{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:22:07Z","timestamp":1773282127947,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12931-019-1044-8","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:38:13Z","timestamp":1556084293000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-7084","authenticated-orcid":false,"given":"Ernesto","family":"Crisafulli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Teopompi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Luceri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiota","family":"Tzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Ielpo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Sverzellati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Palange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Chetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Pisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"issue":"8","key":"1044_CR1","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1164\/rccm.200304-505SO","volume":"168","author":"RL Gibson","year":"2003","unstructured":"Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med. 2003;168(8):918\u201351.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"1044_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ppul.10134","volume":"34","author":"HA Tiddens","year":"2002","unstructured":"Tiddens HA. Detecting early structural lung damage in cystic fibrosis. Pediatr Pulmonol. 2002;34(3):228\u201331.","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"1044_CR3","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/ppul.23474","volume":"51","author":"E Hatziagorou","year":"2016","unstructured":"Hatziagorou E, Kampouras A, Avramidou V, et al. Exercise responses are related to structural lung damage in CF pulmonary disease. Pediatr Pulmonol. 2016;51(9):914\u201320.","journal-title":"Pediatr Pulmonol"},{"key":"1044_CR4","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1186\/2193-1801-3-696","volume":"3","author":"BC Bongers","year":"2014","unstructured":"Bongers BC, Werkman MS, Takken T, Hulzebos EH. Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction. Springerplus. 2014;3:696.","journal-title":"Springerplus."},{"key":"1044_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1471-2466-14-74","volume":"14","author":"J Pastr\u00e9","year":"2014","unstructured":"Pastr\u00e9 J, Pr\u00e9votat A, Tardif C, Langlois C, Duhamel A, Wallaert B. Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease. BMC Pulm Med. 2014;14:74.","journal-title":"BMC Pulm Med"},{"issue":"6","key":"1044_CR6","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jcf.2013.04.010","volume":"12","author":"D Stevens","year":"2013","unstructured":"Stevens D, Stephenson A, Faughnan ME, Leek E, Tullis E. Prognostic relevance of dynamic hyperinflation during cardiopulmonary exercise testing in adult patients with cystic fibrosis. J Cyst Fibros. 2013;12(6):655\u201361.","journal-title":"J Cyst Fibros"},{"issue":"1","key":"1044_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.jpeds.2004.02.038","volume":"145","author":"AS Brody","year":"2004","unstructured":"Brody AS, Klein JS, Molina PL, Quan J, Bean JA, Wilmott RW. High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests. J Pediatr. 2004;145(1):32\u20138.","journal-title":"J Pediatr"},{"issue":"9","key":"1044_CR8","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1164\/rccm.200603-343OC","volume":"175","author":"SD Davis","year":"2007","unstructured":"Davis SD, Fordham LA, Brody AS, et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. Am J Respir Crit Care Med. 2007;175(9):943\u201350.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1044_CR9","first-page":"54","volume":"186","author":"K Weber","year":"2014","unstructured":"Weber K, Paolini M, Schmitz M, et al. Cystic fibrosis in adults: short-term and long-term reproducibility of the Brody score for lung morphology in low-dose MDCT scans. Rofo. 2014;186(1):54\u201360.","journal-title":"Rofo."},{"issue":"7","key":"1044_CR10","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1164\/rccm.201105-0816OC","volume":"184","author":"DB Sanders","year":"2011","unstructured":"Sanders DB, Li Z, Brody AS, Farrell PM. Chest computed tomography scores of severity are associated with future lung disease progression in children with cystic fibrosis. Am J Respir Crit Care Med. 2011;184(7):816\u201321.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1044_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1513\/AnnalsATS.201407-338OC","volume":"12","author":"DB Sanders","year":"2015","unstructured":"Sanders DB, Li Z, Brody AS. Chest computed tomography predicts the frequency of pulmonary exacerbations in children with cystic fibrosis. Ann Am Thorac Soc. 2015;12(1):64\u20139.","journal-title":"Ann Am Thorac Soc"},{"key":"1044_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.rmed.2016.06.016","volume":"117","author":"E Crisafulli","year":"2016","unstructured":"Crisafulli E, Alfieri V, Silva M, et al. Relationships between emphysema and airways metrics at high-resolution computed tomography (HRCT) and ventilatory response to exercise in mild to moderate COPD patients. Respir Med. 2016;117:207\u201314. \n                    https:\/\/doi.org\/10.1016\/j.rmed.2016.06.016\n                    \n                  .","journal-title":"Respir Med"},{"key":"1044_CR13","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","volume":"181S","author":"PM Farrell","year":"2017","unstructured":"Farrell PM, White TB, Ren CL, et al. Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation. J Pediatr. 2017;181S:S4\u2013S15.e1. \n                    https:\/\/doi.org\/10.1016\/j.jpeds.2016.09.064\n                    \n                  .","journal-title":"J Pediatr"},{"issue":"2","key":"1044_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V, et al. ATS\/ERS task force. Standardisation of spirometry. Eur Respir J. 2005;26(2):319\u201338.","journal-title":"Eur Respir J"},{"issue":"3","key":"1044_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1183\/09031936.05.00035005","volume":"26","author":"J Wanger","year":"2005","unstructured":"Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26(3):511\u201322.","journal-title":"Eur Respir J"},{"issue":"2","key":"1044_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1164\/rccm.167.2.211","volume":"167","author":"American Thoracic Society; American College of Chest Physicians","year":"2003","unstructured":"American Thoracic Society; American College of Chest Physicians. ATS\/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003;167(2):211\u201377.","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"1044_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1183\/13993003.00745-2015","volume":"47","author":"L Puente-Maestu","year":"2016","unstructured":"Puente-Maestu L, Palange P, Casaburi R, et al. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J. 2016;47(2):429\u201360. \n                    https:\/\/doi.org\/10.1183\/13993003.00745-2015\n                    \n                  .","journal-title":"Eur Respir J"},{"issue":"3","key":"1044_CR18","doi-asserted-by":"publisher","first-page":"1602036","DOI":"10.1183\/13993003.02036-2016","volume":"49","author":"J. Alberto Neder","year":"2017","unstructured":"Neder JA, Berton DC, Arbex FF, et al. Physiological and clinical relevance of exercise ventilatory efficiency in COPD. Eur Respir J. 2017;49(3). \n                    https:\/\/doi.org\/10.1183\/13993003.02036-2016\n                    \n                  .","journal-title":"European Respiratory Journal"},{"key":"1044_CR19","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1152\/jappl.1980.49.3.511","volume":"49","author":"DG Stubbing","year":"1980","unstructured":"Stubbing DG, Pengelly LD, Morse JL, Jones NL. Pulmonary mechanics during exercise in subjects with chronic airflow obstruction. J Appl Physiol. 1980;49:511\u20135.","journal-title":"J Appl Physiol"},{"key":"1044_CR20","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1164\/ajrccm\/144.3_Pt_1.507","volume":"144","author":"JA Regnis","year":"1991","unstructured":"Regnis JA, Alison JA, Henke KG, Donnelly PM, Bye PT. Changes in end-expiratory lung volume during exercise in cystic fibrosis relate to severity of lung disease. Am Rev Respir Dis. 1991;144:507\u201312.","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"1044_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1161\/01.CIR.57.3.549","volume":"57","author":"FL Gobel","year":"1978","unstructured":"Gobel FL, Norstrom LA, Nelson RR, Jorgensen CR, Wang Y. The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation. 1978;57(3):549\u201356.","journal-title":"Circulation."},{"key":"1044_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1037\/1082-989X.1.1.30","volume":"1","author":"KO McGraw","year":"1996","unstructured":"McGraw KO, Wong SP. Forming inferences about some intraclass correlation coefficients. Psychol Methods. 1996;1:30\u201346.","journal-title":"Psychol Methods"},{"issue":"2","key":"1044_CR23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","volume":"15","author":"TK Koo","year":"2016","unstructured":"Koo TK, Li MY. A guideline of selecting and reporting Intraclass correlation coefficients for reliability research. J Chiropr Med. 2016;15(2):155\u201363. \n                    https:\/\/doi.org\/10.1016\/j.jcm.2016.02.012\n                    \n                  .","journal-title":"J Chiropr Med"},{"issue":"3","key":"1044_CR24","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1203\/00006450-199609000-00023","volume":"40","author":"P Pianosi","year":"1996","unstructured":"Pianosi P, Wolstein R. Carbon dioxide chemosensitivity and exercise ventilation in healthy children and in children with cystic fibrosis. Pediatr Res. 1996;40(3):508\u201313.","journal-title":"Pediatr Res"},{"issue":"12","key":"1044_CR25","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1164\/rccm.201501-0157OC","volume":"191","author":"AF Elbehairy","year":"2015","unstructured":"Elbehairy AF, Ciavaglia CE, Webb KA, et al. Canadian respiratory research network. Pulmonary gas exchange abnormalities in mild chronic obstructive pulmonary disease. Implications for dyspnea and exercise intolerance. Am J Respir Crit Care Med. 2015;191(12):1384\u201394.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"1044_CR26","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/ppul.20091","volume":"38","author":"AS Bonnel","year":"2004","unstructured":"Bonnel AS, Song SM, Kesavarju K, et al. Quantitative air-trapping analysis in children with mild cystic fibrosis lung disease. Pediatr Pulmonol. 2004;38(5):396\u2013405.","journal-title":"Pediatr Pulmonol"},{"issue":"7","key":"1044_CR27","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1007\/s00330-015-4070-z","volume":"26","author":"SM Lee","year":"2016","unstructured":"Lee SM, Seo JB, Lee SM, Kim N, Oh SY, Oh YM. Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients. Eur Radiol. 2016;26(7):2184\u201392.","journal-title":"Eur Radiol"},{"issue":"5","key":"1044_CR28","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1378\/chest.130.5.1424","volume":"130","author":"EP Judge","year":"2006","unstructured":"Judge EP, Dodd JD, Masterson JB, Gallagher CG. Pulmonary abnormalities on high-resolution CT demonstrate more rapid decline than FEV1 in adults with cystic fibrosis. Chest. 2006;130(5):1424\u201332.","journal-title":"Chest."},{"issue":"6","key":"1044_CR29","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1136\/thx.2010.150375","volume":"66","author":"CM Owens","year":"2011","unstructured":"Owens CM, Aurora P, Stanojevic S, et al. London cystic fibrosis collaboration. Lung clearance index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax. 2011;66(6):481\u20138.","journal-title":"Thorax"},{"issue":"9","key":"1044_CR30","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1055\/s-0042-104936","volume":"188","author":"MO Wielp\u00fctz","year":"2016","unstructured":"Wielp\u00fctz MO, Eichinger M, Biederer J, et al. Imaging of cystic fibrosis lung disease and clinical interpretation. Rofo. 2016 Sep;188(9):834\u201345.","journal-title":"Rofo"},{"key":"1044_CR31","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1164\/rccm.201309-1659OC","volume":"189","author":"MO Wielp\u00fctz","year":"2014","unstructured":"Wielp\u00fctz MO, Puderbach M, Kopp-Schneider A, et al. Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med. 2014;189:956\u201365.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"1044_CR32","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1164\/rccm.2202033","volume":"166","author":"XG Sun","year":"2002","unstructured":"Sun XG, Hansen JE, Garatachea N, Storer TW, Wasserman K. Ventilatory efficiency during exercise in healthy subjects. Am J Respir Crit Care Med. 2002;166(11):1443\u20138.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1044_CR33","doi-asserted-by":"publisher","first-page":"e87395","DOI":"10.1371\/journal.pone.0087395","volume":"9","author":"P Gargiulo","year":"2014","unstructured":"Gargiulo P, Apostolo A, Perrone-Filardi P, Sciomer S, Palange P, Agostoni P. A non invasive estimate of dead space ventilation from exercise measurements. PLoS One. 2014;9(1):e87395.","journal-title":"PLoS One"},{"issue":"1","key":"1044_CR34","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1148\/radiol.2532090306","volume":"253","author":"M Loeve","year":"2009","unstructured":"Loeve M, Lequin MH, de Bruijne M, et al. Cystic fibrosis: are volumetric ultra-low-dose expiratory CT scans sufficient for monitoring related lung disease? Radiology. 2009;253(1):223\u20139. \n                    https:\/\/doi.org\/10.1148\/radiol.2532090306\n                    \n                  .","journal-title":"Radiology."}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-019-1044-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12931-019-1044-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-019-1044-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T23:12:52Z","timestamp":1587597172000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-019-1044-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1044"],"URL":"https:\/\/doi.org\/10.1186\/s12931-019-1044-8","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"assertion":[{"value":"5 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The ethical committee of the University Hospital of Parma approved the protocol (approval number: 200084; 07 June 2013).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"78"}}