{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:10:46Z","timestamp":1794330646034,"version":"4.9.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light chain deposition disease (LCDD) is a very rare entity. Clinical manifestations of LCDD vary according to the organs involved. Data on pulmonary LCDD are scarce and limited to small series or case reports. This study aimed to describe the characteristics and outcome of diffuse pulmonary non-amyloid LCDD localized to the lungs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design and methods<\/jats:title>\n                    <jats:p>A multicenter retrospective cohort study was conducted. Clinical characteristics were collected, and chest CTs were centrally reviewed. The diagnosis of pulmonary non-amyloid LCDD was confirmed by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-one cases were identified (68% female), with a median age at diagnosis of 50 years (IQR 20). Baseline FEV1\/FVC was\u2009&lt;\u20090.70 in 45% of patients. Mean (\n                      <jats:bold>\u00b1\u2009<\/jats:bold>\n                      SD) FEV1 and DLCO were 86%\u2009\u00b1\u200926.2 and 52%\u2009\u00b1\u200923.9, respectively. CT revealed peculiar patterns of thin-walled cysts (58%) and thin-walled cystic bronchiectases (27%). Increased serum kappa light chain was found in 87% of patients. Histological analysis showed kappa light chain deposits in all patients, except one with lambda chain deposits. Median annual FEV1 decline was 127 ml (IQR 178) and median DLCO decline was 4.3% (IQR 4.3). Sixteen patients received immunomodulatory treatment or chemotherapy; serum light chain levels decreased in 9 cases (75%), without significant improvement in FEV1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.173). Overall, 48% of patients underwent bilateral lung transplantation. Transplant-free survival at 5 and 10 years were 70% and 30%, respectively. An annual FEV1 decline greater than 127 ml\/year was associated with increased risk of death or transplantation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diffuse pulmonary LCDD is characterised by female predominance, a peculiar imaging pattern with bronchiectasis and\/or cysts, progressive airway obstruction and severe DLCO impairment, and poor outcome. Lung transplantation is a treatment of choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12931-024-02798-y","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T02:01:58Z","timestamp":1712714518000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease"],"prefix":"10.1186","volume":"25","author":[{"given":"Fran\u00e7ois","family":"Lestelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Beigelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rotzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Si-Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamad","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidwine","family":"Wemeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Hirschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bunel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Sohier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Morisse","family":"Pradier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine Reynaud","family":"Gaubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gondouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Lazor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Glerant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise Thivolet","family":"Bejui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Colombat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the OrphaLung network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurdag\u00fcl","family":"Uzunhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Jouneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"2798_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.7326\/0003-4819-76-3-112-6-455","volume":"112","author":"JN Buxbaum","year":"1990","unstructured":"Buxbaum JN, Chuba JV, Hellman GC, Solomon A, Gallo GR. Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. Clinical features, immunopathology and molecular analysis. Ann Intern Med. 1990;112:455\u201364.","journal-title":"Ann Intern Med"},{"key":"2798_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","volume":"60","author":"RE Randall","year":"1976","unstructured":"Randall RE, Williamson WC, Mullinax F, Tung MY, Still WJ. Manifestations of systemic light chain deposition. Am J Med. 1976;60:293\u20139.","journal-title":"Am J Med"},{"key":"2798_CR3","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/S0889-8588(05)70123-4","volume":"13","author":"J Buxbaum","year":"1999","unstructured":"Buxbaum J, Gallo G. Nonamyloidotic monoclonal immunoglobulin deposition disease. Light-chain, heavy-chain, and light-and heavy-chain deposition diseases. Hematol Oncol Clin North Am. 1999;13:1235\u201348.","journal-title":"Hematol Oncol Clin North Am"},{"key":"2798_CR4","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1681\/ASN.V1271482","volume":"12","author":"J Lin","year":"2001","unstructured":"Lin J, Markowitz GS, Valeri AM, Kambham N, Sherman WH, Appel GB, D\u2019Agati VD. Renal monoclonal immunoglobulin deposition disease: the disease spectrum. J Am Soc Nephrol. 2001;12:1482\u201392.","journal-title":"J Am Soc Nephrol"},{"key":"2798_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1164\/rccm.201301-0071LE","volume":"188","author":"M Colombat","year":"2013","unstructured":"Colombat M, Holifanjaniaina S, Guillonneau F, Mal H, Hirschi S, Reynaud-Gaubert M, Stern M. Mass spectrometry-based proteomic analysis: a good diagnostic tool for cystic lung light chain deposition disease. Am J Respir Crit Care Med. 2013;188:404\u20135.","journal-title":"Am J Respir Crit Care Med"},{"key":"2798_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/00000478-198805000-00009","volume":"12","author":"CH Kijner","year":"1988","unstructured":"Kijner CH, Yousem SA. Systemic light chain deposition disease presenting as multiple pulmonary nodules. A case report and review of the literature. Am J Surg Pathol. 1988;12:405\u201313.","journal-title":"Am J Surg Pathol"},{"key":"2798_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1309\/3GECPW2402F6V8EK","volume":"121","author":"A Khoor","year":"2004","unstructured":"Khoor A, Myers JL, Tazelaar HD, Kurtin PJ. Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases. Am J Clin Pathol. 2004;121:200\u20134.","journal-title":"Am J Clin Pathol"},{"key":"2798_CR8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13256-020-02394-w","volume":"14","author":"JN Mezzanotte","year":"2020","unstructured":"Mezzanotte JN, Gibbons-Fideler IS, Shilo K, Lustberg M, Devarakonda S. Nodular pulmonary deposition disease in a patient with the acquired immunodeficiency syndrome: a case report. J Med Case Rep. 2020;14:64.","journal-title":"J Med Case Rep"},{"key":"2798_CR9","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S0300-2896(15)31003-6","volume":"30","author":"O Mir\u00f3","year":"1994","unstructured":"Mir\u00f3 O, Fern\u00e1ndez-Sol\u00e1 J, G\u00f3mez-Angelats E, Andreu MV, Sol\u00e9 M. [Tracheobronchomegaly associated with light chain deposition disease]. Arch Bronconeumol. 1994;30:508\u201310.","journal-title":"Arch Bronconeumol"},{"key":"2798_CR10","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1183\/09031936.00134406","volume":"29","author":"M Colombat","year":"2007","unstructured":"Colombat M, Gounant V, Mal H, Callard P, Milleron B. Light chain deposition disease involving the airways: diagnosis by fibreoptic bonchoscopy. Eur Respir J. 2007;29:1057\u201360.","journal-title":"Eur Respir J"},{"key":"2798_CR11","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1183\/09031936.00004408","volume":"31","author":"N Girard","year":"2008","unstructured":"Girard N, Vasiljevic A, Cottin V, Falchero L, Meyronet D, Thivolet-Bejui F, Cordier JF. Respiratory failure with diffuse bronchiectases and cryoglobulinaemia. Eur Respir J. 2008;31:1374\u20138.","journal-title":"Eur Respir J"},{"key":"2798_CR12","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1183\/09031936.00132007","volume":"32","author":"M Colombat","year":"2008","unstructured":"Colombat M, Caudroy S, Lagonotte E, Mal H, Danel C, Stern M, Fournier M, Birembaut P. Pathomechanisms of cyst formation in pulmonary light chain deposition disease. Eur Respir J. 2008;32:1399\u2013403.","journal-title":"Eur Respir J"},{"key":"2798_CR13","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/j.chest.2017.12.002","volume":"153","author":"T Kato","year":"2018","unstructured":"Kato T, Muto H, Hishima T, Kawashima M, Nagai H, Matsui H, Shimada M, Hebisawa A, Doki N, Miyawaki S, Ohashi K. A 56-Year-old woman with multiple pulmonary cysts and severe chest Pain. Chest. 2018;153:e105\u201312.","journal-title":"Chest"},{"key":"2798_CR14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1164\/rccm.200510-1620CR","volume":"173","author":"M Colombat","year":"2006","unstructured":"Colombat M, Stern M, Groussard O, Droz D, Brauner M, Valeyre D, Mal H, Taille C, Monnet I, Fournier M, Herson S, Danel C. Pulmonary cystic disorder related to light chain deposition disease. Am J Respir Crit Care Med. 2006;173:777\u201380.","journal-title":"Am J Respir Crit Care Med"},{"key":"2798_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.arbres.2016.08.008","volume":"53","author":"L Gorospe Saras\u00faa","year":"2017","unstructured":"Gorospe Saras\u00faa L, Pacios-Blanco RE, Arrieta P, Chinea-Rodr\u00edguez A. Intracystic hemorrhage in a patient with pulmonary cystic disorder related to light-chain deposition disease. Arch Bronconeumol. 2017;53:285\u20137.","journal-title":"Arch Bronconeumol"},{"key":"2798_CR16","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1183\/13993003.00577-2014","volume":"46","author":"AL Borgne","year":"2015","unstructured":"Borgne AL, Pr\u00e9vot G, Rouquette I, Huynh A, T\u00eatu L, Projetti F, Carreiro M, Borie R, Jaccard A, Recher C, Didier A. Blood stem cell transplantation to treat cystic lung light chain deposition disease. Eur Respir J. 2015;46:1199\u2013202.","journal-title":"Eur Respir J"},{"key":"2798_CR17","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1513\/AnnalsATS.201404-137OC","volume":"11","author":"S Hirschi","year":"2014","unstructured":"Hirschi S, Colombat M, Kessler R, Reynaud-Gaubert M, Stern M, Chenard MP, M\u00e9tivier AC, Jeung MY, Mal H. Lung transplantation for advanced cystic lung disease due to nonamyloid kappa light chain deposits. Ann Am Thorac Soc. 2014;11:1025\u201331.","journal-title":"Ann Am Thorac Soc"},{"key":"2798_CR18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.rmr.2020.01.001","volume":"37","author":"P Delaey","year":"2020","unstructured":"Delaey P, Plawny L, Nchimi A, Hirschi S, Weingertner N, Santelmo N, Wirtz G. [Effect of surgery of pulmonary cysts related to immunoglobulin light chain deposits]. Rev Mal Respir. 2020;37:180\u20136.","journal-title":"Rev Mal Respir"},{"key":"2798_CR19","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1182\/blood.2019898577","volume":"133","author":"M Camus","year":"2019","unstructured":"Camus M, Hirschi S, Prevot G, Chenard MP, Mal H, Stern M, Reynaud-Gaubert M, Gilhodes J, Burlet-Schiltz O, Brousset P, Colombat M. Proteomic evidence of specific IGKV1-8 association with cystic lung light chain deposition disease. Blood. 2019;133:2741\u20134.","journal-title":"Blood"},{"key":"2798_CR20","doi-asserted-by":"publisher","first-page":"352","DOI":"10.5858\/arpa.2020-0018-OA","volume":"145","author":"JB Gibier","year":"2021","unstructured":"Gibier JB, Perbet R, Lopez B, Colombat M, Dubois R, Humez S, Terriou L, Copin MC, Gnemmi V. Paraffin immunofluorescence increases light-chain detection in Extra-renal Light Chain Amyloidosis and other Light-Chain-Associated diseases. Arch Pathol Lab Med. 2021;145:352\u20138.","journal-title":"Arch Pathol Lab Med"},{"key":"2798_CR21","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1182\/blood-2007-11-123596","volume":"112","author":"M Colombat","year":"2008","unstructured":"Colombat M, Mal H, Copie-Bergman C, Diebold J, Damotte D, Callard P, Fournier M, Farcet JP, Stern M, fau-Larue MH. Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34\/IGKV1 receptor. Blood. 2008;112:2004\u201312.","journal-title":"Blood"},{"key":"2798_CR22","doi-asserted-by":"publisher","first-page":"105896","DOI":"10.1016\/j.rmed.2020.105896","volume":"164","author":"M Baqir","year":"2020","unstructured":"Baqir M, Moua T, White D, Yi ES, Ryu JH. Pulmonary nodular and cystic light chain deposition disease: a retrospective review of 10 cases. Respir Med. 2020;164:105896.","journal-title":"Respir Med"},{"key":"2798_CR23","doi-asserted-by":"publisher","first-page":"588","DOI":"10.21037\/atm-20-2708","volume":"8","author":"P Wei","year":"2020","unstructured":"Wei P, Tao R, Liu Y, Xie H, Jiang S, Yu D, Lu H, Cao W. Pulmonary light chain deposition disease: a case series and literature review. Annals Transl Med. 2020;8:588.","journal-title":"Annals Transl Med"},{"key":"2798_CR24","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1136\/jclinpath-2015-203342","volume":"69","author":"AV Arrossi","year":"2016","unstructured":"Arrossi AV, Merzianu M, Farver C, Yuan C, Wang SH, Nakashima MO, Cotta CV. Nodular pulmonary light chain deposition disease: an entity associated with Sj\u00f6gren syndrome or marginal zone lymphoma. J Clin Pathol. 2016;69:490\u20136.","journal-title":"J Clin Pathol"},{"key":"2798_CR25","doi-asserted-by":"publisher","first-page":"170046","DOI":"10.1183\/16000617.0046-2017","volume":"26","author":"P Milani","year":"2017","unstructured":"Milani P, Basset M, Russo F, Foli A, Palladini G, Merlini G. The lung in amyloidosis. Eur Respir Rev. 2017;26:170046.","journal-title":"Eur Respir Rev"},{"key":"2798_CR26","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.crad.2015.01.002","volume":"70","author":"S Sheard","year":"2015","unstructured":"Sheard S, Nicholson AG, Edmunds L, Wotherspoon AC, Hansell DM. Pulmonary light-chain deposition disease: CT and pathology findings in nine patients. Clin Radiol. 2015;70:515\u201322.","journal-title":"Clin Radiol"},{"key":"2798_CR27","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2214\/AJR.18.20232","volume":"212","author":"HJ Park","year":"2019","unstructured":"Park HJ, Chae EJ, Do KH, Lee SM, Song JW. Differentiation between Lymphangioleiomyomatosis and Birt-Hogg-Dub\u00e9 Syndrome: analysis of pulmonary cysts on CT images. AJR Am J Roentgenol. 2019;212:766\u201372.","journal-title":"AJR Am J Roentgenol"},{"key":"2798_CR28","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1182\/blood-2018-04-839480","volume":"132","author":"JP Fermand","year":"2018","unstructured":"Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, Merlini G. Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications. Blood. 2018;132:1478\u201385.","journal-title":"Blood"},{"key":"2798_CR29","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/bjh.16236","volume":"188","author":"RC Clayden","year":"2020","unstructured":"Clayden RC, Macdonald D, Oikonomou A, Cheung MC. Cystic lung disease with kappa light chain deposition in newly diagnosed multiple myeloma. Br J Haematol. 2020;188:201.","journal-title":"Br J Haematol"},{"key":"2798_CR30","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1056\/NEJMoa1105482","volume":"365","author":"J Vestbo","year":"2011","unstructured":"Vestbo J, Edwards LD, Scanlon PD, Yates JC, Agusti A, Bakke P, Calverley PM, Celli B, Coxson HO, Crim C, Lomas DA, MacNee W, Miller BE, Silverman EK, Tal-Singer R, Wouters E, Rennard SI. Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med. 2011;365:1184\u201392.","journal-title":"N Engl J Med"},{"key":"2798_CR31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13023-020-01402-y","volume":"15","author":"C Daccord","year":"2020","unstructured":"Daccord C, Cottin V, Pr\u00e9vot G, Uzunhan Y, Mornex JF, Bonniaud P, Borie R, Briault A, Collonge-Rame MA, Crestani B, Devouassoux G, Freynet O, Gondouin A, Hauss PA, Khouatra C, Leroy S, Marchand-Adam S, Marquette C, Montani D, Naccache JM, Nadeau G, Poulalhon N, Reynaud-Gaubert M, Salaun M, Wallaert B, Cordier JF, Faouzi M, Lazor R. Lung function in Birt-Hogg-Dub\u00e9 syndrome: a retrospective analysis of 96 patients. Orphanet J Rare Dis. 2020;15:120.","journal-title":"Orphanet J Rare Dis"},{"key":"2798_CR32","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1378\/chest.126.6.1867","volume":"126","author":"AM Taveira-DaSilva","year":"2004","unstructured":"Taveira-DaSilva AM, Stylianou MP, Hedin CJ, Hathaway O, Moss J. Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone. Chest. 2004;126:1867\u201374.","journal-title":"Chest"},{"key":"2798_CR33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13023-015-0249-2","volume":"10","author":"A Tazi","year":"2015","unstructured":"Tazi A, de Margerie C, Naccache JM, Fry S, Dominique S, Jouneau S, Lorillon G, Bugnet E, Chiron R, Wallaert B, Valeyre D, Chevret S. The natural history of adult pulmonary Langerhans cell histiocytosis: a prospective multicentre study. Orphanet J Rare Dis. 2015;10:30.","journal-title":"Orphanet J Rare Dis"},{"key":"2798_CR34","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0272-6386(12)80314-3","volume":"20","author":"RL Heilman","year":"1992","unstructured":"Heilman RL, Velosa JA, Holley KE, Offord KP, Kyle RA. Long-term follow-up and response to chemotherapy in patients with light-chain deposition disease. Am J Kidney Dis. 1992;20:34\u201341.","journal-title":"Am J Kidney Dis"},{"key":"2798_CR35","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/j.1523-1755.2004.00427.x","volume":"65","author":"B Royer","year":"2004","unstructured":"Royer B, Arnulf B, Martinez F, Roy L, Flageul B, Etienne I, Ronco P, Brouet JC, Fermand JP. High dose chemotherapy in light chain or light and heavy chain deposition disease. Kidney Int. 2004;65:642\u20138.","journal-title":"Kidney Int"},{"key":"2798_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1053\/j.ajkd.2003.09.020","volume":"43","author":"N Leung","year":"2004","unstructured":"Leung N, Lager DJ, Gertz MA, Wilson K, Kanakiriya S, Fervenza FC. Long-term outcome of renal transplantation in light-chain deposition disease. Am J Kidney Dis. 2004;43:147\u201353.","journal-title":"Am J Kidney Dis"},{"key":"2798_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/13506129.2017.1334196","volume":"24","author":"A Aimo","year":"2017","unstructured":"Aimo A, Vergaro G, Pucci A, Bernazzali S, Maccherini M, Buda G, Passino C, Merlini G, Emdin M. Cardiac light-chain deposition disease relapsing in the transplanted heart. Amyloid. 2017;24:135\u20137. OrphaLung network (collaborators) 19 Yurdag\u00fcl UZUNHAN, Avicenne hospital, APHP, Paris Nord university, Paris, France 20 St\u00e9phane JOUNEAU, Pontchaillou Hospital, Rennes, France.","journal-title":"Amyloid"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-02798-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-024-02798-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-02798-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T02:08:05Z","timestamp":1712714885000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-024-02798-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2798"],"URL":"https:\/\/doi.org\/10.1186\/s12931-024-02798-y","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"18 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted with respect to the Declaration of Helsinki. It was approved by the ethics committee of the <i>Hospices Civils de Lyon<\/i> and was registered with the national data protection agency (Commission Nationale de l\u2019Informatique et des Libert\u00e9s, number 20\u2013075). According to the legislation in place at the time of the study, informed consent signature was waived, but each patient was informed by a written letter and could object to the use of their personal data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"159"}}