{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:14:33Z","timestamp":1790018073336,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To report the clinical manifestation and genetic characteristics of a patient having frontotemporal dementia (FTD) with abnormal behavior and unstable walking.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The clinical and imaging features of a patient who was eventually diagnosed with FTD were analyzed. The patient\u2019s neuropsychological, PET-CT, electromyography, and genetic data were collected. Furthermore, the patient\u2019s blood samples were examined for FTD-related genes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The patient was a 52-year-old man with hidden onset. The symptoms progressed gradually, presenting with abnormal behaviors, including repeated shopping, taking away other people\u2019s things, constantly eating snacks, and frequently calling friends at night. The patient also exhibited executive dysfunction, such as the inability to cook and multiple driving problems, e.g., constantly deviates from his lane while driving. In addition, the patient showed personality changes such as irritability, indifference, and withdrawal, as well as motor symptoms, including unstable walking and frequent falls when walking. Brain magnetic resonance imaging revealed hippocampal sclerosis along with widening and deepening of the bilateral temporal lobe sulcus. Brain metabolic imaging via PET-CT demonstrated decreased metabolism in the bilateral prefrontal lobe, with the abnormal energy metabolism indicating FTD. Lastly, blood sample analysis detected mutations in the amyotrophic lateral sclerosis (ALS)-related <jats:italic>GRN<\/jats:italic> gene c.1352C\u2009&gt;\u2009T (p.P451L) and <jats:italic>ErbB4<\/jats:italic> gene c.256\u2009T\u2009&gt;\u2009C (p.Y86H).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This is the first case of heterozygous mutations in the <jats:italic>GRN<\/jats:italic> and <jats:italic>ErbB4<\/jats:italic> genes in FTD alone. The <jats:italic>GRN<\/jats:italic> and <jats:italic>ErbB4<\/jats:italic> genes are likely to be important in the pathogenesis of FTD, expanding the common genetic profile of ALS and FTD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12920-024-01819-5","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T15:02:53Z","timestamp":1706626973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Behavioral variant frontotemporal dementia associated with GRN and ErbB4 gene mutations: a case report and literature review"],"prefix":"10.1186","volume":"17","author":[{"given":"Youde","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiansong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"issue":"10004","key":"1819_CR1","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","volume":"386","author":"J Bang","year":"2015","unstructured":"Bang J, Spina S, Miller BL. Frontotemporal dementia. Lancet. 2015;386(10004):1672\u201382. https:\/\/doi.org\/10.1016\/S0140-6736(15)00461-4.","journal-title":"Lancet"},{"issue":"2","key":"1819_CR2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3109\/09540261.2013.776523","volume":"25","author":"CU Onyike","year":"2013","unstructured":"Onyike CU, Diehl-Schmid J. The epidemiology of frontotemporal dementia. Int Rev Psychiatry. 2013;25(2):130\u20137. https:\/\/doi.org\/10.3109\/09540261.2013.776523.","journal-title":"Int Rev Psychiatry"},{"issue":"4","key":"1819_CR3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1176\/appi.neuropsych.21060166","volume":"34","author":"N Magrath Guimet","year":"2022","unstructured":"Magrath Guimet N, Zapata-Restrepo LM, Miller BL. Advances in treatment of frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2022;34(4):316\u201327. https:\/\/doi.org\/10.1176\/appi.neuropsych.21060166.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"1819_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/B978-0-444-64012-3.00003-4","volume":"165","author":"B Miller","year":"2019","unstructured":"Miller B, Llibre Guerra JJ. Frontotemporal dementia. Handb Clin Neurol. 2019;165:33\u201345. https:\/\/doi.org\/10.1016\/B978-0-444-64012-3.00003-4.","journal-title":"Handb Clin Neurol"},{"key":"1819_CR5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/B978-0-12-804766-8.00015-7","volume":"167","author":"EM Devenney","year":"2019","unstructured":"Devenney EM, Ahmed RM, Hodges JR. Frontotemporal dementia. Handb Clin Neurol. 2019;167:279\u201399. https:\/\/doi.org\/10.1016\/B978-0-12-804766-8.00015-7.","journal-title":"Handb Clin Neurol"},{"issue":"2","key":"1819_CR6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.psc.2020.02.006","volume":"43","author":"K Younes","year":"2020","unstructured":"Younes K, Miller BL. Frontotemporal dementia: neuropathology, genetics, neuroimaging, and treatments. Psychiatr Clin North Am. 2020;43(2):331\u201344. https:\/\/doi.org\/10.1016\/j.psc.2020.02.006.","journal-title":"Psychiatr Clin North Am"},{"key":"1819_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bandl.2019.04.006","volume":"194","author":"S Ash","year":"2019","unstructured":"Ash S, Nevler N, Phillips J, et al. A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia. Brain Lang. 2019;194:46\u201357. https:\/\/doi.org\/10.1016\/j.bandl.2019.04.006.","journal-title":"Brain Lang"},{"issue":"2","key":"1819_CR8","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s13311-021-01101-x","volume":"18","author":"BT Peet","year":"2021","unstructured":"Peet BT, Spina S, Mundada N, et al. Neuroimaging in frontotemporal dementia: heterogeneity and relationships with underlying neuropathology. Neurotherapeutics. 2021;18(2):728\u201352. https:\/\/doi.org\/10.1007\/s13311-021-01101-x.","journal-title":"Neurotherapeutics"},{"issue":"6","key":"1819_CR9","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1177\/08919887211060016","volume":"35","author":"J Caga","year":"2022","unstructured":"Caga J, Kiernan MC, Piguet O. A systematic review of caregiver coping strategies in amyotrophic lateral sclerosis and frontotemporal dementia. J Geriatr Psychiatry Neurol. 2022;35(6):763\u201377. https:\/\/doi.org\/10.1177\/08919887211060016.","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"1819_CR10","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.neubiorev.2021.10.015","volume":"131","author":"A Geraudie","year":"2021","unstructured":"Geraudie A, Battista P, Garc\u00eda AM, et al. Speech and language impairments in behavioral variant frontotemporal dementia: a systematic review. Neurosci Biobehav Rev. 2021;131:1076\u201395. https:\/\/doi.org\/10.1016\/j.neubiorev.2021.10.015.","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"1819_CR11","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/acps.13362","volume":"144","author":"M Roman Meller","year":"2021","unstructured":"Roman Meller M, Patel S, Duarte D, et al. Bipolar disorder and frontotemporal dementia: a systematic review. Acta Psychiatr Scand. 2021;144(5):433\u201347. https:\/\/doi.org\/10.1111\/acps.13362.","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"1819_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/WAD.0000000000000511","volume":"36","author":"DF Campos","year":"2022","unstructured":"Campos DF, Rocca AR, Caixeta LF. Right temporal lobe variant of frontotemporal dementia: systematic review. Alzheimer Dis Assoc Disord. 2022;36(3):272\u20139. https:\/\/doi.org\/10.1097\/WAD.0000000000000511.","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"1","key":"1819_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13195-019-0483-2","volume":"11","author":"ES Valente","year":"2019","unstructured":"Valente ES, Caramelli P, Gambogi LB, et al. Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review. Alzheimers Res Ther. 2019;11(1):30. https:\/\/doi.org\/10.1186\/s13195-019-0483-2.","journal-title":"Alzheimers Res Ther"},{"key":"1819_CR14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.schres.2018.02.051","volume":"199","author":"M Cavelti","year":"2018","unstructured":"Cavelti M, Kircher T, Nagels A, et al. Is formal thought disorder in schizophrenia related to structural and functional aberrations in the language network? A systematic review of neuroimaging findings. Schizophr Res. 2018;199:2\u201316. https:\/\/doi.org\/10.1016\/j.schres.2018.02.051.","journal-title":"Schizophr Res"},{"issue":"3","key":"1819_CR15","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1053\/j.semnuclmed.2020.12.002","volume":"51","author":"JA Duignan","year":"2021","unstructured":"Duignan JA, Haughey A, Kinsella JA, et al. Molecular and anatomical imaging of dementia with Lewy bodies and frontotemporal lobar degeneration. Semin Nucl Med. 2021;51(3):264\u201374. https:\/\/doi.org\/10.1053\/j.semnuclmed.2020.12.002.","journal-title":"Semin Nucl Med"},{"issue":"3\u20134","key":"1819_CR16","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1080\/21678421.2018.1556695","volume":"20","author":"G Vinceti","year":"2019","unstructured":"Vinceti G, Olney N, Mandelli ML, et al. Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates. Amyotroph Lateral Scler Frontotemporal Degener. 2019;20(3\u20134):146\u201358. https:\/\/doi.org\/10.1080\/21678421.2018.1556695.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"1819_CR17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/978-3-030-51140-1_18","volume":"1281","author":"PA Ljubenkov","year":"2021","unstructured":"Ljubenkov PA, Boxer AL. FTLD treatment: current practice and future possibilities. Adv Exp Med Biol. 2021;1281:297\u2013310. https:\/\/doi.org\/10.1007\/978-3-030-51140-1_18.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"1819_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1080\/21541248.2021.1892443","volume":"13","author":"L Jiang","year":"2022","unstructured":"Jiang L, Zhang T, Lu K, et al. The progress in C9orf72 research: ALS\/FTD pathogenesis, functions and structure. Small GTPases. 2022;13(1):56\u201376. https:\/\/doi.org\/10.1080\/21541248.2021.1892443.","journal-title":"Small GTPases"},{"key":"1819_CR19","doi-asserted-by":"publisher","first-page":"714220","DOI":"10.3389\/fnagi.2021.714220","volume":"13","author":"CS Musaeus","year":"2021","unstructured":"Musaeus CS, Pedersen JS, Kj\u00e6r TW, et al. Cortical Frontoparietal network dysfunction in CHMP2B-frontotemporal dementia. Front Aging Neurosci. 2021;13:714220. https:\/\/doi.org\/10.3389\/fnagi.2021.714220.","journal-title":"Front Aging Neurosci"},{"key":"1819_CR20","doi-asserted-by":"publisher","first-page":"105063","DOI":"10.1016\/j.nbd.2020.105063","volume":"145","author":"S H\u00e4kkinen","year":"2020","unstructured":"H\u00e4kkinen S, Chu SA, Lee SE. Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiol Dis. 2020;145:105063. https:\/\/doi.org\/10.1016\/j.nbd.2020.105063.","journal-title":"Neurobiol Dis"},{"issue":"3","key":"1819_CR21","doi-asserted-by":"publisher","first-page":"e547","DOI":"10.1002\/mgg3.547","volume":"7","author":"H Yu","year":"2019","unstructured":"Yu H, Yu W, Luo SS, et al. Association of the TBK1 mutation p.Ile334Thr with frontotemporal dementia and literature review. Mol Genet Genomic Med. 2019;7(3):e547. https:\/\/doi.org\/10.1002\/mgg3.547.","journal-title":"Mol Genet Genomic Med"},{"issue":"9","key":"1819_CR22","doi-asserted-by":"publisher","first-page":"5673","DOI":"10.1007\/s12035-022-02934-z","volume":"59","author":"L Kirola","year":"2022","unstructured":"Kirola L, Mukherjee A, Mutsuddi M. Recent updates on the genetics of amyotrophic lateral sclerosis and frontotemporal dementia. Mol Neurobiol. 2022;59(9):5673\u201394. https:\/\/doi.org\/10.1007\/s12035-022-02934-z.","journal-title":"Mol Neurobiol"},{"issue":"8","key":"1819_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.tips.2021.11.015","volume":"43","author":"H Rhinn","year":"2022","unstructured":"Rhinn H, Tatton N, McCaughey S, et al. Progranulin as a therapeutic target in neurodegenerative diseases. Trends Pharmacol Sci. 2022;43(8):641\u201352. https:\/\/doi.org\/10.1016\/j.tips.2021.11.015.","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"1819_CR24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3233\/JAD-230052","volume":"93","author":"M Chu","year":"2023","unstructured":"Chu M, Nan H, Jiang D, et al. Progranulin gene mutations in Chinese patients with frontotemporal dementia: a case report and literature review. J Alzheimers Dis. 2023;93(1):225\u201334. https:\/\/doi.org\/10.3233\/JAD-230052.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1819_CR25","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12883-017-0959-2","volume":"17","author":"T Hosaka","year":"2017","unstructured":"Hosaka T, Ishii K, Miura T, et al. A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review. BMC Neurol. 2017;17(1):182. https:\/\/doi.org\/10.1186\/s12883-017-0959-2.","journal-title":"BMC Neurol"},{"key":"1819_CR26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.neurobiolaging.2019.02.006","volume":"78","author":"R Ferrari","year":"2019","unstructured":"Ferrari R, Manzoni C, Hardy J. Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues. Neurobiol Aging. 2019;78:98\u2013110. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.02.006.","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1819_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/nan.12526","volume":"45","author":"M Neumann","year":"2019","unstructured":"Neumann M, Mackenzie IRA. Review: neuropathology of non-tau frontotemporal lobar degeneration. Neuropathol Appl Neurobiol. 2019;45(1):19\u201340. https:\/\/doi.org\/10.1111\/nan.12526.","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"1819_CR28","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s40478-022-01387-8","volume":"10","author":"SSM Miedema","year":"2022","unstructured":"Miedema SSM, Mol MO, Koopmans FTW, et al. Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia. Acta Neuropathol Commun. 2022;10(1):100. https:\/\/doi.org\/10.1186\/s40478-022-01387-8.","journal-title":"Acta Neuropathol Commun"},{"key":"1819_CR29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neurobiolaging.2022.12.009","volume":"123","author":"HR Cheng","year":"2023","unstructured":"Cheng HR, Lin RR, Li HL, et al. Identification and functional characterization of novel variants of MAPT and GRN in Chinese patients with frontotemporal dementia. Neurobiol Aging. 2023;123:233\u201343. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2022.12.009.","journal-title":"Neurobiol Aging"},{"issue":"13","key":"1819_CR30","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3390\/cells11132066","volume":"11","author":"T Fang","year":"2022","unstructured":"Fang T, Je G, Pacut P, et al. Gene therapy in amyotrophic lateral sclerosis. Cells. 2022;11(13):2066. https:\/\/doi.org\/10.3390\/cells11132066.","journal-title":"Cells"},{"key":"1819_CR31","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.nbd.2018.12.021","volume":"124","author":"I Lopez-Font","year":"2019","unstructured":"Lopez-Font I, Sogorb-Esteve A, Javier-Torrent M, et al. Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis. Neurobiol Dis. 2019;124:428\u201338. https:\/\/doi.org\/10.1016\/j.nbd.2018.12.021.","journal-title":"Neurobiol Dis"},{"issue":"2","key":"1819_CR32","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3233\/JAD-191230","volume":"74","author":"L Sun","year":"2020","unstructured":"Sun L, Cheng B, Zhou Y, et al. ErbB4 mutation that decreased NRG1-ErbB4 signaling involved in the pathogenesis of amyotrophic lateral sclerosis\/frontotemporal dementia. J Alzheimers Dis. 2020;74(2):535\u201344. https:\/\/doi.org\/10.3233\/JAD-191230.","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"1819_CR33","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/jnnp-2017-316820","volume":"89","author":"O Dols-Icardo","year":"2018","unstructured":"Dols-Icardo O, Garc\u00eda-Redondo A, Rojas-Garc\u00eda R, et al. Analysis of known amyotrophic lateral sclerosis and frontotemporal dementia genes reveals a substantial genetic burden in patients manifesting both diseases not carrying the C9orf72 expansion mutation. J Neurol Neurosurg Psychiatry. 2018;89(2):162\u20138. https:\/\/doi.org\/10.1136\/jnnp-2017-316820.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1819_CR34","doi-asserted-by":"publisher","first-page":"997551","DOI":"10.3389\/fneur.2022.997551","volume":"13","author":"KWP Ng","year":"2022","unstructured":"Ng KWP, Chin HL, Chin AXY, Goh DL. Using gene panels in the diagnosis of neuromuscular disorders: a mini-review. Front Neurol. 2022;13:997551. https:\/\/doi.org\/10.3389\/fneur.2022.997551.","journal-title":"Front Neurol"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-024-01819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12920-024-01819-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-024-01819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T15:05:21Z","timestamp":1706627121000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenomics.biomedcentral.com\/articles\/10.1186\/s12920-024-01819-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1819"],"URL":"https:\/\/doi.org\/10.1186\/s12920-024-01819-5","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,30]]},"assertion":[{"value":"30 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the parents for all clinical data in this manuscript. The study was approved by the Medical Ethics Committee of the Second People\u2019s Hospital of Guiyang City.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s parents for the publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}