{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:04:46Z","timestamp":1770224686377,"version":"3.49.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"S3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1186\/s12920-018-0392-4","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:51:27Z","timestamp":1536915087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records"],"prefix":"10.1186","volume":"11","author":[{"given":"Nicole A.","family":"Restrepo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Laper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Farber-Eger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana C.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"issue":"4","key":"392_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1001\/archopht.122.4.477","volume":"122","author":"The Eye Diseases Prevalence Research Group","year":"2004","unstructured":"The Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004;122(4):477\u201385. https:\/\/doi.org\/10.1001\/archopht.122.4.477 .","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"392_CR2","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.ophtha.2010.10.024","volume":"118","author":"JD Stein","year":"2011","unstructured":"Stein JD, Kim DS, Niziol LM, Talwar N, Nan B, Musch DC, et al. Differences in rates of glaucoma among Asian Americans and other racial groups, and among various asian ethnic groups. Ophthalmology. 2011;118(6):1031\u20137. https:\/\/doi.org\/10.1016\/j.ophtha.2010.10.024 . PMC3109193","journal-title":"Ophthalmology"},{"issue":"4","key":"392_CR3","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1001\/archopht.122.4.532","volume":"122","author":"DS Friedman","year":"2004","unstructured":"Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, et al. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004;122(4):532\u20138. https:\/\/doi.org\/10.1001\/archopht.122.4.532 . PMC2798086","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"392_CR4","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262\u20137. https:\/\/doi.org\/10.1136\/bjo.2005.081224 . PMC1856963","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"392_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1001\/archopthalmol.2011.1224","volume":"130","author":"JA Ladapo","year":"2012","unstructured":"Ladapo JA, Kymes SM, Ladapo JA, Nwosu VC, Pasquale LR. Projected clinical outcomes of glaucoma screening in African American individuals. Arch Ophthalmol. 2012;130(3):365\u201372. https:\/\/doi.org\/10.1001\/archopthalmol.2011.1224 .","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"392_CR6","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/archopht.1995.01100070092031","volume":"113","author":"M Leske","year":"1995","unstructured":"Leske M, Connell AS, Wu S, Hyman LG, Schachat AP. Risk factors for open-angle glaucoma: the Barbados eye study. Arch Ophthalmol. 1995;113(7):918\u201324. https:\/\/doi.org\/10.1001\/archopht.1995.01100070092031 .","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"392_CR7","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.ophtha.2012.07.065","volume":"120","author":"C-W Pan","year":"2013","unstructured":"Pan C-W, Cheung CY, Aung T, Cheung C-M, Zheng Y-F, Wu R-Y, et al. Differential associations of myopia with major age-related eye diseases: the Singapore Indian eye study. Ophthalmology. 2013;120(2):284\u201391. https:\/\/doi.org\/10.1016\/j.ophtha.2012.07.065 .","journal-title":"Ophthalmology"},{"issue":"3","key":"392_CR8","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ophtha.2005.10.050","volume":"113","author":"S Chandrasekaran","year":"2006","unstructured":"Chandrasekaran S, Cumming RG, Rochtchina E, Mitchell P. Associations between elevated intraocular pressure and Glaucoma, use of Glaucoma medications, and 5-year incident cataract: the Blue Mountains eye study. Ophthalmology. 2006;113(3):417\u201324. https:\/\/doi.org\/10.1016\/j.ophtha.2005.10.050 .","journal-title":"Ophthalmology"},{"issue":"11","key":"392_CR9","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.ophtha.2012.05.030","volume":"119","author":"X Jiang","year":"2012","unstructured":"Jiang X, Varma R, Wu S, Torres M, Azen SP, Francis BA, et al. Baseline risk factors that predict the development of open-angle Glaucoma in a population: the Los Angeles Latino eye study. Ophthalmology. 2012;119(11):2245\u201353. https:\/\/doi.org\/10.1016\/j.ophtha.2012.05.030 . PMC3474872","journal-title":"Ophthalmology"},{"issue":"2","key":"392_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/00055735-200004000-00006","volume":"11","author":"WM Budde","year":"2000","unstructured":"Budde WM. Heredity in primary open-angle glaucoma. Curr Opin Ophthalmol. 2000;11(2):101\u20136.","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"392_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/archopht.1994.01090130079022","volume":"112","author":"JM Tielsch","year":"1994","unstructured":"Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Family history and risk of primary open angle glaucoma: the Baltimore eye survey. Arch Ophthalmol. 1994;112(1):69\u201373. https:\/\/doi.org\/10.1001\/archopht.1994.01090130079022 .","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"392_CR12","doi-asserted-by":"publisher","first-page":"e55573","DOI":"10.1371\/journal.pone.0055573","volume":"8","author":"EE Freeman","year":"2013","unstructured":"Freeman EE, Roy-Gagnon M-H, Descovich D, Mass\u00e9 H, Lesk MR. The heritability of glaucoma-related traits corneal hysteresis, central corneal thickness, intraocular pressure, and choroidal blood flow pulsatility. PLoS One. 2013;8(1):e55573. https:\/\/doi.org\/10.1371\/journal.pone.0055573 . PMC3559508","journal-title":"PLoS One"},{"issue":"8","key":"392_CR13","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1167\/iovs.06-1519","volume":"48","author":"LME van Koolwijk","year":"2007","unstructured":"van Koolwijk LME, Despriet DDG, van Duijn CM, Pardo Cortes LM, Vingerling JR, Aulchenko YS, et al. Genetic contributions to Glaucoma: heritability of intraocular pressure, retinal nerve Fiber layer thickness, and optic disc morphology. Invest Ophthalmol Vis Sci. 2007;48(8):3669\u201376. https:\/\/doi.org\/10.1167\/iovs.06-1519 .","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"392_CR14","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1167\/iovs.09-4786","volume":"51","author":"J Charlesworth","year":"2010","unstructured":"Charlesworth J, Kramer PL, Dyer T, Diego V, Samples JR, Craig JE, et al. The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness. Invest Ophthalmol Vis Sci. 2010;51(7):3509\u201314. https:\/\/doi.org\/10.1167\/iovs.09-4786 . PMC2904007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"392_CR15","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.ophtha.2005.03.006","volume":"112","author":"TC Chang","year":"2005","unstructured":"Chang TC, Congdon NG, Wojciechowski R, Mu\u00f1oz B, Gilbert D, Chen P, et al. Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. Ophthalmology. 2005;112(7):1186\u201391. https:\/\/doi.org\/10.1016\/j.ophtha.2005.03.006 . PMC3124001","journal-title":"Ophthalmology"},{"issue":"5","key":"392_CR16","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0002-9394(00)00636-X","volume":"130","author":"O Findl","year":"2000","unstructured":"Findl O, Rainer G, Dallinger S, Dorner G, Polak K, Kiss B, et al. Assessment of optic disk blood flow in patients with open-angle glaucoma. Am J Ophthalmol. 2000;130(5):589\u201396. https:\/\/doi.org\/10.1016\/S0002-9394(00)00636-X .","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"392_CR17","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1136\/bjo.82.7.731","volume":"82","author":"L Fontana","year":"1998","unstructured":"Fontana L, Poinoosawmy D, Bunce CV, O\u2019Brien C, Hitchings RA. Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects. Br J Ophthalmol. 1998;82(7):731\u20136. https:\/\/doi.org\/10.1136\/bjo.82.7.731 . PMC1722652","journal-title":"Br J Ophthalmol"},{"issue":"5300","key":"392_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.275.5300.668","volume":"275","author":"EM Stone","year":"1997","unstructured":"Stone EM, Fingert JH, Alward WLM, Nguyen TD, Polansky JR, Sunden SLF, et al. Identification of a gene that causes primary open angle Glaucoma. Science. 1997;275(5300):668\u201370. https:\/\/doi.org\/10.1126\/science.275.5300.668 .","journal-title":"Science"},{"issue":"5557","key":"392_CR19","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.1066901","volume":"295","author":"T Rezaie","year":"2002","unstructured":"Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, et al. Adult-onset primary open-angle Glaucoma caused by mutations in Optineurin. Science. 2002;295(5557):1077\u20139. https:\/\/doi.org\/10.1126\/science.1066901 .","journal-title":"Science"},{"issue":"6","key":"392_CR20","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/hmg\/ddi068","volume":"14","author":"S Monemi","year":"2005","unstructured":"Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, et al. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum Mol Genet. 2005;14(6):725\u201333. https:\/\/doi.org\/10.1093\/hmg\/ddi068 .","journal-title":"Hum Mol Genet"},{"issue":"12","key":"392_CR21","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1093\/hmg\/6.12.2091","volume":"6","author":"MF Adam","year":"1997","unstructured":"Adam MF, Belmouden A, Binisti P, Br\u00e9zin AP, Valtot F, B\u00e9chetoille A, et al. Recurrent mutations in a single exon encoding the evolutionarily conserved Olfactomedin-homology domain of TIGR in familial open-angle Glaucoma. Hum Mol Genet. 1997;6(12):2091\u20137. https:\/\/doi.org\/10.1093\/hmg\/6.12.2091 .","journal-title":"Hum Mol Genet"},{"issue":"5","key":"392_CR22","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1086\/301612","volume":"61","author":"Y Suzuki","year":"1997","unstructured":"Suzuki Y, Shirato S, Taniguchi F, Ohara K, Nishimaki K, Ohta S. Mutations in the TIGR gene in familial primary open-angle Glaucoma in Japan. Am J Hum Genet. 1997;61(5):1202\u20134. https:\/\/doi.org\/10.1086\/301612 . PMC1716051","journal-title":"Am J Hum Genet"},{"issue":"3","key":"392_CR23","doi-asserted-by":"publisher","first-page":"e33389","DOI":"10.1371\/journal.pone.0033389","volume":"7","author":"M Nakano","year":"2012","unstructured":"Nakano M, Ikeda Y, Tokuda Y, Fuwa M, Omi N, Ueno M, et al. Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PLoS One. 2012;7(3):e33389. https:\/\/doi.org\/10.1371\/journal.pone.0033389 . PMC3299784","journal-title":"PLoS One"},{"issue":"12","key":"392_CR24","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1093\/hmg\/dds103","volume":"21","author":"W Osman","year":"2012","unstructured":"Osman W, Low SK, Takahashi A, Kubo M, Nakamura Y. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet. 2012;21(12):2836\u201342. https:\/\/doi.org\/10.1093\/hmg\/dds103 .","journal-title":"Hum Mol Genet"},{"issue":"4","key":"392_CR25","doi-asserted-by":"publisher","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","volume":"8","author":"JL Wiggs","year":"2012","unstructured":"Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, et al. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in Glaucoma. PLoS Genet. 2012;8(4):e1002654. https:\/\/doi.org\/10.1371\/journal.pgen.1002654 . PMC3342074","journal-title":"PLoS Genet"},{"issue":"10","key":"392_CR26","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/ng.661","volume":"42","author":"G Thorleifsson","year":"2010","unstructured":"Thorleifsson G, Walters GB, Hewitt AW, Masson G, Helgason A, DeWan A, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010;42(10):906\u20139. https:\/\/doi.org\/10.1038\/ng.661 . PMC3222888","journal-title":"Nat Genet"},{"issue":"13","key":"392_CR27","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1093\/hmg\/ddv128","volume":"24","author":"Z Li","year":"2015","unstructured":"Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, et al. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet. 2015;24(13):3880\u201392. https:\/\/doi.org\/10.1093\/hmg\/ddv128 . PMC4459396","journal-title":"Hum Mol Genet"},{"key":"392_CR28","first-page":"2241","volume":"18","author":"W Liu","year":"2012","unstructured":"Liu W, Liu Y, Challa P, Herndon LW, Wiggs JL, Girkin CA, et al. Low prevalence of myocilin mutatons in an African American population wiht primary open-angle glaucoma. Mol Vision. 2012;18:2241\u20136. PMC3429360","journal-title":"Mol Vision"},{"issue":"7","key":"392_CR29","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1093\/aje\/kwr160","volume":"174","author":"TC Matise","year":"2011","unstructured":"Matise TC, Ambite JL, Buyske S, Carlson CS, Cole SA, Crawford DC, et al. The next PAGE in understanding complex traits: design for the analysis of population architecture using genetics and epidemiology (PAGE) study. Am J Epidemiol. 2011;174(7):849\u201359. https:\/\/doi.org\/10.1093\/aje\/kwr160 . PMC3176830","journal-title":"Am J Epidemiol"},{"issue":"4","key":"392_CR30","doi-asserted-by":"publisher","first-page":"e35651","DOI":"10.1371\/journal.pone.0035651","volume":"7","author":"S Buyske","year":"2012","unstructured":"Buyske S, Wu Y, Carty CL, Cheng I, Assimes TL, Dumitrescu L, et al. Evaluation of the Metabochip genotyping Array in African Americans and implications for fine mapping of GWAS-identified Loci: the PAGE study. PLoS One. 2012;7(4):e35651. https:\/\/doi.org\/10.1371\/journal.pone.0035651 . PMC3335090","journal-title":"PLoS One"},{"issue":"3","key":"392_CR31","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/clpt.2008.89","volume":"84","author":"DM Roden","year":"2008","unstructured":"Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, et al. Development of a large-scale De-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther. 2008;84(3):362\u20139. https:\/\/doi.org\/10.1038\/clpt.2008.89 . PMC3763939","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"392_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1752-8062.2010.00175.x","volume":"3","author":"J Pulley","year":"2010","unstructured":"Pulley J, Clayton E, Bernard GR, Roden DM, Masys DR. Principles of Human Subjects Protections Applied in an Opt-Out, De-identified Biobank. Clin Transl Sci. 2010;3(1):42\u20138. https:\/\/doi.org\/10.1111\/j.1752-8062.2010.00175.x . PMC3075971","journal-title":"Clin Transl Sci"},{"issue":"3\u20134","key":"392_CR33","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000381805","volume":"79","author":"DC Crawford","year":"2015","unstructured":"Crawford DC, Goodloe R, Farber-Eger E, Boston J, Pendergrass SA, Haines JL, et al. Leveraging epidemiologic and clinical collections for genomic studies of complex traits. Hum Hered. 2015;79(3\u20134):137\u201346. https:\/\/doi.org\/10.1159\/000381805 . PMC4528966","journal-title":"Hum Hered"},{"issue":"6","key":"392_CR34","doi-asserted-by":"publisher","first-page":"e0127817","DOI":"10.1371\/journal.pone.0127817","volume":"10","author":"NA Restrepo","year":"2015","unstructured":"Restrepo NA, Farber-Eger E, Goodloe R, Haines JL, Crawford DC. Extracting primary open-angle glaucoma from electronic medical records for genetic association studies. PLoS One. 2015;10(6):e0127817. https:\/\/doi.org\/10.1371\/journal.pone.0127817 . PMC4465698","journal-title":"PLoS One"},{"issue":"8","key":"392_CR35","doi-asserted-by":"publisher","first-page":"e1002793","DOI":"10.1371\/journal.pgen.1002793","volume":"8","author":"BF Voight","year":"2012","unstructured":"Voight BF, Kang HM, Ding J, Palmer CD, Sidore C, Chines PS, et al. The Metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 2012;8(8):e1002793. https:\/\/doi.org\/10.1371\/journal.pgen.1002793 . PMC3410907","journal-title":"PLoS Genet"},{"key":"392_CR36","first-page":"188","volume":"18","author":"DC Crawford","year":"2013","unstructured":"Crawford DC, Goodloe R, Brown-Gentry K, Wilson S, Robberson J, Gillani NB, et al. Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Project. Pac Symp Biocomput. 2013;18:188\u201399. PMC3584704","journal-title":"Pac Symp Biocomput"},{"issue":"8","key":"392_CR37","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006;38(8):904\u20139.","journal-title":"Nat Genet"},{"issue":"12","key":"392_CR38","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson N, Price AL, Reich D. Population structure and Eigenanalysis. PLoS Genet. 2006;2(12):e190. https:\/\/doi.org\/10.1371\/journal.pgen.0020190 .","journal-title":"PLoS Genet"},{"issue":"3","key":"392_CR39","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analysis. Am J Hum Genet. 2007;81(3):559\u201375.","journal-title":"Am J Hum Genet"},{"issue":"24","key":"392_CR40","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","volume":"24","author":"AD Johnson","year":"2008","unstructured":"Johnson AD, Handsaker RE, Pulit S, Nizzari MM, ODonnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics. 2008;24(24):2938\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btn564 . PMC2720775","journal-title":"Bioinformatics"},{"issue":"5","key":"392_CR41","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/aje\/155.5.478","volume":"155","author":"WJ Gauderman","year":"2002","unstructured":"Gauderman WJ. Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol. 2002;155(5):478\u201384.","journal-title":"Am J Epidemiol"},{"issue":"10","key":"392_CR42","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/bioinformatics\/bts144","volume":"28","author":"Y Baran","year":"2012","unstructured":"Baran Y, Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Eng C, et al. Fast and accurate inference of local ancestry in Latino populations. Bioinformatics. 2012;28(10):1359\u201367. https:\/\/doi.org\/10.1093\/bioinformatics\/bts144 . PMC3348558","journal-title":"Bioinformatics"},{"key":"392_CR43","unstructured":"R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2013."},{"issue":"2","key":"392_CR44","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1534\/genetics.114.164350","volume":"197","author":"A Raj","year":"2014","unstructured":"Raj A, Stephens M, Pritchard JK. fastSTRUCTURE: Variational inference of population structure in large SNP data sets. Genetics. 2014;197(2):573\u201389. https:\/\/doi.org\/10.1534\/genetics.114.164350 . PMC4063916","journal-title":"Genetics"},{"issue":"1","key":"392_CR45","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/1755-0998.12509","volume":"17","author":"RM Francis","year":"2017","unstructured":"Francis RM. pophelper: an R package and web app to analyse and visualize population structure. Mol Ecol Resour. 2017;17(1):27\u201332. https:\/\/doi.org\/10.1111\/1755-0998.12509 .","journal-title":"Mol Ecol Resour"},{"issue":"6","key":"392_CR46","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1086\/302148","volume":"63","author":"EJ Parra","year":"1998","unstructured":"Parra EJ, Marcini A, Akey J, Martinson J, Batzer MA, Cooper R, et al. Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet. 1998;63(6):1839\u201351. https:\/\/doi.org\/10.1086\/302148 . PMC1377655","journal-title":"Am J Hum Genet"},{"issue":"5","key":"392_CR47","doi-asserted-by":"publisher","first-page":"e1006059","DOI":"10.1371\/journal.pgen.1006059","volume":"12","author":"S Baharian","year":"2016","unstructured":"Baharian S, Barakatt M, Gignoux CR, Shringarpure S, Errington J, Blot WJ, et al. The great migration and African-American genomic diversity. PLoS Genet. 2016;12(5):e1006059. https:\/\/doi.org\/10.1371\/journal.pgen.1006059 . PMC4883799","journal-title":"PLoS Genet"},{"issue":"2","key":"392_CR48","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ng.76","volume":"40","author":"CJ Willer","year":"2008","unstructured":"Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 2008;40(2):161\u20139. https:\/\/doi.org\/10.1038\/ng.76 . PMC5206900","journal-title":"Nat Genet"},{"issue":"2","key":"392_CR49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ng.75","volume":"40","author":"S Kathiresan","year":"2008","unstructured":"Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008;40(2):189\u201397. https:\/\/doi.org\/10.1038\/ng.75 . PMC2682493","journal-title":"Nat Genet"},{"issue":"9","key":"392_CR50","doi-asserted-by":"publisher","first-page":"e1004606","DOI":"10.1371\/journal.pgen.1004606","volume":"10","author":"GW Beecham","year":"2014","unstructured":"Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer\u2019s disease and related dementias. PLoS Genet. 2014;10(9):e1004606. https:\/\/doi.org\/10.1371\/journal.pgen.1004606 . PMC4154667","journal-title":"PLoS Genet"},{"issue":"2","key":"392_CR51","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.ajo.2012.07.023","volume":"155","author":"LR Pasquale","year":"2013","unstructured":"Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, et al. CDKN2B-AS1 genotype\u2013glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013;155(2):342\u201353.e5. https:\/\/doi.org\/10.1016\/j.ajo.2012.07.023 . PMC3544983","journal-title":"Am J Ophthalmol"},{"key":"392_CR52","doi-asserted-by":"publisher","first-page":"8378","DOI":"10.1038\/srep08378","volume":"5","author":"SE Williams","year":"2015","unstructured":"Williams SE, Carmichael TR, Allingham RR, Hauser M, Ramsay M. The genetics of POAG in black South Africans: a candidate gene association study. Sci Rep. 2015;5:8378. https:\/\/doi.org\/10.1038\/srep08378 . PMC4323640","journal-title":"Sci Rep"},{"issue":"6","key":"392_CR53","doi-asserted-by":"publisher","first-page":"e39278","DOI":"10.1371\/journal.pone.0039278","volume":"7","author":"D Cao","year":"2012","unstructured":"Cao D, Jiao X, Liu X, Hennis A, Leske MC, Nemesure B, et al. CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies. PLoS One. 2012;7(6):e39278. https:\/\/doi.org\/10.1371\/journal.pone.0039278 . PMC3384655","journal-title":"PLoS One"},{"key":"392_CR54","doi-asserted-by":"crossref","unstructured":"Jandrot-Perrus M, Busfield S, Lagrue A-H, Xiong X, Debili N, Chickering T, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000;96(5):1798-807.","DOI":"10.1182\/blood.V96.5.1798"},{"key":"392_CR55","doi-asserted-by":"crossref","unstructured":"Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, et al. The Genotype-Tissue Expression (GTEx) project. Nat Genet. 2013;45(6):580-85.","DOI":"10.1038\/ng.2653"},{"issue":"14","key":"392_CR56","doi-asserted-by":"publisher","first-page":"6787","DOI":"10.1093\/nar\/gkv608","volume":"43","author":"Nancy Yiu-Lin Yu","year":"2015","unstructured":"Yu NY-L, Hallstr\u00f6m BM, Fagerberg L, Ponten F, Kawaji H, Carninci P, Forrest ARR. The FANTOM\u00a0Consortium, Yoshihide Hayashizaki, Mathias Uhl\u00e9n, Carsten O. Daub. Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium. Nucleic Acids Res. 2015;43(14):6787-98.","journal-title":"Nucleic Acids Research"},{"issue":"4","key":"392_CR57","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1167\/iovs.15-17437","volume":"57","author":"Pachiappan Arjunan","year":"2016","unstructured":"Arjunan P, Gnanaprakasam JP, Ananth S, Romej MA, Rajalakshmi V-K, Prasad PD, Martin PM, Gurusamy M, Thangaraju M, Bhutia YD, Ganapathy V. Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis. Investigative Opthalmology & Visual Science. 2016;57(4):1612.","journal-title":"Investigative Opthalmology & Visual Science"},{"issue":"7624","key":"392_CR58","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/538161a","volume":"538","author":"Alice B. Popejoy","year":"2016","unstructured":"Popejoy AB, Fullerton SM. Genomics is failing on diversity. Nature 2016;538(7624):161-164","journal-title":"Nature"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0392-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12920-018-0392-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-018-0392-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T06:14:26Z","timestamp":1571897666000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-018-0392-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":58,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["392"],"URL":"https:\/\/doi.org\/10.1186\/s12920-018-0392-4","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"14 September 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The data in this study were de-identified in accordance with provisions of Title 45, Code of Federal Regulations, part 46 (45 CFR 46); therefore, this study was considered non-human subjects research by the Vanderbilt University Internal Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"70"}}