{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:34:36Z","timestamp":1791419676904,"version":"4.3.3"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Wenzhou Science and Technology Bureau","award":["Y20210281"],"award-info":[{"award-number":["Y20210281"]}]},{"name":"the Zhejiang Province Natural Science Foundation of China","award":["LQ21H040009"],"award-info":[{"award-number":["LQ21H040009"]}]},{"name":"the Zhejiang Province Natural Science Foundation of China","award":["Y21H040044"],"award-info":[{"award-number":["Y21H040044"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-024-03039-y","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:08:53Z","timestamp":1732079333000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF\/PI3K\/AKT pathway"],"prefix":"10.1186","volume":"25","author":[{"given":"Xiaoya","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"3039_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1053\/j.semperi.2006.05.010","volume":"30","author":"PJ Anderson","year":"2006","unstructured":"Anderson PJ, Doyle LW. Neurodevelopmental outcome of bronchopulmonary dysplasia. Semin Perinatol. 2006;30:227\u201332.","journal-title":"Semin Perinatol"},{"key":"3039_CR2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00408-018-0084-z","volume":"196","author":"JS Hwang","year":"2018","unstructured":"Hwang JS, Rehan VK. Recent advances in bronchopulmonary dysplasia: pathophysiology, prevention, and treatment. Lung. 2018;196:129\u201338.","journal-title":"Lung"},{"key":"3039_CR3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.14140","volume":"4","author":"MFB Villosis","year":"2021","unstructured":"Villosis MFB, Barseghyan K, Ambat MT, Rezaie KK, Braun D. Rates of bronchopulmonary dysplasia following implementation of a novel prevention bundle. JAMA Netw Open. 2021;4: e2114140.","journal-title":"JAMA Netw Open"},{"key":"3039_CR4","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1053\/j.semperi.2015.09.004","volume":"39","author":"CV Lal","year":"2015","unstructured":"Lal CV, Ambalavanan N. Genetic predisposition to bronchopulmonary dysplasia. Semin Perinatol. 2015;39:584\u201391.","journal-title":"Semin Perinatol"},{"key":"3039_CR5","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s00431-022-04779-z","volume":"182","author":"X Luo","year":"2023","unstructured":"Luo X, Zhao M, Chen C, Lin F, Li X, Huang H, Dou L, Feng J, Xiao S, Liu D, et al. Identification of genetic susceptibility in preterm newborns with bronchopulmonary dysplasia by whole-exome sequencing: BIVM gene may play a role. Eur J Pediatr. 2023;182:1707\u201318.","journal-title":"Eur J Pediatr"},{"key":"3039_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2023.151811","volume":"47","author":"PM Lavoie","year":"2023","unstructured":"Lavoie PM, Rayment JH. Genetics of bronchopulmonary dysplasia: An update. Semin Perinatol. 2023;47: 151811.","journal-title":"Semin Perinatol"},{"key":"3039_CR7","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.clp.2015.08.010","volume":"42","author":"PM Mourani","year":"2015","unstructured":"Mourani PM, Abman SH. Pulmonary hypertension and vascular abnormalities in bronchopulmonary dysplasia. Clin Perinatol. 2015;42:839\u201355.","journal-title":"Clin Perinatol"},{"key":"3039_CR8","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1056\/NEJMra067279","volume":"357","author":"E Baraldi","year":"2007","unstructured":"Baraldi E, Filippone M. Chronic lung disease after premature birth. N Engl J Med. 2007;357:1946\u201355.","journal-title":"N Engl J Med"},{"key":"3039_CR9","doi-asserted-by":"publisher","first-page":"L421","DOI":"10.1152\/ajplung.00316.2019","volume":"318","author":"K Dolma","year":"2020","unstructured":"Dolma K, Freeman AE, Rezonzew G, Payne GA, Xu X, Jilling T, Blalock JE, Gaggar A, Ambalavanan N, Lal CV. Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice. Am J Physiol Lung Cell Mol Physiol. 2020;318:L421\u20138.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3039_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2023.151817","volume":"47","author":"A El-Saie","year":"2023","unstructured":"El-Saie A, Varghese NP, Webb MK, Villafranco N, Gandhi B, Guaman MC, Shivanna B. Bronchopulmonary dysplasia - associated pulmonary hypertension: An updated review. Semin Perinatol. 2023;47: 151817.","journal-title":"Semin Perinatol"},{"key":"3039_CR11","doi-asserted-by":"publisher","first-page":"L600","DOI":"10.1152\/ajplung.2000.279.3.L600","volume":"279","author":"M Jakkula","year":"2000","unstructured":"Jakkula M, Le Cras TD, Gebb S, Hirth KP, Tuder RM, Voelkel NF, Abman SH. Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am J Physiol Lung Cell Mol Physiol. 2000;279:L600\u20137.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3039_CR12","doi-asserted-by":"publisher","first-page":"L832","DOI":"10.1152\/ajplung.00369.2019","volume":"317","author":"E Lignelli","year":"2019","unstructured":"Lignelli E, Palumbo F, Myti D, Morty RE. Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2019;317:L832\u201387.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3039_CR13","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.7150\/thno.26024","volume":"8","author":"B Yu","year":"2018","unstructured":"Yu B, Wang S. Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease. Theranostics. 2018;8:3654\u201375.","journal-title":"Theranostics"},{"key":"3039_CR14","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1093\/cvr\/cvaa050","volume":"116","author":"KR Zahid","year":"2020","unstructured":"Zahid KR, Raza U, Chen J, Raj UJ, Gou D. Pathobiology of pulmonary artery hypertension: role of long non-coding RNAs. Cardiovasc Res. 2020;116:1937\u201347.","journal-title":"Cardiovasc Res"},{"key":"3039_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112421","volume":"145","author":"R Jayasuriya","year":"2022","unstructured":"Jayasuriya R, Ganesan K, Xu B, Ramkumar KM. Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms. Biomed Pharmacother. 2022;145: 112421.","journal-title":"Biomed Pharmacother"},{"key":"3039_CR16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cell.2011.10.003","volume":"147","author":"B-S Ding","year":"2011","unstructured":"Ding B-S, Nolan Daniel J, Guo P, Babazadeh Alexander O, Cao Z, Rosenwaks Z, Crystal Ronald G, Simons M, Sato Thomas N, Worgall S, et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011;147:539\u201353.","journal-title":"Cell"},{"key":"3039_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.semcdb.2023.05.001","volume":"155","author":"CY Ng","year":"2024","unstructured":"Ng CY, Cheung C. Origins and functional differences of blood endothelial cells. Semin Cell Dev Biol. 2024;155:23\u20139.","journal-title":"Semin Cell Dev Biol"},{"key":"3039_CR18","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1126\/science.aar4800","volume":"362","author":"JM Gomez-Salinero","year":"2018","unstructured":"Gomez-Salinero JM, Rafii S. Endothelial cell adaptation in regeneration. Science. 2018;362:1116\u20137.","journal-title":"Science"},{"key":"3039_CR19","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N Ferrara","year":"2003","unstructured":"Ferrara N, Gerber H-P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669\u201376.","journal-title":"Nat Med"},{"key":"3039_CR20","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41580-023-00631-w","volume":"24","author":"L P\u00e9rez-Guti\u00e9rrez","year":"2023","unstructured":"P\u00e9rez-Guti\u00e9rrez L, Ferrara N. Biology and therapeutic targeting of vascular endothelial growth factor A. Nat Rev Mol Cell Biol. 2023;24:816\u201334.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3039_CR21","first-page":"455","volume":"59","author":"CS Melincovici","year":"2018","unstructured":"Melincovici CS, Bo\u015fca AB, \u015eu\u015fman S, M\u0103rginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018;59:455\u201367.","journal-title":"Rom J Morphol Embryol"},{"key":"3039_CR22","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1080\/14767058.2020.1760826","volume":"35","author":"J Mariduena","year":"2022","unstructured":"Mariduena J, Ramagopal M, Hiatt M, Chandra S, Laumbach R, Hegyi T. Vascular endothelial growth factor levels and bronchopulmonary dysplasia in preterm infants. J Matern Fetal Neonatal Med. 2022;35:1517\u201322.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"3039_CR23","doi-asserted-by":"publisher","first-page":"41202","DOI":"10.1038\/srep41202","volume":"7","author":"L Wang","year":"2017","unstructured":"Wang L, Xu Z, Chen B, He W, Hu J, Zhang L, Liu X, Chen F. The role of vascular endothelial growth factor in small-airway remodelling in a rat model of chronic obstructive pulmonary disease. Sci Rep. 2017;7:41202.","journal-title":"Sci Rep"},{"key":"3039_CR24","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.dci.2009.01.004","volume":"33","author":"FB Sow","year":"2009","unstructured":"Sow FB, Gallup JM, Meyerholz DK, Ackermann MR. Gene profiling studies in the neonatal ovine lung show enhancing effects of VEGF on the immune response. Dev Comp Immunol. 2009;33:761\u201371.","journal-title":"Dev Comp Immunol"},{"key":"3039_CR25","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.3390\/ijms24032729","volume":"24","author":"S Perrone","year":"2023","unstructured":"Perrone S, Manti S, Buttarelli L, Petrolini C, Boscarino G, Filonzi L, Gitto E, Esposito SMR, Nonnis Marzano F. Vascular endothelial growth factor as molecular target for bronchopulmonary dysplasia prevention in very low birth weight infants. Int J Mol Sci. 2023;24:2729.","journal-title":"Int J Mol Sci"},{"key":"3039_CR26","doi-asserted-by":"publisher","first-page":"30336","DOI":"10.1074\/jbc.273.46.30336","volume":"273","author":"HP Gerber","year":"1998","unstructured":"Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3\u2019-kinase\/Akt signal transduction pathway. Requirement for Flk-1\/KDR activation. J Biol Chem. 1998;273:30336\u201343.","journal-title":"J Biol Chem"},{"key":"3039_CR27","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1161\/01.RES.0000022200.71892.9F","volume":"90","author":"I Shiojima","year":"2002","unstructured":"Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002;90:1243\u201350.","journal-title":"Circ Res"},{"key":"3039_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13046-017-0495-3","volume":"36","author":"HW Cheng","year":"2017","unstructured":"Cheng HW, Chen YF, Wong JM, Weng CW, Chen HY, Yu SL, Chen HW, Yuan A, Chen JJ. Cancer cells increase endothelial cell tube formation and survival by activating the PI3K\/Akt signalling pathway. J Exp Clin Cancer Res. 2017;36:27.","journal-title":"J Exp Clin Cancer Res"},{"key":"3039_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114654","volume":"162","author":"Y Dun","year":"2023","unstructured":"Dun Y, Hu H, Liu F, Shao Y, He D, Zhang L, Shen J. PTTG1 promotes CD34(+)CD45(+) cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF\/PI3K\/AKT\/eNOS signaling pathway in rats with phosgene-induced acute lung injury. Biomed Pharmacother. 2023;162: 114654.","journal-title":"Biomed Pharmacother"},{"key":"3039_CR30","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"3039_CR31","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.047753","volume":"14","author":"K Giusto","year":"2021","unstructured":"Giusto K, Wanczyk H, Jensen T, Finck C. Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies. Dis Models Mech. 2021;14: dmm047753.","journal-title":"Dis Models Mech"},{"key":"3039_CR32","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nprot.2010.6","volume":"5","author":"I Arnaoutova","year":"2010","unstructured":"Arnaoutova I, Kleinman HK. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat Protoc. 2010;5:628\u201335.","journal-title":"Nat Protoc"},{"key":"3039_CR33","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbrc.2017.04.112","volume":"487","author":"RT Menon","year":"2017","unstructured":"Menon RT, Shrestha AK, Shivanna B. Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants. Biochem Biophys Res Commun. 2017;487:666\u201371.","journal-title":"Biochem Biophys Res Commun"},{"key":"3039_CR34","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","volume":"4","author":"J Karar","year":"2011","unstructured":"Karar J, Maity A. PI3K\/AKT\/mTOR pathway in angiogenesis. Front Mol Neurosci. 2011;4:51.","journal-title":"Front Mol Neurosci"},{"key":"3039_CR35","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1039\/C5MB00101C","volume":"11","author":"T Ersahin","year":"2015","unstructured":"Ersahin T, Tuncbag N, Cetin-Atalay R. The PI3K\/AKT\/mTOR interactive pathway. Mol Biosyst. 2015;11:1946\u201354.","journal-title":"Mol Biosyst"},{"key":"3039_CR36","doi-asserted-by":"publisher","first-page":"1238782","DOI":"10.3389\/fphar.2023.1238782","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Kong H, Cai H, Chen G, Chen H, Ruan W. Progression of the PI3K\/Akt signaling pathway in chronic obstructive pulmonary disease. Front Pharmacol. 2023;14:1238782.","journal-title":"Front Pharmacol"},{"key":"3039_CR37","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s00795-018-0182-2","volume":"51","author":"H Nakanishi","year":"2018","unstructured":"Nakanishi H, Morikawa S, Kitahara S, Yoshii A, Uchiyama A, Kusuda S, Ezaki T. Morphological characterization of pulmonary microvascular disease in bronchopulmonary dysplasia caused by hyperoxia in newborn mice. Med Mol Morphol. 2018;51:166\u201375.","journal-title":"Med Mol Morphol"},{"key":"3039_CR38","doi-asserted-by":"publisher","first-page":"731","DOI":"10.14336\/AD.2018.1001","volume":"10","author":"T Li","year":"2019","unstructured":"Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z. Galectin-3 mediates endothelial-to-mesenchymal transition in pulmonary arterial hypertension. Aging Dis. 2019;10:731\u201345.","journal-title":"Aging Dis"},{"key":"3039_CR39","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/bdra.23226","volume":"100","author":"SK Ahlfeld","year":"2014","unstructured":"Ahlfeld SK, Conway SJ. Assessment of inhibited alveolar-capillary membrane structural development and function in bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100:168\u201379.","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"3039_CR40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1165\/rcmb.2021-0004OC","volume":"65","author":"SV Appuhn","year":"2021","unstructured":"Appuhn SV, Siebert S, Myti D, Wrede C, Surate Solaligue DE, P\u00e9rez-Bravo D, Brandenberger C, Schipke J, Morty RE, Grothausmann R, M\u00fchlfeld C. Capillary changes precede disordered alveolarization in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol. 2021;65:81\u201391.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3039_CR41","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1164\/ajrccm.164.10.2101140","volume":"164","author":"AJ Bhatt","year":"2001","unstructured":"Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM. Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;164:1971\u201380.","journal-title":"Am J Respir Crit Care Med"},{"key":"3039_CR42","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jpeds.2022.04.028","volume":"246","author":"JM Collaco","year":"2022","unstructured":"Collaco JM, McGrath-Morrow SA, Griffiths M, Chavez-Valdez R, Parkinson C, Zhu J, Northington FJ, Graham EM, Everett AD. Perinatal inflammatory biomarkers and respiratory disease in preterm infants. J Pediatr. 2022;246:34-39.e33.","journal-title":"J Pediatr"},{"key":"3039_CR43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/dmcn.15468","volume":"65","author":"O Dammann","year":"2023","unstructured":"Dammann O, Hartnett ME, Stahl A. Retinopathy of prematurity. Dev Med Child Neurol. 2023;65:625\u201331.","journal-title":"Dev Med Child Neurol"},{"key":"3039_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev-vision-093022-021420","volume":"9","author":"ME Hartnett","year":"2023","unstructured":"Hartnett ME. Pathophysiology of retinopathy of prematurity. Annu Rev Vis Sci. 2023;9:39\u201370.","journal-title":"Annu Rev Vis Sci"},{"key":"3039_CR45","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.64.7.11","volume":"64","author":"XC Ling","year":"2023","unstructured":"Ling XC, Kang EY, Chen KJ, Wang NK, Liu L, Chen YP, Hwang YS, Lai CC, Yang SF, Wu WC. Associations of VEGF polymorphisms with retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2023;64:11.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3039_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11248-020-00223-w","volume":"30","author":"MZZ Myint","year":"2021","unstructured":"Myint MZZ, Jia J, Adlat S, Oo ZM, Htoo H, Hayel F, Chen Y, Bah FB, Sah RK, Bahadar N, et al. Effect of low VEGF on lung development and function. Transgenic Res. 2021;30:35\u201350.","journal-title":"Transgenic Res"},{"key":"3039_CR47","doi-asserted-by":"publisher","first-page":"L555","DOI":"10.1152\/ajplung.00408.2001","volume":"283","author":"TD Le Cras","year":"2002","unstructured":"Le Cras TD, Markham NE, Tuder RM, Voelkel NF, Abman SH. Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol. 2002;283:L555\u201362.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3039_CR48","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1165\/rcmb.2004-0287OC","volume":"32","author":"SA McGrath-Morrow","year":"2005","unstructured":"McGrath-Morrow SA, Cho C, Cho C, Zhen L, Hicklin DJ, Tuder RM. Vascular endothelial growth factor receptor 2 blockade disrupts postnatal lung development. Am J Respir Cell Mol Biol. 2005;32:420\u20137.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3039_CR49","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1002\/jcb.30344","volume":"123","author":"A Ahmad","year":"2022","unstructured":"Ahmad A, Nawaz MI. Molecular mechanism of VEGF and its role in pathological angiogenesis. J Cell Biochem. 2022;123:1938\u201365.","journal-title":"J Cell Biochem"},{"key":"3039_CR50","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target Ther. 2023;8:198.","journal-title":"Signal Transduct Target Ther"},{"key":"3039_CR51","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nrc1753","volume":"5","author":"AG Bader","year":"2005","unstructured":"Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer. 2005;5:921\u20139.","journal-title":"Nat Rev Cancer"},{"key":"3039_CR52","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrd2926","volume":"8","author":"P Liu","year":"2009","unstructured":"Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009;8:627\u201344.","journal-title":"Nat Rev Drug Discov"},{"key":"3039_CR53","doi-asserted-by":"publisher","first-page":"235","DOI":"10.32604\/or.2022.025323","volume":"29","author":"ZN Navaei","year":"2021","unstructured":"Navaei ZN, Khalili-Tanha G, Zangouei AS, Abbaszadegan MR, Moghbeli M. PI3K\/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells. Oncol Res. 2021;29:235\u201350.","journal-title":"Oncol Res"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-03039-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-024-03039-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-03039-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:26:11Z","timestamp":1732091171000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-024-03039-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3039"],"URL":"https:\/\/doi.org\/10.1186\/s12931-024-03039-y","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"assertion":[{"value":"22 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Research Ethics Committee of the Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, China (Approval No.LS 2021-K-311-03), and it was performed in accordance with the Declaration of Helsinki. The patients\/participants provided written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"412"}}