{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:40:34Z","timestamp":1778395234614,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Sci"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12929-015-0126-2","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T23:13:23Z","timestamp":1426720403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring"],"prefix":"10.1186","volume":"22","author":[{"given":"Yao-Chang","family":"Chiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ci","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei-Ying","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Wei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Wei","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Jou","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ing-Kang","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pao-Luh","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"issue":"5\u20136","key":"126_CR1","first-page":"347","volume":"67","author":"H Joseph","year":"2000","unstructured":"Joseph H, Stancliff S, Langrod J. Methadone maintenance treatment (MMT): a review of historical and clinical issues. Mt Sinai J Med. 2000;67(5\u20136):347\u201364.","journal-title":"Mt Sinai J Med"},{"issue":"2","key":"126_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/02791072.1991.10472231","volume":"23","author":"A Goldstein","year":"1991","unstructured":"Goldstein A. Heroin addiction: neurobiology, pharmacology, and policy. J Psychoactive Drugs. 1991;23(2):123\u201333.","journal-title":"J Psychoactive Drugs"},{"issue":"6","key":"126_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00228-010-0793-6","volume":"66","author":"P Lobmaier","year":"2010","unstructured":"Lobmaier P, Gossop M, Waal H, Bramness J. The pharmacological treatment of opioid addiction\u2013a clinical perspective. Eur J Clin Pharmacol. 2010;66(6):537\u201345. doi:10.1007\/s00228-010-0793-6.","journal-title":"Eur J Clin Pharmacol"},{"key":"126_CR4","volume-title":"Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings","author":"SAMHSA","year":"2011","unstructured":"SAMHSA. Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. 2011."},{"issue":"3","key":"126_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1017\/S1461145703003523","volume":"6","author":"J Yanai","year":"2003","unstructured":"Yanai J, Huleihel R, Izrael M, Metsuyanim S, Shahak H, Vatury O, et al. Functional changes after prenatal opiate exposure related to opiate receptors\u2019 regulated alterations in cholinergic innervation. Int J Neuropsychopharmacol. 2003;6(3):253\u201365. doi:10.1017\/S1461145703003523.","journal-title":"Int J Neuropsychopharmacol"},{"key":"126_CR6","doi-asserted-by":"crossref","unstructured":"The impact of intrauterine exposure versus postnatal environment in neurodevelopmental toxicity: long-term neurobehavioral studies in children at risk for developmental disorders. Toxicol Lett. 2003;140\u2013141:171\u201381. doi:S0378427402005052","DOI":"10.1016\/S0378-4274(02)00505-2"},{"issue":"1","key":"126_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.bbr.2010.11.059","volume":"218","author":"JJ Byrnes","year":"2011","unstructured":"Byrnes JJ, Babb JA, Scanlan VF, Byrnes EM. Adolescent opioid exposure in female rats: transgenerational effects on morphine analgesia and anxiety-like behavior in adult offspring. Behav Brain Res. 2011;218(1):200\u20135. doi:10.1016\/j.bbr.2010.11.059.","journal-title":"Behav Brain Res"},{"key":"126_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1423-0127-17-46","volume":"17","author":"YC Chiang","year":"2010","unstructured":"Chiang YC, Hung TW, Lee CW, Yan JY, Ho IK. Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine. J Biomed Sci. 2010;17:46. doi:10.1186\/1423-0127-17-46.","journal-title":"J Biomed Sci"},{"issue":"2 Suppl","key":"126_CR9","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.36076\/ppj.2008\/11\/S133","volume":"11","author":"AM Trescot","year":"2008","unstructured":"Trescot AM, Datta S, Lee M, Hansen H. Opioid pharmacology. Pain Physician. 2008;11(2 Suppl):S133\u201353.","journal-title":"Pain Physician"},{"issue":"6","key":"126_CR10","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/j.1751-486X.2007.00243.x","volume":"11","author":"UA Pritham","year":"2007","unstructured":"Pritham UA, Troese M, Stetson A. Methadone and buprenorphine treatment during pregnancy: what are the effects on infants? Nurs Womens Health. 2007;11(6):558\u201367. doi:10.1111\/j.1751-486X.2007.00243.x.","journal-title":"Nurs Womens Health"},{"issue":"2","key":"126_CR11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0002-9378(98)70379-5","volume":"179","author":"HL Brown","year":"1998","unstructured":"Brown HL, Britton KA, Mahaffey D, Brizendine E, Hiett AK, Turnquest MA. Methadone maintenance in pregnancy: a reappraisal. Am J Obstet Gynecol. 1998;179(2):459\u201363.","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"126_CR12","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1046\/j.1360-0443.1998.93710338.x","volume":"93","author":"GK Hulse","year":"1998","unstructured":"Hulse GK, Milne E, English DR, Holman CD. Assessing the relationship between maternal opiate use and neonatal mortality. Addiction. 1998;93(7):1033\u201342.","journal-title":"Addiction"},{"issue":"2","key":"126_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.2174\/157015908784533842","volume":"6","author":"WO Farid","year":"2008","unstructured":"Farid WO, Dunlop SA, Tait RJ, Hulse GK. The effects of maternally administered methadone, buprenorphine and naltrexone on offspring: review of human and animal data. Current Neuropharmacology. 2008;6(2):125\u201350. doi:10.2174\/157015908784533842.","journal-title":"Current Neuropharmacology"},{"issue":"13","key":"126_CR14","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1001\/jama.1972.03200130061012","volume":"220","author":"PS Pierson","year":"1972","unstructured":"Pierson PS, Howard P, Kleber HD. Sudden deaths in infants born to methadone-maintained addicts. Jama. 1972;220(13):1733\u20134.","journal-title":"Jama"},{"key":"126_CR15","volume-title":"Basic & clinical pharmacology","author":"BG Katzung","year":"2001","unstructured":"Katzung BG. Basic & clinical pharmacology. 8th ed. New York: Lange Medical Books\/McGraw-Hill; 2001.","edition":"8"},{"issue":"7","key":"126_CR16","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1002\/bmc.1363","volume":"24","author":"SC Wang","year":"2010","unstructured":"Wang SC, Ho IK, Wu SL, Liu SC, Kuo HW, Lin KM, et al. Development of a method to measure methadone enantiomers and its metabolites without enantiomer standard compounds for the plasma of methadone maintenance patients. Biomedical Chromatography : BMC. 2010;24(7):782\u20138. doi:10.1002\/bmc.1363.","journal-title":"Biomedical Chromatography : BMC"},{"issue":"1\u20133","key":"126_CR17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.drugalcdep.2012.10.025","volume":"130","author":"AP Kennedy","year":"2013","unstructured":"Kennedy AP, Phillips KA, Epstein DH, Reamer DA, Schmittner J, Preston KL. A randomized investigation of methadone doses at or over 100 mg\/day, combined with contingency management. Drug Alcohol Depend. 2013;130(1\u20133):77\u201384. 10.1016\/j.drugalcdep.2012.10.025.","journal-title":"Drug Alcohol Depend"},{"issue":"6","key":"126_CR18","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/S0029-7844(02)02387-6","volume":"100","author":"JS Dashe","year":"2002","unstructured":"Dashe JS, Sheffield JS, Olscher DA, Todd SJ, Jackson GL, Wendel GD. Relationship between maternal methadone dosage and neonatal withdrawal. Obstet Gynecol. 2002;100(6):1244\u20139. doi:S0029784402023876.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"126_CR19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1479-828X.2010.01168.x","volume":"50","author":"AJ Liu","year":"2010","unstructured":"Liu AJ, Jones MP, Murray H, Cook CM, Nanan R. Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. Aust N Z J Obstet Gynaecol. 2010;50(3):253\u20138. doi:10.1111\/j.1479-828X.2010.01168.x.","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"1","key":"126_CR20","doi-asserted-by":"publisher","first-page":"F33","DOI":"10.1136\/fn.89.1.F33","volume":"89","author":"C Sharpe","year":"2004","unstructured":"Sharpe C, Kuschel C. Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. Arch Dis Child Fetal Neonatal Ed. 2004;89(1):F33\u20136.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"126_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1254\/jphs.11R02CR","volume":"116","author":"EJ Shin","year":"2011","unstructured":"Shin EJ, Bach JH, Lee SY, Kim JM, Lee J, Hong JS, et al. Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. J Pharmacol Sci. 2011;116(2):137\u201348.","journal-title":"J Pharmacol Sci"},{"issue":"5","key":"126_CR22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.pediatrneurol.2009.05.005","volume":"41","author":"S Rossi","year":"2009","unstructured":"Rossi S, Daniele I, Bastrenta P, Mastrangelo M, Lista G. Early myoclonic encephalopathy and nonketotic hyperglycinemia. Pediatr Neurol. 2009;41(5):371\u20134. doi:10.1016\/j.pediatrneurol.2009.05.005.","journal-title":"Pediatr Neurol"},{"issue":"1","key":"126_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0022-3476(05)82559-4","volume":"121","author":"A Hamosh","year":"1992","unstructured":"Hamosh A, McDonald JW, Valle D, Francomano CA, Niedermeyer E, Johnston MV. Dextromethorphan and high-dose benzoate therapy for nonketotic hyperglycinemia in an infant. J Pediatr. 1992;121(1):131\u20135.","journal-title":"J Pediatr"},{"issue":"1","key":"126_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/1096-9926(200101)63:1<38::AID-TERA1006>3.0.CO;2-6","volume":"63","author":"ML Martinez-Frias","year":"2001","unstructured":"Martinez-Frias ML, Rodriguez-Pinilla E. Epidemiologic analysis of prenatal exposure to cough medicines containing dextromethorphan: no evidence of human teratogenicity. Teratology. 2001;63(1):38\u201341. doi:10.1002\/1096-9926(200101)63:1<38::AID-TERA1006>3.0.CO;2-6.","journal-title":"Teratology"},{"issue":"5","key":"126_CR25","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s00210-003-0803-7","volume":"368","author":"EY Huang","year":"2003","unstructured":"Huang EY, Liu TC, Tao PL. Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens. Naunyn Schmiedebergs Arch Pharmacol. 2003;368(5):386\u201392. doi:10.1007\/s00210-003-0803-7.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"6","key":"126_CR26","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/syn.20391","volume":"61","author":"WM Lue","year":"2007","unstructured":"Lue WM, Huang EY, Yang SN, Wong CS, Tao PL. Post-treatment of dextromethorphan reverses morphine effect on conditioned place preference in rats. Synapse. 2007;61(6):420\u20138. doi:10.1002\/syn.20391.","journal-title":"Synapse"},{"issue":"5","key":"126_CR27","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.fertnstert.2009.01.143","volume":"93","author":"LY Wu","year":"2010","unstructured":"Wu LY, Huang EY, Tao PL. Coadministration of dextromethorphan during pregnancy and throughout lactation prevents morphine-induced hyperprolactinemia in female rats. Fertil Steril. 2010;93(5):1686\u201394. doi:10.1016\/j.fertnstert.2009.01.143.","journal-title":"Fertil Steril"},{"issue":"2\u20133","key":"126_CR28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0014-2999(02)02426-3","volume":"453","author":"GC Yeh","year":"2002","unstructured":"Yeh GC, Tao PL, Chen JY, Lai MC, Gao FS, Hu CL. Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine. Eur J Pharmacol. 2002;453(2\u20133):197\u2013202.","journal-title":"Eur J Pharmacol"},{"key":"126_CR29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1423-0127-18-64","volume":"18","author":"PL Tao","year":"2011","unstructured":"Tao PL, Chen CF, Huang EY. Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring. J Biomed Sci. 2011;18:64. doi:10.1186\/1423-0127-18-64.","journal-title":"J Biomed Sci"},{"issue":"1","key":"126_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0149-7634(05)80090-9","volume":"15","author":"WJ Dixon","year":"1991","unstructured":"Dixon WJ. Staircase bioassay: the up-and-down method. Neurosci Biobehav Rev. 1991;15(1):47\u201350.","journal-title":"Neurosci Biobehav Rev"},{"issue":"20","key":"126_CR31","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1016\/S0024-3205(01)01316-9","volume":"69","author":"PL Tao","year":"2001","unstructured":"Tao PL, Yeh GC, Su CH, Wu YH. Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life Sci. 2001;69(20):2439\u201350.","journal-title":"Life Sci"},{"issue":"1\u20132","key":"126_CR32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0165-3806(98)00054-6","volume":"108","author":"W Rahman","year":"1998","unstructured":"Rahman W, Dashwood MR, Fitzgerald M, Aynsley-Green A, Dickenson AH. Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia. Brain Res Dev Brain Res. 1998;108(1\u20132):239\u201354.","journal-title":"Brain Res Dev Brain Res"},{"issue":"4","key":"126_CR33","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0891-0618(01)00135-1","volume":"22","author":"CR Neal Jr","year":"2001","unstructured":"Neal Jr CR, Akil H, Watson Jr SJ. Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain. J Chem Neuroanat. 2001;22(4):219\u201349.","journal-title":"J Chem Neuroanat"},{"issue":"4","key":"126_CR34","first-page":"399","volume":"8","author":"C Wang","year":"1986","unstructured":"Wang C, Pasulka P, Perry B, Pizzi WJ, Schnoll SH. Effect of perinatal exposure to methadone on brain opioid and alpha 2-adrenergic receptors. Neurobehav Toxicol Teratol. 1986;8(4):399\u2013402.","journal-title":"Neurobehav Toxicol Teratol"},{"issue":"4","key":"126_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0892-0362(92)90006-V","volume":"14","author":"NA Darmani","year":"1992","unstructured":"Darmani NA, Schnoll SH, Pandey U, Martin BR. Chronic prenatal methadone exposure alters central opioid mu-receptor affinity in both fetal and maternal brain. Neurotoxicol Teratol. 1992;14(4):265\u201371. doi:0892-0362(92)90006-V.","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"126_CR36","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/adb.12055","volume":"19","author":"YC Chiang","year":"2014","unstructured":"Chiang YC, Hung TW, Ho IK. Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine. Addict Biol. 2014;19(4):676\u201386. doi:10.1111\/adb.12055.","journal-title":"Addict Biol"},{"issue":"4","key":"126_CR37","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/sj.bjp.0700942","volume":"120","author":"JH Tian","year":"1997","unstructured":"Tian JH, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK, et al. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol. 1997;120(4):676\u201380. doi:10.1038\/sj.bjp.0700942.","journal-title":"Br J Pharmacol"},{"issue":"5","key":"126_CR38","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.jpain.2008.11.006","volume":"10","author":"MC Ko","year":"2009","unstructured":"Ko MC, Naughton NN. Antinociceptive effects of nociceptin\/orphanin FQ administered intrathecally in monkeys. J Pain. 2009;10(5):509\u201316. doi:10.1016\/j.jpain.2008.11.006.","journal-title":"J Pain"},{"issue":"42","key":"126_CR39","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.2174\/13816128113199990362","volume":"19","author":"M Spetea","year":"2013","unstructured":"Spetea M, Asim MF, Wolber G, Schmidhammer H. The micro opioid receptor and ligands acting at the micro opioid receptor, as therapeutics and potential therapeutics. Curr Pharm Des. 2013;19(42):7415\u201334.","journal-title":"Curr Pharm Des"},{"key":"126_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuint.2015.01.004","volume":"82C","author":"XN Wu","year":"2015","unstructured":"Wu XN, Zhang T, Qian NS, Guo XD, Yang HJ, Huang KB, et al. Antinociceptive effects of endomorphin-2: Suppression of substance P release in the inflammatory pain model rat. Neurochem Int. 2015;82C:1\u20139. doi:10.1016\/j.neuint.2015.01.004.","journal-title":"Neurochem Int"},{"issue":"3","key":"126_CR41","first-page":"70","volume":"69","author":"AS Sprouse-Blum","year":"2010","unstructured":"Sprouse-Blum AS, Smith G, Sugai D, Parsa FD. Understanding endorphins and their importance in pain management. Hawaii Med J. 2010;69(3):70\u20131.","journal-title":"Hawaii Med J"},{"issue":"3","key":"126_CR42","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.neuropharm.2012.04.028","volume":"63","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Donica CL, Standifer KM. Sex differences in the Nociceptin\/Orphanin FQ system in rat spinal cord following chronic morphine treatment. Neuropharmacology. 2012;63(3):427\u201333. doi:10.1016\/j.neuropharm.2012.04.028.","journal-title":"Neuropharmacology"},{"issue":"1","key":"126_CR43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-3565(25)20706-6","volume":"251","author":"HN Bhargava","year":"1989","unstructured":"Bhargava HN, Gulati A, Ramarao P. Effect of chronic administration of U-50,488H on tolerance to its pharmacological actions and on multiple opioid receptors in rat brain regions and spinal cord. J Pharmacol Exp Ther. 1989;251(1):21\u20136.","journal-title":"J Pharmacol Exp Ther"},{"issue":"20","key":"126_CR44","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1523\/JNEUROSCI.20-20-07640.2000","volume":"20","author":"H Ueda","year":"2000","unstructured":"Ueda H, Inoue M, Takeshima H, Iwasawa Y. Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence. J Neurosci. 2000;20(20):7640\u20137.","journal-title":"J Neurosci."},{"issue":"2","key":"126_CR45","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1124\/jpet.102.033159","volume":"302","author":"CD Mandyam","year":"2002","unstructured":"Mandyam CD, Thakker DR, Christensen JL, Standifer KM. Orphanin FQ\/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002;302(2):502\u20139. doi:10.1124\/jpet.102.033159.","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"126_CR46","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1111\/j.1471-4159.2004.02921.x","volume":"92","author":"HL Wang","year":"2005","unstructured":"Wang HL, Hsu CY, Huang PC, Kuo YL, Li AH, Yeh TH, et al. Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist. J Neurochem. 2005;92(6):1285\u201394. doi:10.1111\/j.1471-4159.2004.02921.x.","journal-title":"J Neurochem"},{"issue":"11","key":"126_CR47","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1007\/s11064-011-0525-z","volume":"36","author":"CW Lee","year":"2011","unstructured":"Lee CW, Yan JY, Chiang YC, Hung TW, Wang HL, Chiou LC, et al. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human mu-opioid and opioid receptor-like 1 receptors. Neurochem Res. 2011;36(11):2008\u201321. doi:10.1007\/s11064-011-0525-z.","journal-title":"Neurochem Res"},{"key":"126_CR48","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1423-0127-16-106","volume":"16","author":"LY Wu","year":"2009","unstructured":"Wu LY, Chen JF, Tao PL, Huang EY. Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. J Biomed Sci. 2009;16:106. doi:10.1186\/1423-0127-16-106.","journal-title":"J Biomed Sci"},{"issue":"4","key":"126_CR49","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0091-3057(96)00278-X","volume":"55","author":"R Gagin","year":"1996","unstructured":"Gagin R, Cohen E, Shavit Y. Prenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats. Pharmacol Biochem Behav. 1996;55(4):629\u201334.","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"126_CR50","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1373\/clinchem.2010.154864","volume":"57","author":"A de Castro","year":"2011","unstructured":"de Castro A, Jones HE, Johnson RE, Gray TR, Shakleya DM, Huestis MA. Maternal methadone dose, placental methadone concentrations, and neonatal outcomes. Clin Chem. 2011;57(3):449\u201358. doi:10.1373\/clinchem.2010.154864.","journal-title":"Clin Chem"},{"issue":"4","key":"126_CR51","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1213\/ANE.0b013e31825da0fb","volume":"115","author":"RY Tsai","year":"2012","unstructured":"Tsai RY, Chou KY, Shen CH, Chien CC, Tsai WY, Huang YN, et al. Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats. Anesth Analg. 2012;115(4):944\u201352. doi:10.1213\/ANE.0b013e31825da0fb.","journal-title":"Anesth Analg"},{"issue":"1\u20133","key":"126_CR52","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ejphar.2010.02.007","volume":"633","author":"M Sedaghati","year":"2010","unstructured":"Sedaghati M, Vousooghi N, Goodarzi A, Yaghmaei P, Mokri A, Zarrindast MR. Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies. Eur J Pharmacol. 2010;633(1\u20133):50\u20134. doi:10.1016\/j.ejphar.2010.02.007.","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"126_CR53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.36076\/ppj.2011\/14\/145","volume":"14","author":"M Lee","year":"2011","unstructured":"Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L. A comprehensive review of opioid-induced hyperalgesia. Pain Physician. 2011;14(2):145\u201361.","journal-title":"Pain Physician"},{"issue":"30","key":"126_CR54","first-page":"537","volume":"107","author":"J Mutschler","year":"2010","unstructured":"Mutschler J, Koopmann A, Grosshans M, Hermann D, Mann K, Kiefer F. Dextromethorphan withdrawal and dependence syndrome. Dtsch Arztebl Int. 2010;107(30):537\u201340. doi:10.3238\/arztebl.2010.0537.","journal-title":"Dtsch Arztebl Int"},{"issue":"6","key":"126_CR55","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/1098-1063(2000)10:6<654::AID-HIPO1003>3.0.CO;2-T","volume":"10","author":"SN Yang","year":"2000","unstructured":"Yang SN, Yang JM, Wu JN, Kao YH, Hsieh WY, Chao CC, et al. Prenatal exposure to morphine alters kinetic properties of NMDA receptor-mediated synaptic currents in the hippocampus of rat offspring. Hippocampus. 2000;10(6):654\u201362. doi:10.1002\/1098-1063(2000)10:6<654::AID-HIPO1003>3.0.CO;2-T.","journal-title":"Hippocampus"},{"issue":"3","key":"126_CR56","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0091-3057(01)00456-7","volume":"68","author":"Z Li","year":"2001","unstructured":"Li Z, Wu CF, Pei G, Xu NJ. Reversal of morphine-induced memory impairment in mice by withdrawal in Morris water maze: possible involvement of cholinergic system. Pharmacol Biochem Behav. 2001;68(3):507\u201313.","journal-title":"Pharmacol Biochem Behav"},{"issue":"1\u20132","key":"126_CR57","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0031-9384(01)00469-3","volume":"73","author":"R Slamberova","year":"2001","unstructured":"Slamberova R, Schindler CJ, Pometlova M, Urkuti C, Purow-Sokol JA, Vathy I. Prenatal morphine exposure differentially alters learning and memory in male and female rats. Physiol Behav. 2001;73(1\u20132):93\u2013103.","journal-title":"Physiol Behav"},{"issue":"7","key":"126_CR58","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/hipo.20540","volume":"19","author":"L Niu","year":"2009","unstructured":"Niu L, Cao B, Zhu H, Mei B, Wang M, Yang Y, et al. Impaired in vivo synaptic plasticity in dentate gyrus and spatial memory in juvenile rats induced by prenatal morphine exposure. Hippocampus. 2009;19(7):649\u201357. doi:10.1002\/hipo.20540.","journal-title":"Hippocampus"},{"issue":"12","key":"126_CR59","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1016\/j.peptides.2006.08.008","volume":"27","author":"MJ Barnes","year":"2006","unstructured":"Barnes MJ, Holmes G, Primeaux SD, York DA, Bray GA. Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Peptides. 2006;27(12):3292\u20138. doi:10.1016\/j.peptides.2006.08.008.","journal-title":"Peptides"},{"issue":"4","key":"126_CR60","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1111\/j.1523-1755.2005.00212.x","volume":"67","author":"Y Fu","year":"2005","unstructured":"Fu Y, Xie C, Yan M, Li Q, Joh JW, Lu C, et al. The lipopolysaccharide-triggered mesangial transcriptome: Evaluating the role of interferon regulatory factor-1. Kidney Int. 2005;67(4):1350\u201361. doi:10.1111\/j.1523-1755.2005.00212.x.","journal-title":"Kidney Int"}],"container-title":["Journal of Biomedical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12929-015-0126-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-015-0126-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-015-0126-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-015-0126-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T02:59:02Z","timestamp":1747796342000},"score":1,"resource":{"primary":{"URL":"https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/s12929-015-0126-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,20]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["126"],"URL":"https:\/\/doi.org\/10.1186\/s12929-015-0126-2","relation":{},"ISSN":["1423-0127"],"issn-type":[{"value":"1423-0127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,20]]},"assertion":[{"value":"20 October 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"19"}}