{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:52:36Z","timestamp":1781639556673,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["No.2021BEG03060"],"award-info":[{"award-number":["No.2021BEG03060"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Natural Science Foundation of Ningxia","award":["No. 2023AAC02072; 2024AAC03790"],"award-info":[{"award-number":["No. 2023AAC02072; 2024AAC03790"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenoid cystic carcinoma of the breast (ACCB) is a rare malignant tumor with distinct pathological features and a relatively favorable prognosis compared to other breast cancer subtypes, yet its molecular mechanisms remain poorly understood due to challenges in sample acquisition and targeted research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we employed single-cell RNA sequencing (scRNA-seq) to systematically characterize the cellular heterogeneity and tumor microenvironment in ACCB. We obtained scRNAseq data from a single patient with ACCB and integrated it with publicly available datasets from head and neck adenoid cystic carcinoma (HNACC) and triple-negative breast cancer (TNBC). Through high-resolution gene expression profiling, cell clustering, differential expression analysis, and cell-cell communication analysis, we aimed to identify key malignant subpopulations and regulatory networks in ACCB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Unsupervised clustering revealed seven major cell types in the analyzed ACCB sample, including epithelial cells, fibroblasts, and immune cells. In-depth analysis of epithelial cells identified H19\u2009+\u2009myoepithelial cells (H19\u2009+\u2009myoEpC) as the dominant malignant subpopulation, enriched in ACCB compared to other cancers and characterized by high expression of oncogenic pathways and ligands such as LAMB1 and WNT6. Tumor-associated fibroblasts exhibited significant heterogeneity, with cancer-associated fibroblasts (CAFs) expressing EMT-related genes and interacting closely with H19\u2009+\u2009myoEpC. The tumor microenvironment was immunosuppressive, with reduced infiltration of CD4\u2009+\u2009and CD8\u2009+\u2009T cells and B cells, and lacked classical Treg\/Tex populations. Comprehensive cell-cell communication analysis showed that H19\u2009+\u2009myoEpC orchestrated a signaling network with CAFs, immune cells, and endothelial cells, driving tumor progression and immune evasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides the single-cell resolution map of ACCB from a representative case, highlighting the unique role of H19\u2009+\u2009myoEpC in tumor progression and immune suppression. These findings offer new insights into the molecular classification of ACCB and potential therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12920-026-02329-2","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:46:45Z","timestamp":1772192805000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single-cell RNA sequencing of adenoid cystic carcinoma of the breast reveals cellular heterogeneity and tumor microenvironment features"],"prefix":"10.1186","volume":"19","author":[{"given":"Zhenning","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2329_CR1","doi-asserted-by":"publisher","first-page":"621012","DOI":"10.3389\/fonc.2021.621012","volume":"11","author":"W Zhang","year":"2021","unstructured":"Zhang W, Fang Y, Zhang Z, Wang J. Management of adenoid cystic carcinoma of the breast: A Single-Institution study. Front Oncol. 2021;11:621012.","journal-title":"Front Oncol"},{"issue":"2","key":"2329_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.7150\/jca.22280","volume":"9","author":"HY Liao","year":"2018","unstructured":"Liao HY, Zhang WW, Sun JY, Li FY, He ZY, Wu SG. The clinicopathological features and survival outcomes of different histological subtypes in Triple-negative breast cancer. J Cancer. 2018;9(2):296\u2013303.","journal-title":"J Cancer"},{"issue":"12","key":"2329_CR3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.12998\/wjcc.v2.i12.732","volume":"2","author":"K Miyai","year":"2014","unstructured":"Miyai K, Schwartz MR, Divatia MK, Anton RC, Park YW, Ayala AG, et al. Adenoid cystic carcinoma of breast: recent advances. World J Clin Cases. 2014;2(12):732\u201341.","journal-title":"World J Clin Cases"},{"issue":"4","key":"2329_CR4","doi-asserted-by":"publisher","first-page":"e214123","DOI":"10.1001\/jamanetworkopen.2021.4123","volume":"4","author":"EB Elimimian","year":"2021","unstructured":"Elimimian EB, Samuel TA, Liang H, Elson L, Bilani N, Nahleh ZA. Clinical and demographic Factors, treatment Patterns, and overall survival associated with rare Triple-Negative breast carcinomas in the US. JAMA Netw Open. 2021;4(4):e214123.","journal-title":"JAMA Netw Open"},{"issue":"4","key":"2329_CR5","doi-asserted-by":"publisher","first-page":"R54","DOI":"10.1186\/bcr2613","volume":"12","author":"B Ghabach","year":"2010","unstructured":"Ghabach B, Anderson WF, Curtis RE, Huycke MM, Lavigne JA, Dores GM. Adenoid cystic carcinoma of the breast in the united States (1977 to 2006): a population-based cohort study. Breast Cancer Res. 2010;12(4):R54.","journal-title":"Breast Cancer Res"},{"issue":"1","key":"2329_CR6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s12885-020-06998-9","volume":"20","author":"F Sanges","year":"2020","unstructured":"Sanges F, Floris M, Cossu-Rocca P, Muroni MR, Pira G, Urru SAM, et al. Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis. BMC Cancer. 2020;20(1):491.","journal-title":"BMC Cancer"},{"key":"2329_CR7","doi-asserted-by":"publisher","unstructured":"Vasudevan G, John AM, Vallonthaiel DKV. AG. Adenoid cystic carcinoma of the breast with late recurrence and high-grade transformation. BMJ Case Rep. 2023;16(2):e252336. https:\/\/doi.org\/10.1136\/bcr-2022-252336.","DOI":"10.1136\/bcr-2022-252336"},{"key":"2329_CR8","doi-asserted-by":"publisher","unstructured":"Humtsoe JO, Kim HS, Jones L, Cevallos J, Boileau P, Kuo F, et al. Development and characterization of MYB-NFIB fusion expression in adenoid cystic carcinoma. Cancers (Basel). 2022;14(9):2263. https:\/\/doi.org\/10.3390\/cancers14092263.","DOI":"10.3390\/cancers14092263"},{"issue":"47","key":"2329_CR9","doi-asserted-by":"publisher","first-page":"81725","DOI":"10.18632\/oncotarget.20879","volume":"8","author":"R Ferrarotto","year":"2017","unstructured":"Ferrarotto R, Heymach JV. Taking it up a NOTCH: a novel subgroup of ACC is identified. Oncotarget. 2017;8(47):81725\u20136.","journal-title":"Oncotarget"},{"issue":"1","key":"2329_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2019.05.003","volume":"75","author":"ML Suv\u00e0","year":"2019","unstructured":"Suv\u00e0 ML, Tirosh I, Single-Cell RNA. Sequencing in cancer: lessons learned and emerging challenges. Mol Cell. 2019;75(1):7\u201312.","journal-title":"Mol Cell"},{"issue":"1","key":"2329_CR11","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1038\/s41467-018-06052-0","volume":"9","author":"M Karaayvaz","year":"2018","unstructured":"Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, et al. Unravelling subclonal heterogeneity and aggressive disease States in TNBC through single-cell RNA-seq. Nat Commun. 2018;9(1):3588.","journal-title":"Nat Commun"},{"issue":"4","key":"2329_CR12","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.cell.2018.03.041","volume":"173","author":"C Kim","year":"2018","unstructured":"Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, et al. Chemoresistance evolution in Triple-Negative breast cancer delineated by Single-Cell sequencing. Cell. 2018;173(4):879\u2013e9313.","journal-title":"Cell"},{"issue":"1","key":"2329_CR13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13073-024-01407-3","volume":"16","author":"K Fang","year":"2024","unstructured":"Fang K, Ohihoin AG, Liu T, Choppavarapu L, Nosirov B, Wang Q, et al. Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell States and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer. Genome Med. 2024;16(1):134.","journal-title":"Genome Med"},{"key":"2329_CR14","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.csbj.2025.04.030","volume":"27","author":"T-Y Tseng","year":"2025","unstructured":"Tseng T-Y, Hsieh C-H, Liu J-Y, Huang H-C, Juan H-F. Single-cell and multi-omics integration reveals cholesterol biosynthesis as a synergistic target with HER2 in aggressive breast cancer. Comput Struct Biotechnol J. 2025;27:1719\u201331.","journal-title":"Comput Struct Biotechnol J"},{"issue":"5","key":"2329_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nbt.3192","volume":"33","author":"R Satija","year":"2015","unstructured":"Satija R, Farrell JA, Gennert D, Schier AF, Regev A. Spatial reconstruction of single-cell gene expression data. Nat Biotechnol. 2015;33(5):495\u2013502.","journal-title":"Nat Biotechnol"},{"issue":"2","key":"2329_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20(2):163\u201372.","journal-title":"Nat Immunol"},{"issue":"5","key":"2329_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411\u201320.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"2329_CR18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. ClusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284\u20137.","journal-title":"Omics"},{"issue":"7731","key":"2329_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","volume":"563","author":"R Vento-Tormo","year":"2018","unstructured":"Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018;563(7731):347\u201353.","journal-title":"Nature"},{"key":"2329_CR20","doi-asserted-by":"publisher","first-page":"1221532","DOI":"10.3389\/fimmu.2023.1221532","volume":"14","author":"RA O\u2019Connor","year":"2023","unstructured":"O\u2019Connor RA, Martinez BR, Koppensteiner L, Mathieson L, Akram AR. Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta. Front Immunol. 2023;14:1221532.","journal-title":"Front Immunol"},{"issue":"32","key":"2329_CR21","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.1038\/s41388-018-0263-7","volume":"37","author":"DK Ahirwar","year":"2018","unstructured":"Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuiti\u00f1o MC, Kladney RD, et al. Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation. Oncogene. 2018;37(32):4428\u201342.","journal-title":"Oncogene"},{"issue":"2","key":"2329_CR22","doi-asserted-by":"publisher","first-page":"274","DOI":"10.17305\/bb.2025.13047","volume":"26","author":"Y Jiang","year":"2025","unstructured":"Jiang Y, Wang L, Li Y, Liu J, Lv J, Xu P. Secreted frizzled-related protein 4 (sFRP4) in cancer - Dual roles in tumorigenesis and therapeutic potential: A review. Biomol Biomed. 2025;26(2):274\u201384.","journal-title":"Biomol Biomed"},{"key":"2329_CR23","doi-asserted-by":"publisher","unstructured":"Yamamura Y, Sabiu G, Zhao J, Jung S, Seelam AJ, Li X, et al. CXCL12\u2009+\u2009fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell-mediated alloimmunity. J Clin Invest. 2025;135(9):e182709. https:\/\/doi.org\/10.1172\/JCI182709.","DOI":"10.1172\/JCI182709"},{"issue":"1","key":"2329_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41420-025-02420-0","volume":"11","author":"Z Ma","year":"2025","unstructured":"Ma Z, Yu D, Tan S, Li H, Zhou F, Qiu L, et al. CXCL12 alone is enough to reprogram normal fibroblasts into Cancer-Associated fibroblasts. Cell Death Discov. 2025;11(1):156.","journal-title":"Cell Death Discov"},{"issue":"1","key":"2329_CR25","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.1038\/s41467-024-52153-4","volume":"15","author":"Y Liu","year":"2024","unstructured":"Liu Y, Ye SY, He S, Chi DM, Wang XZ, Wen YF, et al. Single-cell and Spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma. Nat Commun. 2024;15(1):7713.","journal-title":"Nat Commun"},{"issue":"2","key":"2329_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41419-021-03515-z","volume":"12","author":"M Li","year":"2021","unstructured":"Li M, Jiang P, Cheng K, Zhang Z, Lan S, Li X, et al. Regulation of MYB by distal enhancer elements in human myeloid leukemia. Cell Death Dis. 2021;12(2):223.","journal-title":"Cell Death Dis"},{"key":"2329_CR27","doi-asserted-by":"publisher","first-page":"887380","DOI":"10.3389\/fimmu.2022.887380","volume":"13","author":"L Koppensteiner","year":"2022","unstructured":"Koppensteiner L, Mathieson L, O\u2019Connor RA, Akram AR. Cancer associated Fibroblasts - An impediment to effective Anti-Cancer T cell immunity. Front Immunol. 2022;13:887380.","journal-title":"Front Immunol"},{"issue":"11","key":"2329_CR28","doi-asserted-by":"publisher","first-page":"110111","DOI":"10.1016\/j.celrep.2021.110111","volume":"37","author":"Z Tang","year":"2021","unstructured":"Tang Z, Davidson D, Li R, Zhong MC, Qian J, Chen J, et al. Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity. Cell Rep. 2021;37(11):110111.","journal-title":"Cell Rep"},{"issue":"49","key":"2329_CR29","doi-asserted-by":"publisher","first-page":"34342","DOI":"10.1074\/jbc.M109.042671","volume":"284","author":"H Roca","year":"2009","unstructured":"Roca H, Varsos ZS, Sud S, Craig MJ, Ying C, Pienta KJ. CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization. J Biol Chem. 2009;284(49):34342\u201354.","journal-title":"J Biol Chem"},{"key":"2329_CR30","doi-asserted-by":"publisher","first-page":"107681","DOI":"10.1016\/j.intimp.2021.107681","volume":"97","author":"A Gowhari Shabgah","year":"2021","unstructured":"Gowhari Shabgah A, Haleem Al-Qaim Z, Markov A, Valerievich Yumashev A, Ezzatifar F, Ahmadi M, et al. Chemokine CXCL14; a double-edged sword in cancer development. Int Immunopharmacol. 2021;97:107681.","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"2329_CR31","first-page":"417","volume":"12","author":"LA Moraes","year":"2018","unstructured":"Moraes LA, Ampomah PB, Lim LHK. Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment. Cell Adh Migr. 2018;12(5):417\u201323.","journal-title":"Cell Adh Migr"},{"issue":"5","key":"2329_CR32","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.4049\/jimmunol.176.5.2902","volume":"176","author":"F Vianello","year":"2006","unstructured":"Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, et al. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1\/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006;176(5):2902\u201314.","journal-title":"J Immunol"},{"key":"2329_CR33","doi-asserted-by":"publisher","first-page":"8891876","DOI":"10.1155\/2020\/8891876","volume":"2020","author":"LC Yin","year":"2020","unstructured":"Yin LC, Xiao G, Zhou R, Huang XP, Li NL, Tan CL, et al. MicroRNA-361-5p inhibits tumorigenesis and the EMT of HCC by targeting Twist1. Biomed Res Int. 2020;2020:8891876.","journal-title":"Biomed Res Int"},{"issue":"10","key":"2329_CR34","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1007\/s00262-022-03173-w","volume":"71","author":"H Zhang","year":"2022","unstructured":"Zhang H, Liu Z, Wen H, Guo Y, Xu F, Zhu Q, et al. Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer. Cancer Immunol Immunother. 2022;71(10):2511\u201322.","journal-title":"Cancer Immunol Immunother"},{"key":"2329_CR35","doi-asserted-by":"publisher","first-page":"7616696","DOI":"10.1155\/2022\/7616696","volume":"2022","author":"HY Tian","year":"2022","unstructured":"Tian HY, Liang Q, Shi Z, Zhao H. Exosomal CXCL14 contributes to M2 macrophage polarization through NF-\u03baB signaling in prostate cancer. Oxid Med Cell Longev. 2022;2022:7616696.","journal-title":"Oxid Med Cell Longev"},{"issue":"33","key":"2329_CR36","doi-asserted-by":"publisher","first-page":"e2402903121","DOI":"10.1073\/pnas.2402903121","volume":"121","author":"G Yu","year":"2024","unstructured":"Yu G, Corn PG, Mak CSL, Liang X, Zhang M, Troncoso P, et al. Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization. Proc Natl Acad Sci U S A. 2024;121(33):e2402903121.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2329_CR37","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41419-018-0465-5","volume":"9","author":"P Zheng","year":"2018","unstructured":"Zheng P, Luo Q, Wang W, Li J, Wang T, Wang P, et al. Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E. Cell Death Dis. 2018;9(4):434.","journal-title":"Cell Death Dis"},{"issue":"3","key":"2329_CR38","doi-asserted-by":"publisher","first-page":"152900","DOI":"10.1016\/j.imbio.2025.152900","volume":"230","author":"Z Li","year":"2025","unstructured":"Li Z, Li M, Sun S, Bin Y, Zuo S, Huo R, et al. APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion. Immunobiology. 2025;230(3):152900.","journal-title":"Immunobiology"},{"issue":"1","key":"2329_CR39","doi-asserted-by":"publisher","first-page":"17925","DOI":"10.1038\/s41598-017-17622-5","volume":"7","author":"LA Moraes","year":"2017","unstructured":"Moraes LA, Kar S, Foo SL, Gu T, Toh YQ, Ampomah PB, et al. Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment. Sci Rep. 2017;7(1):17925.","journal-title":"Sci Rep"},{"key":"2329_CR40","doi-asserted-by":"publisher","unstructured":"Pearanpan L, Nordin FJ, Siew EL, Kumolosasi E, Mohamad Hanif EA, Masre SF, et al. A cell-based systematic review on the role of Annexin A1 in triple-negative breast cancers. Int J Mol Sci. 2022;23(15):8256. https:\/\/doi.org\/10.3390\/ijms23158256.","DOI":"10.3390\/ijms23158256"},{"issue":"1","key":"2329_CR41","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12943-025-02312-y","volume":"24","author":"H Umeda","year":"2025","unstructured":"Umeda H, Shigeyasu K, Takahashi T, Moriwake K, Kondo Y, Yoshida K, et al. ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer. Mol Cancer. 2025;24(1):116.","journal-title":"Mol Cancer"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12920-026-02329-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-026-02329-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-026-02329-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:01:38Z","timestamp":1781636498000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12920-026-02329-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2329"],"URL":"https:\/\/doi.org\/10.1186\/s12920-026-02329-2","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"15 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study was completed in accordance with the Declaration of Helsinki and approved by the ethics Committee of the General Hospitalof Ningxia Medical University (Ningxia, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patients\/participants provided their written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"55"}}