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Middleton Memorial Veterans Hospital, Madison, Wisconsin"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Accumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains sparsely studied. We tested effects of Chronic Intermittent Hypoxia (CIH) \u2013 a hallmark of OSA \u2013 on airway hyperresponsiveness (AHR), in a rat model of chronic allergen-induced inflammation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Brown Norway rats were exposed to six weeks of CIH or normoxia (NORM) concurrent with weekly house dust mites (HDM) or saline (SAL) challenges. At endpoint, we assessed responses to seven Methacholine (Mch) doses (0, 4, 8, 16, 32, 64, 128\u00a0mg\/mL) on a FlexiVent system (Scireq). Maximal (or plateau) responses (reactivity) for total respiratory system Resistance (R<jats:sub>rs<\/jats:sub>) and Elastance (E<jats:sub>rs<\/jats:sub>), Newtonian airway resistance (R<jats:sub>N,<\/jats:sub> a measure of central airways function) and tissue damping (G, a measure of distal airways function) were plotted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>HDM\/CIH\u2013treated animals demonstrated the highest reactivity to Mch in R<jats:sub>rs<\/jats:sub> and E<jats:sub>rs<\/jats:sub> compared to all other groups (HDM\/NORM, SAL\/CIH and SAL\/NORM <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all comparisons, for doses 5\u20137 for R<jats:sub>rs<\/jats:sub>, and for doses 4\u20137 for E<jats:sub>rs<\/jats:sub>). The enhanced R<jats:sub>rs<\/jats:sub> response was due to an increase in G (doses 4\u20137, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for comparisons to all other groups), whereas R<jats:sub>N<\/jats:sub> was not affected by CIH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In rats chronically challenged with HDM, concurrent CIH exposure induces AHR primarily in the distal airways, which affects the respiratory system frequency-dependent elastic properties.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-023-02493-4","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T11:02:52Z","timestamp":1689764572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats"],"prefix":"10.1186","volume":"24","author":[{"given":"Mihaela","family":"Teodorescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruolin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald L.","family":"Sorkness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"2493_CR1","unstructured":"US Department of Health and Human Services. 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