{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:14Z","timestamp":1785451274245,"version":"3.56.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6\u201320% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC\/Cdc20,\n                      <jats:italic>RBX1<\/jats:italic>\n                      enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the\n                      <jats:italic>BAMBI<\/jats:italic>\n                      gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the\n                      <jats:italic>RBX1<\/jats:italic>\n                      and\n                      <jats:italic>BAMBI<\/jats:italic>\n                      genes between GV and MII oocytes of PCOS and non-PCOS groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with\/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of\n                      <jats:italic>BAMBI<\/jats:italic>\n                      and\n                      <jats:italic>RBX1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to our research, the expression level of\n                      <jats:italic>RBX1<\/jats:italic>\n                      and\n                      <jats:italic>BAMBI<\/jats:italic>\n                      in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This research raises the possibility of\n                      <jats:italic>RBX1<\/jats:italic>\n                      and\n                      <jats:italic>BAMBI<\/jats:italic>\n                      involvement in oocyte quality in PCOS women.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12920-024-01800-2","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:02:08Z","timestamp":1705564928000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women"],"prefix":"10.1186","volume":"17","author":[{"given":"Kimia","family":"Monshizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Tajamolian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Anbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yahya Vahidi","family":"Mehrjardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mehdi","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"issue":"7","key":"1800_CR1","first-page":"410","volume":"24","author":"F Alvandian","year":"2022","unstructured":"Alvandian F, Hosseini E, Hashemian Z, Khosravifar M, Movaghar B, Shahhosein M, et al. 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