{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:19:54Z","timestamp":1785363594296,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL054457"],"award-info":[{"award-number":["HL054457"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL100185"],"award-info":[{"award-number":["HL100185"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL119443"],"award-info":[{"award-number":["HL119443"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL133221"],"award-info":[{"award-number":["HL133221"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS041558"],"award-info":[{"award-number":["NS041558"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12920-018-0363-9","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:03:57Z","timestamp":1525781037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["DNA methylation in the APOE genomic region is associated with cognitive function in African Americans"],"prefix":"10.1186","volume":"11","author":[{"given":"Jiaxuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin B.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"issue":"6","key":"363_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/aje\/155.6.487","volume":"155","author":"JE Eichner","year":"2002","unstructured":"Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002;155(6):487\u201395.","journal-title":"Am J Epidemiol"},{"issue":"3","key":"363_CR2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","volume":"63","author":"J Kim","year":"2009","unstructured":"Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron. 2009;63(3):287\u2013303.","journal-title":"Neuron"},{"key":"363_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.nepig.2016.05.001","volume":"6","author":"AR Smith","year":"2016","unstructured":"Smith AR, Mill J, Smith RG, Lunnon K. Elucidating novel dysfunctional pathways in alzheimer's disease by integrating loci identified in genetic and epigenetic studies. Neuroepigenetics. 2016;6:32\u201350.","journal-title":"Neuroepigenetics"},{"issue":"1","key":"363_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng1934","volume":"39","author":"L Bertram","year":"2007","unstructured":"Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007;39(1):17\u201323.","journal-title":"Nat Genet"},{"key":"363_CR5","doi-asserted-by":"crossref","unstructured":"Cervantes S, Samaranch L, Vidal-Taboada JM, Lamet I, Bullido MJ, Frank-Garcia A, Coria F, Lleo A, Clarimon J, Lorenzo E, et al. Genetic variation in APOE cluster region and Alzheimer's disease risk. Neurobiol Aging. 2011 ;32(11):2107.e7\u20132107.17.","DOI":"10.1016\/j.neurobiolaging.2011.05.023"},{"issue":"1","key":"363_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/mp.2012.159","volume":"19","author":"G Davies","year":"2014","unstructured":"Davies G, Harris SE, Reynolds CA, Payton A, Knight HM, Liewald DC, Lopez LM, Luciano M, Gow AJ, Corley J, et al. A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol Psychiatry. 2014;19(1):76\u201387.","journal-title":"Mol Psychiatry"},{"key":"363_CR7","doi-asserted-by":"crossref","unstructured":"Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go RC, Griffith P, Obisesan T.O., Shatz R, Borenstein A, et al. A comprehensive genetic association study of Alzheimer disease in African Americans. Arch Neurol 2011;68(12):1569\u20131579.","DOI":"10.1001\/archneurol.2011.646"},{"issue":"6","key":"363_CR8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jalz.2016.03.015","volume":"12","author":"A Roses","year":"2016","unstructured":"Roses A, Sundseth S, Saunders A, Gottschalk W, Burns D, Lutz M. Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease. Alzheimers Dement. 2016;12(6):687\u201394.","journal-title":"Alzheimers Dement"},{"issue":"5","key":"363_CR9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ygeno.2009.01.003","volume":"93","author":"N Takei","year":"2009","unstructured":"Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, et al. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics. 2009;93(5):441\u20138.","journal-title":"Genomics"},{"issue":"12","key":"363_CR10","doi-asserted-by":"publisher","first-page":"30483","DOI":"10.3390\/ijms161226236","volume":"16","author":"RJ Caselli","year":"2015","unstructured":"Caselli RJ, Dueck AC, Huentelman MJ, Lutz MW, Saunders AM, Reiman EM, Roses AD. Longitudinal modeling of cognitive aging and the TOMM40 effect. Alzheimers dement. 2012;8(6):490\u2013511. Cacabelos R, Torrellas C. Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response. Int J Mol Sci. 2015 Dec 21;16(12):30483\u2013543.","journal-title":"Int J Mol Sci."},{"key":"363_CR11","doi-asserted-by":"publisher","first-page":"30483","DOI":"10.3390\/ijms161226236","volume":"16","author":"R Cacabelos","year":"2015","unstructured":"Cacabelos R, Torrellas C. Epigenetics of aging and Alzheimer's disease: implications for pharmacogenomics and drug response. Int J Mol Sci. 2015;16:30483\u2013543.","journal-title":"Int J Mol Sci"},{"key":"363_CR12","first-page":"137","volume":"3","author":"JA Smith","year":"2014","unstructured":"Smith JA, Zagel AL, Sun YV, Dolinoy DC, Peyser PA, Bielak LF, Turner ST, Mosley TH, Kardia SLR. Epigenomic indicators of age in African Americans. Her Gen. 2014;3:137.","journal-title":"Her Gen"},{"issue":"1","key":"363_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/acel.12293","volume":"14","author":"Y Ma","year":"2015","unstructured":"Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA, Tsai MY, et al. Genetic variants modify the effect of age on APOE methylation in the genetics of lipid lowering drugs and diet network study. Aging Cell. 2015;14(1):49\u201359.","journal-title":"Aging Cell"},{"issue":"3","key":"363_CR14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3233\/JAD-143060","volume":"48","author":"J Foraker","year":"2015","unstructured":"Foraker J, Millard SP, Leong L, Thomson Z, Chen S, Keene CD, Bekris LM, Yu CE. The APOE gene is differentially methylated in Alzheimer's disease. J Alzheimers Dis. 2015;48(3):745\u201355.","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"363_CR15","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/acn3.201","volume":"2","author":"LB Chibnik","year":"2015","unstructured":"Chibnik LB, Yu L, Eaton ML, Srivastava G, Schneider JA, Kellis M, Bennett DA, De Jager PL. Alzheimer's loci: epigenetic associations and interaction with genetic factors. Ann Clin Transl Neurol. 2015;2(6):636\u201347.","journal-title":"Ann Clin Transl Neurol"},{"issue":"10","key":"363_CR16","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.amjmed.2003.12.032","volume":"116","author":"PR Daniels","year":"2004","unstructured":"Daniels PR, Kardia SL, Hanis CL, Brown CA, Hutchinson R, Boerwinkle E, Turner ST. Genetic epidemiology network of Arteriopathy study. Familial aggregation of hypertension treatment and control in the genetic epidemiology network of Arteriopathy (GENOA) study. Am J Med. 2004;116(10):676\u201381.","journal-title":"Am J Med"},{"issue":"1","key":"363_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1161\/hy1201.100415","volume":"39","author":"FBPP Investigators","year":"2002","unstructured":"Investigators FBPP. Multi-center genetic study of hypertension: the family blood pressure program (FBPP). Hypertension. 2002;39(1):3\u20139.","journal-title":"Hypertension"},{"key":"363_CR18","volume-title":"Neuropsychological assessment","author":"MD Lezak","year":"1995","unstructured":"Lezak MD. Neuropsychological assessment. New York: Oxford University Press; 1995."},{"key":"363_CR19","unstructured":"Smith JA, Mosley TH, Turner ST, Kardia SLR. In: Agrawal A, editor. Shared genetic effects among measures of cognitive function and leukoaraiosis, Brain injury \u2013 pathogenesis, monitoring, recovery and management. Rijeka: InTech; 2012."},{"issue":"2","key":"363_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/mp.2014.188","volume":"20","author":"G Davies","year":"2015","unstructured":"Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015;20(2):183\u201392.","journal-title":"Mol Psychiatry"},{"issue":"10","key":"363_CR21","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","volume":"30","author":"MJ Aryee","year":"2014","unstructured":"Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics. 2014;30(10):1363\u20139.","journal-title":"Bioinformatics"},{"issue":"6","key":"363_CR22","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/gb-2012-13-6-r44","volume":"13","author":"J Maksimovic","year":"2012","unstructured":"Maksimovic J, Gordon L, Oshlack A. SWAN: subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips. Genome Biol. 2012;13(6):R44.","journal-title":"Genome Biol"},{"key":"363_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1471-2105-13-86","volume":"13","author":"EA Houseman","year":"2012","unstructured":"Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT. DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinform. 2012;13:86.","journal-title":"BMC Bioinform."},{"issue":"4","key":"363_CR24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","volume":"98","author":"M Bibikova","year":"2011","unstructured":"Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, Le JM, Delano D, Zhang L, Schroth GP, Gunderson KL, et al. High density DNA methylation array with single CpG site resolution. Genomics. 2011;98(4):288\u201395.","journal-title":"Genomics"},{"key":"363_CR25","unstructured":"RStudio Team. RStudio: integrated development for R. 2015."},{"issue":"5","key":"363_CR26","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1093\/ije\/dyq072","volume":"39","author":"IJ Deary","year":"2010","unstructured":"Deary IJ, Johnson W. Intelligence and education: causal perceptions drive analytic processes and therefore conclusions. Int J Epidemiol. 2010;39(5):1362\u20139.","journal-title":"Int J Epidemiol"},{"key":"363_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12859-015-0568-2","volume":"16","author":"TC Martin","year":"2015","unstructured":"Martin TC, Yet I, Tsai PC, Bell JT. coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns. BMC Bioinform. 2015;16:131. https:\/\/doi.org\/10.1186\/s12859-015-0568-2 .","journal-title":"BMC Bioinform."},{"key":"363_CR28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J Roy Stat Soc B Met. 1995;57:289\u2013300.","journal-title":"J Roy Stat Soc B Met"},{"issue":"1","key":"363_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3233\/JAD-2010-1255","volume":"19","author":"C Reitz","year":"2010","unstructured":"Reitz C, Mayeux R. Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia. J Alzheimers Dis. 2010;19(1):229\u201351.","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"363_CR30","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1080\/15592294.2015.1100786","volume":"10","author":"E Hannon","year":"2015","unstructured":"Hannon E, Lunnon K, Schalkwyk L, Mill J. Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics. 2015;10(11):1024\u201332.","journal-title":"Epigenetics"},{"issue":"8","key":"363_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.171","volume":"7","author":"RD Edgar","year":"2017","unstructured":"Edgar RD, Jones MJ, Meaney MJ, Turecki G, Kobor MS. BECon: a tool for interpreting DNA methylation findings from blood in the context of brain. Transl Psychiatry. 2017;7(8):e1187.","journal-title":"Transl Psychiatry"},{"key":"363_CR32","doi-asserted-by":"crossref","unstructured":"Radwan ZH, Wang X, Waqar F, Pirim D, Niemsiri V, Hokanson JE, Hamman RF, Bunker CH, Barmada MM, Demirci FY, et al. Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks. PLoS One. 2014;9(12):e114618.","DOI":"10.1371\/journal.pone.0114618"},{"issue":"3","key":"363_CR33","first-page":"574","volume":"58","author":"MX Tang","year":"1996","unstructured":"Tang MX, Maestre G, Tsai WY, Liu XH, Feng L, Chung WY, Chun M, Schofield P, Stern Y, Tycko B, et al. Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in new York City. Am J Hum Genet. 1996;58(3):574\u201384.","journal-title":"Am J Hum Genet"},{"issue":"1","key":"363_CR34","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/viro.1998.9218","volume":"246","author":"MS Warner","year":"1998","unstructured":"Warner MS, Geraghty RJ, Martinez WM, Montgomery RI, Whitbeck JC, Xu R, Eisenberg RJ, Cohen GH, Spear PG. A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus. Virology. 1998;246(1):179\u201389.","journal-title":"Virology"},{"issue":"22","key":"363_CR35","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.1128\/JVI.75.22.11185-11195.2001","volume":"75","author":"WM Martinez","year":"2001","unstructured":"Martinez WM, Spear PG. Structural features of nectin-2 (HveB) required for herpes simplex virus entry. J Virol. 2001;75(22):11185\u201395.","journal-title":"J Virol"},{"issue":"1","key":"363_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0928-0197(95)00203-0","volume":"6","author":"L Gordon","year":"1996","unstructured":"Gordon L, McQuaid S, Cosby SL. Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction. Clin Diagn Virol. 1996;6(1):33\u201340.","journal-title":"Clin Diagn Virol"},{"issue":"3","key":"363_CR37","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/path.1127","volume":"197","author":"WR Lin","year":"2002","unstructured":"Lin WR, Wozniak MA, Cooper RJ, Wilcock GK, Itzhaki RF. Herpesviruses in brain and Alzheimer's disease. J Pathol. 2002;197(3):395\u2013402.","journal-title":"J Pathol"},{"issue":"9047","key":"363_CR38","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(96)10149-5","volume":"349","author":"RF Itzhaki","year":"1997","unstructured":"Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Lancet. 1997;349(9047):241\u20134.","journal-title":"Lancet"},{"issue":"35","key":"363_CR39","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1523\/JNEUROSCI.1469-06.2006","volume":"26","author":"L Devi","year":"2006","unstructured":"Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci. 2006;26(35):9057\u201368.","journal-title":"J Neurosci"},{"issue":"1","key":"363_CR40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbadis.2009.10.006","volume":"1802","author":"PI Moreira","year":"2010","unstructured":"Moreira PI, Carvalho C, Zhu X, Smith MA, Perry G. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim Biophys Acta. 2010;1802(1):2\u201310.","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"363_CR41","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.molmed.2010.07.008","volume":"16","author":"V Leduc","year":"2010","unstructured":"Leduc V, Jasmin-Belanger S, Poirier J. APOE and cholesterol homeostasis in Alzheimer's disease. Trends Mol Med. 2010;16(10):469\u201377.","journal-title":"Trends Mol Med"},{"issue":"1","key":"363_CR42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/jhg.2011.123","volume":"57","author":"LM Bekris","year":"2012","unstructured":"Bekris LM, Lutz F, Yu CE. Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. J Hum Genet. 2012;57(1):18\u201325.","journal-title":"J Hum Genet"},{"issue":"10","key":"363_CR43","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1101\/gad.2037511","volume":"25","author":"AM Deaton","year":"2011","unstructured":"Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev. 2011;25(10):1010\u201322.","journal-title":"Genes Dev"},{"key":"363_CR44","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fgene.2014.00280","volume":"5","author":"S Numata","year":"2014","unstructured":"Numata S, Ye T, Herman M, Lipska BK. DNA methylation changes in the postmortem dorsolateral prefrontal cortex of patients with schizophrenia. Front Genet. 2014;5:280.","journal-title":"Front Genet"},{"issue":"6","key":"363_CR45","doi-asserted-by":"publisher","first-page":"692","DOI":"10.4161\/epi.6.6.16196","volume":"6","author":"J Sandoval","year":"2011","unstructured":"Sandoval J, Heyn H, Moran S, Serra-Musach J, Pujana MA, Bibikova M, Esteller M. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics. 2011;6(6):692\u2013702.","journal-title":"Epigenetics"},{"issue":"7","key":"363_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002698","volume":"3","author":"SC Wang","year":"2008","unstructured":"Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One. 2008;3(7):e2698.","journal-title":"PLoS One"},{"key":"363_CR47","first-page":"9","volume":"2","author":"MR Penner","year":"2010","unstructured":"Penner MR, Roth TL, Barnes CA, Sweatt JD. An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci. 2010;2:9.","journal-title":"Front Aging Neurosci"},{"issue":"16","key":"363_CR48","doi-asserted-by":"crossref","first-page":"13922","DOI":"10.18632\/oncotarget.4215","volume":"6","author":"X Xu","year":"2015","unstructured":"Xu X. DNA methylation and cognitive aging. Oncotarget. 2015;6(16):13922\u201332.","journal-title":"Oncotarget"},{"issue":"7","key":"363_CR49","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.neurobiolaging.2010.08.017","volume":"32","author":"D Mastroeni","year":"2011","unstructured":"Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging. 2011;32(7):1161\u201380.","journal-title":"Neurobiol Aging"},{"issue":"7","key":"363_CR50","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/JGP.0b013e318211819b","volume":"20","author":"F Yasuno","year":"2012","unstructured":"Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T. Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype. Am J Geriatr Psychiatry. 2012;20(7):574\u201383.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"363_CR51","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ana.24326","volume":"77","author":"KL Rasmussen","year":"2015","unstructured":"Rasmussen KL, Tybjaerg-Hansen A, Nordestgaard BG, Frikke-Schmidt R. Plasma levels of apolipoprotein E and risk of dementia in the general population. Ann Neurol. 2015;77(2):301\u201311.","journal-title":"Ann Neurol"},{"issue":"7","key":"363_CR52","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1136\/jnnp.2004.048983","volume":"76","author":"JC Lambert","year":"2005","unstructured":"Lambert JC, Mann D, Richard F, Tian J, Shi J, Thaker U, Merrot S, Harris J, Frigard B, Iwatsubo T, et al. Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease? J Neurol Neurosurg Psychiatry. 2005;76(7):928\u201333.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"363_CR53","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jpsychires.2012.03.006","volume":"46","author":"TS Lee","year":"2012","unstructured":"Lee TS, Goh L, Chong MS, Chua SM, Chen GB, Feng L, Lim WS, Chan M, Ng TP, Krishnan KR. Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls. J Psychiatr Res. 2012;46(6):828\u201330.","journal-title":"J Psychiatr Res"},{"issue":"9","key":"363_CR54","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/nn.3786","volume":"17","author":"PL De Jager","year":"2014","unstructured":"De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014;17(9):1156\u201363.","journal-title":"Nat Neurosci"},{"issue":"9","key":"363_CR55","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.jalz.2016.02.009","volume":"12","author":"L Yu","year":"2016","unstructured":"Yu L, Chibnik LB, Yang J, McCabe C, Xu J, Schneider JA, De Jager PL, Bennett DA. Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: the relation to Alzheimer's disease pathology. Alzheimer's Dementia. 2016;12(9):942\u201351.","journal-title":"Alzheimer's Dementia"},{"issue":"9","key":"363_CR56","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/nn.3782","volume":"17","author":"K Lunnon","year":"2014","unstructured":"Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci. 2014;17(9):1164.","journal-title":"Nat Neurosci"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12920-018-0363-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T16:13:05Z","timestamp":1720282385000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-018-0363-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["363"],"URL":"https:\/\/doi.org\/10.1186\/s12920-018-0363-9","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"assertion":[{"value":"11 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Written informed consent was obtained from all participants, and the University of Michigan Institutional Review Board approved this study (HUM00113791, HUM00008655).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"43"}}