{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:55:40Z","timestamp":1790949340961,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Guangzhou Basic Research Plan Jointly Funded by the City, School (Hospital), and\/or Enterprise","award":["No.2023A03J0944 and 2023A03J0465"],"award-info":[{"award-number":["No.2023A03J0944 and 2023A03J0465"]}]},{"name":"Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine","award":["No. 20261300"],"award-info":[{"award-number":["No. 20261300"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genomics"],"DOI":"10.1186\/s12920-026-02420-8","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:08:46Z","timestamp":1783426126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated transcriptomic and metabolomic analysis identifies a core gene-metabolite network linking lysine degradation and propanoate metabolism to psoriasis pathogenesis"],"prefix":"10.1186","volume":"19","author":[{"given":"Hongkai","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"issue":"10281","key":"2420_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"G Cem","year":"2021","unstructured":"Cem G, Aw A, Je G, Jnwn B. Psoriasis Lancet. 2021;397(10281):1301\u201315. : 101016\/S0140-6736(20)32549-6 PMID: 33812488.","journal-title":"Psoriasis Lancet"},{"issue":"10275","key":"2420_CR2","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi K, Balato A, Enerb\u00e4ck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet. 2021;397(10275):754\u201366. : 101016\/S0140-6736(21)00184-7.","journal-title":"Lancet"},{"key":"2420_CR3","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","volume":"2","author":"G Greb Je","year":"2016","unstructured":"Greb Je G, Am E, Jt, et al. Psoriasis Nat Rev Dis Primers. 2016;2:16082.","journal-title":"Psoriasis Nat Rev Dis Primers"},{"key":"2420_CR4","doi-asserted-by":"crossref","unstructured":"Zhou X, Chen Y, Cui L, et al. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13(1):81. .","DOI":"10.1038\/s41419-022-04523-3"},{"key":"2420_CR5","doi-asserted-by":"crossref","unstructured":"Zhang Y, Shi Y, Lin J et al. Immune cell infiltration analysis demonstrates excessive mast cell activation in. Front Immunol. 2021;12:773280 doi: 103389\/fimmu2021773280.","DOI":"10.3389\/fimmu.2021.773280"},{"key":"2420_CR6","doi-asserted-by":"crossref","unstructured":"Parisi R, Orcid Id I, Iyk et al. National, regional, and worldwide epidemiology of psoriasis: systematic analysis. BMJ. 2020;369:m1590 doi: 101136\/bmjm1590.","DOI":"10.1136\/bmj.m1590"},{"issue":"4","key":"2420_CR7","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.jid.2025.08.038","volume":"146","author":"J Wei","year":"2026","unstructured":"Wei J, Wang Y, Chen Y, et al. Global burden of psoriasis from 1990 to 2021 and potential factors: a systematic. J Invest Dermatol. 2026;146(4):1034\u2013e104522. 101016\/jjid202508038.","journal-title":"J Invest Dermatol"},{"issue":"11","key":"2420_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41576-019-0150-2","volume":"20","author":"R Stark","year":"2019","unstructured":"Stark R, Orcid Id, Grzelak M, et al. RNA sequencing: the teenage years. Nat Rev Genet. 2019;20(11):631\u201356. doi: 101038\/s41576-019-0150-2.","journal-title":"Nat Rev Genet"},{"key":"2420_CR9","doi-asserted-by":"crossref","unstructured":"Ci\u0105\u017cy\u0144ska M, Orcid Id, Olejniczak-Staruch I et al. The role of NLRP1, NLRP3, and AIM2 inflammasomes in psoriasis: review. Int J Mol Sci. 2021;22(11):5898 doi: 103390\/ijms22115898.","DOI":"10.3390\/ijms22115898"},{"key":"2420_CR10","doi-asserted-by":"crossref","unstructured":"Salskov-Iversen Ml, Johansen C, Kragballe K, Iversen L. Caspase-5 expression is upregulated in lesional psoriatic skin. J Invest Dermatol. 2011;131(3):670-6 doi: 101038\/jid2010370.","DOI":"10.1038\/jid.2010.370"},{"issue":"3","key":"2420_CR11","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jid.2020.07.012","volume":"141","author":"D Verma","year":"2021","unstructured":"Verma D, Fekri Sz, Sigurdardottir G, et al. Enhanced Inflammasome Activity in Patients with Psoriasis Promotes Systemic. - J Invest Dermatol. 2021;141(3):586\u201395. e5 doi: 101016\/jjid202007012.","journal-title":"- J Invest Dermatol"},{"key":"2420_CR12","doi-asserted-by":"crossref","unstructured":"Ekman Ak, Verma D, Fredrikson M, Bivik C, Enerb\u00e4ck C. Genetic variations of NLRP1: susceptibility in psoriasis. Br J Dermatol. 2014;171(6):1517-20 doi: 101111\/bjd13178.","DOI":"10.1111\/bjd.13178"},{"key":"2420_CR13","doi-asserted-by":"crossref","unstructured":"Chen Y, Peng C, Zhu L et al. Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and. Clin Rev Allergy Immunol. 2024;66(3):294\u2013315 doi: 101007\/s12016-024-08995-3.","DOI":"10.1007\/s12016-024-08995-3"},{"issue":"5","key":"2420_CR14","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.jid.2024.09.003","volume":"145","author":"R La Sanabria-De","year":"2025","unstructured":"La Sanabria-De R, Montero-V\u00edlchez T, Garc\u00eda-Gav\u00edn J, Arias-Santiago S. Current Insights on Lipidomics in Dermatology: A Systematic Review. J Invest Dermatol. 2025;145(5):1105\u201316. e6 doi: 101016\/jjid202409003.","journal-title":"J Invest Dermatol"},{"issue":"15","key":"2420_CR15","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1097\/CM9.0000000000002504","volume":"136","author":"L Guo","year":"2023","unstructured":"Guo L, Jin H. Research progress of metabolomics in psoriasis. Chin Med J (Engl). 2023;136(15):1805\u201316.","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"2420_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1186\/s12866-025-04395-5","volume":"25","author":"F Wu","year":"2025","unstructured":"Wu F, Jiang X, Chen G, Zhang L. Integrated Microbiome and metabolome analysis reveals Microbial-Metabolic. BMC Microbiol. 2025;25(1):665.","journal-title":"BMC Microbiol"},{"key":"2420_CR17","doi-asserted-by":"crossref","unstructured":"Zhang X, Li X, Wang Y et al. Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like. JCI Insight. 2022;7(13):e150223 doi: 101172\/jciinsight150223.","DOI":"10.1172\/jci.insight.150223"},{"issue":"2","key":"2420_CR18","doi-asserted-by":"publisher","first-page":"754","DOI":"10.7150\/thno.51154","volume":"11","author":"C Chen","year":"2021","unstructured":"Chen C, Hou G, Zeng C, et al. Metabolomic profiling reveals amino acid and carnitine alterations as metabolic. Theranostics. 2021;11(2):754\u201367.","journal-title":"Theranostics"},{"key":"2420_CR19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2147\/JIR.S493338","volume":"18","author":"L Yan","year":"2025","unstructured":"Yan L, Orcid I, Wang W, et al. Skin metabolic signatures of psoriasis and psoriasis concurrent with metabolic. J Inflamm Res. 2025;18:505\u201317. : 102147\/JIRS493338.","journal-title":"J Inflamm Res"},{"issue":"1","key":"2420_CR20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1021\/acs.jproteome.4c00173","volume":"24","author":"P Zhang","year":"2025","unstructured":"Zhang P, Orcid Id, Dong Y, et al. Identification of Plasma Metabolites and Dipeptides as Diagnostic Biomarkers for. J Proteome Res. 2025;24(1):46\u201354. doi: 101021\/acsjproteome4c00173.","journal-title":"J Proteome Res"},{"key":"2420_CR21","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.2147\/CCID.S433280","volume":"16","author":"Q Song","year":"2023","unstructured":"Song Q, Chen Y, Ma J, et al. Metabolomics reveals molecular signatures for psoriasis biomarkers and drug. Clin Cosmet Investig Dermatol. 2023;16:3181\u201391. https:\/\/doi.org\/10.2147\/CCID.S433280.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"2420_CR22","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s00403-025-03978-6","volume":"317","author":"N Esmaeli","year":"2025","unstructured":"Esmaeli N, Rezadoost H, Azizpour A, et al. Metabolomics analysis of serum fatty acids in patients with psoriasis. Arch Dermatol Res. 2025;317(1):463. 101007\/s00403-025-03978-6.","journal-title":"Arch Dermatol Res"},{"key":"2420_CR23","doi-asserted-by":"publisher","unstructured":"Cy L, Tm Y, Rw O, etal, et al. Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune. BMC Med. 2021;19(1):27. https:\/\/doi.org\/10.1186\/s12916-021-01903-y.","DOI":"10.1186\/s12916-021-01903-y"},{"key":"2420_CR24","doi-asserted-by":"publisher","first-page":"665647","DOI":"10.3389\/fmed.2021.665647","volume":"8","author":"L Mercurio","year":"2021","unstructured":"Mercurio L, Albanesi C, Madonna S. Recent updates on the involvement of PI3K\/AKT\/mTOR molecular cascade in the. Front Med (Lausanne). 2021;8:665647. 103389\/fmed2021665647.","journal-title":"Front Med (Lausanne)"},{"key":"2420_CR25","doi-asserted-by":"crossref","unstructured":"Lee St O, Id L, Jy et al. Limonin exhibits anti-inflammatory effects by inhibiting mTORC1 and mitochondrial. Antioxidants (Basel). 2024;13(12):1541 doi: 103390\/antiox13121541.","DOI":"10.3390\/antiox13121541"},{"key":"2420_CR26","doi-asserted-by":"crossref","unstructured":"Chen M, Peng Y, Zhu R et al. Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in. - Int J Biol Macromol. 2025;320(Pt 2):145724 doi:doi: 101016\/jijbiomac2025145724.","DOI":"10.1016\/j.ijbiomac.2025.145724"},{"issue":"20","key":"2420_CR27","doi-asserted-by":"publisher","first-page":"8064","DOI":"10.1021\/jacs.9b02553","volume":"141","author":"S Chen","year":"2019","unstructured":"Chen S, Orcid I, Kapilashrami K, et al. Substrate-differentiated transition states of SET7\/9-catalyzed lysine. J Am Chem Soc. 2019;141(20):8064\u20137. doi: 101021\/jacs9b02553.","journal-title":"J Am Chem Soc"},{"issue":"2","key":"2420_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/15548627.2022.2062112","volume":"19","author":"Y Xu","year":"2023","unstructured":"Xu Y, Wan W. Acetylation in the regulation of autophagy. Autophagy. 2023;19(2):379\u201387. 101080\/1554862720222062112.","journal-title":"Autophagy"},{"issue":"18","key":"2420_CR29","doi-asserted-by":"publisher","first-page":"14390","DOI":"10.3390\/ijms241814390","volume":"24","author":"X Wu","year":"2023","unstructured":"Wu X, Orcid Id, Ma Y, Wang L, Qin X. A route for investigating psoriasis: from the perspective of the pathological. Int J Mol Sci. 2023;24(18):14390. 103390\/ijms241814390.","journal-title":"Int J Mol Sci"},{"key":"2420_CR30","doi-asserted-by":"publisher","first-page":"102614","DOI":"10.1016\/j.coi.2025.102614","volume":"96","author":"D Hong","year":"2025","unstructured":"Hong D, Xiong H, Lu S, Ma J, Shi Z. Metabolic regulation of the immune cell in psoriasis: mechanisms and. Curr Opin Immunol. 2025;96:102614. 101016\/jcoi2025102614.","journal-title":"Curr Opin Immunol"},{"key":"2420_CR31","doi-asserted-by":"publisher","first-page":"1201912","DOI":"10.3389\/fmolb.2023.1201912","volume":"10","author":"E Sarandi","year":"2023","unstructured":"Sarandi E, Krueger-Krasagakis S, Tsoukalas D, et al. Psoriasis immunometabolism: progress on metabolic biomarkers and targeted. Front Mol Biosci. 2023;10:1201912. 103389\/fmolb20231201912.","journal-title":"Front Mol Biosci"},{"key":"2420_CR32","doi-asserted-by":"publisher","first-page":"153054","DOI":"10.1016\/j.phymed.2019.153054","volume":"64","author":"L Yue","year":"2019","unstructured":"Yue L, Ailin W, Jinwei Z, et al. PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via. Phytomedicine. 2019;64:153054. 101016\/jphymed2019153054.","journal-title":"Phytomedicine"},{"key":"2420_CR33","doi-asserted-by":"crossref","unstructured":"Roy T, Banang-Mbeumi S, Boateng S et al. Dual targeting of mTOR\/IL-17A and autophagy by fisetin alleviates psoriasis-like. Front Immunol. 2023;13:1075804 doi: 103389\/fimmu20221075804.","DOI":"10.3389\/fimmu.2022.1075804"},{"key":"2420_CR34","doi-asserted-by":"crossref","unstructured":"Varshney P, Saini N. PI3K\/AKT\/mTOR activation and autophagy inhibition plays a key role in increased. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1795\u20131803 doi:101016\/jbbadis201802003.","DOI":"10.1016\/j.bbadis.2018.02.003"},{"key":"2420_CR35","doi-asserted-by":"crossref","unstructured":"Karagianni F, Orcid Id, Pavlidis A, et al. Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential. Int J Mol Sci. 2022;23(3):1693. .","DOI":"10.3390\/ijms23031693"},{"key":"2420_CR36","doi-asserted-by":"crossref","unstructured":"Tu Y, Fan X, Wang X et al. Investigation into the molecular mechanisms of biomarkers in psoriasis vulgaris. Biochim Biophys Acta Mol Basis Dis. 2025;1871(3):167638 doi:101016\/jbbadis2024167638.","DOI":"10.1016\/j.bbadis.2024.167638"}],"container-title":["BMC Medical Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12920-026-02420-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-026-02420-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12920-026-02420-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:02:35Z","timestamp":1790946155000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12920-026-02420-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2420"],"URL":"https:\/\/doi.org\/10.1186\/s12920-026-02420-8","relation":{},"ISSN":["1755-8794"],"issn-type":[{"value":"1755-8794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"28 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol involving human participants was approved by the Institutional Ethics Committee of The Guangzhou Dermatology Hospital. All procedures performed in this study adhered to the ethical standards of the committee, the 1964 Declaration of Helsinki and its subsequent amendments, and relevant national\/institutional regulations. Prior to their participation, written informed consent was obtained from each participant or, where applicable, from their legal guardian or next of kin.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol has been approved by the institutional ethic committee. Informed written consent was received from participants before inclusion in this study, and patients consented to the publication of their images. This includes consent for the publication of identified clinical data and any images (e.g., clinical photographs or diagnostic results) in scientific and educational formats. All identifiable personal information has been removed, and any potentially recognizable features in images have been obscured to protect participant privacy.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"151"}}