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In order to cause disease in vivo, a robust and highly efficient metabolic adaptation is crucial for the survival of this fungal pathogen in human host. In fact, reprogramming of the carbon metabolism is believed to be indispensable for phagocytosed\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      within glucose deprivation condition during infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, the metabolic responses of\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      under acetate growth condition was explored using high-throughput transcriptomic and proteomic approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Collectively, a total of 1482 transcripts (26.96%) and 242 proteins (24.69%) were significantly up- or down-regulated. Both transcriptome and proteome data revealed that the regulation of alternative carbon metabolism in\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      resembled other fungal pathogens such as\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      and\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                      , with up-regulation of many proteins and transcripts from the glyoxylate cycle and gluconeogenesis, namely isocitrate lyase (\n                      <jats:italic>ICL1<\/jats:italic>\n                      ), malate synthase (\n                      <jats:italic>MLS1<\/jats:italic>\n                      ), phosphoenolpyruvate carboxykinase (\n                      <jats:italic>PCK1<\/jats:italic>\n                      ) and fructose 1,6-biphosphatase (\n                      <jats:italic>FBP1<\/jats:italic>\n                      ). In the absence of glucose,\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      shifted its metabolism from glucose catabolism to anabolism of glucose intermediates from the available carbon source. This observation essentially suggests that the glyoxylate cycle and gluconeogenesis are potentially critical for the survival of phagocytosed\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      within the glucose-deficient macrophages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Here, we presented the first global metabolic responses of\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      to alternative carbon source using transcriptomic and proteomic approaches. These findings implicated that reprogramming of the alternative carbon metabolism during glucose deprivation could enhance the survival and persistence of\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      within the host.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12929-020-00700-8","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T09:02:39Z","timestamp":1609578159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata"],"prefix":"10.1186","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-448X","authenticated-orcid":false,"given":"Shu Yih","family":"Chew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-4251","authenticated-orcid":false,"given":"Alistair J. 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