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In epidemiological studies, many occupational and environmental exposures have been linked to sarcoidosis but their relationship with the disease phenotype has barely been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how occupational and environmental exposures prior to diagnosis relate to organ involvement in patients with sarcoidosis<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied patients seen at a sarcoidosis clinic between 2017 and 2020. Patients were included if they had a clinical presentation consistent with sarcoidosis and histologically confirmed epithelioid granulomas or had L\u00f6fgren syndrome. In a case\u2013case analysis using multivariable logistic regression we calculated odds ratios (OR) of prespecified exposure categories (based on expert ascertainment) for cases with a given organ involvement versus cases without this organ involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 238 sarcoidosis patients. Sarcoidosis limited to pulmonary involvement was associated with exposure to inorganic dust prior to diagnosis (OR 2.11; 95% confidence interval [CI] 1.11\u20134.17). Patients with liver involvement had higher odds of contact with livestock (OR 3.68; 95% CI 0.91\u201312.7) or having jobs with close human contact (OR 4.33; 95% CI 1.57\u201311.3) than patients without liver involvement. Similar associations were found for splenic involvement (livestock: OR 4.94, 95% CI 1.46\u201316.1; close human contact: OR 3.78; 95% CI 1.47\u20139.46). Cardiac sarcoidosis was associated with exposure to reactive chemicals (OR 5.08; 95% CI 1.28\u201319.2) or livestock (OR 9.86; 95% CI 1.95\u201349.0). Active smokers had more ocular sarcoidosis (OR 3.26; 95% CI 1.33\u20137.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicates that, in sarcoidosis patients, different exposures might be related to different organ involvements\u2014hereby providing support for the hypothesis that sarcoidosis has more than one cause, each of which may promote a different disease phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12931-021-01818-5","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T07:03:31Z","timestamp":1628492611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Associations between occupational and environmental exposures and organ involvement in sarcoidosis: a retrospective case-case analysis"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-2691","authenticated-orcid":false,"given":"Steven","family":"Ronsmans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Vandebroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Keirsbilck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Nemery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. 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