{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:22:14Z","timestamp":1790266934935,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12931-018-0748-5","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T03:45:16Z","timestamp":1522813516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["G908R NOD2 variant in a family with sarcoidosis"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-629X","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Besnard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Calender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Bouvry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chapelon-Abric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Jeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Plan\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valeyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"748_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.rmr.2010.09.035","volume":"28","author":"Y Pacheco","year":"2011","unstructured":"Pacheco Y. Sarcoidosis and genetics. Rev Mal Respir. 2011;28:409\u201318.","journal-title":"Rev Mal Respir"},{"key":"748_CR2","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/thx.2007.094060","volume":"63","author":"A Sverrild","year":"2008","unstructured":"Sverrild A, Backer V, Kyvik KO, Kaprio J, Milman N, Svendsen CB, Thomsen SF. Heredity in sarcoidosis: a registry-based twin study. Thorax. 2008;63:894\u20136.","journal-title":"Thorax"},{"key":"748_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1399-0039.2008.01180.x","volume":"73","author":"Y Li","year":"2009","unstructured":"Li Y, Pabst S, Lokhande S, Grohe C, Wollnik B. Extended genetic analysis of BTNL2 in sarcoidosis. Tissue Antigens. 2009;73:59\u201361.","journal-title":"Tissue Antigens"},{"key":"748_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1086\/444435","volume":"77","author":"BA Rybicki","year":"2005","unstructured":"Rybicki BA, Walewski JL, Maliarik MJ, Kian H, Iannuzzi MC. The BTNL2 gene and sarcoidosis susceptibility in African Americans and Whites. Am J Hum Genet. 2005;77:491\u20139.","journal-title":"Am J Hum Genet"},{"key":"748_CR5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/ng1519","volume":"37","author":"R Valentonyte","year":"2005","unstructured":"Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet. 2005;37:357\u201364.","journal-title":"Nat Genet"},{"key":"748_CR6","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/ng.198","volume":"40","author":"S Hofmann","year":"2008","unstructured":"Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schurmann M, Muller-Quernheim J, Krawczak M, Rosenstiel P, Schreiber S. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 2008;40:1103\u20136.","journal-title":"Nat Genet"},{"key":"748_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1164\/rccm.201204-0708OC","volume":"186","author":"A Fischer","year":"2012","unstructured":"Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schurmann M, Lipinski S, Rosenstiel P, Zissel G, Hohne K, et al. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. Am J Respir Crit Care Med. 2012;186:877\u201385.","journal-title":"Am J Respir Crit Care Med"},{"key":"748_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ccm.2008.03.007","volume":"29","author":"J Muller-Quernheim","year":"2008","unstructured":"Muller-Quernheim J, Schurmann M, Hofmann S, Gaede KI, Fischer A, Prasse A, Zissel G, Schreiber S. Genetics of sarcoidosis. Clin Chest Med. 2008;29:391\u2013414. viii","journal-title":"Clin Chest Med"},{"key":"748_CR9","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1164\/rccm.201503-0418OC","volume":"192","author":"A Fischer","year":"2015","unstructured":"Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, Rybicki BA, Petrek M, Mrazek F, Pabst S, et al. Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk. Am J Respir Crit Care Med. 2015;192:727\u201336.","journal-title":"Am J Respir Crit Care Med"},{"key":"748_CR10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603\u20136.","journal-title":"Nature"},{"key":"748_CR11","doi-asserted-by":"publisher","first-page":"e000097","DOI":"10.1136\/rmdopen-2015-000097","volume":"1","author":"F Caso","year":"2015","unstructured":"Caso F, Galozzi P, Costa L, Sfriso P, Cantarini L, Punzi L. Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease. RMD Open. 2015;1:e000097.","journal-title":"RMD Open"},{"key":"748_CR12","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1093\/rheumatology\/keu437","volume":"54","author":"CD Rose","year":"2015","unstructured":"Rose CD, Pans S, Casteels I, Anton J, Bader-Meunier B, Brissaud P, Cimaz R, Espada G, Fernandez-Martin J, Hachulla E, et al. Blau syndrome: cross-sectional data from a multicentre study of clinical, radiological and functional outcomes. Rheumatology (Oxford). 2015;54:1008\u201316.","journal-title":"Rheumatology (Oxford)"},{"key":"748_CR13","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fimmu.2016.00367","volume":"7","author":"T Sidiq","year":"2016","unstructured":"Sidiq T, Yoshihama S, Downs I, Kobayashi KS. Nod2: A Critical Regulator of Ileal Microbiota and Crohn's Disease. Front Immunol. 2016;7:367.","journal-title":"Front Immunol"},{"key":"748_CR14","first-page":"115","volume":"22","author":"BA Rybicki","year":"2005","unstructured":"Rybicki BA, Hirst K, Iyengar SK, Barnard JG, Judson MA, Rose CS, Donohue JF, Kavuru MS, Rabin DL, Rossman MD, et al. A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis. 2005;22:115\u201322.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"748_CR15","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/S0895-4356(99)00142-0","volume":"52","author":"Design of a case control etiologic study of sarcoidosis (ACCESS)","year":"1999","unstructured":"Design of a case control etiologic study of sarcoidosis (ACCESS). ACCESS Research Group. J Clin Epidemiol. 1999;52:1173\u201386.","journal-title":"J Clin Epidemiol"},{"key":"748_CR16","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1164\/rccm.201507-1344LE","volume":"192","author":"GA Bello","year":"2015","unstructured":"Bello GA, Adrianto I, Dumancas GG, Levin AM, Iannuzzi MC, Rybicki BA, Montgomery C. Role of NOD2 Pathway Genes in Sarcoidosis Cases with Clinical Characteristics of Blau Syndrome. Am J Respir Crit Care Med. 2015;192:1133\u20135.","journal-title":"Am J Respir Crit Care Med"},{"key":"748_CR17","first-page":"23","volume":"23","author":"M Gazouli","year":"2006","unstructured":"Gazouli M, Koundourakis A, Ikonomopoulos J, Gialafos EJ, Rapti A, Gorgoulis VG, Kittas C. CARD15\/NOD2, CD14, and toll-like receptor 4 gene polymorphisms in Greek patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2006;23:23\u20139.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"748_CR18","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1183\/09031936.03.00040602","volume":"22","author":"M Schurmann","year":"2003","unstructured":"Schurmann M, Valentonyte R, Hampe J, Muller-Quernheim J, Schwinger E, Schreiber S. CARD15 gene mutations in sarcoidosis. Eur Respir J. 2003;22:748\u201354.","journal-title":"Eur Respir J"},{"key":"748_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13023-016-0546-4","volume":"11","author":"Y Pacheco","year":"2016","unstructured":"Pacheco Y, Calender A, Israel-Biet D, Roy P, Lebecque S, Cottin V, Bouvry D, Nunes H, Seve P, Perard L, et al. Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort. Orphanet J Rare Dis. 2016;11:165.","journal-title":"Orphanet J Rare Dis"},{"key":"748_CR20","unstructured":"Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999(160):736\u201355."},{"key":"748_CR21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fimmu.2014.00317","volume":"5","author":"D Corridoni","year":"2014","unstructured":"Corridoni D, Arseneau KO, Cifone MG, Cominelli F. The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation. Front Immunol. 2014;5:317.","journal-title":"Front Immunol"},{"key":"748_CR22","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1183\/09031936.00010209","volume":"35","author":"H Sato","year":"2010","unstructured":"Sato H, Williams HR, Spagnolo P, Abdallah A, Ahmad T, Orchard TR, Copley SJ, Desai SR, Wells AU, du Bois RM, Welsh KI. CARD15\/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis. Eur Respir J. 2010;35:324\u201330.","journal-title":"Eur Respir J"},{"key":"748_CR23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1136\/thx.2004.036871","volume":"60","author":"LP Ho","year":"2005","unstructured":"Ho LP, Merlin F, Gaber K, Davies RJ, McMichael AJ, Hugot JP. CARD 15 gene mutations in sarcoidosis. Thorax. 2005;60:354\u20135.","journal-title":"Thorax"},{"key":"748_CR24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000090638","volume":"74","author":"N Milman","year":"2007","unstructured":"Milman N, Nielsen OH, Hviid TV, Fenger K. CARD15 single nucleotide polymorphisms 8, 12 and 13 are not increased in ethnic Danes with sarcoidosis. Respiration. 2007;74:76\u20139.","journal-title":"Respiration"},{"key":"748_CR25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","volume":"41","author":"R Caruso","year":"2014","unstructured":"Caruso R, Warner N, Inohara N, Nunez G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity. 2014;41:898\u2013908.","journal-title":"Immunity"},{"key":"748_CR26","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1183\/09031936.00025212","volume":"40","author":"H Nunes","year":"2012","unstructured":"Nunes H, Uzunhan Y, Gille T, Lamberto C, Valeyre D, Brillet PY. Imaging of sarcoidosis of the airways and lung parenchyma and correlation with lung function. Eur Respir J. 2012;40:750\u201365.","journal-title":"Eur Respir J"},{"key":"748_CR27","doi-asserted-by":"publisher","first-page":"15813","DOI":"10.1073\/pnas.0907722106","volume":"106","author":"T Petnicki-Ocwieja","year":"2009","unstructured":"Petnicki-Ocwieja T, Hrncir T, Liu YJ, Biswas A, Hudcovic T, Tlaskalova-Hogenova H, Kobayashi KS. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A. 2009;106:15813\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"748_CR28","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1462-5822.2012.01768.x","volume":"14","author":"P Lapaquette","year":"2012","unstructured":"Lapaquette P, Bringer MA, Darfeuille-Michaud A. Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response. Cell Microbiol. 2012;14:791\u2013807.","journal-title":"Cell Microbiol"},{"key":"748_CR29","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1101\/gad.1964410","volume":"24","author":"JT Tigno-Aranjuez","year":"2010","unstructured":"Tigno-Aranjuez JT, Asara JM, Abbott DW. Inhibition of RIP2\u2019s tyrosine kinase activity limits NOD2-driven cytokine responses. Genes Dev. 2010;24:2666\u201377.","journal-title":"Genes Dev"},{"key":"748_CR30","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1177\/1753425910394002","volume":"18","author":"B Zurek","year":"2012","unstructured":"Zurek B, Proell M, Wagner RN, Schwarzenbacher R, Kufer TA. Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation. Innate Immun. 2012;18:100\u201311.","journal-title":"Innate Immun"},{"key":"748_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1165\/ajrcmb.25.2.4327","volume":"25","author":"M Conron","year":"2001","unstructured":"Conron M, Bondeson J, Pantelidis P, Beynon HL, Feldmann M, duBois RM, Foxwell BM. Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways. Am J Respir Cell Mol Biol. 2001;25:141\u20139.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"748_CR32","first-page":"50","volume":"18","author":"M Drent","year":"2001","unstructured":"Drent M, van den Berg R, Haenen GR, van den Berg H, Wouters EF, Bast A. NF-kappaB activation in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2001;18:50\u20136.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"748_CR33","first-page":"49","volume-title":"Sarcoidosis","author":"G Semenzato","year":"2005","unstructured":"Semenzato G, Bortoli M, Brunetta E, Agostini C. Immunology and pathophysiology. In: Sarcoidosis, vol. 32; 2005. p. 49\u201363."},{"key":"748_CR34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1053\/gast.2003.50019","volume":"124","author":"DK Bonen","year":"2003","unstructured":"Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, Tanabe T, Chen FF, Foster SJ, Duerr RH, Brant SR, et al. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology. 2003;124:140\u20136.","journal-title":"Gastroenterology"},{"key":"748_CR35","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","volume":"278","author":"N Inohara","year":"2003","unstructured":"Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem. 2003;278:5509\u201312.","journal-title":"J Biol Chem"},{"key":"748_CR36","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1073\/pnas.0530276100","volume":"100","author":"M Chamaillard","year":"2003","unstructured":"Chamaillard M, Philpott D, Girardin SE, Zouali H, Lesage S, Chareyre F, Bui TH, Giovannini M, Zaehringer U, Penard-Lacronique V, et al. Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A. 2003;100:3455\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"748_CR37","first-page":"1266","volume":"5","author":"M Schuliga","year":"2015","unstructured":"Schuliga M. NF-kappaB Signaling in Chronic Inflammatory Airway Disease. Biomol Ther. 2015;5:1266\u201383.","journal-title":"Biomol Ther"},{"key":"748_CR38","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s10620-011-1977-3","volume":"57","author":"JH Niess","year":"2012","unstructured":"Niess JH, Klaus J, Stephani J, Pfluger C, Degenkolb N, Spaniol U, Mayer B, Lahr G, von Boyen GB. NOD2 polymorphism predicts response to treatment in Crohn's disease--first steps to a personalized therapy. Dig Dis Sci. 2012;57:879\u201386.","journal-title":"Dig Dis Sci"},{"key":"748_CR39","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/377068a0","volume":"377","author":"T Calandra","year":"1995","unstructured":"Calandra T, Bernhagen J, Metz CN, Spiegel LA, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 1995;377:68\u201371.","journal-title":"Nature"},{"key":"748_CR40","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/ni1092","volume":"5","author":"T Watanabe","year":"2004","unstructured":"Watanabe T, Kitani A, Murray PJ, Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol. 2004;5:800\u20138.","journal-title":"Nat Immunol"},{"key":"748_CR41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.it.2013.10.009","volume":"35","author":"AM Keestra","year":"2014","unstructured":"Keestra AM, Baumler AJ. Detection of enteric pathogens by the nodosome. Trends Immunol. 2014;35:123\u201330.","journal-title":"Trends Immunol"},{"key":"748_CR42","doi-asserted-by":"publisher","first-page":"19693","DOI":"10.1074\/jbc.M909860199","volume":"275","author":"JA Frost","year":"2000","unstructured":"Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem. 2000;275:19693\u20139.","journal-title":"J Biol Chem"},{"key":"748_CR43","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1053\/j.gastro.2010.09.009","volume":"140","author":"M Hedl","year":"2011","unstructured":"Hedl M, Abraham C. Secretory mediators regulate Nod2-induced tolerance in human macrophages. Gastroenterology. 2011;140:231\u201341.","journal-title":"Gastroenterology"},{"key":"748_CR44","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.chom.2016.10.003","volume":"20","author":"K Chen","year":"2016","unstructured":"Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, et al. IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae. Cell Host Microbe. 2016;20:596\u2013605.","journal-title":"Cell Host Microbe"},{"key":"748_CR45","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.chom.2016.10.001","volume":"20","author":"HR Conti","year":"2016","unstructured":"Conti HR, Bruno VM, Childs EE, Daugherty S, Hunter JP, Mengesha BG, Saevig DL, Hendricks MR, Coleman BM, Brane L, et al. IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis. Cell Host Microbe. 2016;20:606\u201317.","journal-title":"Cell Host Microbe"},{"key":"748_CR46","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/ibd.20855","volume":"15","author":"DP McGovern","year":"2009","unstructured":"McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, et al. Genetic epistasis of IL23\/IL17 pathway genes in Crohn's disease. Inflamm Bowel Dis. 2009;15:883\u20139.","journal-title":"Inflamm Bowel Dis"},{"key":"748_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/MOH.0000000000000301","volume":"24","author":"P Sakthivel","year":"2017","unstructured":"Sakthivel P, Bruder D. Mechanism of granuloma formation in sarcoidosis. Curr Opin Hematol. 2017;24:59\u201365.","journal-title":"Curr Opin Hematol"},{"key":"748_CR48","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/rheumatology\/ker316","volume":"51","author":"B Ten Berge","year":"2012","unstructured":"Ten Berge B, Paats MS, Bergen IM, van den Blink B, Hoogsteden HC, Lambrecht BN, Hendriks RW, Kleinjan A. Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis. Rheumatology (Oxford). 2012;51:37\u201346.","journal-title":"Rheumatology (Oxford)"},{"key":"748_CR49","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.4049\/jimmunol.0903332","volume":"184","author":"Y Okamoto","year":"2010","unstructured":"Okamoto Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol. 2010;184:4414\u201322.","journal-title":"J Immunol"},{"key":"748_CR50","doi-asserted-by":"publisher","first-page":"e0149455","DOI":"10.1371\/journal.pone.0149455","volume":"11","author":"R Lombard","year":"2016","unstructured":"Lombard R, Doz E, Carreras F, Epardaud M, Le Vern Y, Buzoni-Gatel D, Winter N. IL-17RA in Non-Hematopoietic Cells Controls CXCL-1 and 5 Critical to Recruit Neutrophils to the Lung of Mycobacteria-Infected Mice during the Adaptative Immune Response. PLoS One. 2016;11:e0149455.","journal-title":"PLoS One"},{"key":"748_CR51","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-pathol-011110-130318","volume":"8","author":"CT Weaver","year":"2013","unstructured":"Weaver CT, Elson CO, Fouser LA, Kolls JK. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol. 2013;8:477\u2013512.","journal-title":"Annu Rev Pathol"},{"key":"748_CR52","doi-asserted-by":"publisher","first-page":"13048","DOI":"10.1038\/ncomms13048","volume":"7","author":"AT Kurdi","year":"2016","unstructured":"Kurdi AT, Bassil R, Olah M, Wu C, Xiao S, Taga M, Frangieh M, Buttrick T, Orent W, Bradshaw EM, et al. Tiam1\/Rac1 complex controls Il17a transcription and autoimmunity. Nat Commun. 2016;7:13048.","journal-title":"Nat Commun"},{"key":"748_CR53","first-page":"14","volume":"37","author":"D Celojevic","year":"2016","unstructured":"Celojevic D, Abramsson A, Seibt Palmer M, Tasa G, Juronen E, Zetterberg H, Zetterberg M. EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract. Ophthalmic Genet. 2016;37:14\u20138.","journal-title":"Ophthalmic Genet"},{"key":"748_CR54","first-page":"1553","volume":"17","author":"W Tan","year":"2011","unstructured":"Tan W, Hou S, Jiang Z, Hu Z, Yang P, Ye J. Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population. Mol Vis. 2011;17:1553\u20138.","journal-title":"Mol Vis"},{"key":"748_CR55","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1471-2350-11-165","volume":"11","author":"K Hattersley","year":"2010","unstructured":"Hattersley K, Laurie KJ, Liebelt JE, Gecz J, Durkin SR, Craig JE, Burdon KP. A novel syndrome of paediatric cataract, dysmorphism, ectodermal features, and developmental delay in Australian Aboriginal family maps to 1p35.3-p36.32. BMC Med Genet. 2010;11:165.","journal-title":"BMC Med Genet"},{"key":"748_CR56","first-page":"2042","volume":"14","author":"A Shiels","year":"2008","unstructured":"Shiels A, Bennett TM, Knopf HL, Maraini G, Li A, Jiao X, Hejtmancik JF. The EPHA2 gene is associated with cataracts linked to chromosome 1p. Mol Vis. 2008;14:2042\u201355.","journal-title":"Mol Vis"},{"key":"748_CR57","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1182\/blood-2004-08-2981","volume":"105","author":"HC Aasheim","year":"2005","unstructured":"Aasheim HC, Delabie J, Finne EF. Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2. Blood. 2005;105:2869\u201376.","journal-title":"Blood"},{"key":"748_CR58","doi-asserted-by":"crossref","unstructured":"de Saint-Vis B, Bouchet C, Gautier G, Valladeau J, Caux C, Garrone P: Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. Blood 2003, 102:4431\u20134440.","DOI":"10.1182\/blood-2003-02-0500"},{"key":"748_CR59","doi-asserted-by":"publisher","first-page":"843","DOI":"10.4049\/jimmunol.172.2.843","volume":"172","author":"JG Wohlfahrt","year":"2004","unstructured":"Wohlfahrt JG, Karagiannidis C, Kunzmann S, Epstein MM, Kempf W, Blaser K, Schmidt-Weber CB. Ephrin-A1 suppresses Th2 cell activation and provides a regulatory link to lung epithelial cells. J Immunol. 2004;172:843\u201350.","journal-title":"J Immunol"},{"key":"748_CR60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S1357-2725(99)00096-5","volume":"32","author":"M Nakamoto","year":"2000","unstructured":"Nakamoto M. Eph receptors and ephrins. Int J Biochem Cell Biol. 2000;32:7\u201312.","journal-title":"Int J Biochem Cell Biol"},{"key":"748_CR61","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1242\/jcs.01061","volume":"117","author":"DM Brantley-Sieders","year":"2004","unstructured":"Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci. 2004;117:2037\u201349.","journal-title":"J Cell Sci"},{"key":"748_CR62","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-4598-1-2","volume":"1","author":"N Cheng","year":"2002","unstructured":"Cheng N, Brantley DM, Liu H, Lin Q, Enriquez M, Gale N, Yancopoulos G, Cerretti DP, Daniel TO, Chen J. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res. 2002;1:2\u201311.","journal-title":"Mol Cancer Res"},{"key":"748_CR63","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3109\/08977190109029118","volume":"18","author":"MG Coulthard","year":"2001","unstructured":"Coulthard MG, Lickliter JD, Subanesan N, Chen K, Webb GC, Lowry AJ, Koblar S, Bottema CD, Boyd AW. Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues. Growth Factors. 2001;18:303\u201317.","journal-title":"Growth Factors"},{"key":"748_CR64","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1086\/599096","volume":"199","author":"M Khounlotham","year":"2009","unstructured":"Khounlotham M, Subbian S, Smith R 3rd, Cirillo SL, Cirillo JD. Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor. J Infect Dis. 2009;199:1797\u2013806.","journal-title":"J Infect Dis"},{"key":"748_CR65","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1111\/tra.12123","volume":"14","author":"P Boissier","year":"2013","unstructured":"Boissier P, Chen J, Huynh-Do U. EphA2 signaling following endocytosis: role of Tiam1. Traffic. 2013;14:1255\u201371.","journal-title":"Traffic"},{"key":"748_CR66","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.3748\/wjg.v11.i26.4024","volume":"11","author":"C Hafner","year":"2005","unstructured":"Hafner C, Meyer S, Langmann T, Schmitz G, Bataille F, Hagen I, Becker B, Roesch A, Rogler G, Landthaler M, Vogt T. Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro. World J Gastroenterol. 2005;11:4024\u201331.","journal-title":"World J Gastroenterol"},{"key":"748_CR67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0378-1119(02)00386-4","volume":"284","author":"CE McPherson","year":"2002","unstructured":"McPherson CE, Eipper BA, Mains RE. Genomic organization and differential expression of Kalirin isoforms. Gene. 2002;284:41\u201351.","journal-title":"Gene"},{"key":"748_CR68","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1093\/cercor\/bhu182","volume":"25","author":"Y Yan","year":"2015","unstructured":"Yan Y, Eipper BA, Mains RE. Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching. Cereb Cortex. 2015;25:3487\u2013501.","journal-title":"Cereb Cortex"},{"key":"748_CR69","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1074\/jbc.274.2.993","volume":"274","author":"EA Ratovitski","year":"1999","unstructured":"Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ. Kalirin inhibition of inducible nitric-oxide synthase. J Biol Chem. 1999;274:993\u20139.","journal-title":"J Biol Chem"},{"key":"748_CR70","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1161\/ATVBAHA.112.300234","volume":"33","author":"JH Wu","year":"2013","unstructured":"Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L. Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. Arterioscler Thromb Vasc Biol. 2013;33:702\u20138.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"748_CR71","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.4049\/jimmunol.143.9.3093","volume":"143","author":"R Agah","year":"1989","unstructured":"Agah R, Malloy B, Kerner M, Mazumder A. Generation and characterization of IL-2-activated bone marrow cells as a potent graft vs tumor effector in transplantation. J Immunol. 1989;143:3093\u20139.","journal-title":"J Immunol"},{"key":"748_CR72","doi-asserted-by":"publisher","first-page":"746","DOI":"10.4049\/jimmunol.181.1.746","volume":"181","author":"S Mathew","year":"2008","unstructured":"Mathew S, Bauer KL, Fischoeder A, Bhardwaj N, Oliver SJ. The anergic state in sarcoidosis is associated with diminished dendritic cell function. J Immunol. 2008;181:746\u201355.","journal-title":"J Immunol"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-018-0748-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12931-018-0748-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-018-0748-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:36:51Z","timestamp":1693607811000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-018-0748-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["748"],"URL":"https:\/\/doi.org\/10.1186\/s12931-018-0748-5","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]},"assertion":[{"value":"28 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study received institutional review board approval (CPP IRN number 00009118) according to French legislation. Written informed consent for all participants was obtained for genetic and biological investigations.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"44"}}