{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:19:44Z","timestamp":1769213984668,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Transbronchial cryobiopsy in the evaluation of patients with interstitial lung diseases (ILD) is expected to reduce the need for surgical lung biopsy (SLB).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To evaluate the diagnostic value of cryobiopsy in combination with bronchoalveolar lavage (BAL), radiologic and clinical data in patients with ILD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between 08\/15 and 01\/20 patients with ILD underwent cryobiopsy if they: did <jats:italic>not<\/jats:italic> have (i) an usual interstitial pneumonia (UIP)-pattern on CT, (ii) predominant ground-glass opacities suggesting alveolitis, (iii) findings suggestive of sarcoidosis on CT, or if they <jats:italic>had<\/jats:italic> (i) a CT showing UIP-pattern, but had findings suggesting alternative diagnosis than idiopathic pulmonary fibrosis (IPF), or (ii) had previous non-diagnostic conventional transbronchial forceps biopsy. Histological findings were integrated into the multidisciplinary team discussion (MDTD) and a diagnostic consensus was sought.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred patients underwent cryobiopsy. In 88\/100 patients, cryobiopsy was representative with diagnostic findings in 45\/88 and non-specific histological findings in 43\/88 patients. In 25\/43 with non-specific findings, a consensus diagnosis was reached after MDTD integrating BAL, radiologic and clinical data; eight of the remaining 18 patients with non-specific findings were referred to SLB. In 12\/100 patients cryobiopsy was not representative and three of these patients were also referred to SLB. In 7\/11 patients (64%) SLB was diagnostic. Complications of cryobiopsy included pneumothorax (14%) and locally controlled bleeding (24%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The diagnostic yield of cryobiopsy was 70%:45% of cryobiopsies were diagnostic based on histology alone and an additional 25% provided non-specific, but valuable findings allowing a consensus diagnosis after MDTD. Our data demonstrate that the diagnostic value of cryobiopsy is high if combined with BAL, radiologic and clinical data.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-021-01821-w","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T07:03:13Z","timestamp":1628924593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integration of transbronchial cryobiopsy into multidisciplinary board decision: a single center analysis of one hundred consecutive patients with interstitial lung disease"],"prefix":"10.1186","volume":"22","author":[{"given":"Katrin E.","family":"Hostettler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Bubendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Grendelmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bremerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spasenija Savic","family":"Prince","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"issue":"2","key":"1821_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S2213-2600(19)30342-X","volume":"8","author":"LK Troy","year":"2020","unstructured":"Troy LK, Grainge C, Corte TJ, Williamson JP, Vallely MP, Cooper WA, et al. Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study. Lancet Respir Med. 2020;8(2):171\u201381.","journal-title":"Lancet Respir Med"},{"issue":"6","key":"1821_CR2","doi-asserted-by":"publisher","first-page":"1901520","DOI":"10.1183\/13993003.01520-2019","volume":"56","author":"J Hetzel","year":"2020","unstructured":"Hetzel J, Wells AU, Costabel U, Colby TV, Walsh SLF, Verschakelen J, et al. Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicenter trial. Eur Respir J. 2020;56(6):1901520.","journal-title":"Eur Respir J"},{"issue":"5","key":"1821_CR3","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","volume":"198","author":"G Raghu","year":"2018","unstructured":"Raghu G. Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2018;198(5):e44\u201368.","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"1821_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S2213-2600(16)30033-9","volume":"4","author":"SLF Walsh","year":"2016","unstructured":"Walsh SLF, Wells AU, Desai SR, Poletti V, Piciucchi S, Dubini A, et al. Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study. Lancet Respir Med. 2016;4(7):557\u201365.","journal-title":"Lancet Respir Med"},{"issue":"4","key":"1821_CR5","doi-asserted-by":"publisher","first-page":"1900337","DOI":"10.1183\/13993003.00337-2019","volume":"54","author":"J Pannu","year":"2019","unstructured":"Pannu J, Roller LJ, Maldonado F, Lentz RJ, Chen H, Rickman OB. Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality. Eur Respir J. 2019;54(4):1900337.","journal-title":"Eur Respir J"},{"issue":"2","key":"1821_CR6","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.chest.2016.09.002","volume":"151","author":"K Ussavarungsi","year":"2017","unstructured":"Ussavarungsi K, Kern RM, Roden AC, Ryu JH, Edell ES. Transbronchial cryobiopsy in diffuse parenchymal lung disease: retrospective analysis of 74 cases. Chest. 2017;151(2):400\u20138.","journal-title":"Chest"},{"issue":"1","key":"1821_CR7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12931-020-01487-w","volume":"21","author":"B Bondue","year":"2020","unstructured":"Bondue B, Leduc D, Froidure A, Pieters T, Taton O, Heinen V, et al. Usefulness of surgical lung biopsies after cryobiopsies when pathological results are inconclusive or show a pattern suggestive of a nonspecific interstitial pneumonia. Respir Res. 2020;21(1):231.","journal-title":"Respir Res"},{"issue":"8","key":"1821_CR8","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.3390\/jcm9082499","volume":"9","author":"E Krauss","year":"2020","unstructured":"Krauss E, El-Guelai M, Pons-Kuehnemann J, Dartsch RC, Tello S, Korfei M. Clinical and functional characteristics of patients with unclassifiable interstitial lung disease (uILD): long-term follow-up data from European IPF Registry (eurIPFreg). J Clin Med. 2020;9(8):2499.","journal-title":"J Clin Med"},{"issue":"1","key":"1821_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12931-019-1091-1","volume":"20","author":"J Hetzel","year":"2019","unstructured":"Hetzel J, Eberhardt R, Petermann C, Gesierich W, Darwiche K, Hagmeyer L, et al. Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease\u2014a prospective, randomized, multicentre cross-over trial. 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BMC Pulm Med. 2019;19(1):16.","journal-title":"BMC Pulm Med"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-021-01821-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-021-01821-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-021-01821-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T19:19:43Z","timestamp":1628968783000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-021-01821-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,14]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1821"],"URL":"https:\/\/doi.org\/10.1186\/s12931-021-01821-w","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,14]]},"assertion":[{"value":"14 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients gave written informed consent to the procedure of cryobiopsy. The responsible local ethics committee of the University of Basel considered this retrospective data analysis regarding diagnostic yield of clinically indicated cryobiopsy as quality control and an ethics approval was waved.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"KEH reports no conflict of interest; MT reports no conflict of interest; LB reports no conflict of interest; PG reports no conflict of interest; KJ reports no conflict of interest; DS reports no conflict of interest; JB reports no conflict of interest; SSP reports no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"228"}}