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In this study, we evaluated the association among <jats:italic>DBP<\/jats:italic> SNPs and AIDS progression in antiretroviral treatment (ART)-na\u00efve-HIV-infected patients.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a retrospective study in 667 patients who were classified according to their pattern of AIDS progression (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)) and 113 healthy blood donors (HIV, HCV, and HBV negative subjects). We genotyped seven <jats:italic>DBP<\/jats:italic> SNPs (rs16846876, rs12512631, rs2070741, rs2282679, rs7041, rs1155563, rs2298849) using Agena Bioscience\u2019s MassARRAY platform. The genetic association was evaluated by Generalized Linear Models adjusted by age at the moment of HIV diagnosis, gender, risk group, and <jats:italic>VDR<\/jats:italic> rs2228570 SNP. Multiple testing correction was performed by the false discovery rate (Benjamini and Hochberg procedure; q-value).<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All SNPs were in HWE (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) and had similar genotypic frequencies for <jats:italic>DBP<\/jats:italic> SNPs in healthy-controls and HIV-infected patients. In unadjusted GLMs, we only found significant association with AIDS progression in rs16846876 and rs12512631 SNPs. In adjusted GLMs, <jats:italic>DBP<\/jats:italic> rs16846876 SNP showed significant association under the recessive inheritance model [LTNPs vs. RPs (adjusted odds ratio (aOR)\u2009=\u20093.53; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.044) and LTNPs vs. MPs (aOR\u2009=\u20093.28; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.030)] and codominant [LTNPs vs. RPs (aOR\u2009=\u20094.92; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.030) and LTNPs vs. MPs\u00a0(aOR\u2009=\u20093.15; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.030)]. Also, we found <jats:italic>DBP<\/jats:italic> rs12512631 SNP showed significant association in the inheritance model dominant [LTNPs vs. RPs (aOR\u2009=\u20090.49; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.031) and LTNPs vs. MPs (aOR\u2009=\u20090.6; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.047)], additive [LTNPs vs. RPs (aOR\u2009=\u20090.61; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.031)], overdominant [LTNPs vs. MPs (aOR\u2009=\u20090.55; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.032)], and codominant [LTNPs vs. RPs (aOR\u2009=\u20090.52; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.036) and LTNPs vs. MPs (aOR\u2009=\u20090.55; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.032)]. Additionally, we found a significant association between <jats:italic>DBP<\/jats:italic> haplotypes (composed by rs16846876 and rs12512631) and AIDS progression (LTNPs vs RPs): <jats:italic>DBP<\/jats:italic> haplotype AC (aOR\u2009=\u20090.63; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.028) and the <jats:italic>DBP<\/jats:italic> haplotype TT (aOR\u2009=\u20091.64; <jats:italic>q<\/jats:italic>-value\u2009=\u20090.028).<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p><jats:italic>DBP<\/jats:italic> rs16846876 and rs12512631 SNPs are related to the patterns of clinical AIDS progression (LTNP, MP, and RP) in ART-na\u00efve HIV-infected patients. Our findings provide new knowledge about AIDS progression that may be relevant to understanding the pathogenesis of HIV infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12929-019-0577-y","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T10:59:27Z","timestamp":1571828367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS na\u00efve HIV-infected patients: a retrospective study"],"prefix":"10.1186","volume":"26","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"JIM\u00c9NEZ-SOUSA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"JIM\u00c9NEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"FERN\u00c1NDEZ-RODR\u00cdGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"BELL\u00d3N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"RODR\u00cdGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melchor","family":"RIERA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"PORTILLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"CASTRO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"MU\u00d1OZ-FERN\u00c1NDEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"RESINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"issue":"Suppl A","key":"577_CR1","first-page":"S69","volume":"11","author":"A Munoz","year":"1997","unstructured":"Munoz A, Sabin CA, Phillips AN. 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