{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:13:36Z","timestamp":1761808416504,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Backgrounds<\/jats:title>\n                <jats:p>To explain the excess cardiovascular mortality observed in the SERVE-HF study, it was hypothesized that the high-pressure ASV default settings used lead to inappropriate ventilation, cascading negative consequences (i.e. not only pro-arrythmogenic effects through metabolic\/electrolyte abnormalities, but also lower cardiac output). The aims of this study are: i) to describe ASV-settings for long-term ASV-populations in real-life conditions; ii) to describe the associated minute-ventilations (MV) and therapeutic pressures for servo-controlled-flow versus servo-controlled-volume devices (ASV-F Philips\u00ae-devices versus ASV-V ResMed\u00ae-devices).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The OTRLASV-study is a cross-sectional, 5-centre study including patients who underwent ASV-treatment for at least 1 year. The eight participating clinicians were free to adjust ASV settings, which were compared among i) initial diagnosed sleep-disordered-breathing (SBD) groups (Obstructive-Sleep-Apnea (OSA), Central-Sleep-Apnea (CSA), Treatment-Emergent-Central-Sleep-Apnea (TECSA)), and ii) unsupervised groups (<jats:italic>k<\/jats:italic>-means clusters). To generate these clusters, baseline and follow-up variables were used (age, sex, body mass index (BMI), initial diagnosed Obstructive-Apnea-Index, initial diagnosed Central-Apnea-Index, Continuous-Positive-Airway-Pressure used before ASV treatment, presence of cardiopathy, and presence of a reduced left-ventricular-ejection-fraction (LVEF)). ASV-data were collected using the manufacturer\u2019s software for 6\u2009months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred seventy-seven patients (87.57% male) were analysed with a median (IQ<jats:sub>25\u201375<\/jats:sub>) initial Apnea-Hypopnea-Index of 50 (38\u201362)\/h, an ASV-treatment duration of 2.88 (1.76\u20134.96) years, 61.58% treated with an ASV-V. SDB groups did not differ in ASV settings, MV or therapeutic pressures. In contrast, the five generated <jats:italic>k<\/jats:italic>-means clusters did (generally described as follows: (C1) male-TECSA-cardiopathy, (C2) male-mostly-CSA-cardiopathy, (C3) male-mostly-TECSA-no cardiopathy, (C4) female-mostly-elevated BMI-TECSA-cardiopathy, (C5) male-mostly-OSA-low-LVEF). Of note, the male-mostly-OSA-low-LVEF-cluster-5 had significantly lower fixed end-expiratory-airway-pressure (EPAP) settings versus C1 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.029) and C4 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.007). Auto-EPAP usage was higher in the male-mostly-TECSA-no cardiopathy-cluster-3 versus C1 (<jats:italic>p<\/jats:italic>\u00a0=\u20090.006) and C2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). MV differences between ASV-F (<jats:italic>p<\/jats:italic>\u00a0=\u20090.002) and ASV-V (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) were not homogenously distributed across clusters, suggesting specific cluster and ASV-algorithm interactions. Individual ASV-data suggest that the hyperventilation risk is not related to the cluster nor the ASV-monitoring type.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Real-life ASV settings are associated with combinations of baseline and follow-up variables wherein cardiological variables remain clinically meaningful. At the patient level, a hyperventilation risk exists regardless of cluster or ASV-monitoring type, spotlighting a future role of MV-telemonitoring in the interest of patient-safety.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The OTRLASV study was registered on ClinicalTrials.gov (Identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02429986\">NCT02429986<\/jats:ext-link>). 1 April 2015.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-020-01509-7","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T13:03:52Z","timestamp":1600693432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Patterns of adaptive servo-ventilation settings in a real-life multicenter study: pay attention to volume!"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6964-4766","authenticated-orcid":false,"given":"Dany","family":"Jaffuel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Rabec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolaine","family":"Georges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Redolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Palot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carey M.","family":"Suehs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Nogue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Molinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Bourdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"1509_CR1","doi-asserted-by":"publisher","first-page":"1701516","DOI":"10.1183\/13993003.01516-2017","volume":"50","author":"TD Bradley","year":"2017","unstructured":"Bradley TD. SERVE-HF on-treatment analysis: does the on-treatment analysis SERVE its purpose? Eur Respir J. 2017;50:1701516.","journal-title":"Eur Respir J"},{"key":"1509_CR2","doi-asserted-by":"publisher","first-page":"861","DOI":"10.5664\/jcsm.2982","volume":"9","author":"K Zhu","year":"2013","unstructured":"Zhu K, Kharboutly H, Ma J, Bouzit M, Escourrou P. Bench test evaluation of adaptive servoventilation devices for sleep apnea treatment. J Clin Sleep Med. 2013;9:861\u201371.","journal-title":"J Clin Sleep Med"},{"key":"1509_CR3","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1378\/chest.13-1776","volume":"146","author":"S Javaheri","year":"2014","unstructured":"Javaheri S, Brown LK, Randerath WJ. Positive airway pressure therapy with adaptive servoventilation: part 1: operational algorithms. Chest. 2014;146:514\u201323.","journal-title":"Chest."},{"key":"1509_CR4","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1164\/rccm.201807-1303LE","volume":"199","author":"J Knitter","year":"2019","unstructured":"Knitter J, Bailey OF, Poongkunran C, Martinez AF, Martinez L, Kobayashi U, et al. Comparison of physiological performance of four adaptive servo ventilation devices in patients with complex sleep apnea. Am J Respir Crit Care Med. 2019;199:925\u20138.","journal-title":"Am J Respir Crit Care Med"},{"key":"1509_CR5","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1164\/ajrccm.164.4.9908114","volume":"164","author":"H Teschler","year":"2001","unstructured":"Teschler H, D\u00f6hring J, Wang YM, Berthon-Jones M. Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-stokes respiration in heart failure. Am J Respir Crit Care Med. 2001;164:614\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"1509_CR6","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1253\/circj.CJ-12-0689","volume":"76","author":"O Oldenburg","year":"2012","unstructured":"Oldenburg O. Cheyne-stokes respiration in chronic heart failure. Treatment with adaptive servoventilation therapy. Circ J. 2012;76:2305\u201317.","journal-title":"Circ J"},{"key":"1509_CR7","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","volume":"373","author":"MR Cowie","year":"2015","unstructured":"Cowie MR, Woehrle H, Wegscheider K, Angermann C, d\u2019Ortho M-P, Erdmann E, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. 2015;373:1095\u2013105.","journal-title":"N Engl J Med"},{"key":"1509_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1164\/rccm.201511-2198ED","volume":"193","author":"TD Bradley","year":"2016","unstructured":"Bradley TD, Floras JS. Adaptive servo-ventilation and the treatment of central sleep apnea in heart failure. Let\u2019s not throw the baby out with the bathwater. Am J Respir Crit Care Med. 2016;193:357\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"1509_CR9","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.chest.2015.12.021","volume":"149","author":"S Javaheri","year":"2016","unstructured":"Javaheri S, Brown LK, Randerath W, Khayat R. SERVE-HF: more questions than answers. Chest. 2016;149:900\u20134.","journal-title":"Chest."},{"key":"1509_CR10","first-page":"689","volume":"374","author":"M Yamauchi","year":"2016","unstructured":"Yamauchi M, Combs D, Parthasarathy S. Adaptive servo-ventilation for central sleep apnea in heart failure. N Engl J Med. 2016;374:689.","journal-title":"N Engl J Med"},{"key":"1509_CR11","doi-asserted-by":"publisher","first-page":"909","DOI":"10.5664\/jcsm.7146","volume":"14","author":"MT Naughton","year":"2018","unstructured":"Naughton MT. PRO: persistent central sleep apnea\/hunter-Cheyne-stokes breathing, despite best guideline-based therapy of heart failure with reduced ejection fraction, is a compensatory mechanism and should not be suppressed. J Clin Sleep Med. 2018;14:909\u201314.","journal-title":"J Clin Sleep Med"},{"key":"1509_CR12","doi-asserted-by":"publisher","first-page":"915","DOI":"10.5664\/jcsm.7148","volume":"14","author":"S Javaheri","year":"2018","unstructured":"Javaheri S, Brown LK, Khayat R. CON: persistent central sleep apnea\/hunter-Cheyne-stokes breathing, despite best guideline-based therapy of heart failure with reduced ejection fraction, is not a compensatory mechanism and should be suppressed. J Clin Sleep Med. 2018;14:915\u201321.","journal-title":"J Clin Sleep Med"},{"key":"1509_CR13","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1378\/chest.11-1724","volume":"141","author":"S Javaheri","year":"2012","unstructured":"Javaheri S, Shukla R, Wexler L. Association of smoking, sleep apnea, and plasma alkalosis with nocturnal ventricular arrhythmias in men with systolic heart failure. Chest. 2012;141:1449\u201356.","journal-title":"Chest."},{"key":"1509_CR14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.7326\/0003-4819-128-3-199802010-00006","volume":"128","author":"S Javaheri","year":"1998","unstructured":"Javaheri S, Corbett WS. Association of low PaCO2 with central sleep apnea and ventricular arrhythmias in ambulatory patients with stable heart failure. Ann Intern Med. 1998;128:204\u20137.","journal-title":"Ann Intern Med"},{"key":"1509_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1164\/ajrccm\/145.2_Pt_1.377","volume":"145","author":"TD Bradley","year":"1992","unstructured":"Bradley TD, Holloway RM, McLaughlin PR, Ross BL, Walters J, Liu PP. Cardiac output response to continuous positive airway pressure in congestive heart failure. Am Rev Respir Dis. 1992;145:377\u201382.","journal-title":"Am Rev Respir Dis"},{"key":"1509_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s11325-011-0571-4","volume":"16","author":"O Oldenburg","year":"2012","unstructured":"Oldenburg O, Bartsch S, Bitter T, Schmalgemeier H, Fischbach T, Westerheide N, et al. Hypotensive effects of positive airway pressure ventilation in heart failure patients with sleep-disordered breathing. Sleep Breath. 2012;16:753\u20137.","journal-title":"Sleep Breath"},{"key":"1509_CR17","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1016\/j.ijcard.2013.12.007","volume":"171","author":"N Combes","year":"2014","unstructured":"Combes N, Jaffuel D, Cayla G, Granier M, Borel JC, Corne P, et al. Pressure-dependent hemodynamic effect of continuous positive airway pressure in severe chronic heart failure: a case series. Int J Cardiol. 2014;171:e104\u20135.","journal-title":"Int J Cardiol"},{"key":"1509_CR18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1536\/ihj.15-110","volume":"56","author":"N Asakawa","year":"2015","unstructured":"Asakawa N, Sakakibara M, Noguchi K, Kamiya K, Yamada S, Yoshitani T, et al. Adaptive servo-ventilation has more favorable acute effects on hemodynamics than continuous positive airway pressure in patients with heart failure. Int Heart J. 2015;56:527\u201332.","journal-title":"Int Heart J"},{"key":"1509_CR19","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00380-015-0717-6","volume":"31","author":"J Spie\u00dfh\u00f6fer","year":"2016","unstructured":"Spie\u00dfh\u00f6fer J, Fox H, Lehmann R, Efken C, Heinrich J, Bitter T, et al. Heterogenous haemodynamic effects of adaptive servoventilation therapy in sleeping patients with heart failure and Cheyne-stokes respiration compared to healthy volunteers. Heart Vessel. 2016;31:1117\u201330.","journal-title":"Heart Vessel"},{"key":"1509_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12872-016-0455-4","volume":"17","author":"T Imamura","year":"2017","unstructured":"Imamura T, Nitta D, Kinugawa K. Optimization of pressure settings during adaptive servo-ventilation support using real-time heart rate variability assessment: initial case report. BMC Cardiovasc Disord. 2017;17:11.","journal-title":"BMC Cardiovasc Disord"},{"key":"1509_CR21","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s11325-014-1083-9","volume":"19","author":"O Oldenburg","year":"2015","unstructured":"Oldenburg O, Spie\u00dfh\u00f6fer J, Fox H, Prib N, Horstkotte D. Performance of conventional and enhanced adaptive servoventilation (ASV) in heart failure patients with central sleep apnea who have adapted to conventional ASV. Sleep Breath. 2015;19:795\u2013800.","journal-title":"Sleep Breath"},{"key":"1509_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ijcard.2020.03.078","volume":"315","author":"M Gorbachevski","year":"2020","unstructured":"Gorbachevski M, Spiesshoefer J, Arzt M, Oldenburg O, Becker S, Tuleta I, et al. Adaptive servo-ventilation therapy does not favourably alter sympatho-vagal balance in sleeping patients with systolic heart failure and central apnoeas: preliminary data. Int J Cardiol. 2020;315:59\u201366.","journal-title":"Int J Cardiol"},{"key":"1509_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.sleep.2017.02.007","volume":"37","author":"A-K Brill","year":"2017","unstructured":"Brill A-K, Pichler Hefti J, Geiser T, Ott SR. The SERVE-HF safety notice in clinical practice - experiences of a tertiary sleep center. Sleep Med. 2017;37:201\u20137.","journal-title":"Sleep Med"},{"key":"1509_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12931-019-1221-9","volume":"20","author":"D Jaffuel","year":"2019","unstructured":"Jaffuel D, Philippe C, Rabec C, Mallet J-P, Georges M, Redolfi S, et al. What is the remaining status of adaptive servo-ventilation? The results of a real-life multicenter study (OTRLASV-study): adaptive servo-ventilation in real-life conditions. Respir Res. 2019;20:235.","journal-title":"Respir Res"},{"key":"1509_CR25","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s00392-017-1112-3","volume":"106","author":"MV Malfertheiner","year":"2017","unstructured":"Malfertheiner MV, Lerzer C, Kolb L, Heider K, Zeman F, Gf\u00fcllner F, et al. Whom are we treating with adaptive servo-ventilation? A clinical post hoc analysis. Clin Res Cardiol. 2017;106:702\u201310.","journal-title":"Clin Res Cardiol"},{"key":"1509_CR26","doi-asserted-by":"publisher","first-page":"00078","DOI":"10.1183\/23120541.00078-2017","volume":"3","author":"W Randerath","year":"2017","unstructured":"Randerath W, Schumann K, Treml M, Herkenrath S, Castrogiovanni A, Javaheri S, et al. Adaptive servoventilation in clinical practice: beyond SERVE-HF? ERJ Open Res. 2017;3:00078.","journal-title":"ERJ Open Res"},{"key":"1509_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fmed.2020.00105","volume":"7","author":"C Cantero","year":"2020","unstructured":"Cantero C, Adler D, Pasquina P, Uldry C, Egger B, Prella M, et al. Adaptive servo-ventilation: a comprehensive descriptive study in the Geneva Lake area. Front Med. 2020;7:105.","journal-title":"Front Med"},{"key":"1509_CR28","first-page":"240","volume":"96","author":"M Westhoff","year":"2018","unstructured":"Westhoff M, Litterst P. Ventilation parameters under adaptive servo ventilation: a comparison on behalf of CSA-pattern, BNP\/NT-pro-BNP, and ejection fraction. Respir Int Rev Thorac Dis. 2018;96:240\u20138.","journal-title":"Respir Int Rev Thorac Dis"},{"key":"1509_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5665\/sleep.1580","volume":"35","author":"RN Aurora","year":"2012","unstructured":"Aurora RN, Chowdhuri S, Ramar K, Bista SR, Casey KR, Lamm CI, et al. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. Sleep. 2012;35:17\u201340.","journal-title":"Sleep."},{"key":"1509_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.00959-2016","volume":"49","author":"W Randerath","year":"2017","unstructured":"Randerath W, Verbraecken J, Andreas S, Arzt M, Bloch KE, Brack T, et al. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. Eur Respir J. 2017;49:1.","journal-title":"Eur Respir J"},{"key":"1509_CR31","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1023\/A:1008259009500","volume":"8","author":"S B\u00e9n\u00e9zet","year":"1997","unstructured":"B\u00e9n\u00e9zet S, Guimbaud R, Chatelut E, Chevreau C, Bugat R, Canal P. How to predict carboplatin clearance from standard morphological and biological characteristics in obese patients. Ann Oncol. 1997;8:607\u20139.","journal-title":"Ann Oncol"},{"key":"1509_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11325-007-0118-x","volume":"11","author":"TJ Kuzniar","year":"2007","unstructured":"Kuzniar TJ, Golbin JM, Morgenthaler TI. Moving beyond empiric continuous positive airway pressure (CPAP) trials for central sleep apnea: a multi-modality titration study. Sleep Breath. 2007;11:259\u201366.","journal-title":"Sleep Breath"},{"key":"1509_CR33","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.sleep.2011.07.008","volume":"12","author":"C Carnevale","year":"2011","unstructured":"Carnevale C, Georges M, Rabec C, Tamisier R, Levy P, P\u00e9pin J-L. Effectiveness of adaptive servo ventilation in the treatment of hypocapnic central sleep apnea of various etiologies. Sleep Med. 2011;12:952\u20138.","journal-title":"Sleep Med"},{"key":"1509_CR34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1136\/hrt.2005.060038","volume":"92","author":"C Philippe","year":"2006","unstructured":"Philippe C, Sto\u00efca-Herman M, Drouot X, Raffestin B, Escourrou P, Hittinger L, et al. Compliance with and effectiveness of adaptive servoventilation versus continuous positive airway pressure in the treatment of Cheyne-stokes respiration in heart failure over a six month period. Heart. 2006;92:337\u201342.","journal-title":"Heart."},{"key":"1509_CR35","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1378\/chest.13-1778","volume":"146","author":"S Javaheri","year":"2014","unstructured":"Javaheri S, Brown LK, Randerath WJ. Clinical applications of adaptive servoventilation devices: part 2. Chest. 2014;146:858\u201368.","journal-title":"Chest."},{"key":"1509_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5664\/jcsm.6880","volume":"14","author":"J-LD P\u00e9pin","year":"2018","unstructured":"P\u00e9pin J-LD, Woehrle H, Liu D, Shao S, Armitstead JP, Cistulli PA, et al. Adherence to positive airway therapy after switching from CPAP to ASV: a big data analysis. J Clin Sleep Med. 2018;14:57\u201363.","journal-title":"J Clin Sleep Med"},{"key":"1509_CR37","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.5665\/sleep.1438","volume":"34","author":"S Javaheri","year":"2011","unstructured":"Javaheri S, Goetting MG, Khayat R, Wylie PE, Goodwin JL, Parthasarathy S. The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. Sleep. 2011;34:1693\u20138.","journal-title":"Sleep."},{"key":"1509_CR38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.5664\/jcsm.27133","volume":"4","author":"CA Kushida","year":"2008","unstructured":"Kushida CA, Chediak A, Berry RB, Brown LK, Gozal D, Iber C, et al. Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea. J Clin Sleep Med. 2008;4:157\u201371.","journal-title":"J Clin Sleep Med"},{"key":"1509_CR39","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/sleep\/31.1.141","volume":"31","author":"TI Morgenthaler","year":"2008","unstructured":"Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, et al. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. An American Academy of sleep medicine report. Sleep. 2008;31:141\u20137.","journal-title":"Sleep."},{"key":"1509_CR40","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.rmr.2010.05.011","volume":"27","author":"Soci\u00e9t\u00e9 de Pneumologie de Langue Fran\u00e7aise, Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie R\u00e9animation, Soci\u00e9t\u00e9 Fran\u00e7aise de Cardiologie, Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine du Travail, Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019ORL, Soci\u00e9t\u00e9 de Physiologie","year":"2010","unstructured":"Soci\u00e9t\u00e9 de Pneumologie de Langue Fran\u00e7aise, Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie R\u00e9animation, Soci\u00e9t\u00e9 Fran\u00e7aise de Cardiologie, Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine du Travail, Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019ORL, Soci\u00e9t\u00e9 de Physiologie, et al. Recommendations for clinical practice. Obstructive sleep apnea hypopnea syndrome in adults. Rev Mal Respir. 2010;27:806\u201333.","journal-title":"Rev Mal Respir"},{"key":"1509_CR41","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/ejhf.790","volume":"19","author":"OD Lyons","year":"2017","unstructured":"Lyons OD, Floras JS, Logan AG, Beanlands R, Cantolla JD, Fitzpatrick M, et al. Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial. Eur J Heart Fail. 2017;19:579\u201387.","journal-title":"Eur J Heart Fail"},{"key":"1509_CR42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1164\/rccm.201205-0894OC","volume":"187","author":"D Yumino","year":"2013","unstructured":"Yumino D, Kasai T, Kimmerly D, Amirthalingam V, Floras JS, Bradley TD. Differing effects of obstructive and central sleep apneas on stroke volume in patients with heart failure. Am J Respir Crit Care Med. 2013;187:433\u20138.","journal-title":"Am J Respir Crit Care Med"},{"key":"1509_CR43","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1136\/thoraxjnl-2014-206569","volume":"70","author":"J-C Borel","year":"2015","unstructured":"Borel J-C, Pelletier J, Taleux N, Briault A, Arnol N, Pison C, et al. Parameters recorded by software of non-invasive ventilators predict COPD exacerbation: a proof-of-concept study. Thorax. 2015;70:284\u20135.","journal-title":"Thorax."}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-020-01509-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-020-01509-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-020-01509-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T23:26:17Z","timestamp":1632180377000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-020-01509-7"}},"subtitle":["Adaptive servo-ventilation settings in real-life conditions"],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1509"],"URL":"https:\/\/doi.org\/10.1186\/s12931-020-01509-7","relation":{},"ISSN":["1465-993X"],"issn-type":[{"type":"electronic","value":"1465-993X"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"16 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The OTRLASV study is registered on  (Identifier: NCT02429986). The protocol complied with the Declaration of Helsinki and was reviewed and approved by an independent ethics committee (<i>Comit\u00e9 de Protection des Personnes \u201cSud M\u00e9dit\u00e9rann\u00e9e III\u201d<\/i>; reference number 2014.11.04).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"- Dr. Dany Jaffuel has performed lecturing at sponsored meetings for the following companies in the last 5\u2009years: Apard, Bastide, Loewenstein Medical, Philips, SEFAM. He has sat on advisory boards for the following companies in the last 5\u2009years: Lowenstein Medical, SEFAM. He has received sponsorship support to attend academic meetings in the last 5\u2009years from Lowenstein Medical, Resmed, Philips and SEFAM.- Dr. Alain Palot has performed lecturing at sponsored meetings for the following companies in the last 5\u2009years: ARARD, Resmed, Philips. He has sat on advisory boards for the following company in the last 5\u2009years: Resmed.- Dr. Claudio Rabec has performed lecturing at sponsored meetings and\/or participated in boards for the following companies in the last 5\u2009years: Resmed, Philips, Lowenstein, Air Liquide Medical Systems.- Pr. Arnaud Bourdin reports grants, personal fees, non-financial support and other from AstraZeneca, grants, personal fees, non-financial support and other from Boeringher Ingelheim, grants, personal fees, non-financial support and other from GlaxoSmithKline, personal fees, non-financial support and other from Novartis, personal fees and non-financial support from Teva, personal fees, non-financial support and other from Regeneron, personal fees, non-financial support and other from Chiesi Farmaceuticals, grants, personal fees, non-financial support and other from Actelion, personal fees from Gilead, non-financial support and other from Roche, other from Nuvaira, from null, outside the submitted work.- Dr. Carey Suehs reports one grant from AstraZeneca, outside the submitted work.CP, EN, JPM, NM, MG, SR report no conflicts of interest in relation to the present work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"243"}}