{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:26:45Z","timestamp":1790083605589,"version":"4.0.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009702","name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","doi-asserted-by":"publisher","award":["Ricerca Corrente 2021- Ottimizzazione del supporto respiratorio e gestione del paziente con insufficienza respiratoria"],"award-info":[{"award-number":["Ricerca Corrente 2021- Ottimizzazione del supporto respiratorio e gestione del paziente con insufficienza respiratoria"]}],"id":[{"id":"10.13039\/501100009702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Few data exist on high flow nasal cannula (HFNC) use in patients with acute respiratory failure (ARF) admitted to general wards.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Rationale and objectives<\/jats:title>\n                <jats:p>To retrospectively evaluate feasibility and safety of HFNC in general wards under the intensivist-supervision and after specific training.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with ARF (dyspnea, respiratory rate-RR\u2009&gt;\u200925\/min, 150\u2009&lt;\u2009PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>\u2009&lt;\u2009300\u00a0mmHg during oxygen therapy) admitted to nine wards of an academic hospital were included. Gas-exchange, RR, and comfort were assessed before HFNC and after 2 and 24\u00a0h of application.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>150 patients (81 male, age 74 [60\u201380] years, SOFA 4 [2\u20134]), 123 with de-novo ARF underwent HFNC with flow 60 L\/min [50\u201360], FiO<jats:sub>2<\/jats:sub> 50% [36\u201350] and temperature 34\u00a0\u00b0C [31\u201337]. HFNC was applied a total of 1399\u00a0days, with a median duration of 7 [3\u201311] days. No major adverse events or deaths were reported. HFNC did not affect gas exchange but reduced RR (25\u201322\/min at 2\u201324\u00a0h, p\u2009&lt;\u20090.001), and improved Dyspnea Borg Scale (3\u20131, p\u2009&lt;\u20090.001) and comfort (3\u20134, p\u2009&lt;\u20090.001) after 24\u00a0h. HFNC failed in 20 patients (19.2%): 3 (2.9%) for intolerance, 14 (13.4%) escalated to NIV\/CPAP in the ward, 3 (2.9%) transferred to ICU. Among these, one continued HFNC, while the other 2 were intubated and they both died. Predictors of HFNC failure were higher Charlson\u2019s Comorbidity Index (OR 1.29 [1.07\u20131.55]; p\u2009=\u20090.004), higher APACHE II Score (OR 1.59 [1.09\u20134.17]; p\u2009=\u20090.003), and cardiac failure as cause of ARF (OR 5.26 [1.36\u201320.46]; p\u2009=\u20090.02).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In patients with mild-moderate ARF admitted to general wards, the use of HFNC after an initial training and daily supervision by intensivists was feasible and seemed safe. HFNC was effective in improving comfort, dyspnea, and respiratory rate without effects on gas exchanges.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>\u00a0This is a single-centre, noninterventional, retrospective analysis of clinical data.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-022-02090-x","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T09:02:28Z","timestamp":1656234148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Use of high flow nasal cannula in patients with acute respiratory failure in general wards under intensivists supervision: a single center observational study"],"prefix":"10.1186","volume":"23","author":[{"given":"Sebastiano Maria","family":"Colombo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Scaravilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cortegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Corcione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Guzzardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cassinotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Canetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Carugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Ludovica","family":"Fracanzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Paleari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Galazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Grasselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,26]]},"reference":[{"issue":"12","key":"2090_CR1","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1007\/s00134-020-06312-y","volume":"46","author":"B Rochwerg","year":"2020","unstructured":"Rochwerg B, Einav S, Chaudhuri D, et al. 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The institutional ethics board of Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, approved this study and due to the nature of retrospective analysis, waived the need for informed consent from individual patients (Study RETROFLOW\u20141190_2020bis).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Prof. Grasselli received personal fees from Maquet, Biotest, Pfizer, Draeger Medical, Fisher & Paykel, MSD and received unrestricted research Grants from Fisher & Paykel and MSD. Prof. Blasi received unrestricted research Grants from Fisher & Paykel. The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"171"}}