{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:20:11Z","timestamp":1778804411927,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Science and Technology","award":["MOST 105-2628-B- 038 \u2212001 -MY4"],"award-info":[{"award-number":["MOST 105-2628-B- 038 \u2212001 -MY4"]}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"crossref","award":["12310-0223"],"award-info":[{"award-number":["12310-0223"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["NHRI-107A1-MGCP-1817202"],"award-info":[{"award-number":["NHRI-107A1-MGCP-1817202"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014587","name":"Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University","doi-asserted-by":"crossref","award":["DMR-108-113 and DMR-108-114"],"award-info":[{"award-number":["DMR-108-113 and DMR-108-114"]}],"id":[{"id":"10.13039\/100014587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST 108-2314-B-039 -044 -MY3"],"award-info":[{"award-number":["MOST 108-2314-B-039 -044 -MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Sci"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12929-019-0581-2","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T05:41:22Z","timestamp":1573105282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning"],"prefix":"10.1186","volume":"26","author":[{"given":"Henry Sung-Ching","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ling","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Hsiun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jer-Yuarn","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"issue":"8","key":"581_CR1","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/en.2013-2175","volume":"155","author":"O Nilsson","year":"2014","unstructured":"Nilsson O, Weise M, Landman EB, Meyers JL, Barnes KM, Baron J. Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits. Endocrinology. 2014;155(8):2892\u20139.","journal-title":"Endocrinology"},{"issue":"6","key":"581_CR2","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.jpeds.2005.07.033","volume":"147","author":"JA Emons","year":"2005","unstructured":"Emons JA, Boersma B, Baron J, Wit JM. Catch-up growth: testing the hypothesis of delayed growth plate senescence in humans. J Pediatr. 2005;147(6):843\u20136.","journal-title":"J Pediatr"},{"issue":"1","key":"581_CR3","doi-asserted-by":"publisher","first-page":"T35","DOI":"10.1530\/JME-14-0006","volume":"53","author":"B Sederquist","year":"2014","unstructured":"Sederquist B, Fernandez-Vojvodich P, Zaman F, Savendahl L. Recent research on the growth plate: impact of inflammatory cytokines on longitudinal bone growth. J Mol Endocrinol. 2014;53(1):T35\u201344.","journal-title":"J Mol Endocrinol"},{"issue":"5","key":"581_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00439-011-0969-x","volume":"129","author":"G Lettre","year":"2011","unstructured":"Lettre G. Recent progress in the study of the genetics of height. Hum Genet. 2011;129(5):465\u201372.","journal-title":"Hum Genet"},{"issue":"11","key":"581_CR5","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng.3097","volume":"46","author":"AR Wood","year":"2014","unstructured":"Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet. 2014;46(11):1173\u201386.","journal-title":"Nat Genet"},{"issue":"7640","key":"581_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/nature21039","volume":"542","author":"E Marouli","year":"2017","unstructured":"Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017;542(7640):186\u201390.","journal-title":"Nature"},{"issue":"1","key":"581_CR7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ajhg.2010.11.007","volume":"88","author":"MB Lanktree","year":"2011","unstructured":"Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, et al. Meta-analysis of dense Genecentric association studies reveals common and uncommon variants associated with height. Am J Hum Genet. 2011;88(1):6\u201318.","journal-title":"Am J Hum Genet"},{"issue":"7317","key":"581_CR8","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/nature09410","volume":"467","author":"H Lango Allen","year":"2010","unstructured":"Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010;467(7317):832\u20138.","journal-title":"Nature"},{"issue":"5","key":"581_CR9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/ng.357","volume":"41","author":"YS Cho","year":"2009","unstructured":"Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009;41(5):527\u201334.","journal-title":"Nat Genet"},{"issue":"18","key":"581_CR10","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1093\/hmg\/ddp296","volume":"18","author":"K Estrada","year":"2009","unstructured":"Estrada K, Krawczak M, Schreiber S, van Duijn K, Stolk L, van Meurs JB, Liu F, Penninx BW, Smit JH, Vogelzangs N, et al. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. Hum Mol Genet. 2009;18(18):3516\u201324.","journal-title":"Hum Mol Genet"},{"issue":"5","key":"581_CR11","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/ng.122","volume":"40","author":"DF Gudbjartsson","year":"2008","unstructured":"Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, et al. Many sequence variants affecting diversity of adult human height. Nat Genet. 2008;40(5):609\u201315.","journal-title":"Nat Genet"},{"issue":"1","key":"581_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/jhg.2009.116","volume":"55","author":"JJ Kim","year":"2010","unstructured":"Kim JJ, Lee HI, Park T, Kim K, Lee JE, Cho NH, Shin C, Cho YS, Lee JY, Han BG, et al. Identification of 15 loci influencing height in a Korean population. J Hum Genet. 2010;55(1):27\u201331.","journal-title":"J Hum Genet"},{"issue":"5","key":"581_CR13","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/ng.125","volume":"40","author":"G Lettre","year":"2008","unstructured":"Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008;40(5):584\u201391.","journal-title":"Nat Genet"},{"issue":"11","key":"581_CR14","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1093\/hmg\/ddq091","volume":"19","author":"Y Okada","year":"2010","unstructured":"Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, et al. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Hum Mol Genet. 2010;19(11):2303\u201312.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"581_CR15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1375\/twin.13.2.179","volume":"13","author":"JZ Liu","year":"2010","unstructured":"Liu JZ, Medland SE, Wright MJ, Henders AK, Heath AC, Madden PA, Duncan A, Montgomery GW, Martin NG, McRae AF. Genome-wide association study of height and body mass index in Australian twin families. Twin research and human genetics : the official journal of the International Society for Twin Studies. 2010;13(2):179\u201393.","journal-title":"Twin research and human genetics : the official journal of the International Society for Twin Studies"},{"issue":"4","key":"581_CR16","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jpeds.2013.04.002","volume":"163","author":"S Sisley","year":"2013","unstructured":"Sisley S, Trujillo MV, Khoury J, Backeljauw P. Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic short children. J Pediatr. 2013;163(4):1045\u201351.","journal-title":"J Pediatr"},{"issue":"1","key":"581_CR17","doi-asserted-by":"publisher","first-page":"6372","DOI":"10.1038\/s41598-017-06766-z","volume":"7","author":"YJ Lin","year":"2017","unstructured":"Lin YJ, Liao WL, Wang CH, Tsai LP, Tang CH, Chen CH, Wu JY, Liang WM, Hsieh AR, Cheng CF, et al. Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan. Sci Rep. 2017;7(1):6372.","journal-title":"Sci Rep"},{"issue":"11","key":"581_CR18","doi-asserted-by":"publisher","first-page":"4342","DOI":"10.1210\/jc.2008-0707","volume":"93","author":"K Albertsson-Wikland","year":"2008","unstructured":"Albertsson-Wikland K, Aronson AS, Gustafsson J, Hagenas L, Ivarsson SA, Jonsson B, Kristrom B, Marcus C, Nilsson KO, Ritzen EM, et al. Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab. 2008;93(11):4342\u201350.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"581_CR19","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1210\/jc.2003-031457","volume":"89","author":"EW Leschek","year":"2004","unstructured":"Leschek EW, Rose SR, Yanovski JA, Troendle JF, Quigley CA, Chipman JJ, Crowe BJ, Ross JL, Cassorla FG, Blum WF, et al. Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2004;89(7):3140\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3 Pt 1","key":"581_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S0022-3476(98)70020-4","volume":"132","author":"LT Rekers-Mombarg","year":"1998","unstructured":"Rekers-Mombarg LT, Massa GG, Wit JM, Matranga AM, Buckler JM, Butenandt O, Chaussain JL, Frisch H, Leiberman E, Yturriaga R, et al. Growth hormone therapy with three dosage regimens in children with idiopathic short stature. European study group participating investigators. J Pediatr. 1998;132(3 Pt 1):455\u201360.","journal-title":"J Pediatr"},{"issue":"4","key":"581_CR21","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1530\/EJE-09-0880","volume":"162","author":"SA van Gool","year":"2010","unstructured":"van Gool SA, Kamp GA, Odink RJ, de Muinck Keizer-Schrama SM, Delemarre-van de Waal HA, Oostdijk W, Wit JM. high-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height. Eur J Endocrinol. 2010;162(4):653\u201360.","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"581_CR22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/cge.12465","volume":"86","author":"Y Okada","year":"2014","unstructured":"Okada Y. From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis. Clin Genet. 2014;86(5):432\u201340.","journal-title":"Clin Genet"},{"issue":"6","key":"581_CR23","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.jos.2017.07.009","volume":"22","author":"S Sakaue","year":"2017","unstructured":"Sakaue S, Okada Y. Human genetics contributes to the understanding of disease pathophysiology and drug discovery. J Orthop Sci. 2017;22(6):977\u201381.","journal-title":"J Orthop Sci"},{"issue":"16","key":"581_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 2010;38(16):e164.","journal-title":"Nucleic Acids Res"},{"key":"581_CR25","doi-asserted-by":"crossref","unstructured":"Genomes Project C, Auton A, brooks LD, Durbin RM, garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA et al: a global reference for human genetic variation. Nature 2015, 526(7571):68\u201374.","DOI":"10.1038\/nature15393"},{"issue":"Database issue","key":"581_CR26","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012;40(Database issue):D930\u20134.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"581_CR27","doi-asserted-by":"publisher","first-page":"D767","DOI":"10.1093\/nar\/gkn892","volume":"37","author":"TS Keshava Prasad","year":"2009","unstructured":"Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S, Telikicherla D, Raju R, Shafreen B, Venugopal A, et al. Human protein reference database--2009 update. Nucleic Acids Res. 2009;37(Database issue):D767\u201372.","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"581_CR28","doi-asserted-by":"publisher","first-page":"10883","DOI":"10.1073\/pnas.1814263116","volume":"116","author":"DL Taylor","year":"2019","unstructured":"Taylor DL, Jackson AU, Narisu N, Hemani G, Erdos MR, Chines PS, Swift A, Idol J, Didion JP, Welch RP, et al. Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle. Proc Natl Acad Sci U S A. 2019;116(22):10883\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"581_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"Michael Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT et al: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat Genet 2000, 25(1):25\u201329.","journal-title":"Nature Genetics"},{"issue":"5","key":"581_CR30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/ng0504-431","volume":"36","author":"KG Becker","year":"2004","unstructured":"Becker KG, Barnes KC, Bright TJ, Wang SA. The genetic association database. Nat Genet. 2004;36(5):431\u20132.","journal-title":"Nat Genet"},{"key":"581_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13023-015-0299-5","volume":"10","author":"K Stange","year":"2015","unstructured":"Stange K, Desir J, Kakar N, Mueller TD, Budde BS, Gordon CT, Horn D, Seemann P, Borck G. A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia. Orphanet J Rare Dis. 2015;10:84.","journal-title":"Orphanet J Rare Dis"},{"issue":"12","key":"581_CR32","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nrendo.2015.165","volume":"11","author":"J Baron","year":"2015","unstructured":"Baron J, Savendahl L, De Luca F, Dauber A, Phillip M, Wit JM, Nilsson O. Short and tall stature: a new paradigm emerges. Nat Rev Endocrinol. 2015;11(12):735\u201346.","journal-title":"Nat Rev Endocrinol"},{"key":"581_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0070-2153(06)76001-X","volume":"76","author":"R Pogue","year":"2006","unstructured":"Pogue R, Lyons K. BMP signaling in the cartilage growth plate. Curr Top Dev Biol. 2006;76:1\u201348.","journal-title":"Curr Top Dev Biol"},{"issue":"1","key":"581_CR34","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ajhg.2013.06.005","volume":"93","author":"DA Dyment","year":"2013","unstructured":"Dyment DA, Smith AC, Alcantara D, Schwartzentruber JA, Basel-Vanagaite L, Curry CJ, Temple IK, Reardon W, Mansour S, Haq MR, et al. Mutations in PIK3R1 cause SHORT syndrome. Am J Hum Genet. 2013;93(1):158\u201366.","journal-title":"Am J Hum Genet"},{"key":"581_CR35","doi-asserted-by":"publisher","first-page":"13227","DOI":"10.1038\/ncomms13227","volume":"7","author":"M Fournier","year":"2016","unstructured":"Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, et al. KAT2A\/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification. Nat Commun. 2016;7:13227.","journal-title":"Nat Commun"},{"issue":"2","key":"581_CR36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3349\/ymj.2010.51.2.231","volume":"51","author":"HJ Choi","year":"2010","unstructured":"Choi HJ, Choi JY, Cho SW, Kang D, Han KO, Kim SW, Kim SY, Chung YS, Shin CS. Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women. Yonsei Med J. 2010;51(2):231\u20138.","journal-title":"Yonsei Med J"},{"issue":"1","key":"581_CR37","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/jbm4.10064","volume":"3","author":"P Peris","year":"2019","unstructured":"Peris P, Gonzalez-Roca E, Rodriguez-Garcia SC, Del Mar L-CM, Monegal A, Guanabens N. Incidence of mutations in the ALPL, GGPS1, and CYP1A1 genes in patients with atypical femoral fractures. JBMR Plus. 2019;3(1):29\u201336.","journal-title":"JBMR Plus"},{"issue":"7488","key":"581_CR38","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature12873","volume":"506","author":"Y Okada","year":"2014","unstructured":"Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014;506(7488):376\u201381.","journal-title":"Nature"},{"key":"581_CR39","doi-asserted-by":"crossref","unstructured":"Wong HS, Juan YS, Wu MS, Zhang YF, Hsu YW, Chen HH, Liu WM, Chang WC. Integrative bioinformatic analyses of an oncogenomic profile reveal the biology of endometrial cancer and guide drug discovery. Oncotarget. 2016;7(5):5909\u201323.","DOI":"10.18632\/oncotarget.6716"},{"issue":"4","key":"581_CR40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1097\/MOL.0b013e328361f62d","volume":"24","author":"Francine Petrides","year":"2013","unstructured":"Petrides F, Shearston K, Chatelais M, Guilbaud F, Meilhac O, Lambert G. The promises of PCSK9 inhibition. Curr Opin Lipidol. 2013;24(4):307\u201312.","journal-title":"Current Opinion in Lipidology"}],"container-title":["Journal of Biomedical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-019-0581-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12929-019-0581-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12929-019-0581-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:25:56Z","timestamp":1604622356000},"score":1,"resource":{"primary":{"URL":"https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/s12929-019-0581-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["581"],"URL":"https:\/\/doi.org\/10.1186\/s12929-019-0581-2","relation":{},"ISSN":["1423-0127"],"issn-type":[{"value":"1423-0127","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]},"assertion":[{"value":"27 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This research protocol was approved by the institutional review board (IRB) and the ethics committee of the Human Studies Committee of China Medical University Hospital (CMUH). Our study was conducted in accordance with the <i>Declaration of Helsinki<\/i> principles and meet the requirements of the institute. The samples of familial short stature were recruited by the Children\u2019s Hospital, China Medical University, Taichung, Taiwan. We obtained written informed consent from all participants and their parents (or legal guardians).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the participant for publication of their individual details and accompanying images in this manuscript. The consent form is held by the authors and is available for review by the Editor-in-Chief. We accept the conditions of submission and the BioMed Central Copyright and License Agreement.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}