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Both studies recruited subjects from two UK tertiary centers and received favorable opinions from the Cambridge South Research Ethics Committee. Written informed consent was obtained from all participants and the studies were carried out in accordance with institutional guidelines and the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"CMM, NSH, and JRF have no conflicts of interest to declare. MF and IBW received an educational award from GSK during the study period, GSK provide compensation for 50% of JC\u2019s NHS salary for clinical trial work. JRC received a grant from GSK outside this submitted work, MIP reports grants from GSK and Innovate UK during the conduct of this study, DM and RTS are employees and shareholders of GSK.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"100"}}