1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"JD Rowley","year":"1973","unstructured":"Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining. Nature. 1973;243(5405):290\u20133.","journal-title":"Nature"},{"issue":"3","key":"194_CR2","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(84)90438-0","volume":"37","author":"JB Konopka","year":"1984","unstructured":"Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell. 1984;37(3):1035\u201342.","journal-title":"Cell"},{"issue":"6022","key":"194_CR3","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/315758a0","volume":"315","author":"N Heisterkamp","year":"1985","unstructured":"Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Structural organization of the bcr gene and its role in the Ph\u2019 translocation. Nature. 1985;315(6022):758\u201361.","journal-title":"Nature"},{"issue":"6020","key":"194_CR4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","volume":"315","author":"E Shtivelman","year":"1985","unstructured":"Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature. 1985;315(6020):550\u20134.","journal-title":"Nature"},{"issue":"23","key":"194_CR5","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker BJ, Guilhot F, O\u2019Brien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408\u201317.","journal-title":"N Engl J Med"},{"issue":"4","key":"194_CR6","first-page":"459","volume":"90","author":"LC Crossman","year":"2005","unstructured":"Crossman LC, Mori M, Hsieh YC, Lange T, Paschka P, Harrington CA, Krohn K, Niederwieser DW, Hehlmann R, Hochhaus A, et al. In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures. Haematologica. 2005;90(4):459\u201364.","journal-title":"Haematologica"},{"issue":"5","key":"194_CR7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1248\/bpb.b15-00103","volume":"38","author":"M Miura","year":"2015","unstructured":"Miura M. Therapeutic drug monitoring of imatinib, nilotinib, and dasatinib for patients with chronic myeloid leukemia. Biol Pharm Bull. 2015;38(5):645\u201354.","journal-title":"Biol Pharm Bull"},{"issue":"20","key":"194_CR8","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1200\/JCO.2007.15.8154","volume":"26","author":"H Lavallade de","year":"2008","unstructured":"de Lavallade H, Apperley JF, Khorashad JS, Milojkovic D, Reid AG, Bua M, Szydlo R, Olavarria E, Kaeda J, Goldman JM, et al. Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis. J Clin Oncol. 2008;26(20):3358\u201363.","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"194_CR9","doi-asserted-by":"crossref","first-page":"i37","DOI":"10.1136\/ard.2009.119487","volume":"69","author":"T Haupl","year":"2010","unstructured":"Haupl T, Stuhlmuller B, Grutzkau A, Radbruch A, Burmester GR. Does gene expression analysis inform us in rheumatoid arthritis? Ann Rheum Dis. 2010;69 Suppl 1:i37\u201342.","journal-title":"Ann Rheum Dis"},{"key":"194_CR10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2105-11-50","volume":"11","author":"T Hwang","year":"2010","unstructured":"Hwang T, Sun CH, Yun T, Yi GS. FiGS: a filter-based gene selection workbench for microarray data. BMC Bioinf. 2010;11:50.","journal-title":"BMC Bioinf"},{"issue":"Web Server issu","key":"194_CR11","doi-asserted-by":"crossref","first-page":"W246","DOI":"10.1093\/nar\/gkq516","volume":"38","author":"T Yun","year":"2010","unstructured":"Yun T, Hwang T, Cha K, Yi GS. CLIC: clustering analysis of large microarray datasets with individual dimension-based clustering. Nucleic Acids Res. 2010;38(Web Server issue):W246\u2013253.","journal-title":"Nucleic Acids Res"},{"key":"194_CR12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2164-14-144","volume":"14","author":"T Yun","year":"2013","unstructured":"Yun T, Yi GS. Biclustering for the comprehensive search of correlated gene expression patterns using clustered seed expansion. BMC Genomics. 2013;14:144.","journal-title":"BMC Genomics"},{"issue":"34","key":"194_CR13","doi-asserted-by":"crossref","first-page":"11972","DOI":"10.3748\/wjg.v20.i34.11972","volume":"20","author":"G D\u2019Angelo","year":"2014","unstructured":"D\u2019Angelo G, Di Rienzo T, Ojetti V. Microarray analysis in gastric cancer: a review. World J Gastroenterol. 2014;20(34):11972\u20136.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"194_CR14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jbspin.2014.01.013","volume":"81","author":"TH Kim","year":"2014","unstructured":"Kim TH, Choi SJ, Lee YH, Song GG, Ji JD. Gene expression profile predicting the response to anti-TNF treatment in patients with rheumatoid arthritis; analysis of GEO datasets. Joint Bone Spine. 2014;81(4):325\u201330.","journal-title":"Joint Bone Spine"},{"issue":"2","key":"194_CR15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1182\/blood-2009-03-210732","volume":"115","author":"SK McWeeney","year":"2010","unstructured":"McWeeney SK, Pemberton LC, Loriaux MM, Vartanian K, Willis SG, Yochum G, Wilmot B, Turpaz Y, Pillai R, Druker BJ, et al. A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib. Blood. 2010;115(2):315\u201325.","journal-title":"Blood"},{"issue":"1","key":"194_CR16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1179\/1607845413Y.0000000094","volume":"19","author":"RA Silveira","year":"2014","unstructured":"Silveira RA, Fachel AA, Moreira YB, De Souza CA, Costa FF, Verjovski-Almeida S, Pagnano KB. Protein-coding genes and long noncoding RNAs are differentially expressed in dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib. Hematology. 2014;19(1):31\u201341.","journal-title":"Hematology"},{"issue":"14","key":"194_CR17","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis S, Meltzer PS. GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. Bioinf (Oxford, England). 2007;23(14):1846\u20137.","journal-title":"Bioinf (Oxford, England)"},{"key":"194_CR18","doi-asserted-by":"crossref","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.","DOI":"10.1093\/nar\/gkv007"},{"key":"194_CR19","unstructured":"Gentleman R, Carey V, Huber W, Hahne F. genefilter: methods for filtering genes from high-throughput experiments. R package version 1.52.1. 2015."},{"issue":"19","key":"194_CR20","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/bioinformatics\/bts485","volume":"28","author":"X Wang","year":"2012","unstructured":"Wang X, Kang DD, Shen K, Song C, Lu S, Chang LC, Liao SG, Huo Z, Tang S, Ding Y, et al. An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection. Bioinf (Oxford, England). 2012;28(19):2534\u20136.","journal-title":"Bioinf (Oxford, England)"},{"key":"194_CR21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1471-2105-8-328","volume":"8","author":"R Diaz-Uriarte","year":"2007","unstructured":"Diaz-Uriarte R. GeneSrF and varSelRF: a web-based tool and R package for gene selection and classification using random forest. BMC Bioinf. 2007;8:328.","journal-title":"BMC Bioinf"},{"issue":"1","key":"194_CR22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44\u201357.","journal-title":"Nat Protoc"},{"issue":"9","key":"194_CR23","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrc2900","volume":"10","author":"W Kolch","year":"2010","unstructured":"Kolch W, Pitt A. Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nat Rev Cancer. 2010;10(9):618\u201329.","journal-title":"Nat Rev Cancer"},{"issue":"Database issue","key":"194_CR24","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","volume":"33","author":"A Hamosh","year":"2005","unstructured":"Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 2005;33(Database issue):D514\u2013517.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"194_CR25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng0504-431","volume":"36","author":"KG Becker","year":"2004","unstructured":"Becker KG, Barnes KC, Bright TJ, Wang SA. The genetic association database. Nat Genet. 2004;36(5):431\u20132.","journal-title":"Nat Genet"},{"issue":"4","key":"194_CR26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/clpt.2012.96","volume":"92","author":"M Whirl-Carrillo","year":"2012","unstructured":"Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414\u20137.","journal-title":"Clin Pharmacol Ther"},{"issue":"Database issue","key":"194_CR27","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkp896","volume":"38","author":"M Kanehisa","year":"2010","unstructured":"Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010;38(Database issue):D355\u2013360.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"194_CR28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrc1299","volume":"4","author":"PA Futreal","year":"2004","unstructured":"Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer. 2004;4(3):177\u201383.","journal-title":"Nat Rev Cancer"},{"key":"194_CR29","first-page":"538","volume-title":"Computer science and information technology - spring conference, 2009 IACSITSC \u201909 international association of: 17\u201320 april 2009 2009","author":"H Youngwoong","year":"2009","unstructured":"Youngwoong H, Choong-Hyun S, Min-Sung K, Gwan-Su Y. Combined database system for binary protein interaction and Co-complex association. In: Computer science and information technology - spring conference, 2009 IACSITSC \u201909 international association of: 17\u201320 april 2009 2009. 2009. p. 538\u201342."},{"key":"194_CR30","series-title":"Hematology\/the education program of the american society of hematology american society of hematology education program","first-page":"461","volume-title":"Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance","author":"D Bixby","year":"2009","unstructured":"Bixby D, Talpaz M. Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance, Hematology\/the education program of the american society of hematology american society of hematology education program. 2009. p. 461\u201376."},{"issue":"3","key":"194_CR31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.critrevonc.2014.11.001","volume":"93","author":"K Yang","year":"2015","unstructured":"Yang K, Fu LW. Mechanisms of resistance to BCR-ABL TKIs and the therapeutic strategies: a review. Crit Rev Oncol Hematol. 2015;93(3):277\u201392.","journal-title":"Crit. Rev. Oncol. Hematol"},{"key":"194_CR32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ddtec.2014.03.003","volume":"11","author":"S Balabanov","year":"2014","unstructured":"Balabanov S, Braig M, Brummendorf TH. Current aspects in resistance against tyrosine kinase inhibitors in chronic myelogenous leukemia. Drug Discov Today Technol. 2014;11:89\u201399.","journal-title":"Drug Discov Today Technol"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-016-0194-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T20:34:56Z","timestamp":1498336496000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-016-0194-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":32,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["194"],"URL":"https:\/\/doi.org\/10.1186\/s12920-016-0194-5","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"article-number":"29"}}