{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:56:20Z","timestamp":1765976180553},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"CardioDx"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12920-017-0318-6","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T12:20:21Z","timestamp":1515759621000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events"],"prefix":"10.1186","volume":"11","author":[{"given":"James A.","family":"Wingrove","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Fitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Rhees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Voora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"issue":"3","key":"318_CR1","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","volume":"129","author":"AS Go","year":"2014","unstructured":"Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al. Heart disease and stroke statistics--2014 update: a report from the american heart association. Circulation. 2014;129(3):e28\u2013e292.","journal-title":"Circulation"},{"issue":"24","key":"318_CR2","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMra071014","volume":"357","author":"G Davi","year":"2007","unstructured":"Davi G, Patrono C. Platelet activation and Atherothrombosis. N Engl J Med. 2007;357(24):2482\u201394.","journal-title":"N Engl J Med"},{"issue":"25","key":"318_CR3","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1161\/CIRCULATIONAHA.109.900589","volume":"120","author":"AL Frelinger III","year":"2009","unstructured":"Frelinger AL III, Li Y, Linden MD, Barnard MR, Fox ML, Christie DJ, Furman MI, Michelson AD. Association of Cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization. Circulation. 2009;120(25):2586\u201396.","journal-title":"Circulation"},{"issue":"1","key":"318_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/cts.12195","volume":"8","author":"R Qayyum","year":"2015","unstructured":"Qayyum R, Becker DM, Yanek LR, Faraday N, Vaidya D, Mathias R, Kral BG, Becker LC. Greater collagen-induced platelet aggregation following cyclooxygenase 1 inhibition predicts incident acute coronary syndromes. Clinical and translational science. 2015;8(1):17\u201322.","journal-title":"Clinical and translational science"},{"issue":"10","key":"318_CR5","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/ng.3396","volume":"47","author":"M Nikpay","year":"2015","unstructured":"Nikpay M, Goel A, Won H-H, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, et al. A comprehensive 1000 genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015;47(10):1121\u201330.","journal-title":"Nat Genet"},{"issue":"9763","key":"318_CR6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0140-6736(10)61996-4","volume":"377","author":"MP Reilly","year":"2011","unstructured":"Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011;377(9763):383\u201392.","journal-title":"Lancet"},{"issue":"6","key":"318_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12265-015-9640-6","volume":"8","author":"KA Friede","year":"2015","unstructured":"Friede KA, Ginsburg GS, Voora D. Gene expression signatures and the Spectrum of coronary artery disease. J Cardiovasc Transl Res. 2015;8(6):339\u201352.","journal-title":"J Cardiovasc Transl Res"},{"issue":"6","key":"318_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099509","volume":"9","author":"MR Irvin","year":"2014","unstructured":"Irvin MR, Zhi D, Aslibekyan S, Claas SA, Absher DM, Ordovas JM, Tiwari HK, Watkins S, Arnett DK. Genomics of post-prandial lipidomic phenotypes in the genetics of lipid lowering drugs and diet network (GOLDN) study. PLoS One. 2014;9(6):e99509.","journal-title":"PLoS One"},{"issue":"14","key":"318_CR9","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.jacc.2013.05.073","volume":"62","author":"D Voora","year":"2013","unstructured":"Voora D, Cyr D, Lucas J, Chi J-T, Dungan J, McCaffrey TA, Katz R, Newby LK, Kraus WE, Becker RC, et al. Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. J Am Coll Cardiol. 2013;62(14):1267\u201376.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"318_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.biopsycho.2011.09.013","volume":"89","author":"BH Brummett","year":"2012","unstructured":"Brummett BH, Kuhn CM, Boyle SH, Babyak MA, Siegler IC, Williams RB. Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene. Biol Psychol. 2012;89(1):94\u20138.","journal-title":"Biol Psychol"},{"key":"318_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/srep20544","volume":"6","author":"P Georgiadis","year":"2016","unstructured":"Georgiadis P, Hebels DG, Valavanis I, Liampa I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Chatziioannou A, Jennen DG, et al. Omics for prediction of environmental health effects: blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking. Sci Rep. 2016;6:20544.","journal-title":"Sci Rep"},{"issue":"10","key":"318_CR12","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","volume":"43","author":"J Ambrose","year":"2004","unstructured":"Ambrose J, Barua R. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43(10):1731\u20137.","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"318_CR13","doi-asserted-by":"publisher","first-page":"E175","DOI":"10.1177\/1076029610394440","volume":"17","author":"B Pamukcu","year":"2011","unstructured":"Pamukcu B, Oflaz H, Onur I, Cimen A, Nisanci Y. Effect of cigarette smoking on platelet aggregation. Clin Appl Thromb Hemost. 2011;17(6):E175\u201380.","journal-title":"Clin Appl Thromb Hemost"},{"issue":"9","key":"318_CR14","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1161\/01.CIR.92.9.2432","volume":"92","author":"J Hung","year":"1995","unstructured":"Hung J, Lam JY, Lacoste L, Letchacovski G. Cigarette smoking acutely increases platelet thrombus formation in patients with coronary artery disease taking aspirin. Circulation. 1995;92(9):2432\u20136.","journal-title":"Circulation"},{"issue":"6","key":"318_CR15","first-page":"1289","volume":"102","author":"A Undas","year":"2009","unstructured":"Undas A, Topor-Madry R, Tracz W, Pasowicz M. Effect of cigarette smoking on plasma fibrin clot permeability and susceptibility to lysis. Thromb Haemost. 2009;102(6):1289\u201391.","journal-title":"Thromb Haemost"},{"issue":"3","key":"318_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1161\/CIRCULATIONAHA.112.117283","volume":"127","author":"T Grosser","year":"2013","unstructured":"Grosser T, Fries S, Lawson JA, Kapoor SC, Grant GR, FitzGerald GA. Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation. 2013;127(3):377\u201385.","journal-title":"Circulation"},{"issue":"25","key":"318_CR17","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1161\/CIRCULATIONAHA.106.675587","volume":"115","author":"PA Gurbel","year":"2007","unstructured":"Gurbel PA, Bliden KP, DiChiara J, Newcomer J, Weng W, Neerchal NK, Gesheff T, Chaganti SK, Etherington A, Tantry US. Evaluation of dose-related effects of aspirin on platelet function: results from the aspirin-induced platelet effect (ASPECT) study. Circulation. 2007;115(25):3156\u201364.","journal-title":"Circulation"},{"issue":"5","key":"318_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.amjcard.2006.03.029","volume":"98","author":"A Mirkhel","year":"2006","unstructured":"Mirkhel A, Peyster E, Sundeen J, Greene L, Michelson AD, Hasan A, Domanski M. Frequency of aspirin resistance in a community hospital. Am J Cardiol. 2006;98(5):577\u20139.","journal-title":"Am J Cardiol"},{"issue":"19","key":"318_CR19","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/j.jacc.2007.07.051","volume":"50","author":"PA Gurbel","year":"2007","unstructured":"Gurbel PA, Becker RC, Mann KG, Steinhubl SR, Michelson AD. Platelet function monitoring in patients with coronary artery disease. J Am Coll Cardiol. 2007;50(19):1822\u201334.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"318_CR20","first-page":"58","volume":"5","author":"P Beineke","year":"2012","unstructured":"Beineke P, Fitch K, Tao H, Elashoff M, Rosenberg S, Kraus W, Wingrove J, Investigators P. A whole blood gene expression-based signature for smoking status. BMC Med Genet. 2012;5(1):58.","journal-title":"BMC Med Genet"},{"key":"318_CR21","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ebiom.2016.08.021","volume":"11","author":"D Voora","year":"2016","unstructured":"Voora D, Rao AK, Jalagadugula GS, Myers R, Harris E, Ortel TL, Ginsburg GS. Systems pharmacogenomics finds RUNX1 is an aspirin-responsive transcription factor linked to cardiovascular disease and colon cancer. EBioMedicine. 2016;11:157\u201364.","journal-title":"EBioMedicine"},{"issue":"7","key":"318_CR22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.7326\/0003-4819-153-7-201010050-00005","volume":"153","author":"S Rosenberg","year":"2010","unstructured":"Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, et al. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 2010;153(7):425\u201334.","journal-title":"Ann Intern Med"},{"key":"318_CR23","unstructured":"R: A language and environment for statistical computing. [\n                    http:\/\/www.R-project.org\n                    \n                  \/.]"},{"issue":"14","key":"318_CR24","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","volume":"108","author":"M Naghavi","year":"2003","unstructured":"Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108(14):1664\u201372.","journal-title":"Circulation"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-017-0318-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:19:36Z","timestamp":1547252376000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-017-0318-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,12]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["318"],"URL":"https:\/\/doi.org\/10.1186\/s12920-017-0318-6","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,12]]},"assertion":[{"value":"23 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Subjects in this study were part of PREDICT, a multi-center US study of patients referred for coronary angiography (ExternalRef removed, NCT00500617). The institutional review boards at all centers approved the study (Duke University School of Medicine, Durham, North Carolina; Minneapolis Heart Institute and Foundation, Minneapolis, Minnesota; Piedmont Heart Institute, Atlanta, Georgia; Cleveland Clinic Foundation, Cleveland, Ohio; Oklahoma Cardiovascular Research Group, Oklahoma City, Oklahoma; Cardiovascular Research Institute, Medstar Research Institute, Washington, DC; Vanderbilt Heart and Vascular Institute, Nashville, Tennessee; Cardiovascular Research Foundation, New York, New York; and Scripps Translational Science Institute, La Jolla, California), and all patients gave written informed consent. Specific IRB protocol numbers can be found in Additional file InternalRef removed: Table S3.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JAW, BR, and KF are\/were full-time employees of and hold stock in CardioDx. SR reported serving as a consultant and advisory board member for CardioDx and holding stock and stock options in CardioDx.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"1"}}