{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:26Z","timestamp":1792787906528,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["H28-924"],"award-info":[{"award-number":["H28-924"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charitable Trust Mihara Cerebrovascular Disorder Research Promotion Fund"},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12920-018-0385-3","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T12:10:59Z","timestamp":1535544659000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line"],"prefix":"10.1186","volume":"11","author":[{"given":"Haruto","family":"Uchino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-7198","authenticated-orcid":false,"given":"Masaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kazumata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Hamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Terasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenao","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiro","family":"Houkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"385_CR1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","volume":"20","author":"J Suzuki","year":"1969","unstructured":"Suzuki J, Takaku A. Cerebrovascular \u201cmoyamoya\u201d disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol. 1969;20:288\u201399.","journal-title":"Arch Neurol"},{"key":"385_CR2","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1161\/01.STR.24.12.1960","volume":"24","author":"J Masuda","year":"1993","unstructured":"Masuda J, Ogata J, Yutani C. Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease. Stroke. 1993;24:1960\u20137.","journal-title":"Stroke"},{"key":"385_CR3","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/S1474-4422(08)70240-0","volume":"7","author":"S Kuroda","year":"2008","unstructured":"Kuroda S, Houkin K. Moyamoya disease: current concepts and future perspectives. Lancet Neurol. 2008;7:1056\u201366.","journal-title":"Lancet Neurol"},{"key":"385_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2176\/nmc.52.267","volume":"52","author":"K Houkin","year":"2012","unstructured":"Houkin K, Ito M, Sugiyama T, Shichinohe H, Nakayama N, Kazumata K, et al. Review of past research and current concepts on the etiology of moyamoya disease. Neurol Med Chir (Tokyo). 2012;52:267\u201377.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"385_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1534\/g3.115.020321","volume":"6","author":"LD Shoemaker","year":"2016","unstructured":"Shoemaker LD, Clark MJ, Patwardhan A, Chandratillake G, Garcia S, Chen R, et al. Disease Variant Landscape of a Large Multiethnic Population of Moyamoya Patients by Exome Sequencing. G3 Genes|Genomes|Genetics. 2016;6:41\u20139.","journal-title":"G3 Genes|Genomes|Genetics"},{"key":"385_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.003","volume":"26","author":"M Mukawa","year":"2017","unstructured":"Mukawa M, Nariai T, Onda H, Yoneyama T, Aihara Y, Hirota K, et al. Exome sequencing identified CCER2 as a novel candidate gene for Moyamoya disease. J Stroke Cerebrovasc Dis. 2017;26:150\u201361.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"385_CR7","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1161\/STROKEAHA.114.006244","volume":"45","author":"AC Cecchi","year":"2014","unstructured":"Cecchi AC, Guo D, Ren Z, Flynn K, Santos-Cortez RLP, Leal SM, et al. RNF213 rare variants in an ethnically diverse population with Moyamoya disease. Stroke. 2014;45:3200\u20137.","journal-title":"Stroke"},{"key":"385_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/jhg.2010.132","volume":"56","author":"F Kamada","year":"2011","unstructured":"Kamada F, Aoki Y, Narisawa A, Abe Y, Komatsuzaki S, Kikuchi A, et al. A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. J Hum Genet. 2011;56:34\u201340.","journal-title":"J Hum Genet"},{"key":"385_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022542","volume":"6","author":"W Liu","year":"2011","unstructured":"Liu W, Morito D, Takashima S, Mineharu Y, Kobayashi H, Hitomi T, et al. Identification of RNF213 as a susceptibility gene for Moyamoya disease and its possible role in vascular development. PLoS One. 2011;6:e22542.","journal-title":"PLoS One"},{"key":"385_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bbrc.2013.07.004","volume":"438","author":"T Hitomi","year":"2013","unstructured":"Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, et al. Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients. Biochem Biophys Res Commun. 2013;438:13\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"385_CR11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002496","volume":"4","author":"H Kobayashi","year":"2015","unstructured":"Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, et al. Biochemical and functional characterization of RNF213 (Mysterin) R4810K, a susceptibility mutation of Moyamoya disease, in angiogenesis in vitro and in vivo. J Am Heart Assoc. 2015;4:e002146.","journal-title":"J Am Heart Assoc"},{"key":"385_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163561","volume":"11","author":"S Hamauchi","year":"2016","unstructured":"Hamauchi S, Shichinohe H, Uchino H, Yamaguchi S, Nakayama N, Kazumata K, et al. Cellular functions and gene and Protein expression profiles in endothelial cells derived from Moyamoya disease-specific iPS cells. PLoS One. 2016;11:e0163561.","journal-title":"PLoS One"},{"key":"385_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.brainres.2014.01.011","volume":"1552","author":"S Sonobe","year":"2014","unstructured":"Sonobe S, Fujimura M, Niizuma K, Nishijima Y, Ito A, Shimizu H, et al. Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease. Brain Res. 2014;1552:64\u201371.","journal-title":"Brain Res"},{"key":"385_CR14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.brainres.2014.11.014","volume":"1594","author":"A Ito","year":"2015","unstructured":"Ito A, Fujimura M, Niizuma K, Kanoke A, Sakata H, Morita-Fujimura Y, et al. Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease. Brain Res. 2015;1594:310\u201320.","journal-title":"Brain Res"},{"key":"385_CR15","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1097\/WNR.0000000000000289","volume":"25","author":"S Sonobe","year":"2014","unstructured":"Sonobe S, Fujimura M, Niizuma K, Fujimura T, Furudate S, Nishijima Y, et al. Increased vascular MMP-9 in mice lacking RNF213. Neuroreport. 2014;25:1442\u20136.","journal-title":"Neuroreport"},{"key":"385_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102382","volume":"9","author":"D Dai","year":"2014","unstructured":"Dai D, Lu Q, Huang Q, Yang P, Hong B, Xu Y, et al. Serum miRNA signature in Moyamoya disease. PLoS One. 2014;9:e102382.","journal-title":"PLoS One"},{"key":"385_CR17","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.041","volume":"24","author":"S Zhao","year":"2015","unstructured":"Zhao S, Gong Z, Zhang J, Xu X, Liu P, Guan W, et al. Elevated serum MicroRNA let-7c in Moyamoya disease. J Stroke Cerebrovasc Dis. 2015;24:1709\u201314.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"385_CR18","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neulet.2012.05.062","volume":"521","author":"YS Park","year":"2012","unstructured":"Park YS, Jeon YJ, Lee BE, Kim TG, Choi J-U, Kim D-S, et al. Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population. Neurosci Lett. 2012;521:71\u20135.","journal-title":"Neurosci Lett"},{"key":"385_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1161\/STROKEAHA.116.013942","volume":"48","author":"S Uhlmann","year":"2017","unstructured":"Uhlmann S, Mracsko E, Javidi E, Lamble S, Teixeira A, Hotz-Wagenblatt A, et al. Genome-wide analysis of the circulating miRNome after cerebral ischemia reveals a reperfusion-induced MicroRNA cluster. Stroke. 2017;48:762\u20139.","journal-title":"Stroke"},{"key":"385_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13073-014-0060-z","volume":"6","author":"JE Castillo-Fernandez","year":"2014","unstructured":"Castillo-Fernandez JE, Spector TD, Bell JT. Epigenetics of discordant monozygotic twins: implications for disease. Genome Med. 2014;6:60.","journal-title":"Genome Med"},{"key":"385_CR21","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105:10513\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"385_CR22","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1161\/01.STR.31.4.930","volume":"31","author":"T Yamauchi","year":"2000","unstructured":"Yamauchi T, Tada M, Houkin K, Tanaka T, Nakamura Y, Kuroda S, et al. Linkage of familial moyamoya disease (spontaneous occlusion of the circle of Willis) to chromosome 17q25. Stroke. 2000;31:930\u20135.","journal-title":"Stroke"},{"issue":"Issue 24, Part","key":"385_CR23","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1212\/01.wnl.0000291012.49986.f9","volume":"70","author":"Y Mineharu","year":"2008","unstructured":"Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S, Takenaka K, et al. Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology. 2008;70(Issue 24, Part 2):2357\u201363.","journal-title":"Neurology"},{"key":"385_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2176\/nmc.52.245","volume":"52","author":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measures for Infractable Diseases","year":"2012","unstructured":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measures for Infractable Diseases. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis). Neurol medico-chirurgica. 2012;52:245\u201366.","journal-title":"Neurol medico-chirurgica"},{"key":"385_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000087935","volume":"20","author":"K Houkin","year":"2005","unstructured":"Houkin K, Nakayama N, Kuroda S, Nonaka T, Shonai T, Yoshimoto T. Novel magnetic resonance angiography stage grading for Moyamoya disease. Cerebrovasc Dis. 2005;20:347\u201354.","journal-title":"Cerebrovasc Dis"},{"key":"385_CR26","doi-asserted-by":"publisher","first-page":"11673","DOI":"10.1093\/nar\/gks901","volume":"40","author":"CE Vejnar","year":"2012","unstructured":"Vejnar CE, Zdobnov EM. miRmap: comprehensive prediction of microRNA target repression strength. Nucleic Acids Res. 2012;40:11673\u201383.","journal-title":"Nucleic Acids Res"},{"key":"385_CR27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4103\/2394-8108.166377","volume":"1","author":"S Hamauchi","year":"2015","unstructured":"Hamauchi S, Shichinohe H, Houkin K. Review of past and present research on experimental models of moyamoya disease. Brain Circ. 2015;1:88.","journal-title":"Brain Circ"},{"key":"385_CR28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45.","journal-title":"Nucleic Acids Res"},{"key":"385_CR29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/jnnp-2011-301387","volume":"83","author":"R Kleinloog","year":"2012","unstructured":"Kleinloog R, Regli L, Rinkel GJE, Klijn CJM. Regional differences in incidence and patient characteristics of moyamoya disease: a systematic review. J Neurol Neurosurg Psychiatry. 2012;83:531\u20136.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"385_CR30","doi-asserted-by":"publisher","unstructured":"Hori S, Kashiwazaki D, Yamamoto S, Acker G, Czabanka M, Akioka N, et al. Impact of interethnic difference of collateral Angioarchitectures on prevalence of hemorrhagic stroke in Moyamoya disease. Neurosurgery. 2018; \n                    https:\/\/doi.org\/10.1093\/neuros\/nyy236\n                    \n                  .","DOI":"10.1093\/neuros\/nyy236"},{"key":"385_CR31","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2174\/2211552811201040299","volume":"4","author":"NA Finn","year":"2012","unstructured":"Finn NA, Searles CD. Intracellular and extracellular miRNAs in regulation of angiogenesis signaling. Curr Angiogenes. 2012;4:299\u2013307.","journal-title":"Curr Angiogenes"},{"key":"385_CR32","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/CIRCULATIONAHA.114.013003","volume":"131","author":"CJ Hoffmann","year":"2015","unstructured":"Hoffmann CJ, Harms U, Rex A, Szulzewsky F, Wolf SA, Grittner U, et al. Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke. Circulation. 2015;131:1772\u201382.","journal-title":"Circulation"},{"key":"385_CR33","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/STROKEAHA.116.016563","volume":"48","author":"H Saber","year":"2017","unstructured":"Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, et al. Serum insulin-like growth factor 1 and the risk of ischemic stroke: the Framingham study. Stroke. 2017;48:1760\u20135.","journal-title":"Stroke"},{"key":"385_CR34","doi-asserted-by":"publisher","first-page":"9472","DOI":"10.1073\/pnas.1101296108","volume":"108","author":"M Koide","year":"2011","unstructured":"Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, et al. Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K\/Akt pathway in endothelial and endothelial progenitor cells. Proc Natl Acad Sci. 2011;108:9472\u20137.","journal-title":"Proc Natl Acad Sci"},{"key":"385_CR35","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1101\/gad.1308805","volume":"19","author":"K Hamada","year":"2005","unstructured":"Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, et al. The PTEN\/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005;19:2054\u201365.","journal-title":"Genes Dev"},{"key":"385_CR36","doi-asserted-by":"publisher","first-page":"13191","DOI":"10.1038\/srep13191","volume":"5","author":"K Ohkubo","year":"2015","unstructured":"Ohkubo K, Sakai Y, Inoue H, Akamine S, Ishizaki Y, Matsushita Y, et al. Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells. Sci Rep. 2015;5:13191.","journal-title":"Sci Rep"},{"key":"385_CR37","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.ejca.2014.10.027","volume":"51","author":"J Bogaerts","year":"2015","unstructured":"Bogaerts J, Sydes MR, Keat N, McConnell A, Benson A, Ho A, et al. Clinical trial designs for rare diseases: studies developed and discussed by the international rare cancers initiative. Eur J Cancer. 2015;51:271\u201381.","journal-title":"Eur J Cancer"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0385-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12920-018-0385-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0385-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T14:08:23Z","timestamp":1589465303000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-018-0385-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["385"],"URL":"https:\/\/doi.org\/10.1186\/s12920-018-0385-3","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"22 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The present study was approved by the Hokkaido University Graduate School of Medicine medical ethics committee on human experimentation, including genetic analysis (14\u2013053). Written informed consent was obtained from all participants (or guardians) to participate in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from all participants (or guardians) whose individual data were presented for publication in this study in any form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"HU, YH, ST, HS: Nothing to report relating to this study. MI received research fellowship from SENSHIN Medical Research Foundation fellowship for research abroad (2015). SH received a grant funded by Grant-in-Aid for Scientific Research (Grant Number 17\u00a0K1662007). KK received a grant funded by Grant-in-Aid for Scientific Research (Grant Number JP15K1028605) and research support from Nihon Medi-Physics Co., Ltd. KH serves on the executive editorial board of Neurologia Medico-Chirurgica and the editorial board of the Journal of Stroke & Cerebrovascular Diseases.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"72"}}