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The study was conducted as per the guidelines in the Declaration of Helsinki and Good Clinical Practice guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Jadwiga A. Wedzicha (JAW) has not received any speaker or consulting fees since January 2015. She has received research grants from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, and Johnson and Johnson. Dave Singh (DS) reports grants and personal fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Glenmark, Johnson and Johnson, Merck, NAPP, Novartis, Pfizer, Takeda, Teva, Theravance, and Verona, and personal fees from Genentech and Skyepharma. Ioanna Tsiligianni (IT) has received honoraria for educational activities, speaking engagements and advisory boards from Boehringer Ingelheim, Novartis, AstraZeneca and GlaxoSmithKline. Christine Jenkins (CJ) reports personal fees from Novartis Pharma AG, during the conduct of the study; grants and personal fees from GlaxoSmithKline, personal fees from AstraZeneca, Boehringer Ingelheim, Menarini, outside the submitted work. Robert Fogel (RF), Sebastian Fucile (SF), Steven Shen (SS), Pankaj Goyal (PG), Karen Mezzi (KM) are employees and shareholders of the analysis sponsor, Novartis. Konstantinos Kostikas (KK) was an employee of Novartis Pharma AG at the time of the conduct of this study. None of the authors received any compensation for the development of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"4"}}