{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T19:17:18Z","timestamp":1722885438681},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Recurrent malignant pleural effusions (MPE) are common and associated with significant morbidity in cancer patients. A new pump connecting the pleural cavity and the bladder may have application for the management of recurrent MPE. In a pre-clinical study, we investigated the utility of this pump in healthy pigs.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A novel pump system (Pleurapump\u00ae system) was inserted into four pigs under general anaesthesia. A tunnelled-pleural catheter was connected to a subcutaneously implanted pump while the urinary bladder was connected by percutaneous technique. Animals were ventilated mechanically and pump functioning was tested using a range of ventilation parameters and spontaneous breathing. Fluid was added to the pleural space to mimic pleural effusion and to assess the effectiveness of the pump at removing fluid to the bladder.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The \u2018pleurapump\u2019 system successfully transported fluid from the pleural cavity to the bladder. Pressure variations caused by respiration and variations in the amount of fluid in the pleural cavity had no impact on the pumping. Pumping stopped when the pleural cavity was drained.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This pump can be implanted into pigs and successfully removed fluid from the pleural cavity to the bladder and may represent a new treatment for management of recurrent MPE. Evaluation in humans is planned.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12931-020-01447-4","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T12:02:48Z","timestamp":1594814568000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A novel pleural-bladder pump for the management of recurrent malignant pleural effusions: a feasibility animal study"],"prefix":"10.1186","volume":"21","author":[{"given":"S.","family":"Laroumagne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Guinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Berdah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Dutau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Capel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Astoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"1447_CR1","doi-asserted-by":"publisher","unstructured":"Bibby AC, Dorn P, Psallidas I, et al. ERS\/EACTS statement on the management of malignant pleural effusions. Eur Respir J 2018; 52: 1800349 [https:\/\/doi.org\/https:\/\/doi.org\/10.1183\/13993003.00349-2018].","DOI":"10.1183\/13993003.00349-2018"},{"key":"1447_CR2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.ccm.2013.05.004","volume":"34","author":"JM Thomas","year":"2013","unstructured":"Thomas JM, Musani AI. Malignant pleural effusions: a review. Clin Chest Med. 2013;34:459\u201371.","journal-title":"Clin Chest Med"},{"key":"1447_CR3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/MCP.0b013e3283615b67","volume":"19","author":"HE Davies","year":"2013","unstructured":"Davies HE, Lee YC. Management of malignant pleural effusions: questions that need answers. 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Thorax. 2010;65(Suppl 2):ii32\u201340.","journal-title":"Thorax"},{"key":"1447_CR6","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1001\/jama.2012.5535","volume":"307","author":"HE Davies","year":"2012","unstructured":"Davies HE, Mishra EK, Kahan BC, Wrightson JM, Stanton AE, Guhan A, Davies CW, Grayez J, Harrison R, Prasad A, Crosthwaite N, Lee YC, Davies RJ, Miller RF, Rahman NM. Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial. JAMA. 2012;307:2383\u20139.","journal-title":"JAMA"},{"key":"1447_CR7","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000342343","volume":"85","author":"NF Sabur","year":"2013","unstructured":"Sabur NF, Chee A, Stather DR, Maceachern P, Amjadi K, Hergott CA, Dumoulin E, Gonzalez AV, Tremblay A. The impact of tunneled pleural catheters on the quality of life of patients with malignant pleural effusions. Respiration. 2013;85:36\u201342.","journal-title":"Respiration"},{"key":"1447_CR8","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1378\/chest.13-2481","volume":"146","author":"ED Penz","year":"2014","unstructured":"Penz ED, Mishra EK, Davies HE, Manns BJ, Miller RF, Rahman NM. Comparing cost of indwelling pleural catheter vs talc pleurodesis for malignant pleural effusion. Chest. 2014;146:991\u20131000.","journal-title":"Chest"},{"key":"1447_CR9","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.jhep.2012.12.020","volume":"58","author":"P Bellot","year":"2013","unstructured":"Bellot P, Welker MW, Soriano G, von Schaewen M, Appenrodt B, Wiest R, Whittaker S, Tzonev R, Handshiev S, Verslype C, Moench C, Zeuzem S, Sauerbruch T, Guarner C, Schott E, Johnson N, Petrov A, Katzarov K, Nevens F, Zapater P, Such J. Automated low flow pump system for the treatment of refractory ascites: a multi-center safety and efficacy study. J Hepatol. 2013;58:922\u20137.","journal-title":"J Hepatol"},{"key":"1447_CR10","unstructured":"Council of Europe. European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes. Strasbourg, 18III 1986."},{"key":"1447_CR11","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1055\/s-0034-1395796","volume":"35","author":"JH Skalski","year":"2014","unstructured":"Skalski JH, Astoul PJ, Maldonado F. Medical thoracoscopy. 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JC is an employee of Sequana Medical AG. LS, BS, DH have declared no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"184"}}