{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:34:45Z","timestamp":1787020485082,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Sci"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12929-017-0345-9","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T03:30:12Z","timestamp":1497497412000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiaochao","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"345_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.11.017","volume":"90","author":"O Chen","year":"2016","unstructured":"Chen O, Ye Z, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W, Sun X. Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radic Biol Med. 2016;90:1\u201311.","journal-title":"Free Radic Biol Med."},{"issue":"5","key":"345_CR2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cjca.2014.12.026","volume":"31","author":"KG Shyu","year":"2015","unstructured":"Shyu KG, Wang BW, Cheng WP, Lo HM. MicroRNA-208a increases myocardial endoglin expression and myocardial fibrosis in acute myocardial infarction. Can J Cardiol. 2015;31(5):679\u201390.","journal-title":"Can J Cardiol"},{"key":"345_CR3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.02.002","volume":"82","author":"H Pei","year":"2015","unstructured":"Pei H, Song X, Peng C, Tan Y, Li Y, Li X, Ma S, Wang Q, Huang R, Yang D, Li D, Gao E, Yang Y. TNF-\u03b1 inhibitor protects against myocardial ischemia\/reperfusion injury via Notch1-mediated suppression of oxidative\/nitrative stress. Free Radic Biol Med. 2015;82:114\u201321.","journal-title":"Free Radic Biol Med."},{"key":"345_CR4","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s11064-004-6869-x","volume":"29","author":"PH Chan","year":"2004","unstructured":"Chan PH. Mitochondria and neuronal death\/survival signaling pathways in cerebral ischemia. Neurochem Res. 2004;29:1943\u20139.","journal-title":"Neurochem Res."},{"issue":"2","key":"345_CR5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00395-014-0459-0","volume":"110","author":"XM Yang","year":"2015","unstructured":"Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV. Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia\/reperfusion. Basic Res Cardiol. 2015;110(2):3.","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"345_CR6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1530\/JOE-14-0638","volume":"225","author":"F Wang","year":"2015","unstructured":"Wang F, Yang J, Sun J, Dong Y, Zhao H, Shi H, Fu L. Testosterone replacement attenuates mitochondrial damage in a rat model of myocardial infarction. J Endocrinol. 2015;225(2):101\u201311.","journal-title":"J Endocrinol"},{"issue":"4","key":"345_CR7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00004647-200104000-00001","volume":"21","author":"G Cao","year":"2001","unstructured":"Cao G, Minami M, Pei W, et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab. 2001;21(4):321\u201333.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"345_CR8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.phrs.2011.06.018","volume":"64","author":"M Aldakkak","year":"2011","unstructured":"Aldakkak M, Camara AK, Heisner JS, Yang M, Stowe DF. Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res. 2011;64(4):381\u201392.","journal-title":"Pharmacol Res"},{"issue":"7","key":"345_CR9","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/ATVBAHA.110.206011","volume":"30","author":"F Montecucco","year":"2010","unstructured":"Montecucco F, Lenglet S, Braunersreuther V, Pelli G, Pellieux C, Montessuit C, Lerch R, Deruaz M, Proudfoot AE, Mach F. Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice. Arterioscler Thromb Vasc Biol. 2010;30(7):1371\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"345_CR10","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1186\/1423-0127-17-S1-S23","volume":"17 Suppl 1","author":"SH Hansen","year":"2010","unstructured":"Hansen SH, Andersen ML, Cornett C, Gradinaru R, Grunnet N. A role for taurine in mitochondrial function. J Biomed Sci. 2010;17 Suppl 1:S23.","journal-title":"J Biomed Sci"},{"issue":"5","key":"345_CR11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/abbs\/gmt034","volume":"45","author":"Y Yang","year":"2013","unstructured":"Yang Y, Zhang Y, Liu X, Zuo J, Wang K, Liu W, Ge J. Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes. Acta Biochim Biophys Sin (Shanghai). 2013;45(5):359\u201367.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"18","key":"345_CR12","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.3760\/cma.j.issn.0366-6999.20123240","volume":"126","author":"LY Cui","year":"2013","unstructured":"Cui LY, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 2013;126(18):3405\u201310.","journal-title":"Chin Med J (Engl)"},{"issue":"8","key":"345_CR13","first-page":"796","volume":"24","author":"Q Chang","year":"2003","unstructured":"Chang Q, Wang XL. Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats. Acta Pharmacol Sin. 2003;24(8):796\u2013804.","journal-title":"Acta Pharmacol Sin"},{"issue":"24","key":"345_CR14","doi-asserted-by":"crossref","first-page":"8180","DOI":"10.1523\/JNEUROSCI.0340-10.2010","volume":"30","author":"Y Peng","year":"2010","unstructured":"Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer\u2019s disease. J Neurosci. 2010;30(24):8180\u20139.","journal-title":"J Neurosci"},{"issue":"2","key":"345_CR15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/aps.2010.210","volume":"32","author":"XC Ji","year":"2011","unstructured":"Ji XC, Zhao WH, Cao DX, Shi QQ, Wang XL. Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1. Acta Pharmacol Sin. 2011;32(2):182\u20137.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"345_CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000350139","volume":"32","author":"HM Wang","year":"2013","unstructured":"Wang HM, Zhang T, Huang JK, Sun XJ. 3-N-butylphthalide (NBP) attenuates the amyloid-\u03b2-induced inflammatory responses in cultured astrocytes via the nuclear factor-\u03baB signaling pathway. Cell Physiol Biochem. 2013;32(1):235\u201342.","journal-title":"Cell Physiol Biochem"},{"key":"345_CR17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-319-38810-6_4","volume":"923","author":"L Zhang","year":"2016","unstructured":"Zhang L, Puchowicz MA, LaManna JC, Xu K. Protective Effect of Dl-3-n-Butylphthalide on recovery from cardiac arrest and resuscitation in rats. Adv Exp Med Biol. 2016;923:31\u20136.","journal-title":"Adv Exp Med Biol."},{"key":"345_CR18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2009.07.020","volume":"1290","author":"L Li","year":"2009","unstructured":"Li L, Zhang B, Tao Y, Wang Y, Wei H, Zhao J, Huang R, Pei Z. DL-3-n-butylphthalide protects endothelial cells against oxidative\/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro. Brain Res. 2009;1290:91\u2013101.","journal-title":"Brain Res."},{"issue":"3","key":"345_CR19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/apha.12186","volume":"210","author":"YG Wang","year":"2014","unstructured":"Wang YG, Li Y, Wang CY, Ai JW, Dong XY, Huang HY, Feng ZY, Pan YM, Lin Y, Wang BX, Yao LL. L-3-n-Butylphthalide protects rats\u2019 cardiomyocytes from ischaemia\/reperfusion-induced apoptosis by affecting the mitochondrial apoptosis pathway. Acta Physiol (Oxf). 2014;210(3):524\u201333.","journal-title":"Acta Physiol (Oxf)"},{"issue":"7178","key":"345_CR20","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature06504","volume":"451","author":"EJ Miller","year":"2008","unstructured":"Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature. 2008;451(7178):578\u201382.","journal-title":"Nature"},{"issue":"3-4","key":"345_CR21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s11418-011-0544-8","volume":"65","author":"B Aristatile","year":"2011","unstructured":"Aristatile B, Al-Numair KS, Al-Assaf AH, Pugalendi KV. Pharmacological effect of carvacrol on D: -galactosamine-induced mitochondrial enzymes and DNA damage by single-cell gel electrophoresis. J Nat Med. 2011;65(3-4):568\u201377.","journal-title":"J Nat Med"},{"issue":"6","key":"345_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/clc.20745","volume":"33","author":"C Zhang","year":"2010","unstructured":"Zhang C, Sun A, Zhang S, Yao K, Wu C, Fu M, Wang K, Zou Y, Ge J. Efficacy and safety of intracoronary autologous bone marrow-derived cell transplantation in patients with acute myocardial infarction: insights from randomized controlled trials with 12 or more months follow-up. Clin Cardiol. 2010;33(6):353\u201360.","journal-title":"Clin Cardiol"},{"issue":"3","key":"345_CR23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/147323001204000315","volume":"40","author":"W Wei","year":"2012","unstructured":"Wei W, Zhang W, Huang Y, Li Y, Zhu G, Chen F, Li J. The therapeutic effect of (DL)-3-n-butylphthalide in rats with chronic cerebral hypoperfusion through downregulation of amyloid precursor protein and matrix metalloproteinase-2. J Int Med Res. 2012;40(3):967\u201375.","journal-title":"J Int Med Res"},{"issue":"5","key":"345_CR24","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3892\/etm.2016.3139","volume":"11","author":"LX Xue","year":"2016","unstructured":"Xue LX, Zhang T, Zhao YW, Geng Z, Chen JJ, Chen H. Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: effects on neurological and behavioral outcomes in acute ischemic stroke. Exp Ther Med. 2016;11(5):2015\u201320.","journal-title":"Exp Ther Med"},{"issue":"2","key":"345_CR25","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuropharm.2011.10.009","volume":"62","author":"X Feng","year":"2012","unstructured":"Feng X, Peng Y, Liu M, Cui L. DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis. Neuropharmacology. 2012;62(2):1004\u201310.","journal-title":"Neuropharmacology"},{"issue":"2","key":"345_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2010.03.053","volume":"475","author":"JZ Huang","year":"2010","unstructured":"Huang JZ, Chen YZ, Su M, Zheng HF, Yang YP, Chen J, Liu CF. dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson\u2019s disease. Neurosci Lett. 2010;475(2):89\u201394.","journal-title":"Neurosci Lett"},{"key":"345_CR27","doi-asserted-by":"crossref","first-page":"19396","DOI":"10.1038\/srep19396","volume":"6","author":"F Wang","year":"2016","unstructured":"Wang F, Ma J, Han F, Guo X, Meng L, Sun Y, Jin C, Duan H, Li H, Peng Y. DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. Sci Rep. 2016;6:19396.","journal-title":"Sci Rep."},{"issue":"4","key":"345_CR28","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbrc.2014.12.022","volume":"456","author":"T Silambarasan","year":"2015","unstructured":"Silambarasan T, Manivannan J, Priya MK, Suganya N, Chatterjee S, Raja B. Sinapic acid protects heart against ischemia\/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress. Biochem Biophys Res Commun. 2015;456(4):853\u20139.","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"345_CR29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/CIRCULATIONAHA.104.524835","volume":"112","author":"M Ikeuchi","year":"2005","unstructured":"Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, Fujiwara T, Hamasaki N, Takeshita A, Sunagawa K, Tsutsui H. Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Circulation. 2005;112(5):683\u201390.","journal-title":"Circulation"},{"issue":"8","key":"345_CR30","doi-asserted-by":"crossref","first-page":"e0134666","DOI":"10.1371\/journal.pone.0134666","volume":"10","author":"P Yu","year":"2015","unstructured":"Yu P, Zhang J, Yu S, Luo Z, Hua F, Yuan L, Zhou Z, Liu Q, Du X, Chen S, Zhang L, Xu G. Protective effect of sevoflurane postconditioning against cardiac ischemia\/reperfusion injury via ameliorating mitochondrial impairment, Oxidative Stress and Rescuing Autophagic Clearance. PLoS One. 2015;10(8):e0134666.","journal-title":"PLoS One"},{"issue":"6","key":"345_CR31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1161\/CIRCIMAGING.114.001857","volume":"7","author":"MS Dodd","year":"2014","unstructured":"Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ. Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. Circ Cardiovasc Imaging. 2014;7(6):895\u2013904.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"12","key":"345_CR32","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.3727\/096368914X685799","volume":"24","author":"T Higuchi","year":"2015","unstructured":"Higuchi T, Miyagawa S, Pearson JT, Fukushima S, Saito A, Tsuchimochi H, Sonobe T, Fujii Y, Yagi N, Astolfo A, Shirai M, Sawa Y. Functional and electrical integration of induced pluripotent stem cell-derived cardiomyocytes in a myocardial infarction rat heart. Cell Transplant. 2015;24(12):2479\u201389.","journal-title":"Cell Transplant"},{"issue":"7","key":"345_CR33","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0006-2952(03)00478-7","volume":"66","author":"C Park","year":"2003","unstructured":"Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, Lee HS, Lee DW, Park R. Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol. 2003;66(7):1287\u201395.","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"345_CR34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neulet.2012.04.003","volume":"516","author":"B Sun","year":"2012","unstructured":"Sun B, Feng M, Tian X, Lu X, Zhang Y, Ke X, Huang S, Cao J, Ding X. DL-3-n-Butylphthalide protects rat bone marrow stem cells against hydrogen peroxide-induced cell death through antioxidation and activation of PI3K-Akt pathway. Neurosci Lett. 2012;516(2):247\u201352.","journal-title":"Neurosci Lett"},{"issue":"8","key":"345_CR35","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.neurobiolaging.2011.03.007","volume":"33","author":"N Xiong","year":"2012","unstructured":"Xiong N, Huang J, Chen C, Zhao Y, Zhang Z, Jia M, Zhang Z, Hou L, Yang H, Cao X, Liang Z, Zhang Y, Sun S, Lin Z, Wang T. Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson\u2019s disease. Neurobiol Aging. 2012;33(8):1777\u201391.","journal-title":"Neurobiol Aging"},{"issue":"12","key":"345_CR36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tibs.2010.07.003","volume":"35","author":"E Verdin","year":"2010","unstructured":"Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. 2010;35(12):669\u201375.","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"345_CR37","doi-asserted-by":"crossref","first-page":"e00045","DOI":"10.1042\/AN20100019","volume":"2","author":"A Cheng","year":"2010","unstructured":"Cheng A, Hou Y, Mattson MP. Mitochondria and neuroplasticity. ASN Neuro. 2010;2(5):e00045.","journal-title":"ASN Neuro"},{"issue":"Pt 15","key":"345_CR38","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/jcs.070490","volume":"123","author":"AY Seo","year":"2010","unstructured":"Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci. 2010;123(Pt 15):2533\u201342.","journal-title":"J Cell Sci"},{"issue":"3","key":"345_CR39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tcm.2005.05.001","volume":"15","author":"CJ McLeod","year":"2005","unstructured":"McLeod CJ, Pagel I, Sack MN. The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention. Trends Cardiovasc Med. 2005;15(3):118\u201323.","journal-title":"Trends Cardiovasc Med"},{"issue":"1","key":"345_CR40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000430342","volume":"37","author":"L Tao","year":"2015","unstructured":"Tao L, Bei Y, Lin S, Zhang H, Zhou Y, Jiang J, Chen P, Shen S, Xiao J, Li X. Exercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesis. Cell Physiol Biochem. 2015;37(1):162\u201375.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"345_CR41","first-page":"27","volume":"29","author":"SK Powers","year":"2014","unstructured":"Powers SK, Smuder AJ, Kavazis AN, Quindry JC. Mechanisms of exercise-induced cardioprotection. Physiology (Bethesda). 2014;29(1):27\u201338.","journal-title":"Physiology (Bethesda)"},{"issue":"3","key":"345_CR42","doi-asserted-by":"crossref","first-page":"H509","DOI":"10.1152\/ajpheart.00044.2016","volume":"311","author":"T Inoue","year":"2016","unstructured":"Inoue T, Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S, Saku K, Sunagawa K. Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. Am J Physiol Heart Circ Physiol. 2016;311(3):H509\u2013519.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"345_CR43","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.CIR.0000136997.53612.6C","volume":"110","author":"CJ McLeod","year":"2004","unstructured":"McLeod CJ, Jeyabalan AP, Minners JO, Clevenger R, Hoyt Jr RF, Sack MN. Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recovery. Circulation. 2004;110(5):534\u20139.","journal-title":"Circulation"},{"key":"345_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1196\/annals.1338.010","volume":"1042","author":"D Kang","year":"2005","unstructured":"Kang D, Hamasaki N. Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles. Ann N Y Acad Sci. 2005;1042:101\u20138.","journal-title":"Ann N Y Acad Sci."}],"container-title":["Journal of Biomedical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-017-0345-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T12:52:21Z","timestamp":1750337541000},"score":1,"resource":{"primary":{"URL":"http:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/s12929-017-0345-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["345"],"URL":"https:\/\/doi.org\/10.1186\/s12929-017-0345-9","relation":{},"ISSN":["1423-0127"],"issn-type":[{"value":"1423-0127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]},"article-number":"38"}}