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Early risk assessment is a prerequisite for the best possible support of high-risk patients during the weaning process. We aimed to identify risk factors for long-term IMV within 96\u00a0h (h) after the onset of IMV.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The analysis was based on data from one of Germany's largest statutory health insurance funds; patients who received IMV\u2009\u2265\u200996\u00a0h and were admitted in January 2015 at the earliest and discharged in December 2017 at the latest were analysed. OPS and ICD codes of IMV patients were considered, including the 365\u00a0days before intubation and 30\u00a0days after discharge. Long-term IMV was defined as evidence of invasive home mechanical ventilation (HMV), IMV\u2009\u2265\u2009500\u00a0h, or readmission with (re)prolonged ventilation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the analysis of 7758 hospitalisations, criteria for long-term IMV were met in 38.3% of cases, of which 13.9% had evidence of HMV, 73.1% received IMV\u2009\u2265\u2009500\u00a0h and\/or 40.3% were re-hospitalised with IMV. Several independent risk factors were identified (p\u2009&lt;\u20090.005 each), including pre-diagnoses such as pneumothorax (OR 2.10), acute pancreatitis (OR 2.64), eating disorders (OR 1.99) or rheumatic mitral valve disease (OR 1.89). Among ICU admissions, previous dependence on an aspirator or respirator (OR 5.13), and previous tracheostomy (OR 2.17) were particularly important, while neurosurgery (OR 2.61), early tracheostomy (OR 3.97) and treatment for severe respiratory failure such as positioning treatment (OR 2.31) and extracorporeal lung support (OR 1.80) were relevant procedures in the first 96\u00a0h after intubation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This comprehensive analysis of health claims has identified several risk factors for the risk of long-term ventilation. In addition to the known clinical risks, the information obtained may help to identify patients at risk at an early stage.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic>\u00a0The PRiVENT study was retrospectively registered at ClinicalTrials.gov (NCT05260853). Registered at March 2, 2022.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-024-02693-6","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T07:02:27Z","timestamp":1706338947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors for long-term invasive mechanical ventilation: a longitudinal study using German health claims data"],"prefix":"10.1186","volume":"25","clinical-trial-number":[{"clinical-trial-number":"nct05260853","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-7586","authenticated-orcid":false,"given":"Franziska C.","family":"Trudzinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia D.","family":"Michels-Zetsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Neetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Kempa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Neurohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix J. 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Data protection is guaranteed in accordance with the European Data Protection Regulation, the Baden-W\u00fcrttemberg State Data Protection Act, and the Federal Data Protection Act. Furthermore, the data protection concept has been reviewed and accepted by the data protection officer of the Heidelberg University Hospital. In accordance with the data protection regulations and the ethics vote, written patient consent was not considered necessary in this contex.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"In addition to the stated funding from the Innovation Fund of the Federal Joint Committee (G-BA), FCT reports payment or honoraria for lectures, or reimbursement of travel expenses from Novartis AG, GlaxoSmithKline, Chiesi, Boehringer Ingelheim Gmbh, Grifols and AstraZeneca. JS holds stocks of the aQua Institute for Applied Quality Improvement and Research in Health Care. JDM, BN, JM, MM, AK, CN, AS, FJFH, EB, TF, MW, SB, JSH, TB and TF have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}