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This study mainly explored the association of <jats:italic>IL-6<\/jats:italic> variants and ONFH susceptibility among the Chinese Han population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Two variants (rs2069837, and rs13306435) in the <jats:italic>IL-6<\/jats:italic> gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between <jats:italic>IL-6<\/jats:italic> polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The potential function of these two variants was predicted by the HaploReg online database.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results of the overall analysis revealed that <jats:italic>IL-6<\/jats:italic> rs2069837 was correlated with decreased risk of ONFH among the Chinese Han population (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In stratified analysis, rs2069837 also reduced the susceptibility to ONFH in older people (&gt;\u200951\u00a0years), males, nonsmokers, and nondrinkers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, no associations between rs13306435 and ONFH susceptibility were observed (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To sum up, we suggested that rs2069837 G&gt;A polymorphism in the <jats:italic>IL-6<\/jats:italic> gene was significantly associated with a decreased risk of ONFH among the Chinese Hans. These findings underscored the crucial role of <jats:italic>IL-6<\/jats:italic> rs2069837 in the occurrence of ONFH.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12920-021-01142-3","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T14:03:58Z","timestamp":1641391438000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development"],"prefix":"10.1186","volume":"15","author":[{"given":"Ruisong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"issue":"8","key":"1142_CR1","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/rheumatology\/ken206","volume":"47","author":"C S\u00e9guin","year":"2008","unstructured":"S\u00e9guin C, Kassis J, Busque L, Bestawros A, Theodoropoulos J, Alonso ML, Harvey EJ. 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