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The study aimed to evaluate the predicting ability of N-terminal pro brain natriuretic peptide (NT-pro BNP) in patients with AECOPD-PH and its relationship with the severity of PH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A large retrospective case-controlled study (n\u2009=\u20091072) was performed in the First Affiliated Hospital of Xinjiang Medical University from January 2018 to December 2020, and patients were divided into stable COPD (n\u2009=\u2009178), AECOPD (n\u2009=\u2009688) and AECOPD-PH group (n\u2009=\u2009206). Different statistical models were used to screen for reliable and stable biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In unadjusted analysis and PSM (model 1, 2, 3), red cell distribution width (RDW), total bilirubin (TBIL), and NT-pro BNP were higher in patients with AECOPD-PH than those in AECOPD group. Logistic regression analysis showed, when the range of NT-proBNP was 271\u20131165\u00a0pg\/mL (OR: 0.293; 95%CI: 0.184\u20130.467; P\u2009&lt;\u20090.001) and NT-proBNP\u2009&gt;\u20091165\u00a0pg\/mL (OR: 0.559; 95%CI: 0.338\u20130.926; P\u2009=\u20090.024), the morbidity risk of PH in AECOPD patients was increased, so did TBIL. In receiver operating characteristic (ROC) curves, at the cut-off value of NT-proBNP was 175.14\u00a0pg\/mL, AUC was 0.651 (P\u2009&lt;\u20090.001), which was better than TBIL (AUC: 0.590, P\u2009&lt;\u20090.001). As for the results of rank correlation analysis, NT-proBNP had a weak correlation with severity of PH with AECOPD (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.299, P\u2009=\u20090.001) and its relative relevance with other biomarkers (RDW was 0.359 and TBIL was 0.238, P\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that NT-proBNP has a diagnostic efficacy in AECOPD-PH and NT-proBNP has a weak correlation with severity of PH with AECOPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12931-021-01917-3","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T04:03:55Z","timestamp":1640577835000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["NT-pro BNP in AECOPD-PH: old biomarker, new insights-based on a large retrospective case-controlled study"],"prefix":"10.1186","volume":"22","author":[{"given":"Fengming","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-7513","authenticated-orcid":false,"given":"Xiumin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"issue":"16","key":"1917_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019089","volume":"99","author":"J Liu","year":"2020","unstructured":"Liu J, Yang J, Xu S, Zhu Y, Xu S, Wei L, et al. 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