{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T15:40:00Z","timestamp":1767800400725,"version":"3.49.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Administration of Traditional Chinese Medicine","award":["No. GZY-KJS-SD-2023-049"],"award-info":[{"award-number":["No. GZY-KJS-SD-2023-049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"DOI":"10.1186\/s12920-025-02283-5","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:37:14Z","timestamp":1764578234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of hub genes contributing to acute eczema using transcriptome sequencing and machine-learning approaches"],"prefix":"10.1186","volume":"19","author":[{"given":"Yingying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingjun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"issue":"Suppl 1","key":"2283_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jdv.16061","volume":"34","author":"T Agner","year":"2020","unstructured":"Agner T, Elsner P. Hand eczema: Epidemiology, prognosis and prevention. J Eur Acad Dermatol Venereol. 2020;34(Suppl 1):4\u201312. https:\/\/doi.org\/10.1111\/jdv.16061.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2283_CR2","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1016\/S0140-6736(24)01810-5","volume":"404","author":"S Weidinger","year":"2024","unstructured":"Weidinger S, Novak N. Hand eczema. Lancet. 2024;404:2476\u201386. https:\/\/doi.org\/10.1016\/S0140-6736(24)01810-5.","journal-title":"Lancet"},{"key":"2283_CR3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jaip.2012.09.002","volume":"1","author":"PD Arkwright","year":"2013","unstructured":"Arkwright PD, Motala C, Subramanian H, Spergel J, Schneider LC, Wollenberg A, et al. Management of difficult-to-treat atopic dermatitis. J Allergy Clin Immunol Pract. 2013;1:142\u201351. https:\/\/doi.org\/10.1016\/j.jaip.2012.09.002.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2283_CR4","doi-asserted-by":"publisher","first-page":"5318","DOI":"10.3390\/ijms23105318","volume":"23","author":"V Moosbrugger-Martinz","year":"2022","unstructured":"Moosbrugger-Martinz V, Leprince C, M\u00e9chin M-C, Simon M, Blunder S, Gruber R, et al. Revisiting the roles of Filaggrin in atopic dermatitis. Int J Mol Sci. 2022;23:5318. https:\/\/doi.org\/10.3390\/ijms23105318.","journal-title":"Int J Mol Sci"},{"key":"2283_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2500\/aap.2019.40.4265","volume":"40","author":"N Peters","year":"2019","unstructured":"Peters N, Peters AT. Atopic dermatitis. Allergy Asthma Proc. 2019;40:433\u20136. https:\/\/doi.org\/10.2500\/aap.2019.40.4265.","journal-title":"Allergy Asthma Proc"},{"key":"2283_CR6","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/cod.14384","volume":"89","author":"M Chapsa","year":"2023","unstructured":"Chapsa M, R\u00f6nsch H, L\u00f6we T, Gunzer F, Beissert S, Bauer A. The role of bacterial colonisation in severity, symptoms and aetiology of hand eczema: the importance of Staphylococcus aureus and presence of commensal skin flora. Contact Dermat. 2023;89:270\u20136. https:\/\/doi.org\/10.1111\/cod.14384.","journal-title":"Contact Dermat"},{"key":"2283_CR7","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/cea.14287","volume":"53","author":"R Rodriguez","year":"2023","unstructured":"Rodriguez R, Dellavalle RP. Epidemiological characteristics of eczema and the global burden of disease network. Clin Exp Allergy. 2023;53:380\u20133. https:\/\/doi.org\/10.1111\/cea.14287.","journal-title":"Clin Exp Allergy"},{"key":"2283_CR8","doi-asserted-by":"publisher","unstructured":"Diego JL, Caroline JL, Dinh SB, Nilakshi TW, Michael JA, Jennifer LP, et al. Establishing subclasses of childhood eczema, their risk factors and prognosis. Clin Experimental Allergy: J Br Soc Allergy Clin Immunol. 2022;52. https:\/\/doi.org\/10.1111\/cea.14139.","DOI":"10.1111\/cea.14139"},{"key":"2283_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.13702\/j.1000-0607.20231124","volume":"50","author":"X Li","year":"2025","unstructured":"Li X, Zhao Y, Li ZJ, Long H, Tang X, Li H, et al. Joss-stick moxibustion reduces inflammatory response of acute eczema by inhibiting IL-6\/STAT3 signaling, and balancing Th17\/treg to normalize Filaggrin and caspase-14 levels in rats. Zhen Ci Yan Jiu. 2025;50:295\u2013301. https:\/\/doi.org\/10.13702\/j.1000-0607.20231124.","journal-title":"Zhen Ci Yan Jiu"},{"key":"2283_CR10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559. https:\/\/doi.org\/10.1186\/1471-2105-9-559.","journal-title":"BMC Bioinformatics"},{"key":"2283_CR11","unstructured":"Anders S, Huber W. Di\ufb00erential expression of RNA-seq data at the gene level \u2013 the DESeq package. Heidelberg, Germany: European Molecular Biology Laboratory (EMBL); 2013."},{"key":"2283_CR12","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607\u201313. https:\/\/doi.org\/10.1093\/nar\/gky1131.","journal-title":"Nucleic Acids Res"},{"key":"2283_CR13","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Cytoscape. A software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498\u2013504. https:\/\/doi.org\/10.1101\/gr.1239303.","journal-title":"Genome Res"},{"key":"2283_CR14","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137. https:\/\/doi.org\/10.1089\/omi.2011.0118.","journal-title":"OMICS"},{"key":"2283_CR15","doi-asserted-by":"publisher","first-page":"914781","DOI":"10.3389\/fcell.2022.914781","volume":"10","author":"Y Duan","year":"2022","unstructured":"Duan Y, Ni S, Zhao K, Qian J, Hu X. Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: identification and validation. Front Cell Dev Biol. 2022;10:914781. https:\/\/doi.org\/10.3389\/fcell.2022.914781.","journal-title":"Front Cell Dev Biol"},{"key":"2283_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12967-023-04807-y","volume":"22","author":"W Wang","year":"2024","unstructured":"Wang W, Li T, Xie Z, Zhao J, Zhang Y, Ruan Y, et al. Integrating single-cell and bulk RNA sequencing data unveils antigen presentation and process-related CAFS and establishes a predictive signature in prostate cancer. J Transl Med. 2024;22:57. https:\/\/doi.org\/10.1186\/s12967-023-04807-y.","journal-title":"J Transl Med"},{"key":"2283_CR17","doi-asserted-by":"publisher","unstructured":"Graziella O, William P-Y, Andre FM, Giuseppe S, Andrea M. Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: A critical review. Neurosci Biobehav Rev. 2012;36. https:\/\/doi.org\/10.1016\/j.neubiorev.2012.01.004.","DOI":"10.1016\/j.neubiorev.2012.01.004"},{"key":"2283_CR18","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.aca.2020.06.043","volume":"1131","author":"L Blanchet","year":"2020","unstructured":"Blanchet L, Vitale R, van Vorstenbosch R, Stavropoulos G, Pender J, Jonkers D, et al. Constructing bi-plots for random forest: tutorial. Anal Chim Acta. 2020;1131:146\u201355. https:\/\/doi.org\/10.1016\/j.aca.2020.06.043.","journal-title":"Anal Chim Acta"},{"key":"2283_CR19","doi-asserted-by":"publisher","first-page":"bbad002","DOI":"10.1093\/bib\/bbad002","volume":"24","author":"J Hu","year":"2023","unstructured":"Hu J, Szymczak S. A review on longitudinal data analysis with random forest. Brief Bioinform. 2023;24:bbad002. https:\/\/doi.org\/10.1093\/bib\/bbad002.","journal-title":"Brief Bioinform"},{"key":"2283_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/s1734-1140(09)70004-0","volume":"61","author":"C Lawson","year":"2009","unstructured":"Lawson C, Wolf S. ICAM-1 signaling in endothelial cells. Pharmacol Rep. 2009;61:22\u201332. https:\/\/doi.org\/10.1016\/s1734-1140(09)70004-0.","journal-title":"Pharmacol Rep"},{"key":"2283_CR21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/331086a0","volume":"331","author":"MW Makgoba","year":"1988","unstructured":"Makgoba MW, Sanders ME, Ginther Luce GE, Dustin ML, Springer TA, Clark EA, et al. ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature. 1988;331:86\u20138. https:\/\/doi.org\/10.1038\/331086a0.","journal-title":"Nature"},{"key":"2283_CR22","doi-asserted-by":"publisher","first-page":"1574455","DOI":"10.3389\/fimmu.2025.1574455","volume":"16","author":"F Casciano","year":"2025","unstructured":"Casciano F, Severi P, Marongiu L, Caproni A, Terranova C, Spitilli A, et al. Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis. Front Immunol. 2025;16:1574455. https:\/\/doi.org\/10.3389\/fimmu.2025.1574455.","journal-title":"Front Immunol"},{"key":"2283_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000442749","volume":"168","author":"A Zinkevi\u010dien\u0117","year":"2015","unstructured":"Zinkevi\u010dien\u0117 A, Kainov D, Lastauskien\u0117 E, Kvedarien\u0117 V, Bychkov D, Byrne M, et al. Serum biomarkers of allergic contact dermatitis: A pilot study. Int Arch Allergy Immunol. 2015;168:161\u20134. https:\/\/doi.org\/10.1159\/000442749.","journal-title":"Int Arch Allergy Immunol"},{"key":"2283_CR24","doi-asserted-by":"publisher","first-page":"113843","DOI":"10.1016\/j.jep.2021.113843","volume":"271","author":"Y Kim","year":"2021","unstructured":"Kim Y, Oh Y, Lee H, Yang B, Choi C-H, Jeong H, et al. Prediction of the therapeutic mechanism responsible for the effects of sophora Japonica flower buds on contact dermatitis by network-based Pharmacological analysis. J Ethnopharmacol. 2021;271:113843. https:\/\/doi.org\/10.1016\/j.jep.2021.113843.","journal-title":"J Ethnopharmacol"},{"key":"2283_CR25","doi-asserted-by":"publisher","first-page":"1229516","DOI":"10.3389\/fimmu.2023.1229516","volume":"14","author":"P Ruscitti","year":"2023","unstructured":"Ruscitti P, Esposito M, Di Cola I, Pellegrini C, De Berardinis A, Mastrangelo M, et al. Cytokine profile characterization of na\u00efve patients with psoriasis and psoriatic arthritis: implications for a pathogenic disease continuum. Front Immunol. 2023;14:1229516. https:\/\/doi.org\/10.3389\/fimmu.2023.1229516.","journal-title":"Front Immunol"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-025-02283-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12920-025-02283-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-025-02283-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:56:42Z","timestamp":1767790602000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12920-025-02283-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2283"],"URL":"https:\/\/doi.org\/10.1186\/s12920-025-02283-5","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"30 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted in accordance with the guidelines of the Institutional Animal Care and Use Committee of China and the ARRIVE guidelines. All procedures involving animals were approved by the Committee on the Ethics of Animal Experiments of Shandong University of Traditional Chinese Medicine (approval number: SDUTCM202401201). The animals were obtained from Speifu Biotechnology Co., Ltd. (Beijing, China; production license No. SCXK [Beijing] 2019-0008) and were not privately owned; therefore, owner consent was not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5"}}