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The ceRNA regulatory network was constructed, then functional and pathway enrichment analysis was conducted. AT1DM-related ceRNA regulatory network was established based on the Human microRNA Disease Database to carry out pathway enrichment analysis. Meanwhile, the T1DM-related pathways were retrieved from the Comparative Toxicogenomics Database (CTD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 847 mRNAs, 41 lncRNAs, and 38 miRNAs were significantly differentially expressed. The ceRNA regulatory network consisted of 12 lncRNAs, 10 miRNAs, and 24 mRNAs. Two miRNAs (<jats:italic>hsa-miR-181a<\/jats:italic> and <jats:italic>hsa-miR-1275<\/jats:italic>) were screened as T1DM-related miRNAs to build the T1DM-related ceRNA regulatory network, in which genes were considerably enriched in seven pathways. Moreover, three overlapping pathways, including the phosphatidylinositol signaling system (involving <jats:italic>PIP4K2A<\/jats:italic>, <jats:italic>INPP4A<\/jats:italic>, <jats:italic>PIP4K2C<\/jats:italic>, and <jats:italic>CALM1<\/jats:italic>); dopaminergic synapse (involving <jats:italic>CALM1<\/jats:italic> and <jats:italic>PPP2R5C<\/jats:italic>); and the insulin signaling pathway (involving <jats:italic>CBLB<\/jats:italic> and <jats:italic>CALM1<\/jats:italic>) were revealed by comparing with T1DM-related pathways in the CTD, which involved four lncRNAs (<jats:italic>LINC01278<\/jats:italic>, <jats:italic>TRG-AS1<\/jats:italic>, <jats:italic>MIAT<\/jats:italic>, and <jats:italic>GAS5-AS1<\/jats:italic>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The identified signature RNAs may serve as important regulators in the pathogenesis of T1DM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12920-021-00931-0","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T09:02:48Z","timestamp":1621328568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Signature RNAS and related regulatory roles in type 1 diabetes mellitus based on competing endogenous RNA regulatory network analysis"],"prefix":"10.1186","volume":"14","author":[{"given":"Qinghong","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-2085","authenticated-orcid":false,"given":"Hanxin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"931_CR1","doi-asserted-by":"publisher","first-page":"17016","DOI":"10.1038\/nrdp.2017.16","volume":"3","author":"A Katsarou","year":"2017","unstructured":"Katsarou A, Gudbj\u00f6rnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson B, et al. 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