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The minimum inhibitory concentrations (MICs) of vancomycin and linezolid were validated by broth dilution method. The resistance genes\n                      <jats:italic>optr<\/jats:italic>\n                      A,\n                      <jats:italic>cfr<\/jats:italic>\n                      ,\n                      <jats:italic>van<\/jats:italic>\n                      A,\n                      <jats:italic>van<\/jats:italic>\n                      B and\n                      <jats:italic>van<\/jats:italic>\n                      M were investigated using polymerase chain reaction (PCR). Housekeeping genes and resistance genes were obtianed through whole-genome sequencing (WGS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 2842\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      isolates, 88.5% (2516) originated from urine, with\n                      <jats:italic>E. faecium<\/jats:italic>\n                      accounted for 60.1% of these. The\n                      <jats:italic>van<\/jats:italic>\n                      A gene was identified in 27\/28 vancomycin resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      (VRE) isolates, 4 of which carried both\n                      <jats:italic>van<\/jats:italic>\n                      A and\n                      <jats:italic>van<\/jats:italic>\n                      M genes. The remaining strain was\n                      <jats:italic>van<\/jats:italic>\n                      M positive. The\n                      <jats:italic>optr<\/jats:italic>\n                      A gene was identified in all\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      isolates among linezolid resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      (LRE).\n                      <jats:italic>E. faecium<\/jats:italic>\n                      showed a higher multiple antibiotic resistance index (MAR index) compared to\n                      <jats:italic>E. faecalis.<\/jats:italic>\n                      The multi-locus sequence typing (MLST) showed the sequence type of\n                      <jats:italic>E. faecium<\/jats:italic>\n                      mainly belongs to clonal complex (CC) 17, nearly\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      isolates analyzed were differentiated into 7 characteristics of sequence types (STs), among which ST16 of CC16 were the major lineage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Urine was the primary source of VRE and LRE isolates in this study.\n                      <jats:italic>E. faecium<\/jats:italic>\n                      showed higher levels of resistance compared to\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      .\n                      <jats:italic>Optr<\/jats:italic>\n                      A gene was detected in 91.6% of LRE, which could explain linezolid resistance, and\n                      <jats:italic>van<\/jats:italic>\n                      genes were detected in all vancomycin resistant\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      strains, while\n                      <jats:italic>van<\/jats:italic>\n                      A was a key resistance mechanism in VRE identified in this study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12920-024-01948-x","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T11:02:49Z","timestamp":1719831769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of molecular epidemiological characteristics and antimicrobial susceptibility of vancomycin-resistant and linezolid-resistant Enterococcus in China"],"prefix":"10.1186","volume":"17","author":[{"given":"Ping","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"1948_CR1","doi-asserted-by":"crossref","unstructured":"Fiore E, Van Tyne D, Gilmore MS. 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