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Recent research has demonstrated that the microbiome can affect both prostatitis and the inflammation of the prostate that is linked to prostate cancer. It is still unclear, though, whether this relationship indicates causation. We conducted a Mendelian randomization investigation on two samples to fully uncover gut microbiota\u2019s potential genetic causal role in prostatitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Prostatitis (1859 prostatitis cases and 72,799 controls) was utilized as the outcome, while SNPs highly linked with 196 microbial taxa (18 340 people) were chosen as instrumental factors. Random effects, inverse variance weighting, weighted medians, and MR-Egger were used to analyze causal effects. The Cochran\u2019s Q test, funnel plot, leave-one-out analysis, and MR-Egger intercept test were all used in the sensitivity analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A causal effect in lowering the incidence of prostatitis is anticipated for five gut microorganisms (<jats:italic>Methanobacteria<\/jats:italic>, <jats:italic>Methanobacteriaceae<\/jats:italic>, <jats:italic>Erysipelatoclostridium<\/jats:italic>, <jats:italic>Parasutterella<\/jats:italic>, and <jats:italic>Slackia<\/jats:italic>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Four gut bacteria, including <jats:italic>Faecalibacterium<\/jats:italic>, <jats:italic>LachnospiraceaeUCG004<\/jats:italic>, <jats:italic>Sutterella<\/jats:italic>, and <jats:italic>Gastranaerophilales<\/jats:italic>, are predicted to play a causal role in increasing the risk of prostatitis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were no discernible estimates of pleiotropy or heterogeneity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our investigation established the genetic links between nine gut microorganisms and prostatitis, which may offer fresh perspectives and a theoretical framework for the future prevention and management of prostatitis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12920-024-01812-y","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:02:43Z","timestamp":1706176963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preliminary study of the effect of gut microbiota on the development of prostatitis"],"prefix":"10.1186","volume":"17","author":[{"given":"Cheng","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"1812_CR1","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1097\/01.ju.0000182152.28519.e7","volume":"174","author":"JQ Clemens","year":"2005","unstructured":"Clemens JQ, Meenan RT, O\u2019Keeffe Rosetti MC, Gao SY, Calhoun EA. 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