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Clinical isolates frequently exhibit resistance to one or more first-line antifungal drugs, and management is further complicated by persistent colonization, biofilm formation, and historical misidentification in diagnostic laboratories. Rapid species-level identification and accurate antifungal susceptibility testing are critical for effective patient care and infection control. In this article, we summarize the clinical spectrum of\n                    <jats:italic>C. auris<\/jats:italic>\n                    infections, highlight key pathogenic traits and clade-specific biological differences, and discuss emerging diagnostic, therapeutic, and preventative strategies\u2014including novel antifungal agents, host-directed therapies, and vaccine development\u2014that may improve detection and expand treatment options for\n                    <jats:italic>C. auris<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1186\/s12929-026-01230-5","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T15:15:18Z","timestamp":1771686918000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The emerging pathogen Candida auris: host interactions and disease drivers"],"prefix":"10.1186","volume":"33","author":[{"given":"Daniel Ruben Akiola","family":"Sanya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Valle","family":"Arevalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"On\u00e9sime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa J.","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"issue":"10","key":"1230_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008921","volume":"16","author":"H Du","year":"2020","unstructured":"Du H, et al. 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