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We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7\u00a0Hz (R<jats:sub>7<\/jats:sub>), frequency-dependence of resistance (R<jats:sub>7\u2009\u2212\u200919<\/jats:sub>), reactance at 7\u00a0Hz (X<jats:sub>7<\/jats:sub>), area of the reactance curve (AX), end-inspiratory and end-expiratory R (R<jats:sub>eI<\/jats:sub>, R<jats:sub>eE<\/jats:sub>) and X (X<jats:sub>eI<\/jats:sub>, X<jats:sub>eE<\/jats:sub>), and volume-dependence of resistance (\u0394R\u2009=\u2009R<jats:sub>eE<\/jats:sub>-R<jats:sub>eI<\/jats:sub>) was estimated by linear regression adjusted on confounders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher R<jats:sub>eI<\/jats:sub>, R<jats:sub>eE<\/jats:sub>, \u0394R and R<jats:sub>7<\/jats:sub> and wheezing was associated with higher \u0394R. Bronchiolitis was associated with higher R<jats:sub>7<\/jats:sub> and AX and lower X<jats:sub>eI<\/jats:sub> and bronchitis with higher R<jats:sub>eI<\/jats:sub>. No statistically significant association was observed for hospitalisation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12931-024-02701-9","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T05:02:34Z","timestamp":1708750954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort"],"prefix":"10.1186","volume":"25","author":[{"given":"Val\u00e9rie","family":"Siroux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lyon-Caen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joane","family":"Quentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Gioria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Hantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"2701_CR1","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/S0140-6736(07)61379-8","volume":"370","author":"DA Stern","year":"2007","unstructured":"Stern DA, Morgan WJ, Wright AL, Guerra S, Martinez FD. 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The cohort was approved by the relevant ethical committees (Comit\u00e9 de Protection des Personnes (CPP) Sud-Est V et Commission Nationale de L\u2019informatique et des Libert\u00e9s (CNIL)). All participating women provided a written informed consent for themselves and their children.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"99"}}